메뉴 건너뛰기




Volumn 52, Issue , 2016, Pages 110-118

Stem cell mitochondria during aging

Author keywords

Aging; Degeneration; Mitochondria; MtDNA; Regeneration; Stem cells

Indexed keywords

ADENYLATE KINASE; INSULIN; LIN28 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; RAS PROTEIN; RNA BINDING PROTEIN; TCL1 PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; REACTIVE OXYGEN METABOLITE;

EID: 84958128060     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2016.02.005     Document Type: Review
Times cited : (23)

References (152)
  • 1
    • 77955891911 scopus 로고    scopus 로고
    • The epigenome and the mitochondrion: bioenergetics and the environment
    • Wallace D.C. The epigenome and the mitochondrion: bioenergetics and the environment. Genes Dev. 2010, 24:1571-1573.
    • (2010) Genes Dev. , vol.24 , pp. 1571-1573
    • Wallace, D.C.1
  • 2
    • 84875953755 scopus 로고    scopus 로고
    • Stem cell metabolism in tissue development and aging
    • Shyh-Chang N., Daley G.Q., Cantley L.C. Stem cell metabolism in tissue development and aging. Development 2013, 140:2535-2547.
    • (2013) Development , vol.140 , pp. 2535-2547
    • Shyh-Chang, N.1    Daley, G.Q.2    Cantley, L.C.3
  • 3
    • 84924350833 scopus 로고    scopus 로고
    • Metabolic switches linked to pluripotency and embryonic stem cell differentiation
    • Shyh-Chang N., Daley G.Q. Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metab. 2015, 21:349-350.
    • (2015) Cell Metab. , vol.21 , pp. 349-350
    • Shyh-Chang, N.1    Daley, G.Q.2
  • 5
    • 83455169174 scopus 로고    scopus 로고
    • Human pluripotent stem cells decouple respiration from energy production
    • Shyh-Chang N., Zheng Y., Locasale J.W., Cantley L.C. Human pluripotent stem cells decouple respiration from energy production. EMBO J. 2011, 30:4851-4852.
    • (2011) EMBO J. , vol.30 , pp. 4851-4852
    • Shyh-Chang, N.1    Zheng, Y.2    Locasale, J.W.3    Cantley, L.C.4
  • 6
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • Rossi D.J., Jamieson C.H., Weissman I.L. Stems cells and the pathways to aging and cancer. Cell 2008, 132:681-696.
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.2    Weissman, I.L.3
  • 7
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 8
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
    • Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 2005, 39:359-407.
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 9
    • 84958117331 scopus 로고    scopus 로고
    • Lin28 and let-7 in the metabolic physiology of aging
    • Jun-Hao E.T., Gupta R.R., Shyh-Chang N. Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol. Metab. 2016, pii: S1043-2760(15) 00251-9. 10.1016/j.tem.2015.12.006.
    • (2016) Trends Endocrinol. Metab.
    • Jun-Hao, E.T.1    Gupta, R.R.2    Shyh-Chang, N.3
  • 12
    • 84857784512 scopus 로고    scopus 로고
    • Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
    • Benhamed M., Herbig U., Ye T., Dejean A., Bischof O. Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells. Nat. Cell Biol. 2012, 14:266-275.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 266-275
    • Benhamed, M.1    Herbig, U.2    Ye, T.3    Dejean, A.4    Bischof, O.5
  • 14
    • 84863762192 scopus 로고    scopus 로고
    • The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche
    • Toledano H., D'Alterio C., Czech B., Levine E., Jones D.L. The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche. Nature 2012, 485:605-610.
    • (2012) Nature , vol.485 , pp. 605-610
    • Toledano, H.1    D'Alterio, C.2    Czech, B.3    Levine, E.4    Jones, D.L.5
  • 15
    • 84862776981 scopus 로고    scopus 로고
    • Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis
    • Yuan J., Nguyen C.K., Liu X., Kanellopoulou C., Muljo S.A. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 2012, 335:1195-1200.
    • (2012) Science , vol.335 , pp. 1195-1200
    • Yuan, J.1    Nguyen, C.K.2    Liu, X.3    Kanellopoulou, C.4    Muljo, S.A.5
  • 18
    • 85019295619 scopus 로고    scopus 로고
    • Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice
    • Tolonen, et al. Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice. Pharmacol. Res. Perspect. 2014, 2(4):e00056.
