-
1
-
-
77955891911
-
The epigenome and the mitochondrion: bioenergetics and the environment
-
Wallace D.C. The epigenome and the mitochondrion: bioenergetics and the environment. Genes Dev. 2010, 24:1571-1573.
-
(2010)
Genes Dev.
, vol.24
, pp. 1571-1573
-
-
Wallace, D.C.1
-
2
-
-
84875953755
-
Stem cell metabolism in tissue development and aging
-
Shyh-Chang N., Daley G.Q., Cantley L.C. Stem cell metabolism in tissue development and aging. Development 2013, 140:2535-2547.
-
(2013)
Development
, vol.140
, pp. 2535-2547
-
-
Shyh-Chang, N.1
Daley, G.Q.2
Cantley, L.C.3
-
3
-
-
84924350833
-
Metabolic switches linked to pluripotency and embryonic stem cell differentiation
-
Shyh-Chang N., Daley G.Q. Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metab. 2015, 21:349-350.
-
(2015)
Cell Metab.
, vol.21
, pp. 349-350
-
-
Shyh-Chang, N.1
Daley, G.Q.2
-
4
-
-
84872160110
-
Influence of threonine metabolism on S-adenosylmethionine and histone methylation
-
Shyh-Chang N., Locasale J.W., Lyssiotis C.A., Zheng Y., Teo R.Y., Ratanasirintrawoot S., Zhang J., Onder T., Unternaehrer J.J., Zhu H., Asara J.M., Daley G.Q., Cantley L.C. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 2013, 339:222-226.
-
(2013)
Science
, vol.339
, pp. 222-226
-
-
Shyh-Chang, N.1
Locasale, J.W.2
Lyssiotis, C.A.3
Zheng, Y.4
Teo, R.Y.5
Ratanasirintrawoot, S.6
Zhang, J.7
Onder, T.8
Unternaehrer, J.J.9
Zhu, H.10
Asara, J.M.11
Daley, G.Q.12
Cantley, L.C.13
-
5
-
-
83455169174
-
Human pluripotent stem cells decouple respiration from energy production
-
Shyh-Chang N., Zheng Y., Locasale J.W., Cantley L.C. Human pluripotent stem cells decouple respiration from energy production. EMBO J. 2011, 30:4851-4852.
-
(2011)
EMBO J.
, vol.30
, pp. 4851-4852
-
-
Shyh-Chang, N.1
Zheng, Y.2
Locasale, J.W.3
Cantley, L.C.4
-
6
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi D.J., Jamieson C.H., Weissman I.L. Stems cells and the pathways to aging and cancer. Cell 2008, 132:681-696.
-
(2008)
Cell
, vol.132
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
7
-
-
77950265945
-
Linking functional decline of telomeres, mitochondria and stem cells during ageing
-
Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
-
(2010)
Nature
, vol.464
, pp. 520-528
-
-
Sahin, E.1
Depinho, R.A.2
-
8
-
-
23844558266
-
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
-
Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 2005, 39:359-407.
-
(2005)
Annu. Rev. Genet.
, vol.39
, pp. 359-407
-
-
Wallace, D.C.1
-
10
-
-
80053481600
-
The Lin28/let-7 axis regulates glucose metabolism
-
Zhu H., Shyh-Chang N., Segrè A.V., Shinoda G., Shah S.P., Einhorn W.S., Takeuchi A., Engreitz J.M., Hagan J.P., Kharas M.G., Urbach A., Thornton J.E., Triboulet R., Gregory R.I., DIAGRAM Consortium, MAGIC Investigators, Altshuler D., Daley G.Q. The Lin28/let-7 axis regulates glucose metabolism. Cell 2011, 147:81-94.
-
(2011)
Cell
, vol.147
, pp. 81-94
-
-
Zhu, H.1
Shyh-Chang, N.2
Segrè, A.V.3
Shinoda, G.4
Shah, S.P.5
Einhorn, W.S.6
Takeuchi, A.7
Engreitz, J.M.8
Hagan, J.P.9
Kharas, M.G.10
Urbach, A.11
Thornton, J.E.12
Triboulet, R.13
Gregory, R.I.14
DIAGRAM, Consortium15
MAGIC, Investigators16
Altshuler, D.17
Daley, G.Q.18
-
11
-
-
84887984423
-
Lin28 enhances tissue repair by reprogramming cellular metabolism
-
Shyh-Chang N., Zhu H., Yvanka de Soysa T., Shinoda G., Seligson M.T., Tsanov K.M., Nguyen L., Asara J.M., Cantley L.C., Daley G.Q. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 2013, 155:778-792.
-
(2013)
Cell
, vol.155
, pp. 778-792
-
-
Shyh-Chang, N.1
Zhu, H.2
Yvanka de Soysa, T.3
Shinoda, G.4
Seligson, M.T.5
Tsanov, K.M.6
Nguyen, L.7
Asara, J.M.8
Cantley, L.C.9
Daley, G.Q.10
-
12
-
-
84857784512
-
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
-
Benhamed M., Herbig U., Ye T., Dejean A., Bischof O. Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells. Nat. Cell Biol. 2012, 14:266-275.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 266-275
-
-
Benhamed, M.1
Herbig, U.2
Ye, T.3
Dejean, A.4
Bischof, O.5
-
13
-
-
79957647418
-
Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis
-
Drummond M.J., McCarthy J.J., Sinha M., Spratt H.M., Volpi E., Esser K.A., Rasmussen B.B. Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis. Physiol. Genomics 2011, 43:595-603.
-
(2011)
Physiol. Genomics
, vol.43
, pp. 595-603
-
-
Drummond, M.J.1
McCarthy, J.J.2
Sinha, M.3
Spratt, H.M.4
Volpi, E.5
Esser, K.A.6
Rasmussen, B.B.7
-
14
-
-
84863762192
-
The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche
-
Toledano H., D'Alterio C., Czech B., Levine E., Jones D.L. The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche. Nature 2012, 485:605-610.
-
(2012)
Nature
, vol.485
, pp. 605-610
-
-
Toledano, H.1
D'Alterio, C.2
Czech, B.3
Levine, E.4
Jones, D.L.5
-
15
-
-
84862776981
-
Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis
-
Yuan J., Nguyen C.K., Liu X., Kanellopoulou C., Muljo S.A. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 2012, 335:1195-1200.
-
(2012)
Science
, vol.335
, pp. 1195-1200
-
-
Yuan, J.1
Nguyen, C.K.2
Liu, X.3
Kanellopoulou, C.4
Muljo, S.A.5
-
16
-
-
84881460310
-
The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
-
Copley M.R., Babovic S., Benz C., Knapp D.J., Beer P.A., Kent D.G., Wohrer S., Treloar D.Q., Day C., Rowe K., Mader H., Kuchenbauer F., Humphries R.K., Eaves C.J. The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat. Cell Biol. 2013, 15:916-925.
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 916-925
-
-
Copley, M.R.1
Babovic, S.2
Benz, C.3
Knapp, D.J.4
Beer, P.A.5
Kent, D.G.6
Wohrer, S.7
Treloar, D.Q.8
Day, C.9
Rowe, K.10
Mader, H.11
Kuchenbauer, F.12
Humphries, R.K.13
Eaves, C.J.14
-
17
-
-
84899740983
-
Lin28 sustains early renal progenitors and induces Wilms tumor
-
Urbach A., Yermalovich A., Zhang J., Spina C.S., Zhu H., Perez-Atayde A.R., Shukrun R., Charlton J., Sebire N., Mifsud W., Dekel B., Pritchard-Jones K., Daley G.Q. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014, 28:971-982.
-
(2014)
Genes Dev.
, vol.28
, pp. 971-982
-
-
Urbach, A.1
Yermalovich, A.2
Zhang, J.3
Spina, C.S.4
Zhu, H.5
Perez-Atayde, A.R.6
Shukrun, R.7
Charlton, J.8
Sebire, N.9
Mifsud, W.10
Dekel, B.11
Pritchard-Jones, K.12
Daley, G.Q.13
-
18
-
-
85019295619
-
Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice
-
Tolonen, et al. Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice. Pharmacol. Res. Perspect. 2014, 2(4):e00056.
-
(2014)
Pharmacol. Res. Perspect.
, vol.2
, Issue.4
, pp. e00056
-
-
Tolonen1
-
19
-
-
84929952785
-
Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway
-
Zhang, et al. Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway. J. Cell. Mol. Med. 2015, 19(6):1174-1182.
-
(2015)
J. Cell. Mol. Med.
, vol.19
, Issue.6
, pp. 1174-1182
-
-
Zhang1
-
20
-
-
84908006900
-
Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions
-
Zhang, et al. Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions. PLoS One 2014, 9(10):e110580.
-
(2014)
PLoS One
, vol.9
, Issue.10
, pp. e110580
-
-
Zhang1
-
21
-
-
84949908492
-
Precise let-7 expression levels balance organ regeneration against tumor suppression
-
Wu L., et al. Precise let-7 expression levels balance organ regeneration against tumor suppression. Elife 2015, 4. 10.7554/eLife.09431.
-
(2015)
Elife
, vol.4
-
-
Wu, L.1
-
22
-
-
84922646378
-
In vivo activation of a conserved microRNA program induces mammalian heart regeneration
-
Aguirre, et al. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell 2014, 15(5):589-604.
