Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway

Journal of Cellular and Molecular Medicine

Volumn 19, Issue 6, 2015, Pages 1174-1182

  Zhang, Mingming ^a   Sun, Dongdong ^a   Li, Shuang ^a   Pan, Xietian ^a   Zhang, Xiaotian ^a   Zhu, Di ^a   Li, Congye ^a   Zhang, Rongqing ^a   Gao, Erhe ^b   Wang, Haichang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Ischaemia reperfusion injury; Lin28a

Indexed keywords

ANIMALIA; LENTIVIRUS; MUS;

ANTIDIABETIC AGENT; CYTOKINE; INSULIN; LIN-28 PROTEIN, MOUSE; MICRORNA; MIRNLET7 MICRORNA, MOUSE; MTOR PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTECTIVE AGENT; PROTEIN KINASE B; RAPAMYCIN; RNA BINDING PROTEIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL; APOPTOSIS; C57BL MOUSE; CARDIAC MUSCLE; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HEART; MALE; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION; HEART; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE, INBRED C57BL; MICRORNAS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84929952785     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12369     Document Type: Article

References (28)

1. Mokdad AH, Bowman BA, Ford ES, et al. The continuing epidemics of obesity and diabetes in the United States. JAMA. 2001; 286: 1195-200.
2. Stovring H, Andersen M, Beck-Nielsen H, et al. Rising prevalence of diabetes: evidence from a Danish pharmaco-epidemiological database. Lancet. 2003; 362: 537-8.
3. Fox CS, Pencina MJ, Meigs JB, et al. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation. 2006; 113: 2914-8.
4. Gu K, Cowie CC, Harris MI. Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971-1993. Diabetes Care. 1998; 21: 1138-45.
5. Lee WL, Cheung AM, Cape D, et al. Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies. Diabetes Care. 2000; 23: 962-8.
6. Fox CS, Coady S, Sorlie PD, et al. Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study. Circulation. 2007; 115: 1544-50.
7. Small EM, Olson EN. Pervasive roles of microRNAs in cardiovascular biology. Nature. 2011; 469: 336-42.
8. Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science. 2008; 320: 97-100.
9. Viswanathan SR, Daley GQ. Lin28: a microRNA regulator with a macro role. Cell. 2010; 140: 445-9.
10. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 2008; 79: 581-8.
11. Thornton JE, Gregory RI. How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012; 22: 474-82.
12. Sen CK, Gordillo GM, Khanna S, et al. Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res. 2009; 46: 527-40.
13. Zhu H, Shyh-Chang N, Segre AV, et al. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011; 147: 81-94.
14. Si R, Tao L, Zhang HF, et al. Survivin: a novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury. J Mol Cell Cardiol. 2011; 50: 16-24.
15. Spence T, Perotti C, Sin-Chan P, et al. A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes. Neuro Oncol. 2014; 16: 62-71.
16. Shinoda G, Shyh-Chang N, Soysa TY, et al. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013; 31: 1563-73.
17. Ma H, Li SY, Xu P, et al. Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy. J Cell Mol Med. 2009; 13: 1751-64.
18. Sun D, Huang J, Zhang Z, et al. Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats. PLoS ONE. 2012; 7: e33491.
19. Gao HK, Yin Z, Zhou N, et al. Glycogen synthase kinase 3 inhibition protects the heart from acute ischemia-reperfusion injury via inhibition of inflammation and apoptosis. J Cardiovasc Pharm. 2008; 52: 286-92.
20. Donahoe SM, Stewart GC, McCabe CH, et al. Diabetes and mortality following acute coronary syndromes. JAMA. 2007; 298: 765-75.
21. Miller BA, Hoffman NE, Merali S, et al. TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria. J Biol Chem. 2014; 289: 7615-29.
22. Woodman OL, Long R, Pons S, et al. The cardioprotectant 3′, 4′-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats. Pharmacol Res. 2014; 81: 26-33.
23. Kristensen JM, Skov V, Petersson SJ, et al. A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance. Diabetologia. 2014; 57: 1006-15.
24. Henagan TM, Lenard NR, Gettys TW, et al. Dietary quercetin supplementation in mice increases skeletal muscle PGC1a expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS ONE. 2014; 9: e89365.
25. Fliss H, Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circ Res. 1996; 79: 949-56.
26. Fu J, Huang H, Liu J, et al. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmacol. 2007; 568: 213-21.
27. Song JQ, Teng X, Cai Y, et al. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis. 2009; 14: 1061-9.
28. Shyh-Chang N, Zhu H, Yvanka de Soysa T, et al. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 2013; 155: 778-92.