Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia

Developmental Neuroscience

Volumn 35, Issue 6, 2013, Pages 491-503

  Traudt, Christopher M ^a   McPherson, Ronald J ^a   Bauer, Larry A ^b   Richards, Todd L ^a   Burbacher, Thomas M ^b   McAdams, Ryan M ^a   Juul, Sandra E ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cerebellum; Choline; Diffusion tensor imaging; Hypoxic ischemic encephalopathy; Pharmacokinetics; Spectroscopy

Indexed keywords

4 AMINOBUTYRIC ACID; ADRENALIN; BICARBONATE; CHOLINE; CREATINE; N ACETYLASPARTIC ACID; PHENOBARBITAL; RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANISOTROPY; APGAR SCORE; AREA UNDER THE CURVE; ARTERY OCCLUSION; ARTICLE; ARTIFICIAL VENTILATION; ASPIRATION PNEUMONIA; BEHAVIOR DISORDER; BLOOD SAMPLING; BRAIN SIZE; BRAZELTON NEONATAL BEHAVIORAL ASSESSMENT SCALE; CAUSE OF DEATH; CEREBRAL PALSY; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DISABILITY; DRUG CLEARANCE; DRUG HALF LIFE; FRACTIONAL ANISOTROPY; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; LOADING DRUG DOSE; MACACA NEMESTRINA; MAXIMUM PLASMA CONCENTRATION; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PERINATAL ASPHYXIA; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHYSIOTHERAPY; PLASMA CONCENTRATION-TIME CURVE; PRIMATE MODEL; PRIORITY JOURNAL; RANDOMIZATION; RELATIVE ANISOTROPY; RESUSCITATION; RISK FACTOR; RISK REDUCTION; SEIZURE; SURVIVAL; UMBILICAL CORD; UREA NITROGEN BLOOD LEVEL; WEIGHT GAIN; WHITE MATTER; ANIMAL TISSUE; BLOOD CELL COUNT; BRAIN GROWTH; CEREBELLUM; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG SAFETY; ELIMINATION HALF-LIFE; ELIMINATION RATE CONSTANT; MEAN RESIDENCE TIME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; VOLUME OF DISTRIBUTION;

ANIMALS; ASPHYXIA; BRAIN; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; HUMANS; HYPOTHERMIA; HYPOXIA-ISCHEMIA, BRAIN; INFANT; MACACA NEMESTRINA; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 84890561886     PISSN: 03785866     EISSN: 14219859     Source Type: Journal    
DOI: 10.1159/000355460     Document Type: Article

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