-
(2014)
Cell Stem Cell
, vol.15
, Issue.5
, pp. 589-604
-
-
Aguirre1
-
23
-
-
79952065525
-
Transient regenerative potential of the neonatal mouse heart
-
Porrello E.R., Mahmoud A.I., Simpson E., Hill J.A., Richardson J.A., Olson E.N., Sadek H.A. Transient regenerative potential of the neonatal mouse heart. Science 2011, 331:1078-1080.
-
(2011)
Science
, vol.331
, pp. 1078-1080
-
-
Porrello, E.R.1
Mahmoud, A.I.2
Simpson, E.3
Hill, J.A.4
Richardson, J.A.5
Olson, E.N.6
Sadek, H.A.7
-
24
-
-
77955320529
-
PNPASE regulates RNA import into mitochondria
-
Wang G., Chen H.W., Oktay Y., Zhang J., Allen E.L., Smith G.M., Fan K.C., Hong J.S., French S.W., McCaffery J.M., Lightowlers R.N., Morse H.C., Koehler C.M., Teitell M.A. PNPASE regulates RNA import into mitochondria. Cell 2010, 142:456-467.
-
(2010)
Cell
, vol.142
, pp. 456-467
-
-
Wang, G.1
Chen, H.W.2
Oktay, Y.3
Zhang, J.4
Allen, E.L.5
Smith, G.M.6
Fan, K.C.7
Hong, J.S.8
French, S.W.9
McCaffery, J.M.10
Lightowlers, R.N.11
Morse, H.C.12
Koehler, C.M.13
Teitell, M.A.14
-
25
-
-
84941024717
-
Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming
-
Khaw S.L., Min-Wen C., Koh C.G., Lim B., Shyh-Chang N. Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Rep. 2015, 12:1080-1088.
-
(2015)
Cell Rep.
, vol.12
, pp. 1080-1088
-
-
Khaw, S.L.1
Min-Wen, C.2
Koh, C.G.3
Lim, B.4
Shyh-Chang, N.5
-
26
-
-
33847259227
-
The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity
-
French S.W., Dawson D.W., Chen H.W., Rainey R.N., Sievers S.A., Balatoni C.E., Wong L., Troke J.J., Nguyen M.T., Koehler C.M., Teitell M.A. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. Cancer Lett. 2007, 248:198-210.
-
(2007)
Cancer Lett.
, vol.248
, pp. 198-210
-
-
French, S.W.1
Dawson, D.W.2
Chen, H.W.3
Rainey, R.N.4
Sievers, S.A.5
Balatoni, C.E.6
Wong, L.7
Troke, J.J.8
Nguyen, M.T.9
Koehler, C.M.10
Teitell, M.A.11
-
27
-
-
84868504132
-
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss
-
von Ameln S., Wang G., Boulouiz R., Rutherford M.A., Smith G.M., Li Y., Pogoda H.M., Nürnberg G., Stiller B., Volk A.E., et al. A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss. Am. J. Hum. Genet. 2012, 91(5):919-927.
-
(2012)
Am. J. Hum. Genet.
, vol.91
, Issue.5
, pp. 919-927
-
-
von Ameln, S.1
Wang, G.2
Boulouiz, R.3
Rutherford, M.A.4
Smith, G.M.5
Li, Y.6
Pogoda, H.M.7
Nürnberg, G.8
Stiller, B.9
Volk, A.E.10
-
28
-
-
84868456264
-
Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency
-
Vedrenne V., Gowher A., De Lonlay P., Nitschke P., Serre V., Boddaert N., Altuzarra C., Mager-Heckel A.M., Chretien F., Entelis N., Munnich A., Tarassov I., Rötig A. Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency. Am. J. Hum. Genet. 2012, 91:912-918.
-
(2012)
Am. J. Hum. Genet.
, vol.91
, pp. 912-918
-
-
Vedrenne, V.1
Gowher, A.2
De Lonlay, P.3
Nitschke, P.4
Serre, V.5
Boddaert, N.6
Altuzarra, C.7
Mager-Heckel, A.M.8
Chretien, F.9
Entelis, N.10
Munnich, A.11
Tarassov, I.12
Rötig, A.13
-
29
-
-
0037168641
-
old-35, in the context of terminal differentiation and cellular senescence
-
old-35, in the context of terminal differentiation and cellular senescence. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:16636-16641.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 16636-16641
-
-
Leszczyniecka, M.1
Kang, D.C.2
Sarkar, D.3
Su, Z.Z.4
Holmes, M.5
Valerie, K.6
Fisher, P.B.7
-
30
-
-
0141887674
-
old-35, a type I interferon inducible early response gene
-
old-35, a type I interferon inducible early response gene. Gene 2003, 316:143-156.
-
(2003)
Gene
, vol.316
, pp. 143-156
-
-
Leszczyniecka, M.1
Su, Z.Z.2
Kang, D.C.3
Sarkar, D.4
Fisher, P.B.5
-
31
-
-
0041589211
-
old-35) in human melanoma cells
-
old-35) in human melanoma cells. J. Biol. Chem. 2003, 278:24542-24551.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24542-24551
-
-
Sarkar, D.1
Leszczyniecka, M.2
Kang, D.C.3
Lebedeva, I.V.4
Valerie, K.5
Dhar, S.6
Pandita, T.K.7
Fisher, P.B.8
-
32
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco M., Schiltz R.L., Iezzi S., King M.T., Zhao P., Kashiwaya Y., Hoffman E., Veech R.L., Sartorelli V. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell. 2003, 12:51-62.
-
(2003)
Mol. Cell.
, vol.12
, pp. 51-62
-
-
Fulco, M.1
Schiltz, R.L.2
Iezzi, S.3
King, M.T.4
Zhao, P.5
Kashiwaya, Y.6
Hoffman, E.7
Veech, R.L.8
Sartorelli, V.9
-
33
-
-
84924857323
-
+-dependent SIRT deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells
-
+-dependent SIRT deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells. Cell Stem Cell 2015, 16:171-183.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 171-183
-
-
Ryall, J.G.1
Dell'Orso, S.2
Derfoul, A.3
Juan, A.4
Zare, H.5
Feng, X.6
Clermont, D.7
Koulnis, M.8
Gutierrez-Cruz, G.9
Fulco, M.10
Sartorelli, V.11
-
34
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999, 98:115-124.
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
Zhang, C.4
Adelmant, G.5
Mootha, V.6
Troy, A.7
Cinti, S.8
Lowell, B.9
Scarpulla, R.C.10
Spiegelman, B.M.11
-
35
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
36
-
-
34247259630
-
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
-
Gerhart-Hines Z., Rodgers J.T., Bare O., Lerin C., Kim S.H., Mostoslavsky R., Alt F.W., Wu Z., Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007, 26:1913-1923.
-
(2007)
EMBO J.
, vol.26
, pp. 1913-1923
-
-
Gerhart-Hines, Z.1
Rodgers, J.T.2
Bare, O.3
Lerin, C.4
Kim, S.H.5
Mostoslavsky, R.6
Alt, F.W.7
Wu, Z.8
Puigserver, P.9
-
37
-
-
6944247865
-
Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals
-
Machida S., Booth F.W. Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals. Exp. Gerontol. 2004, 39:1521-1525.
-
(2004)
Exp. Gerontol.
, vol.39
, pp. 1521-1525
-
-
Machida, S.1
Booth, F.W.2
-
38
-
-
73949099327
-
Increased muscle PGC1a expression protects from sarcopenia and metabolic disease during aging
-
Wenz T., Rossi S.G., Rotundo R.L., Spiegelman B.M., Moraes C.T. Increased muscle PGC1a expression protects from sarcopenia and metabolic disease during aging. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:20405-20410.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 20405-20410
-
-
Wenz, T.1
Rossi, S.G.2
Rotundo, R.L.3
Spiegelman, B.M.4
Moraes, C.T.5
-
39
-
-
65649148341
-
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity
-
Liang H., Balas B., Tantiwong P., Dube J., Goodpaster B.H., O'Doherty R.M., DeFronzo R.A., Richardson A., Musi N., Ward W.F. Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E945-54.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
, pp. E945-E954
-
-
Liang, H.1
Balas, B.2
Tantiwong, P.3
Dube, J.4
Goodpaster, B.H.5
O'Doherty, R.M.6
DeFronzo, R.A.7
Richardson, A.8
Musi, N.9
Ward, W.F.10
-
40
-
-
67651208171
-
PGC-1alpha-induced improvements in skeletal muscle metabolism and insulin sensitivity
-
Bonen A. PGC-1alpha-induced improvements in skeletal muscle metabolism and insulin sensitivity. Appl. Physiol. Nutr. Metab. 2009, 34:307-314.
-
(2009)
Appl. Physiol. Nutr. Metab.
, vol.34
, pp. 307-314
-
-
Bonen, A.1
-
41
-
-
79551610653
-
Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
-
Hochmuth C.E., Biteau B., Bohmann D., Jasper H. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell 2011, 8:188-199.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 188-199
-
-
Hochmuth, C.E.1
Biteau, B.2
Bohmann, D.3
Jasper, H.4
-
42
-
-
80455143200
-
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
-
Rera M., Bahadorani S., Cho J., Koehler C.L., Ulgherait M., Hur J.H., Ansari W.S., Lo T., Jones D.L., Walker D.W. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 2011, 14:623-634.
