메뉴 건너뛰기




Volumn 14, Issue 6, 2012, Pages 608-619

Therapeutic hypothermia for neonatal encephalopathy

Author keywords

Adjuvant therapies; Knowledge gaps; Neonatal encephalopathy; Neonatal hypoxic ischemic encephalopathy . Pathophysiology . Neurodevelopmental outcome . Neuroprotection . Head cooling; Randomized controlled trials; Term infants; Therapeutic hypothermia; Treatment; Whole body cooling

Indexed keywords

ANTICONVULSIVE AGENT; GENTAMICIN; MORPHINE; NEUROMUSCULAR BLOCKING AGENT; NITRIC OXIDE; SEDATIVE AGENT;

EID: 84870820418     PISSN: 10928480     EISSN: 15343138     Source Type: Journal    
DOI: 10.1007/s11940-012-0200-y     Document Type: Review
Times cited : (57)

References (53)
  • 1
    • 77954315863 scopus 로고    scopus 로고
    • Epidemiology of neonatal encephalopathy and hypoxic-ischemic encephalopathy
    • Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischemic encephalopathy. Early Hum Dev. 2010;86:329-38.
    • (2010) Early Hum Dev , vol.86 , pp. 329-338
    • Kurinczuk, J.J.1    White-Koning, M.2    Badawi, N.3
  • 2
    • 0025765904 scopus 로고
    • Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants
    • Shankaran S, Woldt E, Koepke T, et al. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev. 1991;25:135-48.
    • (1991) Early Hum Dev , vol.25 , pp. 135-148
    • Shankaran, S.1    Woldt, E.2    Koepke, T.3
  • 3
    • 33745896323 scopus 로고    scopus 로고
    • Long-term follow-up of term infants with perinatal asphyxia
    • Stevenson DK, Benitz WE, Sunshine P, editors. 3rd ed. New York: Cambridge University
    • Robertson CMT. Long-term follow-up of term infants with perinatal asphyxia. In: Stevenson DK, Benitz WE, Sunshine P, editors. Fetal and neonatal brain injury. 3rd ed. New York: Cambridge University; 2003. p. 829-58.
    • (2003) Fetal and Neonatal Brain Injury , pp. 829-858
    • Robertson, C.M.T.1
  • 5
    • 24044548649 scopus 로고    scopus 로고
    • Neuropsychological and educational problems at school age associated with neonatal encephalopathy
    • Marlow N, Rose AS, Rands CE, et al. Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2005;90:F380-7.
    • (2005) Arch Dis Child Fetal Neonatal Ed , vol.90
    • Marlow, N.1    Rose, A.S.2    Rands, C.E.3
  • 6
    • 33750741104 scopus 로고    scopus 로고
    • Does perinatal asphyxia impair cognitive function without cerebral palsy?
    • Gonzalez FF, Miller SP. Does perinatal asphyxia impair cognitive function without cerebral palsy? Arch Dis Child Fetal Neonatal Ed. 2006;91:454-9.
    • (2006) Arch Dis Child Fetal Neonatal Ed , vol.91 , pp. 454-459
    • Gonzalez, F.F.1    Miller, S.P.2
  • 7
    • 0021165604 scopus 로고
    • Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants
    • Hope PL, Costello AM, Cady EB, et al. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet. 1984;2:366-70.
    • (1984) Lancet , vol.2 , pp. 366-370
    • Hope, P.L.1    Costello, A.M.2    Cady, E.B.3
  • 8
    • 0024521338 scopus 로고
    • Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy
    • Azzopardi D, Wyatt JS, Cady EB, et al. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1989;25:445-51.
    • (1989) Pediatr Res , vol.25 , pp. 445-451
    • Azzopardi, D.1    Wyatt, J.S.2    Cady, E.B.3
  • 9
    • 0028079731 scopus 로고
    • Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy
    • Lorek A, Takei Y, Cady EB, et al. Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1994;36:699-706.
    • (1994) Pediatr Res , vol.36 , pp. 699-706
    • Lorek, A.1    Takei, Y.2    Cady, E.B.3
  • 10
    • 0031026883 scopus 로고    scopus 로고
    • Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischemia in the developing brain
    • Blumberg RM, Cady EB, Wigglesworth JS, et al. Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischemia in the developing brain. Exp Brain Res. 1997;113:130-7.
