Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model

Neonatology

Volumn 99, Issue 4, 2011, Pages 302-310

  Cetinkaya, Merih ^a   Alkan, Tülin ^a   Ozyener, Fadil ^a   Kafa, Ilker Mustafa ^a   Kurt, Mustafa Ayberk ^a   Koksal, Nilgun ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Hypoxia ischemia; Magnesium sulfate; Melatonin; Neuroprotection

Indexed keywords

MAGNESIUM SULFATE; MELATONIN; SODIUM CHLORIDE;

ADRENAL CORTEX; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BRAIN HYPOXIA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONFERENCE PAPER; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT;

ALGORITHMS; ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; FEMALE; HYPOXIA-ISCHEMIA, BRAIN; MAGNESIUM SULFATE; MELATONIN; NEUROPROTECTIVE AGENTS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 78649713485     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000320643     Document Type: Conference Paper

References (42)

1. Vanucci SJ, Hagberg H: Hypoxia-ischemia in the immature brain. J Exp Biol 2004; 207: 3149-3154. (Pubitemid 39275289)
2. Volpe JJ: Hypoxic-ischemic encephalopathy; in Volpe JJ (ed): Neurology of the Newborn. Philadelphia, Saunders, 2001.
3. Shalak L, Perlman JM: Hypoxic-ischemic brain injury in the term infant-current concepts. Early Hum Dev 2004; 80: 125-141. (Pubitemid 39410486)
4. van Bel F, Groenendaal F: Long-term pharmacologic neuroprotection after birth asphyxia: where do we stand? Neonatology 2008; 94: 203-210.
5. Ovbiagele B, Kidwell CS, Starkman S, Saver JL: Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep 2003; 3: 9-20. (Pubitemid 38898978)
6. 4 infusion on NMDA receptor binding characteristics during cerebral cortical hypoxia in the newborn piglet. Brain Res 1994; 644: 144-149.
7. Turkyilmaz C, Turkyilmaz Z, Atalay Y, Soylemezoglu F, Celasun B: Magnesium pretreatment reduces neuronal apoptosis in newborn rats in hypoxia-ischemia. Brain Res 2002; 955: 133-137. (Pubitemid 35284843)
8. Ichiba H, Tamai H, Negishi H, Ueda T, Kim TJ, Sumida Y, Takahashi Y, Fujinaga H, Minami H, Kansai Magnesium Study Group: Randomized controlled trial of magnesium sulfate infusion for severe birth asphyxia. Pediatr Int 2002; 44: 505-509.
9. Bhat MA, Charoo BA, Bhat JI, Ahmad SM, Ali SW: Magnesium sulfate in severe perinatal asphyxia: a randomized, placebo-controlled trial. Pediatrics 2009; 123:e764-e769.
10. McDonald JW, Silverstein FS, Johnston MV: Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neurosci Lett 1994; 644: 144-149.
11. Groenendaal F, Rademaker CMA, Toet MC, de Vries LS: Effects of magnesium sulfate on amplitude-integrated continuous EEG in asphyxiated term neonates. Acta Paediatr 2002; 91: 1073-1077. (Pubitemid 35210153)
12. Penrice J, Amess PN, Punwani S, Punwani S, Wylezinska M, Tyszczuk L, D'Souza P, Edwards AD, Cady EB, Wyatt JS, Reynolds EO: Magnesium sulfate after transient hypoxiaischemia fails to prevent delayed cerebral energy failure in the newborn piglet. Pediatr Res 1997; 41: 443-447. (Pubitemid 27097917)
13. Greenwood K, Cox P, Mehmet H, Penrice J, Amess PN, Cady EB, Wyatt JS, Edwards AD: Magnesium sulfate after transient hypoxiaischemia in the newborn piglet does not protect against cerebral damage. Pediatr Res 2000; 48: 346-350. (Pubitemid 30637335)
14. 4 administration after cerebral hypoxia-ischemia in newborn rats is related to the severity of brain damage. Reprod Sci 2007; 14: 667-677. (Pubitemid 351903569)
15. Sameshima H, Ota A, Ikenoue T: Pretreatment with magnesium sulfate protects against hypoxic-ischemic brain injury but postasphyxial treatment worsens brain damage in seven-day-old rats. Am J Obstet Gynecol 1999; 180: 725-730. (Pubitemid 29149153)
16. de Haan HH, Gunn AJ, Williams CE, Heymann MA, Gluckman PD: Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury. Am J Obstet Gynecol 1997; 176: 18-27. (Pubitemid 127780741)
17. Dribben WH, Creeley CE, Wang HH, Smith DJ, Farber NB, Olney JW: High dose magnesium sulfate exposure induces apoptotic cell death in the developing neonatal mouse brain. Neonatology 2009; 96: 23-32.
18. Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ: One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007; 42: 28-42. (Pubitemid 44924323)