-
(2011)
Cell Metab.
, vol.14
, pp. 623-634
-
-
Rera, M.1
Bahadorani, S.2
Cho, J.3
Koehler, C.L.4
Ulgherait, M.5
Hur, J.H.6
Ansari, W.S.7
Lo, T.8
Jones, D.L.9
Walker, D.W.10
-
43
-
-
84939248341
-
Differentiation of human neural stem cells into motor neurons stimulates mitochondrial biogenesis and decreases glycolytic flux
-
O'Brien L.C., Keeney P.M., Bennett J.P. Differentiation of human neural stem cells into motor neurons stimulates mitochondrial biogenesis and decreases glycolytic flux. Stem Cells Dev. 2015, 24:1984-1994.
-
(2015)
Stem Cells Dev.
, vol.24
, pp. 1984-1994
-
-
O'Brien, L.C.1
Keeney, P.M.2
Bennett, J.P.3
-
44
-
-
84941711126
-
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration
-
Stevens D.A., Lee Y., Kang H.C., Lee B.D., Lee Y.I., Bower A., Jiang H., Kang S.U., Andrabi S.A., Dawson V.L., Shin J.H.O., Dawson T.M. Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proc. Natl. Acad. Sci. U. S. A. 2015, 112:1701-11696.
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. 1701-11696
-
-
Stevens, D.A.1
Lee, Y.2
Kang, H.C.3
Lee, B.D.4
Lee, Y.I.5
Bower, A.6
Jiang, H.7
Kang, S.U.8
Andrabi, S.A.9
Dawson, V.L.10
Shin, J.H.O.11
Dawson, T.M.12
-
45
-
-
84929273586
-
Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic iPSC lines
-
Shaltouki A., Sivapatham R., Pei Y., Gerencser A.A., Momčilović O., Rao M.S., Zeng X. Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic iPSC lines. Stem Cell Rep. 2015, 4:847-859.
-
(2015)
Stem Cell Rep.
, vol.4
, pp. 847-859
-
-
Shaltouki, A.1
Sivapatham, R.2
Pei, Y.3
Gerencser, A.A.4
Momčilović, O.5
Rao, M.S.6
Zeng, X.7
-
46
-
-
84882900207
-
Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains
-
Goh L.H., Zhou X., Lee M.C., Lin S., Wang H., Luo Y., Yang X. Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains. Dev. Biol. 2013, 381:353-364.
-
(2013)
Dev. Biol.
, vol.381
, pp. 353-364
-
-
Goh, L.H.1
Zhou, X.2
Lee, M.C.3
Lin, S.4
Wang, H.5
Luo, Y.6
Yang, X.7
-
47
-
-
84905661973
-
Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiationinduced mitochondrial stress
-
Xavier J.M., Morgado A.L., Solá S., Rodrigues C.M. Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiationinduced mitochondrial stress. Antioxid. Redox Signal. 2014, 21:1009-1024.
-
(2014)
Antioxid. Redox Signal.
, vol.21
, pp. 1009-1024
-
-
Xavier, J.M.1
Morgado, A.L.2
Solá, S.3
Rodrigues, C.M.4
-
48
-
-
66249086606
-
P53 regulates mtDNA copy number and mitocheckpoint pathway
-
Kulawiec M., Ayyasamy V., Singh K.K. p53 regulates mtDNA copy number and mitocheckpoint pathway. J. Carcinog. 2009, 8.
-
(2009)
J. Carcinog.
, vol.8
-
-
Kulawiec, M.1
Ayyasamy, V.2
Singh, K.K.3
-
49
-
-
85020580872
-
Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage
-
Buechner N., Droese S., Jakob S., Brandt U., Altschmied J., Haendeler J. Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage. Cell Commun. Signal. 2009, 7:A57.
-
(2009)
Cell Commun. Signal.
, vol.7
, pp. A57
-
-
Buechner, N.1
Droese, S.2
Jakob, S.3
Brandt, U.4
Altschmied, J.5
Haendeler, J.6
-
50
-
-
84894441595
-
Human mesenchymal stem cellí-replicative senescence and oxidative stress are closely linked to aneuploidy
-
Estrada J.C., Torres Y., Benguría A., Dopazo A., Roche E., Carrera-Quintanar L., Pérez R.A., Enríquez J.A., Torres R., Ramírez J.C., Samper E., Bernad A. Human mesenchymal stem cellí-replicative senescence and oxidative stress are closely linked to aneuploidy. Cell Death Dis. 2013, 4:e691.
-
(2013)
Cell Death Dis.
, vol.4
, pp. e691
-
-
Estrada, J.C.1
Torres, Y.2
Benguría, A.3
Dopazo, A.4
Roche, E.5
Carrera-Quintanar, L.6
Pérez, R.A.7
Enríquez, J.A.8
Torres, R.9
Ramírez, J.C.10
Samper, E.11
Bernad, A.12
-
51
-
-
77953256244
-
A mutant telomerase defective in nuclear--cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction
-
Kovalenko O.A., Caron M.J., Ulema P., Medrano C., Thomas A.P., Kimura M., Bonini M.G., Herbig U., Santos J.H. A mutant telomerase defective in nuclear--cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell 2010, 9:203-219.
-
(2010)
Aging Cell
, vol.9
, pp. 203-219
-
-
Kovalenko, O.A.1
Caron, M.J.2
Ulema, P.3
Medrano, C.4
Thomas, A.P.5
Kimura, M.6
Bonini, M.G.7
Herbig, U.8
Santos, J.H.9
-
52
-
-
79953033356
-
Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence
-
Rai P., Young J.J., Burton D.G., Giribaldi M.G., Onder T.T., Weinberg R.A. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene 2011, 30:1489-1496.
-
(2011)
Oncogene
, vol.30
, pp. 1489-1496
-
-
Rai, P.1
Young, J.J.2
Burton, D.G.3
Giribaldi, M.G.4
Onder, T.T.5
Weinberg, R.A.6
-
53
-
-
84878679199
-
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
-
Kaplon J., Zheng L., Meissl K., Chaneton B., Selivanov V.A., Mackay G., van der Burg S.H., Verdegaal E.M., Cascante M., Shlomi T., Gottlieb E., Peeper D.S. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature 2013, 498:109-112.
-
(2013)
Nature
, vol.498
, pp. 109-112
-
-
Kaplon, J.1
Zheng, L.2
Meissl, K.3
Chaneton, B.4
Selivanov, V.A.5
Mackay, G.6
van der Burg, S.H.7
Verdegaal, E.M.8
Cascante, M.9
Shlomi, T.10
Gottlieb, E.11
Peeper, D.S.12
-
54
-
-
84922445353
-
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth
-
Schell J.C., Olson K.A., Jiang L., Hawkins A.J., Van Vranken J.G., Xie J., Egnatchik R.A., Earl E.G., DeBerardinis R.J., Rutter J. A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Mol. Cell 2014, 56:400-413.
-
(2014)
Mol. Cell
, vol.56
, pp. 400-413
-
-
Schell, J.C.1
Olson, K.A.2
Jiang, L.3
Hawkins, A.J.4
Van Vranken, J.G.5
Xie, J.6
Egnatchik, R.A.7
Earl, E.G.8
DeBerardinis, R.J.9
Rutter, J.10
-
55
-
-
84930486276
-
Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative stress
-
Ho J.H., Chen Y.F., Ma W.H., Tseng T.C., Chen M.H., Lee O.K. Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative stress. Cell Transplant. 2011, 20:1209-1220.
-
(2011)
Cell Transplant.
, vol.20
, pp. 1209-1220
-
-
Ho, J.H.1
Chen, Y.F.2
Ma, W.H.3
Tseng, T.C.4
Chen, M.H.5
Lee, O.K.6
-
56
-
-
0348047391
-
The retardation of aging by caloric restriction: its significance in the transgenic era
-
Barger J.L., Walford R.L., Weindruch R. The retardation of aging by caloric restriction: its significance in the transgenic era. Exp. Gerontol. 2003, 38:1343-1351.
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 1343-1351
-
-
Barger, J.L.1
Walford, R.L.2
Weindruch, R.3
-
57
-
-
80051609656
-
Calorie restriction: is AMPK a key sensor and effector?
-
Cantó C., Auwerx J. Calorie restriction: is AMPK a key sensor and effector?. Physiology (Bethesda) 2011, 26:214-224.
-
(2011)
Physiology (Bethesda)
, vol.26
, pp. 214-224
-
-
Cantó, C.1
Auwerx, J.2
-
58
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Cantó C., Gerhart-Hines Z., Feige J.N., Lagouge M., Noriega L., Milne J.C., Elliott P.J., Puigserver P., Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009, 458:1056-1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
59
-
-
84860614281
-
Short-term calorie restriction enhances skeletal muscle stem cell function
-
Cerletti M., Jang Y.C., Finley L.W.S., Haigis M.C., Wagers A.J. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell 2012, 10:515-519.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 515-519
-
-
Cerletti, M.1
Jang, Y.C.2
Finley, L.W.S.3
Haigis, M.C.4
Wagers, A.J.5
-
60
-
-
0142195931
-
Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction
-
Chen J., Astle C.M., Harrison D.E. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp. Hematol. 2003, 31:1097-1103.