    • (2014) Pharmacol. Res. Perspect. , vol.2 , Issue.4 , pp. e00056
    • Tolonen1
  • 19
    • 84929952785 scopus 로고    scopus 로고
    • Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway
    • Zhang, et al. Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway. J. Cell. Mol. Med. 2015, 19(6):1174-1182.
    • (2015) J. Cell. Mol. Med. , vol.19 , Issue.6 , pp. 1174-1182
    • Zhang1
  • 20
    • 84908006900 scopus 로고    scopus 로고
    • Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions
    • Zhang, et al. Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions. PLoS One 2014, 9(10):e110580.
    • (2014) PLoS One , vol.9 , Issue.10 , pp. e110580
    • Zhang1
  • 21
    • 84949908492 scopus 로고    scopus 로고
    • Precise let-7 expression levels balance organ regeneration against tumor suppression
    • Wu L., et al. Precise let-7 expression levels balance organ regeneration against tumor suppression. Elife 2015, 4. 10.7554/eLife.09431.
    • (2015) Elife , vol.4
    • Wu, L.1
  • 22
    • 84922646378 scopus 로고    scopus 로고
    • In vivo activation of a conserved microRNA program induces mammalian heart regeneration
    • Aguirre, et al. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell 2014, 15(5):589-604.
    • (2014) Cell Stem Cell , vol.15 , Issue.5 , pp. 589-604
    • Aguirre1
  • 25
    • 84941024717 scopus 로고    scopus 로고
    • Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming
    • Khaw S.L., Min-Wen C., Koh C.G., Lim B., Shyh-Chang N. Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Rep. 2015, 12:1080-1088.
    • (2015) Cell Rep. , vol.12 , pp. 1080-1088
    • Khaw, S.L.1    Min-Wen, C.2    Koh, C.G.3    Lim, B.4    Shyh-Chang, N.5
  • 35
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 37
    • 6944247865 scopus 로고    scopus 로고
    • Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals
    • Machida S., Booth F.W. Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals. Exp. Gerontol. 2004, 39:1521-1525.
    • (2004) Exp. Gerontol. , vol.39 , pp. 1521-1525
    • Machida, S.1    Booth, F.W.2
  • 40
    • 67651208171 scopus 로고    scopus 로고
    • PGC-1alpha-induced improvements in skeletal muscle metabolism and insulin sensitivity
    • Bonen A. PGC-1alpha-induced improvements in skeletal muscle metabolism and insulin sensitivity. Appl. Physiol. Nutr. Metab. 2009, 34:307-314.
    • (2009) Appl. Physiol. Nutr. Metab. , vol.34 , pp. 307-314
    • Bonen, A.1
  • 41
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    • Hochmuth C.E., Biteau B., Bohmann D., Jasper H. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell 2011, 8:188-199.
    • (2011) Cell Stem Cell , vol.8 , pp. 188-199
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3    Jasper, H.4
  • 43
    • 84939248341 scopus 로고    scopus 로고
    • Differentiation of human neural stem cells into motor neurons stimulates mitochondrial biogenesis and decreases glycolytic flux
    • O'Brien L.C., Keeney P.M., Bennett J.P. Differentiation of human neural stem cells into motor neurons stimulates mitochondrial biogenesis and decreases glycolytic flux. Stem Cells Dev. 2015, 24:1984-1994.
    • (2015) Stem Cells Dev. , vol.24 , pp. 1984-1994
    • O'Brien, L.C.1    Keeney, P.M.2    Bennett, J.P.3
  • 45
    • 84929273586 scopus 로고    scopus 로고
    • Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic iPSC lines
    • Shaltouki A., Sivapatham R., Pei Y., Gerencser A.A., Momčilović O., Rao M.S., Zeng X. Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic iPSC lines. Stem Cell Rep. 2015, 4:847-859.
    • (2015) Stem Cell Rep. , vol.4 , pp. 847-859
    • Shaltouki, A.1    Sivapatham, R.2    Pei, Y.3    Gerencser, A.A.4    Momčilović, O.5    Rao, M.S.6    Zeng, X.7
  • 46
    • 84882900207 scopus 로고    scopus 로고
    • Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains
    • Goh L.H., Zhou X., Lee M.C., Lin S., Wang H., Luo Y., Yang X. Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains. Dev. Biol. 2013, 381:353-364.