19. Tomas-Zapico C, Coto-Montes A: A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. J Pineal Res 2005; 39: 99-104. (Pubitemid 41140746)
20. Tutunculer F, Eskiocak S, Basaran UN, Ekuklu G, Ayvaz S, Vatansever U: The protective role of melatonin in experimental hypoxic brain damage. Pediatr Int 2005; 47: 434-439. (Pubitemid 41169579)
21. Welin AK, Svedin P, Lapatto R, Sultan B, Hagberg H, Gressens P, Kjellmer I, Mallard C: Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion. Pediatr Res 2007; 61: 153-158. (Pubitemid 46146871)
22. Carloni S, Perrone S, Buonocore G, Longini M, Proietti F, Balduini W: Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats. J Pineal Res 2008; 44: 157-164. (Pubitemid 351252918)
23. Gitto E, Karbownik M, Reiter RJ, Tan DX, Cuzzocrea S, Chiurazzi P, Cordaro S, Corona G, Trimarchi G, Barberi I: Effects of melatonin treatment in septic newborns. Pediatr Res 2001; 50: 756-760. (Pubitemid 33121647)
24. Gitto E, Reiter RJ, Amodio A, Romeo C, Cuzzocrea E, Sabatino G, Buonocore G, Cordaro V, Trimarchi G, Barberi I: Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin. J Pineal Res 2004; 36: 250-255. (Pubitemid 38530472)
25. Fulia F, Gitto E, Cuzzocrea S, Reiter RJ, Dugo L, Gitto P, Barberi S, Cordaro S, Barberi I: Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. J Pineal Res 2001; 31: 343-349. (Pubitemid 33032950)
26. Vannucci RC, Vanucci SJ: A model of perinatal hypoxic-ischemic brain damage. Ann NY Acad Sci 1997; 835: 234-429.
27. Vannucci RC, Vannucci SJ: Perinatal Hypoxic-ischemic brain damage: evolution of an animal model. Dev Neuroscience 2005; 27: 81-86. (Pubitemid 41096212)
28. 4. Neonatology 2008; 94: 272-278.
29. Hutton LC, Abbass M, Dickinson H, Ireland Z, Walker DW: Neuroprotective effects of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus). Dev Neurosci 2009; 31: 437-451.
30. Sameshima H, Ikenoue T: Long term magnesium sulfate treatment as protection against hypoxic-ischemic brain injury in seven-day old rats. Am J Obstet Gynecol 2001; 184: 185-190. (Pubitemid 32141663)
31. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR: A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Met 1990; 10: 290-293. (Pubitemid 20096202)
32. 4. Neonatology 2009; 95: 33-40.
33. Ichiba H, Ykoi T, Tamai H, Ueda T, Kim TJ, Yamano T: Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate. Pediatr Int 2006; 48: 70-75.
34. Levene M, Blennow M, Whitelaw A, Hankø E, Fellman V, Hartley R: Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia. Arch Dis Child Fetal Neonatal Med 1995; 73: 174-177.
35. Zhu H, Meloni BP, Moore SR, Majda BT, Knuckey NW: Intravenous administration of magnesium is only neuroprotective following transient global ischemia when present with post-ischemic mild hypothermia. Brain Res 2004; 1014: 53-60. (Pubitemid 38798452)
36. Zhu H, Meloni BP, Bojarski C, Knuckey MW, Knuckey NW: Post-ischemic modest hypothermia (35 degrees C) combined with intravenous magnesium is more effective at reducing CA1 neuronal death than either treatment used alone following global cerebral ischemia in rats. Exp Neurol 2005; 193: 361-368. (Pubitemid 40616185)
37. Gonzalez FD, Ferriero DM: Neuroprotection in the newborn infant. Clin Perinatol 2009; 36: 859-880.
38. Fatemi A, Wilson MA, Johnston MV: Hypoxic-ischemic encephalopathy in the term infant. Clin Perinatol 2009; 26: 835-858.
39. Hagberg H, Mallard C, Rousset CI, Wang X: Apoptotic mechanisms in the immature brain: Involvement of mitochondria. J Child Neurol 2009; 24: 1141-1146.
40. Hamada F, Watanabe K, Wakatsuki A, Nagai R, Shinohara K, Hayashi Y, Imamura R, Fukaya T: Therapeutic effects of maternal melatonin administration on ischemia/reperfusion-induced oxidative cerebral damage in neonatal rats. Neonatology 2010; 98: 33-40.
41. Kim CR, Oh W, Stonestreet BS: Magnesium is a cerebrovasodilator in newborn piglets. Am J Physiol 1997; 272: 511-516.
42. Regriny O, Delagrange P, Scalbert E, Atkinson J, Lartaaud-Idjouadiene I: Melatonin improves cerebral circulation security margin in rats. Am J Physiol Heart Circ Physiol 1998; 275: 139-144.