    • (1997) Exp Brain Res , vol.113 , pp. 130-137
    • Blumberg, R.M.1    Cady, E.B.2    Wigglesworth, J.S.3
  • 11
    • 0034991340 scopus 로고    scopus 로고
    • Neurobiology of hypoxic-ischemic injury in the developing brain
    • Johnston MV, Trescher WH, Ishida A, et al. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatr Res. 2001;49:735-41.
    • (2001) Pediatr Res , vol.49 , pp. 735-741
    • Johnston, M.V.1    Trescher, W.H.2    Ishida, A.3
  • 12
    • 79952722818 scopus 로고    scopus 로고
    • Treatment advances in neonatal neuroprotection and neurointensive care
    • Johnston MV, Fatemi A, Wilson MA, Northington F. Treatment advances in neonatal neuroprotection and neurointensive care. Lancet Neurol. 2011;10:372-82.
    • (2011) Lancet Neurol , vol.10 , pp. 372-382
    • Johnston, M.V.1    Fatemi, A.2    Wilson, M.A.3    Northington, F.4
  • 13
    • 78650787134 scopus 로고    scopus 로고
    • Modes of neuronal calcium entry and homeostasis following cerebral ischemia
    • Cross JL, Meloni BP, Bakker AJ, et al.Modes of neuronal calcium entry and homeostasis following cerebral ischemia. Stroke Res Treat. 2010;316862:1-9.
    • (2010) Stroke Res Treat , vol.3168 , pp. 1-9
    • Cross, J.L.1    Meloni, B.P.2    Bakker, A.J.3
  • 14
    • 70349315125 scopus 로고    scopus 로고
    • Apoptotic mechanisms in the immature brain: Involvement of mitochondria
    • Hagberg H, Mallard C, Rousset CI, et al. Apoptotic mechanisms in the immature brain: involvement of mitochondria. J Child Neurol. 2009;24:1141-6.
    • (2009) J Child Neurol , vol.24 , pp. 1141-1146
    • Hagberg, H.1    Mallard, C.2    Rousset, C.I.3
  • 15
    • 0031034474 scopus 로고    scopus 로고
    • Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs
    • Gunn AJ, Gunn TR, de Haan HH, et al. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest. 1997;99:248-56.
    • (1997) J Clin Invest , vol.99 , pp. 248-256
    • Gunn, A.J.1    Gunn, T.R.2    De Haan, H.H.3
  • 16
    • 0032795555 scopus 로고    scopus 로고
    • Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep
    • Gunn AJ, Bennet L, Gunning MI, et al. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res. 1999;46(3):274-80.
    • (1999) Pediatr Res , vol.46 , Issue.3 , pp. 274-280
    • Gunn, A.J.1    Bennet, L.2    Gunning, M.I.3
  • 17
    • 13844321255 scopus 로고    scopus 로고
    • Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicenter randomized trial
    • Gluckman PD, Wyatt J, Azzopardi DV, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicenter randomized trial. Lancet. 2005;365:663-70.
    • (2005) Lancet , vol.365 , pp. 663-670
    • Gluckman, P.D.1    Wyatt, J.2    Azzopardi, D.V.3
  • 18
    • 77955983840 scopus 로고    scopus 로고
    • Selective head cooling withmild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: A multicenter randomized controlled trial in China
    • 372.e1-3
    • Zhou WH, Cheng GQ, Shao XM, et al. Selective head cooling withmild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China. J Pediatr. 2010;157:367-72, 372.e1-3.
    • (2010) J Pediatr , vol.157 , pp. 367-372
    • Zhou, W.H.1    Cheng, G.Q.2    Shao, X.M.3
  • 19
    • 26444452073 scopus 로고    scopus 로고
    • Whole-body hypothermia for neonates with hypoxicischemic encephalopathy
    • Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxicischemic encephalopathy. N Engl J Med. 2005;353:1574-84.
    • (2005) N Engl J Med , vol.353 , pp. 1574-1584
    • Shankaran, S.1    Laptook, A.R.2    Ehrenkranz, R.A.3
  • 20
    • 70349611684 scopus 로고    scopus 로고
    • Moderate hypothermia to treat perinatal asphyxial encephalopathy
    • Largest trial of whole body cooling for neonatal HIE, very well controlled, and excellent follow rates
    • Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349-58. Largest trial of whole body cooling for neonatal HIE, very well controlled, and excellent follow rates.
    • (2009) N Engl J Med , vol.361 , pp. 1349-1349
    • Azzopardi, D.V.1    Strohm, B.2    Edwards, A.D.3
  • 21
    • 77957704402 scopus 로고    scopus 로고
    • Systemic hypothermia after neonatal encephalopathy: Outcomes of neo.nEURO.network RCT
    • Simbruner G, Mittal RA, Rohlmann F, et al. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics. 2010;126(4):e771-8.