    • (2013) Dev. Biol. , vol.381 , pp. 353-364
    • Goh, L.H.1    Zhou, X.2    Lee, M.C.3    Lin, S.4    Wang, H.5    Luo, Y.6    Yang, X.7
  • 47
    • 84905661973 scopus 로고    scopus 로고
    • Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiationinduced mitochondrial stress
    • Xavier J.M., Morgado A.L., Solá S., Rodrigues C.M. Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiationinduced mitochondrial stress. Antioxid. Redox Signal. 2014, 21:1009-1024.
    • (2014) Antioxid. Redox Signal. , vol.21 , pp. 1009-1024
    • Xavier, J.M.1    Morgado, A.L.2    Solá, S.3    Rodrigues, C.M.4
  • 48
    • 66249086606 scopus 로고    scopus 로고
    • P53 regulates mtDNA copy number and mitocheckpoint pathway
    • Kulawiec M., Ayyasamy V., Singh K.K. p53 regulates mtDNA copy number and mitocheckpoint pathway. J. Carcinog. 2009, 8.
    • (2009) J. Carcinog. , vol.8
    • Kulawiec, M.1    Ayyasamy, V.2    Singh, K.K.3
  • 49
    • 85020580872 scopus 로고    scopus 로고
    • Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage
    • Buechner N., Droese S., Jakob S., Brandt U., Altschmied J., Haendeler J. Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage. Cell Commun. Signal. 2009, 7:A57.
    • (2009) Cell Commun. Signal. , vol.7 , pp. A57
    • Buechner, N.1    Droese, S.2    Jakob, S.3    Brandt, U.4    Altschmied, J.5    Haendeler, J.6
  • 51
    • 77953256244 scopus 로고    scopus 로고
    • A mutant telomerase defective in nuclear--cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction
    • Kovalenko O.A., Caron M.J., Ulema P., Medrano C., Thomas A.P., Kimura M., Bonini M.G., Herbig U., Santos J.H. A mutant telomerase defective in nuclear--cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell 2010, 9:203-219.
    • (2010) Aging Cell , vol.9 , pp. 203-219
    • Kovalenko, O.A.1    Caron, M.J.2    Ulema, P.3    Medrano, C.4    Thomas, A.P.5    Kimura, M.6    Bonini, M.G.7    Herbig, U.8    Santos, J.H.9
  • 52
    • 79953033356 scopus 로고    scopus 로고
    • Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence
    • Rai P., Young J.J., Burton D.G., Giribaldi M.G., Onder T.T., Weinberg R.A. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene 2011, 30:1489-1496.
    • (2011) Oncogene , vol.30 , pp. 1489-1496
    • Rai, P.1    Young, J.J.2    Burton, D.G.3    Giribaldi, M.G.4    Onder, T.T.5    Weinberg, R.A.6
  • 55
    • 84930486276 scopus 로고    scopus 로고
    • Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative stress
    • Ho J.H., Chen Y.F., Ma W.H., Tseng T.C., Chen M.H., Lee O.K. Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative stress. Cell Transplant. 2011, 20:1209-1220.
    • (2011) Cell Transplant. , vol.20 , pp. 1209-1220
    • Ho, J.H.1    Chen, Y.F.2    Ma, W.H.3    Tseng, T.C.4    Chen, M.H.5    Lee, O.K.6
  • 56
    • 0348047391 scopus 로고    scopus 로고
    • The retardation of aging by caloric restriction: its significance in the transgenic era
    • Barger J.L., Walford R.L., Weindruch R. The retardation of aging by caloric restriction: its significance in the transgenic era. Exp. Gerontol. 2003, 38:1343-1351.
    • (2003) Exp. Gerontol. , vol.38 , pp. 1343-1351
    • Barger, J.L.1    Walford, R.L.2    Weindruch, R.3
  • 57
    • 80051609656 scopus 로고    scopus 로고
    • Calorie restriction: is AMPK a key sensor and effector?
    • Cantó C., Auwerx J. Calorie restriction: is AMPK a key sensor and effector?. Physiology (Bethesda) 2011, 26:214-224.
    • (2011) Physiology (Bethesda) , vol.26 , pp. 214-224
    • Cantó, C.1    Auwerx, J.2
  • 59
  • 60
    • 0142195931 scopus 로고    scopus 로고
    • Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction
    • Chen J., Astle C.M., Harrison D.E. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp. Hematol. 2003, 31:1097-1103.