-
(2003)
Exp. Hematol.
, vol.31
, pp. 1097-1103
-
-
Chen, J.1
Astle, C.M.2
Harrison, D.E.3
-
61
-
-
34249882777
-
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
-
Miyamoto K., Araki K.Y., Naka K., Arai F., Takubo K., Yamazaki S., Matsuoka S., Miyamoto T., Ito K., Ohmura M., Chen C., Hosokawa K., Nakauchi H., Nakayama K., Nakayama K.I., Harada M., Motoyama N., Suda T., Hirao A. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 2007, 1:101-112.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 101-112
-
-
Miyamoto, K.1
Araki, K.Y.2
Naka, K.3
Arai, F.4
Takubo, K.5
Yamazaki, S.6
Matsuoka, S.7
Miyamoto, T.8
Ito, K.9
Ohmura, M.10
Chen, C.11
Hosokawa, K.12
Nakauchi, H.13
Nakayama, K.14
Nakayama, K.I.15
Harada, M.16
Motoyama, N.17
Suda, T.18
Hirao, A.19
-
62
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z., Kollipara R., Huntly B.J., Lee B.H., Castrillon D.H., Cullen D.E., McDowell E.P., Lazo-Kallanian S., Williams I.R., Sears C., et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007, 128:325-339.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
-
63
-
-
54449092731
-
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
-
Yalcin S., Zhang X., Luciano J.P., Mungamuri S.K., Marinkovic D., Vercherat C., Sarkar A., Grisotto M., Taneja R., Ghaffari S. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J. Biol. Chem. 2008, 283:2705-25692.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 2705-25692
-
-
Yalcin, S.1
Zhang, X.2
Luciano, J.P.3
Mungamuri, S.K.4
Marinkovic, D.5
Vercherat, C.6
Sarkar, A.7
Grisotto, M.8
Taneja, R.9
Ghaffari, S.10
-
64
-
-
78650302424
-
-/- mice
-
-/- mice. EMBO J. 2010, 29:4118-4131.
-
(2010)
EMBO J.
, vol.29
, pp. 4118-4131
-
-
Yalcin, S.1
Marinkovic, D.2
Mungamuri, S.K.3
Zhang, X.4
Tong, W.5
Sellers, R.6
Ghaffari, S.7
-
65
-
-
84874192375
-
FOXO3A directs a protective autophagy program in haematopoietic stem cells
-
Warr M.R., Binnewies M., Flach J., Reynaud D., Garg T., Malhotra R., Debnath J., Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 2013, 494:323-327.
-
(2013)
Nature
, vol.494
, pp. 323-327
-
-
Warr, M.R.1
Binnewies, M.2
Flach, J.3
Reynaud, D.4
Garg, T.5
Malhotra, R.6
Debnath, J.7
Passegué, E.8
-
66
-
-
84940797231
-
Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3
-
Rimmelé P., Liang R., Bigarella C.L., Kocabas F., Xie J., Serasinghe M.N., Chipuk J., Sadek H., Zhang C.C., Ghaffari S. Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3. EMBO Rep. 2015, 16:1164-1176.
-
(2015)
EMBO Rep.
, vol.16
, pp. 1164-1176
-
-
Rimmelé, P.1
Liang, R.2
Bigarella, C.L.3
Kocabas, F.4
Xie, J.5
Serasinghe, M.N.6
Chipuk, J.7
Sadek, H.8
Zhang, C.C.9
Ghaffari, S.10
-
67
-
-
0035281979
-
Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis
-
Drummond-Barbosa D., Spradling A.C. Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev. Biol. 2001, 231:265-278.
-
(2001)
Dev. Biol.
, vol.231
, pp. 265-278
-
-
Drummond-Barbosa, D.1
Spradling, A.C.2
-
68
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997, 277:942-946.
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
69
-
-
23644444460
-
Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila
-
LaFever L., Drummond-Barbosa D. Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 2005, 309:1071-1073.
-
(2005)
Science
, vol.309
, pp. 1071-1073
-
-
LaFever, L.1
Drummond-Barbosa, D.2
-
70
-
-
37849019064
-
Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila
-
Hsu H.-J., LaFever L., Drummond-Barbosa D. Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev. Biol. 2008, 313:700-712.
-
(2008)
Dev. Biol.
, vol.313
, pp. 700-712
-
-
Hsu, H.-J.1
LaFever, L.2
Drummond-Barbosa, D.3
-
71
-
-
67650266694
-
Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila
-
Ueishi S., Shimizu H., H Inoue Y. Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila. Cell Struct. Funct. 2009, 34:61-69.
-
(2009)
Cell Struct. Funct.
, vol.34
, pp. 61-69
-
-
Ueishi, S.1
Shimizu, H.2
H Inoue, Y.3
-
72
-
-
84860309087
-
Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS
-
Wang Z.A., Huang J., Kalderon D. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Nat. Commun. 2012, 3:769.
-
(2012)
Nat. Commun.
, vol.3
, pp. 769
-
-
Wang, Z.A.1
Huang, J.2
Kalderon, D.3
-
73
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan D.F., Shackelford D.B., Mihaylova M.M., Gelino S., Kohnz R.A., Mair W., Vasquez D.S., Joshi A., Gwinn D.M., Taylor R., Asara J.M., Fitzpatrick J., Dillin A., Viollet B., Kundu M., Hansen M., Shaw R.J. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331:456-461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
Asara, J.M.11
Fitzpatrick, J.12
Dillin, A.13
Viollet, B.14
Kundu, M.15
Hansen, M.16
Shaw, R.J.17
-
74
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
Schieke S.M., et al. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 2006, 281:627-643.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 627-643
-
-
Schieke, S.M.1
-
75
-
-
36749081539
-
MTOR controls mitochondrial oxidative function through a YY1-PGC-1α riptional complex
-
Cunningham J.T., et al. mTOR controls mitochondrial oxidative function through a YY1-PGC-1α riptional complex. Nature 2007, 450:736-740.
-
(2007)
Nature
, vol.450
, pp. 736-740
-
-
Cunningham, J.T.1
-
77
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen C., Liu Y., Liu R., Ikenoue T., Guan K.L., Liu Y., Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 2008, 205:2397-2408.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Liu, Y.6
Zheng, P.7
-
78
-
-
75549090275
-
MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
Chen C., Liu Y., Liu Y., Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2009, 2:ra75.
-
(2009)
Sci. Signal.
, vol.2
, pp. ra75
-
-
Chen, C.1
Liu, Y.2
Liu, Y.3
Zheng, P.4
-
79
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison D.E., Strong R., Sharp Z.D., Nelson J.F., Astle C.M., Flurkey K., Nadon N.L., Wilkinson J.E., Frenkel K., Carter C.S., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
80
-
-
84859429092
-
Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila
-
Shim J., Mukherjee T., Banerjee U. Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. Nat. Cell Biol. 2012, 14:394-400.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 394-400
-
-
Shim, J.1
Mukherjee, T.2
Banerjee, U.3
-
81
-
-
69249206717
-
MTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
-
Castilho R.M., Squarize C.H., Chodosh L.A., Williams B.O., Gutkind J.S. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009, 5:279-289.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 279-289
-
-
Castilho, R.M.1
Squarize, C.H.2
Chodosh, L.A.3
Williams, B.O.4
Gutkind, J.S.5
-
82
-
-
84862994618
-
MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
-
Yilmaz O.H., Katajisto P., Lamming D.W., Gültekin Y., Bauer-Rowe K.E., Sengupta S., Birsoy K., Dursun A., Yilmaz V.O., Selig M., et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 2012, 486:490-495.
-
(2012)
Nature
, vol.486
, pp. 490-495
-
-
Yilmaz, O.H.1
Katajisto, P.2
Lamming, D.W.3
Gültekin, Y.4
Bauer-Rowe, K.E.5
Sengupta, S.6
Birsoy, K.7
Dursun, A.8
Yilmaz, V.O.9
Selig, M.10
-
83
-
-
78649874959
-
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
-
Gan B., Hu J., Jiang S., Liu Y., Sahin E., Zhuang L., Fletcher-Sananikone E., Colla S., Wang Y.A., Chin L., et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010, 468:701-704.
-
(2010)
Nature
, vol.468
, pp. 701-704
-
-
Gan, B.1
Hu, J.2
Jiang, S.3
Liu, Y.4
Sahin, E.5
Zhuang, L.6
Fletcher-Sananikone, E.7
Colla, S.8
Wang, Y.A.9
Chin, L.10
-
84
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
Gurumurthy S., Xie S.Z., Alagesan B., Kim J., Yusuf R.Z., Saez B., Tzatsos A., Ozsolak F., Milos P., Ferrari F., et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 2010, 468:659-663.
-
(2010)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
Xie, S.Z.2
Alagesan, B.3
Kim, J.4
Yusuf, R.Z.5
Saez, B.6
Tzatsos, A.7
Ozsolak, F.8
Milos, P.9
Ferrari, F.10
-
85
-
-
78649811793
-
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
-
Nakada D., Saunders T.L., Morrison S.J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010, 468:653-658.
-
(2010)
Nature
, vol.468
, pp. 653-658
-
-
Nakada, D.1
Saunders, T.L.2
Morrison, S.J.3
-
86
-
-
59649101100
-
AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development
-
Dasgupta B., Milbrandt J. AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev. Cell 2009, 16:256-270.