    • (2010) Pediatrics , vol.126 , Issue.4
    • Simbruner, G.1    Mittal, R.A.2    Rohlmann, F.3
  • 22
    • 79961108502 scopus 로고    scopus 로고
    • Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: A randomized controlled trial
    • PMID: 21464374
    • Jacobs SE, Morley CJ, Inder TE, et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011;165 (8):692-700. PMID: 21464374
    • (2011) Arch Pediatr Adolesc Med , vol.165 , Issue.8 , pp. 692-692
    • Jacobs, S.E.1    Morley, C.J.2    Inder, T.E.3
  • 23
    • 84861521265 scopus 로고    scopus 로고
    • Hypothermia for neonatal hypoxic ischemic encephalopathy: An updated systematic review and meta-analysis
    • Tagin MA, Woolcott CG, Vincer MJ, et al. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med. 2012;166(6):558-66.
    • (2012) Arch Pediatr Adolesc Med , vol.166 , Issue.6 , pp. 558-566
    • Tagin, M.A.1    Woolcott, C.G.2    Vincer, M.J.3
  • 24
    • 77149149663 scopus 로고    scopus 로고
    • Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischemic encephalopathy: Synthesis and meta-analysis of trial data
    • Excellent meta-analyses of trials for hypothermia for neuroprotection foe neonatal HIE
    • Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischemic encephalopathy: synthesis and meta-analysis of trial data. BMJ. 2010;9:340:c363. Excellent meta-analyses of trials for hypothermia for neuroprotection foe neonatal HIE.
    • (2010) BMJ , vol.9 , Issue.340
    • Edwards, A.D.1    Brocklehurst, P.2    Gunn, A.J.3
  • 25
    • 72049097914 scopus 로고    scopus 로고
    • Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischemic encephalopathy: A nested substudy of a randomized controlled trial
    • Rutherford M, Ramenghi LA, Edwards AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischemic encephalopathy: a nested substudy of a randomized controlled trial. Lancet Neurol. 2010;9:39-45.
    • (2010) Lancet Neurol , vol.9 , pp. 39-45
    • Rutherford, M.1    Ramenghi, L.A.2    Edwards, A.D.3
  • 26
    • 85082027049 scopus 로고    scopus 로고
    • Brain Injury Following Trial of hypothermia for neonatal hypox-ic-ischaemic encephalopathy
    • doi:10.1136/archdischild-2011-301524
    • Shankaran S, Barnes, PD, Hintz SR, et al. Brain Injury Following Trial of hypothermia for neonatal hypox-ic-ischaemic encephalopathy. Arch Dis Child. 2012.1-9. doi:10.1136/archdischild-2011-301524.
    • (2012) Arch Dis Child , pp. 1-9
    • Shankaran, S.1    Barnes, P.D.2    Hintz, S.R.3
  • 27
    • 84862763065 scopus 로고    scopus 로고
    • Hypoglycemia is associated with increased risk of brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy
    • Tam EWY, Haeusslein LA, Bonafacio SL, et al. Hypoglycemia is associated with increased risk of brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy. J Pediatr. 2012;161:88-93.
    • (2012) J Pediatr , vol.161 , pp. 88-93
    • Ewy, T.1    Haeusslein, L.A.2    Bonafacio, S.L.3
  • 28
    • 33750965782 scopus 로고    scopus 로고
    • Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy
    • Ambalavanan N, Carlo WA, Shankaran S, et al. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics. 2006;118(5):2084-93.
    • (2006) Pediatrics , vol.118 , Issue.5 , pp. 2084-2093
    • Ambalavanan, N.1    Carlo, W.A.2    Shankaran, S.3
  • 29
    • 79959931411 scopus 로고    scopus 로고
    • Predictive value of an early amplitude integrated electroencephalogram and neurologic examination
    • Shankaran S, Pappas A, McDonald SA, et al. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. 2011;128:e112-20.
    • (2011) Pediatrics , vol.128
    • Shankaran, S.1    Pappas, A.2    McDonald, S.A.3
  • 30
    • 84858340160 scopus 로고    scopus 로고
    • Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy
    • Shankaran S, Laptook AR, Tyson JE, et al. Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. J Pediatr. 2012;160:567-72.e3.
    • (2012) J Pediatr , vol.160
    • Shankaran, S.1    Laptook, A.R.2    Tyson, J.E.3
  • 31
    • 54049103227 scopus 로고    scopus 로고
    • Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy
    • Shankaran S, Pappas A, Laptook AR, et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2008;122:e791-8.