    • (2003) Exp. Hematol. , vol.31 , pp. 1097-1103
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3
  • 67
    • 0035281979 scopus 로고    scopus 로고
    • Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis
    • Drummond-Barbosa D., Spradling A.C. Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev. Biol. 2001, 231:265-278.
    • (2001) Dev. Biol. , vol.231 , pp. 265-278
    • Drummond-Barbosa, D.1    Spradling, A.C.2
  • 68
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997, 277:942-946.
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 69
    • 23644444460 scopus 로고    scopus 로고
    • Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila
    • LaFever L., Drummond-Barbosa D. Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 2005, 309:1071-1073.
    • (2005) Science , vol.309 , pp. 1071-1073
    • LaFever, L.1    Drummond-Barbosa, D.2
  • 70
    • 37849019064 scopus 로고    scopus 로고
    • Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila
    • Hsu H.-J., LaFever L., Drummond-Barbosa D. Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev. Biol. 2008, 313:700-712.
    • (2008) Dev. Biol. , vol.313 , pp. 700-712
    • Hsu, H.-J.1    LaFever, L.2    Drummond-Barbosa, D.3
  • 71
    • 67650266694 scopus 로고    scopus 로고
    • Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila
    • Ueishi S., Shimizu H., H Inoue Y. Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila. Cell Struct. Funct. 2009, 34:61-69.
    • (2009) Cell Struct. Funct. , vol.34 , pp. 61-69
    • Ueishi, S.1    Shimizu, H.2    H Inoue, Y.3
  • 72
    • 84860309087 scopus 로고    scopus 로고
    • Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS
    • Wang Z.A., Huang J., Kalderon D. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Nat. Commun. 2012, 3:769.
    • (2012) Nat. Commun. , vol.3 , pp. 769
    • Wang, Z.A.1    Huang, J.2    Kalderon, D.3
  • 74
    • 33748752151 scopus 로고    scopus 로고
    • The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    • Schieke S.M., et al. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 2006, 281:627-643.
    • (2006) J. Biol. Chem. , vol.281 , pp. 627-643
    • Schieke, S.M.1
  • 75
    • 36749081539 scopus 로고    scopus 로고
    • MTOR controls mitochondrial oxidative function through a YY1-PGC-1α riptional complex
    • Cunningham J.T., et al. mTOR controls mitochondrial oxidative function through a YY1-PGC-1α riptional complex. Nature 2007, 450:736-740.
    • (2007) Nature , vol.450 , pp. 736-740
    • Cunningham, J.T.1
  • 77
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen C., Liu Y., Liu R., Ikenoue T., Guan K.L., Liu Y., Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 2008, 205:2397-2408.
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7
  • 78
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C., Liu Y., Liu Y., Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2009, 2:ra75.
    • (2009) Sci. Signal. , vol.2 , pp. ra75
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 80
    • 84859429092 scopus 로고    scopus 로고
    • Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila
    • Shim J., Mukherjee T., Banerjee U. Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. Nat. Cell Biol. 2012, 14:394-400.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 394-400
    • Shim, J.1    Mukherjee, T.2    Banerjee, U.3
  • 85
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada D., Saunders T.L., Morrison S.J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010, 468:653-658.
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 86
    • 59649101100 scopus 로고    scopus 로고
    • AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development
    • Dasgupta B., Milbrandt J. AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev. Cell 2009, 16:256-270.
    • (2009) Dev. Cell , vol.16 , pp. 256-270
    • Dasgupta, B.1    Milbrandt, J.2
  • 87
    • 33645090940 scopus 로고    scopus 로고
    • Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
    • Narbonne P., Roy R. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 2006, 133:611-619.
    • (2006) Development , vol.133 , pp. 611-619
    • Narbonne, P.1    Roy, R.2
  • 88
    • 0015319592 scopus 로고
    • A biologic clock: the mitochondria?
    • Harman D. A biologic clock: the mitochondria?. J. Am. Geriatr. Soc. 1972, 20(4):145-147.
    • (1972) J. Am. Geriatr. Soc. , vol.20 , Issue.4 , pp. 145-147
    • Harman, D.1
  • 92
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., Weissman I.L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007, 447:725-729.
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 94
    • 79955698235 scopus 로고    scopus 로고
    • Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
    • Norddahl G.L., Pronk C.J., Wahlestedt M., Sten G., Nygren J.M., Ugale A., Sigvardsson M., Bryder D. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 2011, 8:499-510.
