Protective effects of moderate hypothermia after neonatal hypoxia- ischemia: Short- and long-term outcome

Pediatric Research

Volumn 43, Issue 6, 1998, Pages 738-745

  Bona, Elsa ^a   Hagberg, Henrik ^a,b   Løberg, Else Marit ^c   Bågenholm, Ralph ^a   Thoresen, Marianne ^c,d,e  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e ST MICHAEL'S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; CONTROLLED STUDY; HISTOPATHOLOGY; HYPOTHERMIA; HYPOXIA; ISCHEMIA; NEUROPATHOLOGY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; TREATMENT OUTCOME;

EID: 0031801912     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199806000-00005     Document Type: Article

References (34)

1. Westin B, Nyberg R, Miller JA, Wedenberg E 1962 Hypothermia and transfusion with oxygenated blood in the treatment of asphyxia neonatorum. Acta Paediatr Scand Suppl 51:1-80
2. Metz C, Holzschuh M, Bein T, Woertgen C, Frey A, Frey I, Taeger K, Brawanski A 1996 Moderate hypothermia in patients with severe head injury: cerebral and extracerebral effects. J Neurosurg 85:533-541
3. Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST 1997 Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med 336:540-546
4. Mahler J, Hachinski V 1993 Hypothermia as a potential treatment for cerebral ischemia. Cerebrovasc Brain Metab Rev 5:277-300
5. Ginsberg MD, Sternau LL, Globus MY-T, Dietrich WD, Busto R 1992 Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev 4:189-225
6. Colbourne F, Corbett D 1994 Delayed and prolonged post-ischaemic hypothermia is neuroprotective in the gerbil. Brain Res 654:265-272
7. Colbourne F, Corbett D 1995 Delayed postischaemic hypothermia: a six month survival study using behavioral and histological assessment of neuroprotection. J Neurosci 15:7250-7260
8. Coimbra C, Drake M, Boris-Möller F, Wieloch T 1996 Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/ antipyretic drug - evidence for chronic encephalopathic processes following ischemia. Stroke 27:1578-1585
9. Dietrich WD, Busto R, Alonso O, Globus MY-T, Ginsberg MD 1993 Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab 13:541-549
10. Amess PN, Penrice J, Cady EB, Lorek A, Wylezinska M, Cooper CE, Dsouza P, Tyszczuk L, Thoresen M, Edwards AD, Wyatt JS, Reynolds EOR 1997 Mild hypothermia after severe transient hypoxia ischemia reduces the delayed rise in cerebral lactate in the newborn piglet. Pediatr Res 41:803-808
11. Haaland K, Løberg EM, Steen PA, Thoresen M 1997 Posthypoxic hypothermia in newborn piglets. Pediatr Res 41:505-512
12. Laptook AR, Corbett RJT, Sterett R, Burns DK, Garcia D, Tollefsbol G 1997 Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia. Pediatr Res 42:17-24
13. Thoresen M, Penrice U, Lorek A, Cady EB, Wylezinska M, Kirkbride V, Cooper CE, Brown GC, Edwards AD, Wyatt JS, Reynolds EOR 1995 Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res 37:667-670
14. Thoresen M, Bågenholm R, Løberg EM, Apricena F, Kjellmer I 1996 Posthypoxic cooling of neonatal rats provides protection against brain injury. Arch Dis Child 74:F3-9
15. Thoresen M, Wyatt J Keeping a cool head, posthypoxic hypothermia - an old idea revisited. Acta Paediatr Scand 86:1029-1033
16. Rice JE, Vannucci RC, Brierley JB 1981 The influence of immaturity on hypoxicischemic brain damage in the rat. Ann Neurol 9:131-141
17. Romijn HJ, Hofman MA, Gramsbergen A 1991 At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby? Early Hum Dev 26:61-67
18. Hagberg H, Bona E, Gilland E, Puka-Sundvall M 1997 Hypoxia-ischemia model in the 7-day-old rat: possibilities and shortcomings. Acta Paediatr Suppl 442:85-88
19. Bona E, Johansson BB, Hagberg H 1997 Sensorimotor function and neuropathology five to six weeks after hypoxia-ischemia in seven-day-old rats. Pediatr Res 42:678-683
20. Barth TM, Stanfield BB 1990 The recovery of forelimb-placing behavior in rats with neonatal unilateral cortical damage involves the remaining hemisphere. J Neurosci 10:3449-3459
21. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H 1986 Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476
22. De Ryck M, Van Reempts J, Borgers M, Wauquier A, Janssen AJ 1989 Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 20:1383-1390
23. Ohlsson A-L, Johansson BB 1995 Environment influences functional outcome of cerebral infarction in rats. Stroke 26:644-649
24. Borlongan CV, Randall TS, Cahill DW, Sanberg PR 1995 Asymmetrical motor behavior in rats with unilateral striatal excitotoxic lesions as revealed by the elevated body swing test. Brain Res 676:231-234
25. Boksa P, Krishnamurthy A, Brooks W 1995 Effects of a period of asphyxia during birth on spatial learning in the rat. Pediatr Res 37:489-496
26. Yager JY, Heitjan DF, Towfighi J, Vannucci RC 1992 Effect of insulin-induced and fasting hypoglycemia on perinatal hypoxic-ischemic brain damage. Pediatr Res 31:138-142
27. Trescher WH, Ishiwa S, Johnston MV 1997 Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury. Brain Dev 19:326-338
28. Gunn AJ, Gunn TR, deHaan HH, Williams CE, Gluckman PD 1997 Dramatic neuronal rescue with prolonged selective heed cooling after ischemia in fetal lambs. J Clin Invest 99:248-56
29. Castro AJ 1977 Limb preferences after lesions of the cerebral hemisphere in adult and neonatal rats. Physiol Behav 18:605-608
30. Pazos AJ, Orezzoli SL, McCabe PM, Dietrich WD, Green EJ 1995 Recovery of vibrissae-dependent behavioral responses following barrelfield damage is not dependent upon the remaining somatosensory cortical tissue. Brain Res 689:224-232
31. Johansson BB 1996 Functional outcome in rats transferred to an enriched environment 15 days after focal brain ischemia. Stroke 27:324-326
32. Markgraf CG, Green EJ, Hurwitz BE, Morikawa E, Dietrich WD, McCabe PM, Ginsberg MD, Schneiderman N 1992 Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats. Brain Res 575:238-246
33. Young RSK, Kolnich J, Woods CL, Yagel SK 1986 Behavioral performance of rats following neonatal hypoxia-ischemia. Stroke 17:1313-1316
34. Nakano M, Mizuno T, Gotoh S 1990 Accumulation of cardiac lipofuscin in mammals: correlation between sexual maturation and the first appearance of lipofuscin. Mech Ageing Dev 52:93-106