    • (2008) Pediatrics , vol.122
    • Shankaran, S.1    Pappas, A.2    Laptook, A.R.3
  • 32
    • 34248209089 scopus 로고    scopus 로고
    • Determinants of outcomes after head cooling for neonatal encephalopathy
    • Wyatt JS, Gluckman PD, Liu PY, et al. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics. 2007;119(5):912-21.
    • (2007) Pediatrics , vol.119 , Issue.5 , pp. 912-921
    • Wyatt, J.S.1    Gluckman, P.D.2    Liu, P.Y.3
  • 33
    • 37249042147 scopus 로고    scopus 로고
    • Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy
    • 58.e1. Epub 2007 Oct 24
    • Gunn AJ, Wyatt JS, Whitelaw A, et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr. 2008;152:55-8; 58.e1. Epub 2007 Oct 24.
    • (2008) J Pediatr , vol.152 , pp. 55-8
    • Gunn, A.J.1    Wyatt, J.S.2    Whitelaw, A.3
  • 34
    • 79952637126 scopus 로고    scopus 로고
    • Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: Secondary analyses of data from the neonatal research network hypothermia trial
    • Kwon JM, Guillet R, Shankaran S, et al. Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial. J Child Neurol. 2011;26(3):322-8.
    • (2011) J Child Neurol , vol.26 , Issue.3 , pp. 322-328
    • Kwon, J.M.1    Guillet, R.2    Shankaran, S.3
  • 35
    • 79954416823 scopus 로고    scopus 로고
    • Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy
    • Pappas A, Shankaran S, Laptook AR, et al. Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy. J Pediatr. 2011;158:752-58.e1.
    • (2011) J Pediatr , vol.158
    • Pappas, A.1    Shankaran, S.2    Laptook, A.R.3
  • 36
    • 51649086699 scopus 로고    scopus 로고
    • Elevated temperature after hypoxic-ischemic encephalopathy: A risk factor for adverse outcome
    • Laptook A, Tyson J, Shankaran S, et al. Elevated temperature after hypoxic-ischemic encephalopathy: A risk factor for adverse outcome. Pediatrics. 2008;122:491-9.
    • (2008) Pediatrics , vol.122 , pp. 491-499
    • Laptook, A.1    Tyson, J.2    Shankaran, S.3
  • 37
    • 84855704182 scopus 로고    scopus 로고
    • Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy
    • Shankaran S, Laptook AR, McDonald SA, et al. Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatr Crit Care Med. 2012;13(1):53-9.
    • (2012) Pediatr Crit Care Med , vol.13 , Issue.1 , pp. 53-59
    • Shankaran, S.1    Laptook, A.R.2    McDonald, S.A.3
  • 38
    • 84859313369 scopus 로고    scopus 로고
    • Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy
    • Sant'Anna G, Laptook AR, Shankaran S, et al. Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy. J Child Neurol. 2012;27(4):451-7.
    • (2012) J Child Neurol , vol.27 , Issue.4 , pp. 451-457
    • Sant'Anna, G.1    Laptook, A.R.2    Shankaran, S.3
  • 39
    • 78049433742 scopus 로고    scopus 로고
    • Neonatal resuscitation: 2010 American heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care
    • Kattwinkel J, Perlman JM, Aziz K, et al. Neonatal resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Pediatrics. 2010;126(5):e1400-13.
    • (2010) Pediatrics , vol.126 , Issue.5
    • Kattwinkel, J.1    Perlman, J.M.2    Aziz, K.3
  • 40
    • 78049446500 scopus 로고    scopus 로고
    • Neonatal resuscitation: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations
    • Perlman JM, Wyllie J, Kattwinkel J, et al. Neonatal Resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics. 2010;126(5):e1319-44.
    • (2010) Pediatrics , vol.126 , Issue.5
    • Perlman, J.M.1    Wyllie, J.2    Kattwinkel, J.3
  • 41
    • 79957859109 scopus 로고    scopus 로고
    • Physiologic and pharmacologic considerations for hypothermia therapy in neonates
    • Zanelli S, Buck M, Fairchild K. Physiologic and pharmacologic considerations for hypothermia therapy in neonates. J Perinatol. 2011;31(.6):377-86.
    • (2011) J Perinatol , vol.31 , Issue.6 , pp. 377-386
    • Zanelli, S.1    Buck, M.2    Fairchild, K.3
  • 42
    • 42949158332 scopus 로고    scopus 로고
    • Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy
    • Róka A, Melinda KT, Vásárhelyi B, et al. Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy. Pediatrics. 2008;121(4):e844-9.