-
(2009)
Dev. Cell
, vol.16
, pp. 256-270
-
-
Dasgupta, B.1
Milbrandt, J.2
-
87
-
-
33645090940
-
Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
-
Narbonne P., Roy R. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 2006, 133:611-619.
-
(2006)
Development
, vol.133
, pp. 611-619
-
-
Narbonne, P.1
Roy, R.2
-
88
-
-
0015319592
-
A biologic clock: the mitochondria?
-
Harman D. A biologic clock: the mitochondria?. J. Am. Geriatr. Soc. 1972, 20(4):145-147.
-
(1972)
J. Am. Geriatr. Soc.
, vol.20
, Issue.4
, pp. 145-147
-
-
Harman, D.1
-
89
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., Bohlooly Y.M., Gidlof S., Oldfors A., Wibom R., Tornell J., Jacobs H.T., Larsson N.G. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004, 429:417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.M.7
Gidlof, S.8
Oldfors, A.9
Wibom, R.10
Tornell, J.11
Jacobs, H.T.12
Larsson, N.G.13
-
90
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth G.C., Hiona A., Pugh T.D., Someya S., Panzer K., Wohlgemuth S.E., Hofer T., Seo A.Y., Sullivan R., Jobling W.A., Morrow J.D., Van Remmen H., Sedivy J.M., Yamasoba T., Tanokura M., Weindruch R., Leeuwenburgh C., Prolla T.A. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005, 309:481-484.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
Morrow, J.D.11
Van Remmen, H.12
Sedivy, J.M.13
Yamasoba, T.14
Tanokura, M.15
Weindruch, R.16
Leeuwenburgh, C.17
Prolla, T.A.18
-
91
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito K., Hirao A., Arai F., Matsuoka S., Takubo K., Hamaguchi I., Nomiyama K., Hosokawa K., Sakurada K., Nakagata N., Ikeda Y., Mak T.W., Suda T. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004, 431:997-1002.
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Matsuoka, S.4
Takubo, K.5
Hamaguchi, I.6
Nomiyama, K.7
Hosokawa, K.8
Sakurada, K.9
Nakagata, N.10
Ikeda, Y.11
Mak, T.W.12
Suda, T.13
-
92
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., Weissman I.L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007, 447:725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
93
-
-
77950236668
-
Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction
-
Chen M.L., Logan T.D., Hochberg M.L., Shelat S.G., Yu X., Wilding G.E., Tan W., Kujoth G.C., Prolla T.A., Selak M.A., Kundu M., Carroll M., Thompson J.E. Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood 2009, 114:4045-4053.
-
(2009)
Blood
, vol.114
, pp. 4045-4053
-
-
Chen, M.L.1
Logan, T.D.2
Hochberg, M.L.3
Shelat, S.G.4
Yu, X.5
Wilding, G.E.6
Tan, W.7
Kujoth, G.C.8
Prolla, T.A.9
Selak, M.A.10
Kundu, M.11
Carroll, M.12
Thompson, J.E.13
-
94
-
-
79955698235
-
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
-
Norddahl G.L., Pronk C.J., Wahlestedt M., Sten G., Nygren J.M., Ugale A., Sigvardsson M., Bryder D. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 2011, 8:499-510.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 499-510
-
-
Norddahl, G.L.1
Pronk, C.J.2
Wahlestedt, M.3
Sten, G.4
Nygren, J.M.5
Ugale, A.6
Sigvardsson, M.7
Bryder, D.8
-
95
-
-
84855417557
-
Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice
-
Ahlqvist K.J., Hamalainen R.H., Yatsuga S., Uutela M., Terzioglu M., Gotz A., Forsstrom S., Salven P., Angers-Loustau A., Kopra O.H., Tyynismaa H., Larsson N.G., Wartiovaara K., Prolla T., Trifunovic A., Suomalainen A. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab. 2012, 15:100-109.
-
(2012)
Cell Metab.
, vol.15
, pp. 100-109
-
-
Ahlqvist, K.J.1
Hamalainen, R.H.2
Yatsuga, S.3
Uutela, M.4
Terzioglu, M.5
Gotz, A.6
Forsstrom, S.7
Salven, P.8
Angers-Loustau, A.9
Kopra, O.H.10
Tyynismaa, H.11
Larsson, N.G.12
Wartiovaara, K.13
Prolla, T.14
Trifunovic, A.15
Suomalainen, A.16
-
96
-
-
84860524508
-
Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption
-
Fox R.G., Magness S., Kujoth G.C., Prolla T.A., Maeda N. Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 302:G914-G924.
-
(2012)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.302
, pp. G914-G924
-
-
Fox, R.G.1
Magness, S.2
Kujoth, G.C.3
Prolla, T.A.4
Maeda, N.5
-
97
-
-
42249112646
-
Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes
-
Wulfert M., Kupper A.C., Tapprich C., Bottomley S.S., Bowen D., Germing U., Haas R., Gattermann N. Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes. Exp. Hematol. 2008, 36:577-586.
-
(2008)
Exp. Hematol.
, vol.36
, pp. 577-586
-
-
Wulfert, M.1
Kupper, A.C.2
Tapprich, C.3
Bottomley, S.S.4
Bowen, D.5
Germing, U.6
Haas, R.7
Gattermann, N.8
-
98
-
-
84874515942
-
Accumulation of mtDNA variations in human single CD34 + cells from maternally related individuals: effects of aging and family genetic background
-
Yao Y.G., Kajigaya S., Feng X., Samsel L., McCoy J.P., Torelli G., Young N.S. Accumulation of mtDNA variations in human single CD34 + cells from maternally related individuals: effects of aging and family genetic background. Stem Cell Res. 2013, 10:361-370.
-
(2013)
Stem Cell Res.
, vol.10
, pp. 361-370
-
-
Yao, Y.G.1
Kajigaya, S.2
Feng, X.3
Samsel, L.4
McCoy, J.P.5
Torelli, G.6
Young, N.S.7
-
99
-
-
84902989327
-
Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
-
Baines H.L., Stewart J.B., Stamp C., Zupanic A., Kirkwood T.B., Larsson N.G., Turnbull D.M., Greaves L.C. Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans. Mech. Ageing Dev. 2014, 139:22-30.
-
(2014)
Mech. Ageing Dev.
, vol.139
, pp. 22-30
-
-
Baines, H.L.1
Stewart, J.B.2
Stamp, C.3
Zupanic, A.4
Kirkwood, T.B.5
Larsson, N.G.6
Turnbull, D.M.7
Greaves, L.C.8
-
100
-
-
77951498581
-
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
-
Deng W., Aimone J.B., Gage F.H. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?. Nat. Rev. Neurosci. 2010, 11:339-350.
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 339-350
-
-
Deng, W.1
Aimone, J.B.2
Gage, F.H.3
-
101
-
-
0029863342
-
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
-
Kuhn H.G., Dickinson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 1996, 16:2027-2033.
-
(1996)
J. Neurosci.
, vol.16
, pp. 2027-2033
-
-
Kuhn, H.G.1
Dickinson-Anson, H.2
Gage, F.H.3
-
102
-
-
84901294948
-
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease
-
Kukreja L., Kujoth G.C., Prolla T.A., Van Leuven F., Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol. Neurodegener. 2014, 9:16.
-
(2014)
Mol. Neurodegener.
, vol.9
, pp. 16
-
-
Kukreja, L.1
Kujoth, G.C.2
Prolla, T.A.3
Van Leuven, F.4
Vassar, R.5
-
103
-
-
84937642681
-
MtDNA mutagenesis disrupts pluripotent stem cell function by altering redox signaling
-
Hämäläinen R.H., Ahlqvist K.J., Ellonen P., Lepistö M., Logan A., Otonkoski T., Murphy M.P., Suomalainen A. mtDNA mutagenesis disrupts pluripotent stem cell function by altering redox signaling. Cell Rep. 2015, 11:1-11.
-
(2015)
Cell Rep.
, vol.11
, pp. 1-11
-
-
Hämäläinen, R.H.1
Ahlqvist, K.J.2
Ellonen, P.3
Lepistö, M.4
Logan, A.5
Otonkoski, T.6
Murphy, M.P.7
Suomalainen, A.8
-
104
-
-
78049434938
-
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria
-
Dai D.F., Chen T., Wanagat J., Laflamme M., Marcinek D.J., Emond M.J., Ngo C.P., Prolla T.A., Rabinovitch P.S. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell 2010, 9:536-544.
-
(2010)
Aging Cell
, vol.9
, pp. 536-544
-
-
Dai, D.F.1
Chen, T.2
Wanagat, J.3
Laflamme, M.4
Marcinek, D.J.5
Emond, M.J.6
Ngo, C.P.7
Prolla, T.A.8
Rabinovitch, P.S.9
-
105
-
-
84904988972
-
In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice
-
Logan A., Shabalina I.G., Prime T.A., Rogatti S., Kalinovich A.V., Hartley R.C., Budd R.C., Cannon B., Murphy M.P. In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell 2014, 13:765-768.