    • (2011) Cell Stem Cell , vol.8 , pp. 499-510
    • Norddahl, G.L.1    Pronk, C.J.2    Wahlestedt, M.3    Sten, G.4    Nygren, J.M.5    Ugale, A.6    Sigvardsson, M.7    Bryder, D.8
  • 96
    • 84860524508 scopus 로고    scopus 로고
    • Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption
    • Fox R.G., Magness S., Kujoth G.C., Prolla T.A., Maeda N. Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 302:G914-G924.
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.302 , pp. G914-G924
    • Fox, R.G.1    Magness, S.2    Kujoth, G.C.3    Prolla, T.A.4    Maeda, N.5
  • 98
    • 84874515942 scopus 로고    scopus 로고
    • Accumulation of mtDNA variations in human single CD34 + cells from maternally related individuals: effects of aging and family genetic background
    • Yao Y.G., Kajigaya S., Feng X., Samsel L., McCoy J.P., Torelli G., Young N.S. Accumulation of mtDNA variations in human single CD34 + cells from maternally related individuals: effects of aging and family genetic background. Stem Cell Res. 2013, 10:361-370.
    • (2013) Stem Cell Res. , vol.10 , pp. 361-370
    • Yao, Y.G.1    Kajigaya, S.2    Feng, X.3    Samsel, L.4    McCoy, J.P.5    Torelli, G.6    Young, N.S.7
  • 100
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
    • Deng W., Aimone J.B., Gage F.H. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?. Nat. Rev. Neurosci. 2010, 11:339-350.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 101
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • Kuhn H.G., Dickinson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 1996, 16:2027-2033.
    • (1996) J. Neurosci. , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 102
    • 84901294948 scopus 로고    scopus 로고
    • Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease
    • Kukreja L., Kujoth G.C., Prolla T.A., Van Leuven F., Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol. Neurodegener. 2014, 9:16.
    • (2014) Mol. Neurodegener. , vol.9 , pp. 16
    • Kukreja, L.1    Kujoth, G.C.2    Prolla, T.A.3    Van Leuven, F.4    Vassar, R.5
  • 104
  • 109
    • 0030740621 scopus 로고    scopus 로고
    • Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
    • Simoneau J.A., Kelley D.E. Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J. Appl. Physiol. 1997, 83:166-171.
    • (1997) J. Appl. Physiol. , vol.83 , pp. 166-171
    • Simoneau, J.A.1    Kelley, D.E.2
  • 110
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley D.E., He J., Menshikova E.V., Ritov V.B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002, 51:2944-2950.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 115
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen K.F., Dufour S., Befroy D., Garcia R., Shulman G.I. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 2004, 350:664-671.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 116
    • 25644448096 scopus 로고    scopus 로고
    • Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Petersen K.F., Dufour S., Shulman G.I. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005, 2:e233.
    • (2005) PLoS Med. , vol.2 , pp. e233
    • Petersen, K.F.1    Dufour, S.2    Shulman, G.I.3
  • 117
    • 17744393686 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human disease
    • Taylor R.W., Turnbull D.M. Mitochondrial DNA mutations in human disease. Nat. Rev. Genet. 2005, 6:389-402.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 389-402
    • Taylor, R.W.1    Turnbull, D.M.2
  • 121
    • 0034164636 scopus 로고    scopus 로고
    • Fatal hypertrophic cardiomyopathy associated with an A8296G mutation in the mitochondrial tRNA(Lys) gene
    • Akita Y., Koga Y., Iwanaga R., Wada N., Tsubone J., Fukuda S., Nakamura Y., Kato H. Fatal hypertrophic cardiomyopathy associated with an A8296G mutation in the mitochondrial tRNA(Lys) gene. Hum. Mutat. 2000, 15:382.
    • (2000) Hum. Mutat. , vol.15 , pp. 382
    • Akita, Y.1    Koga, Y.2    Iwanaga, R.3    Wada, N.4    Tsubone, J.5    Fukuda, S.6    Nakamura, Y.7    Kato, H.8
  • 125
    • 33744456730 scopus 로고    scopus 로고
    • The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216TNC and m.4917ANG variants
    • Crispim D., Canani L.H., Gross J.L., Tschiedel B., Souto K.E.P., Roisenberg I. The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216TNC and m.4917ANG variants. Ann. Hum. Genet. 2006, 70:488-495.
