Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: A randomized trial

Stroke

Volumn 45, Issue 1, 2014, Pages 159-167

  Hougaard, Kristina Dupont ^a,c   Hjort, Niels ^a,c   Zeidler, Dora ^c   SØrensen, Leif ^b   NØrgaard, Anne ^b   Hansen, Troels Martin ^a   Von Weitzel Mudersbach, Paul ^a   Simonsen, Claus Z ^a   Damgaard, Dorte ^a   Gottrup, Hanne ^a   Svendsen, Kristina ^a   Rasmussen, Peter Vestergaard ^a   Ribe, Lars R ^c   Mikkelsen, Irene K ^c   Nagenthiraja, Kartheban ^c   Cho, Tae Hee ^d   Redington, Andrew N ^e   BØtker, Hans Erik ^b   Østergaard, Leif ^b,c   Mouridsen, Kim ^c   Andersen, Grethe ^a   more..

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Department of Neuroradiology ^*  (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d UNIVERSITÉ DE LYON   (France)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Magnetic resonance scan; Neuroprotection; Perconditioning; Stroke

Indexed keywords

EID: 84893657726     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.001346     Document Type: Article

References (37)

1. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al; ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329.
2. Ginsberg MD. Current status of neuroprotection for cerebral ischemia: synoptic overview. Stroke. 2009;40(3 suppl):S111-S114.
3. Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993;87:893-899.
4. Schmidt MR, Smerup M, Konstantinov IE, Shimizu M, Li J, Cheung M, et al. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning. Am J Physiol Heart Circ Physiol. 2007;292:H1883-H1890.
5. Hahn CD, Manlhiot C, Schmidt MR, Nielsen TT, Redington AN. Remote ischemic per-conditioning: a novel therapy for acute stroke? Stroke. 2011;42:2960-2962.
6. Ren C, Gao X, Steinberg GK, Zhao H. Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning. Neuroscience. 2008;151:1099-1103.
7. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, et al. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012;43:2794-2799.
8. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391-397.
9. Iadecola C, Anrather J. Stroke research at a crossroad: asking the brain for directions. Nat Neurosci. 2011;14:1363-1368.
10. Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol. 2009;8:398-412.
11. Saxena P, Newman MA, Shehatha JS, Redington AN, Konstantinov IE. Remote ischemic conditioning: evolution of the concept, mechanisms, and clinical application. J Card Surg. 2010;25:127-134.
12. Bøtker HE, Kharbanda R, Schmidt MR, Bøttcher M, Kaltoft AK, Terkelsen CJ, et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet. 2010;375:727-734.
13. Hougaard KD, Hjort N, Zeidler D, Sørensen L, Nørgaard A, Thomsen RB, et al. Remote ischemic perconditioning in thrombolysed stroke patients: randomized study of activating endogenous neuroprotection -design and MRI measurements. Int J Stroke. 2013;8:141-146.
14. Harbison J, Hossain O, Jenkinson D, Davis J, Louw SJ, Ford GA. Diagnostic accuracy of stroke referrals from primary care, emergency room physicians, and ambulance staff using the face arm speech test. Stroke. 2003;34:71-76.
15. Mouridsen K, Christensen S, Gyldensted L, Ostergaard L. Automatic selection of arterial input function using cluster analysis. Magn Reson Med. 2006;55:524-531.
16. Wu O, Østergaard L, Weisskoff RM, Benner T, Rosen BR, Sorensen AG. Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med. 2003;50:164-174.
17. Olivot JM, Mlynash M, Thijs VN, Kemp S, Lansberg MG, Wechsler L, et al. Optimal Tmax threshold for predicting penumbral tissue in acute stroke. Stroke. 2009;40:469-475.
18. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med 1985;312:932-936.
19. Khatri P, Neff J, Broderick JP, Khoury JC, Carrozzella J, Tomsick T; IMS-I Investigators. Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I. Stroke. 2005;36:2400-2403.
20. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al; EPITHET investigators. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. 2008;7:299-309.
21. Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR, Zuccarello M, et al. The ABCs of measuring intracerebral hemorrhage volumes. Stroke. 1996;27:1304-1305.
22. Bath PM, Lees KR, Schellinger PD, Altman H, Bland M, Hogg C, et al; European Stroke Organisation Outcomes Working Group. Statistical analysis of the primary outcome in acute stroke trials. Stroke. 2012;43:1171-1178.
23. Wu O, Christensen S, Hjort N, Dijkhuizen RM, Kucinski T, Fiehler J, et al. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI. Brain. 2006;129(pt 9):2384-2393.
24. Jonsdottir KY, Østergaard L, Mouridsen K. Predicting tissue outcome from acute stroke magnetic resonance imaging: improving model performance by optimal sampling of training data. Stroke. 2009;40:3006-3011.
25. Venables WN, Ripley BD. Modern Applied Statistics With S. 4th ed. New York: Springer; 2002.
26. Pinheiro JC, Bates DM. Mixed-Effects Models in S and S-PLUS. New York: Springer; 2000.
27. Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, et al. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion-and perfusion-weighted MR imaging. Stroke. 2001;32:933-942.
28. Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, et al. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab. 2007;27:196-204.
29. Kidwell CS, Saver JL, Mattiello J, Starkman S, Vinuela F, Duckwiler G, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol. 2000;47:462-469.
30. Chemmanam T, Campbell BC, Christensen S, Nagakane Y, Desmond PM, Bladin CF, et al; EPITHET Investigators. Ischemic diffusion lesion reversal is uncommon and rarely alters perfusion-diffusion mismatch. Neurology. 2010;75:1040-1047.
31. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79:1853-1861.
32. Gibson LM, Whiteley W. The differential diagnosis of suspected stroke: a systematic review J R Coll Physicians Edinb. 2013;43:114-118.
33. Gibson L, Whiteley WN. Stroke patients as a proportion of patients with suspected stroke: a systematic review and meta-analysis. Paper presented at: 21. European Stroke Conference; May 22-25, 2012; Lisbon, Portugal. http://www.karger.com/ProdukteDB/miscArchiv/CED-2012-033-s-2/index.html#/14/ 22-5-2012. Accessed May 15, 2013.
34. Koch S, Katsnelson M, Dong C, Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage: a phase Ib study of safety and feasibility. Stroke. 2011;42:1387-1391.
35. Walsh SR, Nouraei SA, Tang TY, Sadat U, Carpenter RH, Gaunt ME. Remote ischemic preconditioning for cerebral and cardiac protection during carotid endarterectomy: results from a pilot randomized clinical trial. Vasc Endovascular Surg. 2010;44:434-439.
36. Rentoukas I, Giannopoulos G, Kaoukis A, Kossyvakis C, Raisakis K, Driva M, et al. Cardioprotective role of remote ischemic periconditioning in primary percutaneous coronary intervention: enhancement by opioid action. JACC Cardiovasc Interv. 2010;3:49-55.
37. Wei M, Xin P, Li S, Tao J, Li Y, Li J, et al. Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circ Res. 2011;108:1220-1225.