-
(2014)
Aging Cell
, vol.13
, pp. 765-768
-
-
Logan, A.1
Shabalina, I.G.2
Prime, T.A.3
Rogatti, S.4
Kalinovich, A.V.5
Hartley, R.C.6
Budd, R.C.7
Cannon, B.8
Murphy, M.P.9
-
106
-
-
84860445228
-
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse
-
Dillon L.M., Williams S.L., Hida A., Peacock J.D., Prolla T.A., Lincoln J., Moraes C.T. Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum. Mol. Genet. 2012, 21:2288-2297.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 2288-2297
-
-
Dillon, L.M.1
Williams, S.L.2
Hida, A.3
Peacock, J.D.4
Prolla, T.A.5
Lincoln, J.6
Moraes, C.T.7
-
107
-
-
84927732079
-
Stem cells: asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
-
Katajisto P., Döhla J., Chaffer C.L., Pentinmikko N., Marjanovic N., Iqbal S., Zoncu R., Chen W., Weinberg R.A., Sabatini D.M. Stem cells: asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science 2015, 348:340-343.
-
(2015)
Science
, vol.348
, pp. 340-343
-
-
Katajisto, P.1
Döhla, J.2
Chaffer, C.L.3
Pentinmikko, N.4
Marjanovic, N.5
Iqbal, S.6
Zoncu, R.7
Chen, W.8
Weinberg, R.A.9
Sabatini, D.M.10
-
108
-
-
84901298851
-
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity
-
Dimas A.S., Lagou V., Barker A., Knowles J.W., Mägi R., Hivert M.F., Benazzo A., Rybin D., Jackson A.U., Stringham H.M., Song C., et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes 2014, 63:2158-2171.
-
(2014)
Diabetes
, vol.63
, pp. 2158-2171
-
-
Dimas, A.S.1
Lagou, V.2
Barker, A.3
Knowles, J.W.4
Mägi, R.5
Hivert, M.F.6
Benazzo, A.7
Rybin, D.8
Jackson, A.U.9
Stringham, H.M.10
Song, C.11
-
109
-
-
0030740621
-
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
-
Simoneau J.A., Kelley D.E. Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J. Appl. Physiol. 1997, 83:166-171.
-
(1997)
J. Appl. Physiol.
, vol.83
, pp. 166-171
-
-
Simoneau, J.A.1
Kelley, D.E.2
-
110
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley D.E., He J., Menshikova E.V., Ritov V.B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002, 51:2944-2950.
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
111
-
-
12144275294
-
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
-
Ritov V.B., Menshikova E.V., He J., Ferrell R.E., Goodpaster B.H., Kelley D.E. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 2005, 54:8-14.
-
(2005)
Diabetes
, vol.54
, pp. 8-14
-
-
Ritov, V.B.1
Menshikova, E.V.2
He, J.3
Ferrell, R.E.4
Goodpaster, B.H.5
Kelley, D.E.6
-
112
-
-
0038054341
-
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstrale M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., Groop L.C. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 2003, 34:267-273.
-
(2003)
Nat. Genet.
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstrale, M.9
Laurila, E.10
Houstis, N.11
Daly, M.J.12
Patterson, N.13
Mesirov, J.P.14
Golub, T.R.15
Tamayo, P.16
Spiegelman, B.17
Lander, E.S.18
Hirschhorn, J.N.19
Altshuler, D.20
Groop, L.C.21
more..
-
113
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1
-
Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., Landaker E.J., Goldfine A.B., Mun E., DeFronzo R., Finlayson J., Kahn C.R., Mandarino L.J. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:8466-8471.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
Butte, A.J.2
Crunkhorn, S.3
Cusi, K.4
Berria, R.5
Kashyap, S.6
Miyazaki, Y.7
Kohane, I.8
Costello, M.9
Saccone, R.10
Landaker, E.J.11
Goldfine, A.B.12
Mun, E.13
DeFronzo, R.14
Finlayson, J.15
Kahn, C.R.16
Mandarino, L.J.17
-
114
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
-
Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothman D.L., DiPietro L., Cline G.W., Shulman G.I. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003, 300:1140-1142.
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
Dziura, J.4
Ariyan, C.5
Rothman, D.L.6
DiPietro, L.7
Cline, G.W.8
Shulman, G.I.9
-
115
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
-
Petersen K.F., Dufour S., Befroy D., Garcia R., Shulman G.I. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 2004, 350:664-671.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
116
-
-
25644448096
-
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents
-
Petersen K.F., Dufour S., Shulman G.I. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005, 2:e233.
-
(2005)
PLoS Med.
, vol.2
, pp. e233
-
-
Petersen, K.F.1
Dufour, S.2
Shulman, G.I.3
-
117
-
-
17744393686
-
Mitochondrial DNA mutations in human disease
-
Taylor R.W., Turnbull D.M. Mitochondrial DNA mutations in human disease. Nat. Rev. Genet. 2005, 6:389-402.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 389-402
-
-
Taylor, R.W.1
Turnbull, D.M.2
-
118
-
-
0026906885
-
Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
-
van den Ouweland J.M., Lemkes H.H., Ruitenbeek W., Sandkuijl L.A., de Vijlder M.F., Struyvenberg P.A., van de Kamp J.J., Maassen J.A. Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet. 1992, 1:368-371.
-
(1992)
Nat. Genet.
, vol.1
, pp. 368-371
-
-
van den Ouweland, J.M.1
Lemkes, H.H.2
Ruitenbeek, W.3
Sandkuijl, L.A.4
de Vijlder, M.F.5
Struyvenberg, P.A.6
van de Kamp, J.J.7
Maassen, J.A.8
-
119
-
-
8444228909
-
A cluster of metabolic defects caused by mutation in a mitochondrial tRNA
-
Wilson F.H., Hariri A., Farhi A., Zhao H., Petersen K.F., Toka H.R., Nelson-Williams C., Raja K.M., Kashgarian M., Shulman G.I., Scheinman S.J., Lifton R.P. A cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Science 2004, 306:1190-1194.
-
(2004)
Science
, vol.306
, pp. 1190-1194
-
-
Wilson, F.H.1
Hariri, A.2
Farhi, A.3
Zhao, H.4
Petersen, K.F.5
Toka, H.R.6
Nelson-Williams, C.7
Raja, K.M.8
Kashgarian, M.9
Shulman, G.I.10
Scheinman, S.J.11
Lifton, R.P.12
-
120
-
-
0029385110
-
Hypertrophic cardiomyopathy in patients with diabetes mellitus associated with mitochondrial tRNA(Leu)(UUR) gene mutation
-
Yoshida R., Ishida Y., Abo K., Hozumi T., Ueno H., Shiotani H., Kishimoto-Hashiramoto M., Hashiramoto M., Matsunaga K., Kasuga M., et al. Hypertrophic cardiomyopathy in patients with diabetes mellitus associated with mitochondrial tRNA(Leu)(UUR) gene mutation. Intern. Med. 1995, 34:953-958.
-
(1995)
Intern. Med.
, vol.34
, pp. 953-958
-
-
Yoshida, R.1
Ishida, Y.2
Abo, K.3
Hozumi, T.4
Ueno, H.5
Shiotani, H.6
Kishimoto-Hashiramoto, M.7
Hashiramoto, M.8
Matsunaga, K.9
Kasuga, M.10
-
121
-
-
0034164636
-
Fatal hypertrophic cardiomyopathy associated with an A8296G mutation in the mitochondrial tRNA(Lys) gene
-
Akita Y., Koga Y., Iwanaga R., Wada N., Tsubone J., Fukuda S., Nakamura Y., Kato H. Fatal hypertrophic cardiomyopathy associated with an A8296G mutation in the mitochondrial tRNA(Lys) gene. Hum. Mutat. 2000, 15:382.
-
(2000)
Hum. Mutat.
, vol.15
, pp. 382
-
-
Akita, Y.1
Koga, Y.2
Iwanaga, R.3
Wada, N.4
Tsubone, J.5
Fukuda, S.6
Nakamura, Y.7
Kato, H.8
-
122
-
-
85008397132
-
Whole mitochondrial genome analysis in two families with dilated mitochondrial cardiomyopathy: detection of mutations in MT-ND2 and MT-TL1 genes
-
Alila O.F., Rebai E.M., Tabebi M., Tej A., Chamkha I., Tlili A., Bouguila J., Tilouche S., Soyah N., Boughamoura L., Fakhfakh F. Whole mitochondrial genome analysis in two families with dilated mitochondrial cardiomyopathy: detection of mutations in MT-ND2 and MT-TL1 genes. Mitochondrial DNA 2015, 10:1-8.
-
(2015)
Mitochondrial DNA
, vol.10
, pp. 1-8
-
-
Alila, O.F.1
Rebai, E.M.2
Tabebi, M.3
Tej, A.4
Chamkha, I.5
Tlili, A.6
Bouguila, J.7
Tilouche, S.8
Soyah, N.9
Boughamoura, L.10
Fakhfakh, F.11
-
123
-
-
84924029112
-
Early onset cardiomyopathy associated with the mitochondrial tRNALeu((UUR)) 3271T > C MELAS mutation
-
Brisca G., Fiorillo C., Nesti C., Trucco F., Derchi M., Andaloro A., Assereto S., Morcaldi G., Pedemonte M., Minetti C., Santorelli F.M., Bruno C. Early onset cardiomyopathy associated with the mitochondrial tRNALeu((UUR)) 3271T > C MELAS mutation. Biochem. Biophys. Res. Commun. 2015, 456:601-604.
