Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Mechanisms of Ageing and Development

Volumn 139, Issue 1, 2014, Pages 22-30

  Baines, Holly L ^a   Stewart, James B ^b   Stamp, Craig ^a   Zupanic, Anze ^c   Kirkwood, Thomas B L ^c   Larsson, Nils Göran ^b   Turnbull, Douglass M ^a,c   Greaves, Laura C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Ageing; Colon; Mitochondria; Mouse; MtDNA

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; MITOCHONDRIAL DNA; DNA DIRECTED DNA POLYMERASE; POLG PROTEIN, HUMAN; POLG PROTEIN, MOUSE;

AGE; AGED; AGING; ANIMAL TISSUE; ARTICLE; CLONAL VARIATION; COLON; COLON MUCOSA; COMPUTER SIMULATION; CONTROLLED STUDY; GENETIC DRIFT; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; INTESTINE CRYPT; MOUSE; MUTATION RATE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SOMATIC MUTATION; ANIMAL; BIOLOGICAL MODEL; FEMALE; GENETICS; MALE; METABOLISM; MUTANT MOUSE STRAIN;

AGED; AGING; ANIMALS; COMPUTER SIMULATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FEMALE; HUMANS; MALE; MICE; MICE, MUTANT STRAINS; MODELS, GENETIC; POINT MUTATION;

EID: 84902989327     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2014.06.003     Document Type: Article

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