Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3

EMBO Reports

Volumn 16, Issue 9, 2015, Pages 1164-1176

  Rimmelé, Pauline ^a   Liang, Raymond ^a   Bigarella, Carolina L ^a   Kocabas, Fatih ^b   Xie, Jingjing ^b   Serasinghe, Madhavika N ^a   Chipuk, Jerry ^a   Sadek, Hesham ^b,c   Zhang, Cheng Cheng ^c   Ghaffari, Saghi ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

FOXO3; HSC; metabolism; mitochondria; ROS

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FOXO; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CELL AGING; CONTROLLED STUDY; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AGING; ANIMAL; GENETICS; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PHYSIOLOGY;

AGING; ANIMALS; FORKHEAD BOX PROTEIN O3; FORKHEAD TRANSCRIPTION FACTORS; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; MICE; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TOR SERINE-THREONINE KINASES;

EID: 84940797231     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201439704     Document Type: Article

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