-
(2015)
Biochem. Biophys. Res. Commun.
, vol.456
, pp. 601-604
-
-
Brisca, G.1
Fiorillo, C.2
Nesti, C.3
Trucco, F.4
Derchi, M.5
Andaloro, A.6
Assereto, S.7
Morcaldi, G.8
Pedemonte, M.9
Minetti, C.10
Santorelli, F.M.11
Bruno, C.12
-
124
-
-
27944473305
-
Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns
-
Mohlke K.L., Jackson A.U., Scott L.J., Peck E.C., Suh Y.D., Chines P.S., Watanabe R.M., Buchanan T.A., Conneely K.N., Erdos M.R., Narisu N., Enloe S., Valle T.T., Tuomilehto J., Bergman R.N., Boehnke M., Collins F.S. Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns. Hum. Genet. 2005, 118:245-254.
-
(2005)
Hum. Genet.
, vol.118
, pp. 245-254
-
-
Mohlke, K.L.1
Jackson, A.U.2
Scott, L.J.3
Peck, E.C.4
Suh, Y.D.5
Chines, P.S.6
Watanabe, R.M.7
Buchanan, T.A.8
Conneely, K.N.9
Erdos, M.R.10
Narisu, N.11
Enloe, S.12
Valle, T.T.13
Tuomilehto, J.14
Bergman, R.N.15
Boehnke, M.16
Collins, F.S.17
-
125
-
-
33744456730
-
The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216TNC and m.4917ANG variants
-
Crispim D., Canani L.H., Gross J.L., Tschiedel B., Souto K.E.P., Roisenberg I. The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216TNC and m.4917ANG variants. Ann. Hum. Genet. 2006, 70:488-495.
-
(2006)
Ann. Hum. Genet.
, vol.70
, pp. 488-495
-
-
Crispim, D.1
Canani, L.H.2
Gross, J.L.3
Tschiedel, B.4
Souto, K.E.P.5
Roisenberg, I.6
-
126
-
-
33847191391
-
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians
-
Fuku N., Park K.S., Yamada Y., Nishigaki Y., Cho Y.M., Matsuo H., Segawa T., Watanabe S., Kato K., Yokoi K., Nozawa Y., Lee H.K., Tanaka M. Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am. J. Hum. Genet. 2007, 80:407-415.
-
(2007)
Am. J. Hum. Genet.
, vol.80
, pp. 407-415
-
-
Fuku, N.1
Park, K.S.2
Yamada, Y.3
Nishigaki, Y.4
Cho, Y.M.5
Matsuo, H.6
Segawa, T.7
Watanabe, S.8
Kato, K.9
Yokoi, K.10
Nozawa, Y.11
Lee, H.K.12
Tanaka, M.13
-
127
-
-
84866627877
-
Mitochondrial DNA coding and control region variants as genetic risk factors for type 2 diabetes
-
Liou C.-W., Chen J.-B., Tiao M.-M., Weng S.-W., Huang T.-L., Chuang J.-H., Chen S.-D., Chuang Y.-C., Lee W.-C., Lin T.-K., Wang P.-W. Mitochondrial DNA coding and control region variants as genetic risk factors for type 2 diabetes. Diabetes 2012, 61:2642-2651.
-
(2012)
Diabetes
, vol.61
, pp. 2642-2651
-
-
Liou, C.-W.1
Chen, J.-B.2
Tiao, M.-M.3
Weng, S.-W.4
Huang, T.-L.5
Chuang, J.-H.6
Chen, S.-D.7
Chuang, Y.-C.8
Lee, W.-C.9
Lin, T.-K.10
Wang, P.-W.11
-
128
-
-
65749119166
-
Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study
-
Kofler B., Mueller E.E., Eder W., Stanger O., Maier R., Weger M., Haas A., Winker R., Schmut O., Paulweber B., Iglseder B., Renner W., Wiesbauer M., Aigner I., Santic D., Zimmermann F.A., Mayr J.A., Sperl W. Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study. BMC Med. Genet. 2009, 10:35.
-
(2009)
BMC Med. Genet.
, vol.10
, pp. 35
-
-
Kofler, B.1
Mueller, E.E.2
Eder, W.3
Stanger, O.4
Maier, R.5
Weger, M.6
Haas, A.7
Winker, R.8
Schmut, O.9
Paulweber, B.10
Iglseder, B.11
Renner, W.12
Wiesbauer, M.13
Aigner, I.14
Santic, D.15
Zimmermann, F.A.16
Mayr, J.A.17
Sperl, W.18
-
129
-
-
79958285686
-
Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole
-
Achilli A., Olivieri A., Pala M., Kashani B.H., Carossa V., Perego U.A., Gandini F., Santoro A., Battaglia V., Grugni V., Lancioni H., Sirolla C., Bonfigli A.R., Cormio A., Boemi M., Testa I., Semino O., Ceriello A., Spazzafumo L., Gadaleta M.N., Marra M., Testa R., Franceschi C., Torroni A. Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole. PLoS One 2011, 6:e21029.
-
(2011)
PLoS One
, vol.6
, pp. e21029
-
-
Achilli, A.1
Olivieri, A.2
Pala, M.3
Kashani, B.H.4
Carossa, V.5
Perego, U.A.6
Gandini, F.7
Santoro, A.8
Battaglia, V.9
Grugni, V.10
Lancioni, H.11
Sirolla, C.12
Bonfigli, A.R.13
Cormio, A.14
Boemi, M.15
Testa, I.16
Semino, O.17
Ceriello, A.18
Spazzafumo, L.19
Gadaleta, M.N.20
Marra, M.21
Testa, R.22
Franceschi, C.23
Torroni, A.24
more..
-
130
-
-
84874507192
-
Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup
-
Strauss K.A., DuBiner L., Simon M., Zaragoza M., Sengupta P.P., Li P., Narula N., Dreike S., Platt J., Procaccio V., Ortiz-González X.R., Puffenberger E.G., Kelley R.I., Morton D.H., Narula J., Wallace D.C. Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:3453-3458.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 3453-3458
-
-
Strauss, K.A.1
DuBiner, L.2
Simon, M.3
Zaragoza, M.4
Sengupta, P.P.5
Li, P.6
Narula, N.7
Dreike, S.8
Platt, J.9
Procaccio, V.10
Ortiz-González, X.R.11
Puffenberger, E.G.12
Kelley, R.I.13
Morton, D.H.14
Narula, J.15
Wallace, D.C.16
-
131
-
-
79960218332
-
Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups
-
Hwang S., Kwak S.H., Bhak J., Kang H.S., Lee Y.R., Koo B.K., Park K.S., Lee H.K., Cho Y.M. Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups. PLoS One 2011, 6:e22116.
-
(2011)
PLoS One
, vol.6
, pp. e22116
-
-
Hwang, S.1
Kwak, S.H.2
Bhak, J.3
Kang, H.S.4
Lee, Y.R.5
Koo, B.K.6
Park, K.S.7
Lee, H.K.8
Cho, Y.M.9
-
134
-
-
77957822416
-
Evidence for sub-haplogroup H5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease
-
Santoro A., Balbi V., Balducci E., Pirazzini C., Rosini F., Tavano F., Achilli A., Siviero P., Minicuci N., Bellavista E., Mishto M., Salvioli S., Marchegiani F., Cardelli M., Olivieri F., Nacmias B., Chiamenti A.M., Benussi L., Ghidoni R., Rose G., Gabelli C., Binetti G., Sorbi S., Crepaldi G., Passarino G., Torroni A., Franceschi C. Evidence for sub-haplogroup H5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. PLoS One 2010, 5:e12037.
-
(2010)
PLoS One
, vol.5
, pp. e12037
-
-
Santoro, A.1
Balbi, V.2
Balducci, E.3
Pirazzini, C.4
Rosini, F.5
Tavano, F.6
Achilli, A.7
Siviero, P.8
Minicuci, N.9
Bellavista, E.10
Mishto, M.11
Salvioli, S.12
Marchegiani, F.13
Cardelli, M.14
Olivieri, F.15
Nacmias, B.16
Chiamenti, A.M.17
Benussi, L.18
Ghidoni, R.19
Rose, G.20
Gabelli, C.21
Binetti, G.22
Sorbi, S.23
Crepaldi, G.24
Passarino, G.25
Torroni, A.26
Franceschi, C.27
more..
-
135
-
-
84855268661
-
Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmy
-
Coto E., Gómez J., Alonso B., Corao A.I., Díaz M., Menéndez M., Martínez C., Calatayud M.T., Morís G., Álvarez V. Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmy. Neurogenetics 2011, 12:345-346.
-
(2011)
Neurogenetics
, vol.12
, pp. 345-346
-
-
Coto, E.1
Gómez, J.2
Alonso, B.3
Corao, A.I.4
Díaz, M.5
Menéndez, M.6
Martínez, C.7
Calatayud, M.T.8
Morís, G.9
Álvarez, V.10
-
136
-
-
17744397107
-
Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease
-
Carrieri G., Bonafè M., De Luca M., Rose G., Varcasia O., Bruni A., Maletta R., Nacmias B., Sorbi S., Corsonello F., Feraco E., Andreev K.F., Yashin A.I., Franceschi C., DeBenedictis G. Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease. Hum. Genet. 2001, 108:194-198.