    • (2006) Ann. Hum. Genet. , vol.70 , pp. 488-495
    • Crispim, D.1    Canani, L.H.2    Gross, J.L.3    Tschiedel, B.4    Souto, K.E.P.5    Roisenberg, I.6
  • 131
    • 79960218332 scopus 로고    scopus 로고
    • Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups
    • Hwang S., Kwak S.H., Bhak J., Kang H.S., Lee Y.R., Koo B.K., Park K.S., Lee H.K., Cho Y.M. Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups. PLoS One 2011, 6:e22116.
    • (2011) PLoS One , vol.6 , pp. e22116
    • Hwang, S.1    Kwak, S.H.2    Bhak, J.3    Kang, H.S.4    Lee, Y.R.5    Koo, B.K.6    Park, K.S.7    Lee, H.K.8    Cho, Y.M.9
  • 137
    • 0033516529 scopus 로고    scopus 로고
    • Phylogenetic analysis of themitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population
    • Chagnon P., Gee M., Filion M., Robitaille Y., Belouchi M., Gauvreau D. Phylogenetic analysis of themitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population. Am. J. Med. Genet. 1999, 85:20-30.
    • (1999) Am. J. Med. Genet. , vol.85 , pp. 20-30
    • Chagnon, P.1    Gee, M.2    Filion, M.3    Robitaille, Y.4    Belouchi, M.5    Gauvreau, D.6
  • 142
    • 67649803186 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease
    • Reddy P.H. Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp. Neurol. 2009, 218:286-292.
    • (2009) Exp. Neurol. , vol.218 , pp. 286-292
    • Reddy, P.H.1
  • 143
  • 144
    • 84884879594 scopus 로고    scopus 로고
    • Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
    • Yan M.H., Wang X., Zhu X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic. Biol. Med. 2013, 62:90-101.
    • (2013) Free Radic. Biol. Med. , vol.62 , pp. 90-101
    • Yan, M.H.1    Wang, X.2    Zhu, X.3
  • 145
    • 84859709003 scopus 로고    scopus 로고
    • Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death
    • Cha M.-Y., Han S.-H., Son S.M., Hong H.-S., Choi Y.-J., Byun J., et al. Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One 2012, 7:e34929.
    • (2012) PLoS One , vol.7 , pp. e34929
    • Cha, M.-Y.1    Han, S.-H.2    Son, S.M.3    Hong, H.-S.4    Choi, Y.-J.5    Byun, J.6
  • 147
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Kraytsberg Y., Kudryavtseva E., McKee A.C., Geula C., Kowall N.W., Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet. 2006, 38:518-520.
    • (2006) Nat. Genet. , vol.38 , pp. 518-520
    • Kraytsberg, Y.1    Kudryavtseva, E.2    McKee, A.C.3    Geula, C.4    Kowall, N.W.5    Khrapko, K.6
  • 148
    • 71849084134 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease
    • Winklhofer K.F., Haass C. Mitochondrial dysfunction in Parkinson's disease. Biochim. Biophys. Acta 2010, 1802:29-44.
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 29-44
    • Winklhofer, K.F.1    Haass, C.2
  • 149
    • 84903301367 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes
    • Jin H., Kanthasamy A., Ghosh A., Anantharam V., Kalyanaraman B., Kanthasamy A.G. Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim. Biophys. Acta 2013, 1842:1282-1294.
    • (2013) Biochim. Biophys. Acta , vol.1842 , pp. 1282-1294
    • Jin, H.1    Kanthasamy, A.2    Ghosh, A.3    Anantharam, V.4    Kalyanaraman, B.5    Kanthasamy, A.G.6
  • 150
    • 82555174637 scopus 로고    scopus 로고
    • Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease
    • Pickrell A.M., Pinto M., Hida A., Moraes C.T. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. J. Neurosci. 2011, 31:17649-17658.
    • (2011) J. Neurosci. , vol.31 , pp. 17649-17658
    • Pickrell, A.M.1    Pinto, M.2    Hida, A.3    Moraes, C.T.4
  • 151
    • 84895904175 scopus 로고    scopus 로고
    • Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease
    • Tufi R., Gandhi S., de Castro I.P., Lehmann S., Angelova P.R., Dinsdale D., et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat. Cell Biol. 2014, 16:157-166.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 157-166
    • Tufi, R.1    Gandhi, S.2    de Castro, I.P.3    Lehmann, S.4    Angelova, P.R.5    Dinsdale, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.