Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy

Pediatric Critical Care Medicine

Volumn 14, Issue 8, 2013, Pages 786-795

  Jenkins, Dorothea D ^a   Lee, Timothy ^b   Chiuzan, Cody ^a   Perkel, Jessica K ^a   Rollins, Laura Grace ^c   Wagner, Carol L ^a   Katikaneni, Lakshmi P ^a   Bass, W Thomas ^d   Kaufman, David A ^e   Horgan, Michael J ^f   Laungani, Sheela ^g   Givelichian, Laurence M ^h   Sankaran, Koravangatta ^h   Yager, Jerome Y ⁱ   Martin, Renee ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b AKRON CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^d EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

^f ALBANY MEDICAL CENTER   (United States)

^g BROOKLYN HOSPITAL CENTER   (United States)

^h UNIVERSITY OF SASKATCHEWAN   (Canada)

ⁱ UNIVERSITY OF ALBERTA   (Canada)

Author keywords

chemokines; hypoxic ischemic brain injury; induced hypothermia; leukocytes

Indexed keywords

CHEMOKINE; HYDROCORTISONE; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADVERSE OUTCOME; ARTICLE; BODY TEMPERATURE; BONE MARROW SUPPRESSION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; FEMALE; HUMAN; HYPOTENSION; HYPOTHERMIA; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; INFANT; INTENSIVE CARE UNIT; LEUKOCYTE; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROLOGIC DISEASE; NEUTROPHIL CHEMOTAXIS; NEWBORN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THERMOREGULATION; WARMING;

CHEMOKINES; FEMALE; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; LEUKOCYTE COUNT; LEUKOCYTES; MALE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84885645495     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3182975cc9     Document Type: Article

References (52)