-
(2001)
Hum. Genet.
, vol.108
, pp. 194-198
-
-
Carrieri, G.1
Bonafè, M.2
De Luca, M.3
Rose, G.4
Varcasia, O.5
Bruni, A.6
Maletta, R.7
Nacmias, B.8
Sorbi, S.9
Corsonello, F.10
Feraco, E.11
Andreev, K.F.12
Yashin, A.I.13
Franceschi, C.14
DeBenedictis, G.15
-
137
-
-
0033516529
-
Phylogenetic analysis of themitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population
-
Chagnon P., Gee M., Filion M., Robitaille Y., Belouchi M., Gauvreau D. Phylogenetic analysis of themitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population. Am. J. Med. Genet. 1999, 85:20-30.
-
(1999)
Am. J. Med. Genet.
, vol.85
, pp. 20-30
-
-
Chagnon, P.1
Gee, M.2
Filion, M.3
Robitaille, Y.4
Belouchi, M.5
Gauvreau, D.6
-
138
-
-
34248597788
-
Do haplogroups H and U act to increase the penetrance of Alzheimer's disease?
-
Fesahat F., Houshmand M., Panahi M.S.S., Gharagozli K., Mirzajani F. Do haplogroups H and U act to increase the penetrance of Alzheimer's disease?. Cell. Mol. Neurobiol. 2007, 27:329-334.
-
(2007)
Cell. Mol. Neurobiol.
, vol.27
, pp. 329-334
-
-
Fesahat, F.1
Houshmand, M.2
Panahi, M.S.S.3
Gharagozli, K.4
Mirzajani, F.5
-
139
-
-
77954034861
-
Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort
-
Lakatos A., Derbeneva O., Younes D., Keator D., Bakken T., Lvova M., Brandon M., Guffanti G., Reglodi D., Saykin A., Weiner M., Macciardi F., Schork N., Wallace D.C., Potkin S.G. Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort. Neurobiol. Aging 2010, 31:1355-1363.
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 1355-1363
-
-
Lakatos, A.1
Derbeneva, O.2
Younes, D.3
Keator, D.4
Bakken, T.5
Lvova, M.6
Brandon, M.7
Guffanti, G.8
Reglodi, D.9
Saykin, A.10
Weiner, M.11
Macciardi, F.12
Schork, N.13
Wallace, D.C.14
Potkin, S.G.15
-
140
-
-
70049112960
-
Mitochondrial haplogroup H and Alzheimer's disease-is there a connection?
-
Maruszak A., Canter J.A., Styczyńska M., Zekanowski C., Barcikowska M. Mitochondrial haplogroup H and Alzheimer's disease-is there a connection?. Neurobiol. Aging 2009, 30:1749-1755.
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 1749-1755
-
-
Maruszak, A.1
Canter, J.A.2
Styczyńska, M.3
Zekanowski, C.4
Barcikowska, M.5
-
141
-
-
3242707016
-
Analysis of European mitochondrial haplogroups with Alzheimer disease risk
-
Van Der Walt J.M., Dementieva Y.A., Martin E.R., Scott W.K., Nicodemus K.K., Kroner C.C., Welsh-Bohmer K.A., Saunders A.M., Roses A.D., Small G.W., Schmechel D.E., Murali Doraiswamy P., Gilbert J.R., Haines J.L., Vance J.M., Pericak-Vance M.A. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci. Lett. 2004, 365:28-32.
-
(2004)
Neurosci. Lett.
, vol.365
, pp. 28-32
-
-
Van Der Walt, J.M.1
Dementieva, Y.A.2
Martin, E.R.3
Scott, W.K.4
Nicodemus, K.K.5
Kroner, C.C.6
Welsh-Bohmer, K.A.7
Saunders, A.M.8
Roses, A.D.9
Small, G.W.10
Schmechel, D.E.11
Murali Doraiswamy, P.12
Gilbert, J.R.13
Haines, J.L.14
Vance, J.M.15
Pericak-Vance, M.A.16
-
142
-
-
67649803186
-
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease
-
Reddy P.H. Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp. Neurol. 2009, 218:286-292.
-
(2009)
Exp. Neurol.
, vol.218
, pp. 286-292
-
-
Reddy, P.H.1
-
143
-
-
84863446929
-
Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease
-
Krishnan K.J., Ratnaike T.E., De Gruyter H.L.M., Jaros E., Turnbull D.M. Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease. Neurobiol. Aging 2012, 33:2210-2214.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2210-2214
-
-
Krishnan, K.J.1
Ratnaike, T.E.2
De Gruyter, H.L.M.3
Jaros, E.4
Turnbull, D.M.5
-
144
-
-
84884879594
-
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
-
Yan M.H., Wang X., Zhu X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic. Biol. Med. 2013, 62:90-101.
-
(2013)
Free Radic. Biol. Med.
, vol.62
, pp. 90-101
-
-
Yan, M.H.1
Wang, X.2
Zhu, X.3
-
145
-
-
84859709003
-
Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death
-
Cha M.-Y., Han S.-H., Son S.M., Hong H.-S., Choi Y.-J., Byun J., et al. Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One 2012, 7:e34929.
-
(2012)
PLoS One
, vol.7
, pp. e34929
-
-
Cha, M.-Y.1
Han, S.-H.2
Son, S.M.3
Hong, H.-S.4
Choi, Y.-J.5
Byun, J.6
-
146
-
-
0037385480
-
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
-
Van der Walt J.M., Nicodemus K.K., Martin E.R., Scott W.K., Nance M.A., Watts R.L., Hubble J.P., Haines J.L., Koller W.C., Lyons K., Pahwa R., Stern M.B., Colcher A., Hiner B.C., Jankovic J., Ondo W.G., Allen F.H., Goetz C.G., Small G.W., Mastaglia F., Stajich J.M., McLaurin A.C., Middleton L.T., Scott B.L., Schmechel D.E., Pericak-Vance M.A., Vance J.M. Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am. J. Hum. Genet. 2003, 72:804-811.
-
(2003)
Am. J. Hum. Genet.
, vol.72
, pp. 804-811
-
-
Van der Walt, J.M.1
Nicodemus, K.K.2
Martin, E.R.3
Scott, W.K.4
Nance, M.A.5
Watts, R.L.6
Hubble, J.P.7
Haines, J.L.8
Koller, W.C.9
Lyons, K.10
Pahwa, R.11
Stern, M.B.12
Colcher, A.13
Hiner, B.C.14
Jankovic, J.15
Ondo, W.G.16
Allen, F.H.17
Goetz, C.G.18
Small, G.W.19
Mastaglia, F.20
Stajich, J.M.21
McLaurin, A.C.22
Middleton, L.T.23
Scott, B.L.24
Schmechel, D.E.25
Pericak-Vance, M.A.26
Vance, J.M.27
more..
-
147
-
-
33646351299
-
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
-
Kraytsberg Y., Kudryavtseva E., McKee A.C., Geula C., Kowall N.W., Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet. 2006, 38:518-520.
-
(2006)
Nat. Genet.
, vol.38
, pp. 518-520
-
-
Kraytsberg, Y.1
Kudryavtseva, E.2
McKee, A.C.3
Geula, C.4
Kowall, N.W.5
Khrapko, K.6
-
148
-
-
71849084134
-
Mitochondrial dysfunction in Parkinson's disease
-
Winklhofer K.F., Haass C. Mitochondrial dysfunction in Parkinson's disease. Biochim. Biophys. Acta 2010, 1802:29-44.
-
(2010)
Biochim. Biophys. Acta
, vol.1802
, pp. 29-44
-
-
Winklhofer, K.F.1
Haass, C.2
-
149
-
-
84903301367
-
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes
-
Jin H., Kanthasamy A., Ghosh A., Anantharam V., Kalyanaraman B., Kanthasamy A.G. Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim. Biophys. Acta 2013, 1842:1282-1294.
-
(2013)
Biochim. Biophys. Acta
, vol.1842
, pp. 1282-1294
-
-
Jin, H.1
Kanthasamy, A.2
Ghosh, A.3
Anantharam, V.4
Kalyanaraman, B.5
Kanthasamy, A.G.6
-
150
-
-
82555174637
-
Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease
-
Pickrell A.M., Pinto M., Hida A., Moraes C.T. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. J. Neurosci. 2011, 31:17649-17658.
-
(2011)
J. Neurosci.
, vol.31
, pp. 17649-17658
-
-
Pickrell, A.M.1
Pinto, M.2
Hida, A.3
Moraes, C.T.4
-
151
-
-
84895904175
-
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease
-
Tufi R., Gandhi S., de Castro I.P., Lehmann S., Angelova P.R., Dinsdale D., et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat. Cell Biol. 2014, 16:157-166.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 157-166
-
-
Tufi, R.1
Gandhi, S.2
de Castro, I.P.3
Lehmann, S.4
Angelova, P.R.5
Dinsdale, D.6
-
152
-
-
79961233786
-
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
-
Liu W., Acín-Peréz R., Geghman K.D., Manfredi G., Lu B., Li C. Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:12920-12924.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 12920-12924
-
-
Liu, W.1
Acín-Peréz, R.2
Geghman, K.D.3
Manfredi, G.4
Lu, B.5
Li, C.6
|