    • (2008) Pediatrics , vol.121 , Issue.4
    • Róka, A.1    Melinda, K.T.2    Vásárhelyi, B.3
  • 43
    • 67649593001 scopus 로고    scopus 로고
    • Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermia
    • Liu X, Borooah M, Stone J, et al. Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermia. Pediatrics. 2009;124(1):310-5.
    • (2009) Pediatrics , vol.124 , Issue.1 , pp. 310-315
    • Liu, X.1    Borooah, M.2    Stone, J.3
  • 44
    • 79953676303 scopus 로고    scopus 로고
    • Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: A pharmacokinetic study during whole body hypothermia
    • Filippi L, la Marca G, Cavallaro G, et al. Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia. Epilepsia. 2011;52(4):794-801.
    • (2011) Epilepsia , vol.52 , Issue.4 , pp. 794-801
    • Filippi, L.1    La Marca, G.2    Cavallaro, G.3
  • 45
    • 78649958503 scopus 로고    scopus 로고
    • Effects of hypothermia on pharmacokinetics and pharmacodynamics: A systematic review of preclinical and clinical studies
    • van den Broek MP, Groenendaal F, Egberts AC, et al. Effects of hypothermia on pharmacokinetics and pharmacodynamics: a systematic review of preclinical and clinical studies. Clin Pharmacokinet. 2010;49(5):277-94.
    • (2010) Clin Pharmacokinet , vol.49 , Issue.5 , pp. 277-294
    • Van Den Broek, M.P.1    Groenendaal, F.2    Egberts, A.C.3
  • 46
    • 84855910493 scopus 로고    scopus 로고
    • Seven-to8-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy
    • Guillet R, EdwardsAD, ThoresenM, et al.Seven-to8-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy. Pediatr Res. 2012;71(2):205-9.
    • (2012) Pediatr Res , vol.71 , Issue.2 , pp. 205-209
    • Guillet, R.1    Edwards, A.D.2    Thoresen, M.3
  • 47
    • 84861705307 scopus 로고    scopus 로고
    • Childhood outcomes after hypothermia for neonatal encephalopathy
    • Shankaran S, Pappas A, McDonald SA, et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012;366:2085-92.
    • (2012) N Engl J Med , vol.366 , pp. 2085-2092
    • Shankaran, S.1    Pappas, A.2    McDonald, S.A.3
  • 48
    • 77951878675 scopus 로고    scopus 로고
    • Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU
    • Fairchild K, Sokora D, Scott J, et al. Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU. J Perinatol. 2010;30 (5):324-9.
    • (2010) J Perinatol , vol.30 , Issue.5 , pp. 324-329
    • Fairchild, K.1    Sokora, D.2    Scott, J.3
  • 50
    • 80054732942 scopus 로고    scopus 로고
    • Hypothermia and other treatment options for neonatal encephalopathy: An executive summary of the Eunice Kennedy Shriver NICHD workshop
    • Higgins RD, Raju T, Edwards AD, et al. Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr. 2011;159:851-8.
    • (2011) J Pediatr , vol.159 , pp. 851-858
    • Higgins, R.D.1    Raju, T.2    Edwards, A.D.3
  • 51
    • 84858337595 scopus 로고    scopus 로고
    • Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?
    • Robertson NJ, Tan S, Groenendaal F, et al. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? J Pediatr. 2012;160(4):544-52.e4.
    • (2012) J Pediatr , vol.160 , Issue.4
    • Robertson, N.J.1    Tan, S.2    Groenendaal, F.3
  • 52
    • 77955982977 scopus 로고    scopus 로고
    • Synergistic neuroprotective therapies with hypothermia
    • Cilio MR, Ferriero DM. Synergistic neuroprotective therapies with hypothermia. Semin Fetal Neonatal Med. 2010;15(5):293-8.
    • (2010) Semin Fetal Neonatal Med , vol.15 , Issue.5 , pp. 293-298
    • Cilio, M.R.1    Ferriero, D.M.2
  • 53
    • 84864317687 scopus 로고    scopus 로고
    • Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy
    • Part 2
    • Pimentel-Coelho PM, Rosado-de-Castro PH, da Fonseca LM, et al. Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy. Pediatr Res. 2012;71(4 Part 2):464-73.
    • (2012) Pediatr Res , vol.71 , Issue.4 , pp. 464-473
    • Pimentel-Coelho, P.M.1    Rosado-De-Castro, P.H.2    Da Fonseca, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.