1. Wang Q, Tang XN, Yenari MA: The inflammatory response in stroke. J Neuroimmunol 2007; 184:53-68
2. Chapman KZ, Dale VQ, Dénes A, et al: A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke. J Cereb Blood Flow Metab 2009; 29:1764-1768
3. Gelderblom M, Leypoldt F, Steinbach K, et al: Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke 2009; 40:1849-1857
4. Weston RM, Jones NM, Jarrott B, et al: Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: Histochemical and myeloperoxidase correlation with temporal changes in brain injury. J Cereb Blood Flow Metab 2007; 27:100-114
5. Jin Y, Silverman AJ, Vannucci SJ: Mast cells are early responders after hypoxia-ischemia in immature rat brain. Stroke 2009; 40: 3107-3112
6. Liesz A, Suri-Payer E, Veltkamp C, et al: Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 2009; 15:192-199
7. Bona E, Andersson AL, Blomgren K, et al: Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats. Pediatr Res 1999; 45(4, Part 1):500-509
8. Grau AJ, Reis A, Buggle F, et al: Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke. J Neurol Sci 2001; 192:41-47
9. Hughes PM, Allegrini PR, Rudin M, et al: Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model. J Cereb Blood Flow Metab 2002; 22:308-317
10. Pitchford SC, Furze RC, Jones CP, et al: Differential mobilization of subsets of progenitor cells from the bone marrow. Cell Stem Cell 2009; 4:62-72
11. Campbell SJ, Perry VH, Pitossi FJ, et al: Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver. Am J Pathol 2005; 166:1487-1497
12. Chen Y, Hallenbeck JM, Ruetzler C, et al: Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells. J Cereb Blood Flow Metab 2003; 23:748-755
13. Ormstad H, Aass HC, Lund-Sørensen N, et al: Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume. J Neurol 2011; 258:677-685
14. Meisel C, Schwab JM, Prass K, et al: Central nervous system injuryinduced immune deficiency syndrome. Nat Rev Neurosci 2005; 6:775-786
15. Klehmet J, Harms H, Richter M, et al: Stroke-induced immunodepression and post-stroke infections: Lessons from the preventive antibacterial therapy in stroke trial. Neuroscience 2009; 158:1184-1193
16. Biggar WD, Bohn D, Kent G: Neutrophil circulation and release from bone marrow during hypothermia. Infect Immun 1983; 40:708-712
17. Balaji S, Sullivan I, Deanfield J, et al: Moderate hypothermia in the management of resistant automatic tachycardias in children. Br Heart J 1991; 66:221-224
18. Matthys D, Verhaaren H, Deryck Y: Fatal pneumonia complicating hypothermia for the treatment of postoperative junctional ectopic tachycardia. Pediatr Cardiol 1995; 16:294-296
19. Jenkins DD, Rollins LG, Perkel JK, et al: Serum cytokines in a clinical trial of hypothermia for neonatal hypoxic-ischemic encephalopathy. J Cereb Blood Flow Metab 2012; 32:1888-1896
20. Kirchoff C, Buhmann B, Bogner V, et al: Cerebrospinal IL-10 concentration is elevated in non-survivors as compared to survivors after severe traumatic brain injury. Eur J Med Res 2008; 13: 464-468
21. Broxmeyer HE, Cooper S, Cacalano G, et al: Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: Evidence from mice lacking the murine IL-8 receptor homologue. J Exp Med 1996; 184:1825-1832
22. Reid S, Ritchie A, Boring L, et al: Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2. Blood 1999; 93:1524-1533
23. Eicher DJ, Wagner CL, Katikaneni LP, et al: Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes. Pediatr Neurol 2005; 32:11-17
24. Eicher DJ, Wagner CL, Katikaneni LP, et al: Moderate hypothermia in neonatal encephalopathy: Safety outcomes. Pediatr Neurol 2005; 32:18-24
25. Manroe BL, Weinberg AG, Rosenfeld CR, et al: The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. J Pediatr 1979; 95:89-98
26. Newman TB, Puopolo KM, Wi S, et al: Interpreting complete blood counts soon after birth in newborns at risk for sepsis. Pediatrics 2010; 126:903-909
27. Zozulya AL, Reinke E, Baiu DC, et al: Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. J Immunol 2007; 178:520-529
28. Garcia JH, Yoshida Y, Chen H, et al: Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol 1993; 142:623-635
29. Summers C, Rankin SM, Condliffe AM, et al: Neutrophil kinetics in health and disease. Trends Immunol 2010; 31:318-324
30. Pruenster M, Mudde L, Bombosi P, et al: The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol 2009; 10:101-108
31. Denes A, McColl BW, Leow-Dyke SF, et al: Experimental strokeinduced changes in the bone marrow reveal complex regulation of leukocyte responses. J Cereb Blood Flow Metab 2011; 31:1036-1050
32. Smith CJ, Emsley HC, Gavin CM, et al: Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and longterm outcome. BMC Neurol 2004; 4:2
33. Buck BH, Liebeskind DS, Saver JL, et al: Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke 2008; 39:355-360
34. Oto J, Suzue A, Inui D, et al: Plasma proinflammatory and anti-inflammatory cytokine and catecholamine concentrations as predictors of neurological outcome in acute stroke patients. J Anesth 2008; 22:207-212
35. Kline AE, Bolinger BD, Kochanek PM, et al: Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats. Brain Res 2002; 937:22-31
36. Liesz A, Hagmann S, Zschoche C, et al: The spectrum of systemic immune alterations after murine focal ischemia: Immunodepression versus immunomodulation. Stroke 2009; 40:2849-2858
37. Hug A, Dalpke A, Wieczorek N, et al: Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection. Stroke 2009; 40:3226-3232
38. Offner H, Vandenbark AA, Hurn PD: Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuroscience 2009; 158:1098-1111
39. Deng H, Han HS, Cheng D, et al: Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke 2003; 34:2495-2501
40. van Oss CJ, Absolom DR, Moore LL, et al: Effect of temperature on the chemotaxis, phagocytic engulfment, digestion and O2 consumption of human polymorphonuclear leukocytes. J Reticuloendothel Soc 1980; 27:561-565
41. Ceulemans AG, Zgavc T, Kooijman R, et al: The dual role of the neuroinflammatory response after ischemic stroke: Modulatory effects of hypothermia. J Neuroinflammation 2010; 7:74
42. Wengner AM, Pitchford SC, Furze RC, et al: The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood 2008; 111:42-49
43. Downes CE, Crack PJ: Neural injury following stroke: Are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol 2010; 160:1872-1888
44. Colditz IG, Schneider MA, Pruenster M, et al: Chemokines at large: In-vivo mechanisms of their transport, presentation and clearance. Thromb Haemost 2007; 97:688-693
45. Dirnagl U, Klehmet J, Braun JS, et al: Stroke-induced immunodepression: Experimental evidence and clinical relevance. Stroke 2007; 38(2 Suppl):770-773
46. Vogelgesang A, Grunwald U, Langner S, et al: Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke. Stroke 2008; 39:237-241
47. Shankaran S, Pappas A, Laptook AR, et al; NICHD Neonatal Research Network: Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics 2008; 122:e791-e798
48. Azzopardi DV, Strohm B, Edwards AD, et al; TOBY Study Group: Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009; 361:1349-1358
49. Jacobs SE, Morley CJ, Inder TE, et al; Infant Cooling Evaluation Collaboration: Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: A randomized controlled trial. Arch Pediatr Adolesc Med 2011; 165:692-700
50. Simbruner G, Mittal RA, Rohlmann F, et al; neo.nEURO.network Trial Participants: Systemic hypothermia after neonatal encephalopathy: Outcomes of neo.nEURO.network RCT. Pediatrics 2010; 126:e771-e778
51. Gluckman PD, Wyatt JS, Azzopardi D, et al: Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial. Lancet 2005; 365:663-670
52. Zhou WH, Cheng GQ, Shao XM, et al; China Study Group: Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: A multicenter randomized controlled trial in China. J Pediatr 2010; 157:367-372, 372.e1-372.e3