-
1
-
-
80054755695
-
Pathological roles of alpha-synuclein in neurological disorders
-
Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L. Pathological roles of alpha-synuclein in neurological disorders. Lancet Neurol 2011;10:1015–1025.
-
(2011)
Lancet Neurol
, vol.10
, pp. 1015-1025
-
-
Vekrellis, K.1
Xilouri, M.2
Emmanouilidou, E.3
Rideout, H.J.4
Stefanis, L.5
-
3
-
-
84879606955
-
Alpha-synuclein and protein degradation systems: a reciprocal relationship
-
Xilouri M, Brekk OR, Stefanis L. Alpha-synuclein and protein degradation systems: a reciprocal relationship. Mol Neurobiol 2013;47:537–551.
-
(2013)
Mol Neurobiol
, vol.47
, pp. 537-551
-
-
Xilouri, M.1
Brekk, O.R.2
Stefanis, L.3
-
4
-
-
84883420073
-
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies
-
Manzoni C, Lewis PA. Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. FASEB J 2013;27:3424–3429.
-
(2013)
FASEB J
, vol.27
, pp. 3424-3429
-
-
Manzoni, C.1
Lewis, P.A.2
-
5
-
-
69249106881
-
Pathways and mechanisms of endocytic recycling
-
Grant BD, Donaldson JG. Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol 2009;10:597–608.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 597-608
-
-
Grant, B.D.1
Donaldson, J.G.2
-
6
-
-
0034735536
-
Autophagic tubes: vacuolar invaginations involved in lateral membrane sorting and inverse vesicle budding
-
Muller O, Sattler T, Flotenmeyer M, Schwarz H, Plattner H, Mayer A. Autophagic tubes: vacuolar invaginations involved in lateral membrane sorting and inverse vesicle budding. J Cell Biol 2000;151:519–528.
-
(2000)
J Cell Biol
, vol.151
, pp. 519-528
-
-
Muller, O.1
Sattler, T.2
Flotenmeyer, M.3
Schwarz, H.4
Plattner, H.5
Mayer, A.6
-
7
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011;13:132–141.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
8
-
-
77951214016
-
Mammalian autophagy: core molecular machinery and signaling regulation
-
Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010;22:124–131.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 124-131
-
-
Yang, Z.1
Klionsky, D.J.2
-
10
-
-
79957663035
-
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy
-
Lee S, Sato Y, Nixon RA. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci 2011;31:7817–7830.
-
(2011)
J Neurosci
, vol.31
, pp. 7817-7830
-
-
Lee, S.1
Sato, Y.2
Nixon, R.A.3
-
11
-
-
84904266112
-
Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway
-
Maday S, Holzbaur EL. Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway. Dev Cell 2014;30:71–85.
-
(2014)
Dev Cell
, vol.30
, pp. 71-85
-
-
Maday, S.1
Holzbaur, E.L.2
-
13
-
-
84901815187
-
Cargo recognition and trafficking in selective autophagy
-
Stolz A, Ernst A, Dikic I. Cargo recognition and trafficking in selective autophagy. Nat Cell Biol 2014;16:495–501.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 495-501
-
-
Stolz, A.1
Ernst, A.2
Dikic, I.3
-
14
-
-
70350450808
-
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
-
Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol 2009;10:1215–1221.
-
(2009)
Nat Immunol
, vol.10
, pp. 1215-1221
-
-
Thurston, T.L.1
Ryzhakov, G.2
Bloor, S.3
von Muhlinen, N.4
Randow, F.5
-
15
-
-
74049153002
-
Nix is a selective autophagy receptor for mitochondrial clearance
-
Novak I, Kirkin V, McEwan DG, et al. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep 2009;11:45–51.
-
(2009)
EMBO Rep
, vol.11
, pp. 45-51
-
-
Novak, I.1
Kirkin, V.2
McEwan, D.G.3
-
16
-
-
67650264633
-
Atg32 is a mitochondrial protein that confers selectivity during mitophagy
-
Kanki T, Wang K, Cao Y, Baba M, Klionsky DJ. Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell 2009;17:98–109.
-
(2009)
Dev Cell
, vol.17
, pp. 98-109
-
-
Kanki, T.1
Wang, K.2
Cao, Y.3
Baba, M.4
Klionsky, D.J.5
-
17
-
-
60849099049
-
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
-
Kirkin V, Lamark T, Sou YS, et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009;33:505–516.
-
(2009)
Mol Cell
, vol.33
, pp. 505-516
-
-
Kirkin, V.1
Lamark, T.2
Sou, Y.S.3
-
18
-
-
84883451249
-
Selective autophagy: talking with the UPS
-
Park C, Cuervo AM. Selective autophagy: talking with the UPS. Cell Biochem Biophys 2013;67:3–13.
-
(2013)
Cell Biochem Biophys
, vol.67
, pp. 3-13
-
-
Park, C.1
Cuervo, A.M.2
-
19
-
-
0025294506
-
Peptide sequences that target cytosolic proteins for lysosomal proteolysis
-
Dice JF. Peptide sequences that target cytosolic proteins for lysosomal proteolysis. Trends Biochem Sci 1990;15:305–309.
-
(1990)
Trends Biochem Sci
, vol.15
, pp. 305-309
-
-
Dice, J.F.1
-
20
-
-
0023891846
-
Peptide sequences that target proteins for enhanced degradation during serum withdrawal
-
Chiang HL, Dice JF. Peptide sequences that target proteins for enhanced degradation during serum withdrawal. J Biol Chem 1988;263:6797–6805.
-
(1988)
J Biol Chem
, vol.263
, pp. 6797-6805
-
-
Chiang, H.L.1
Dice, J.F.2
-
21
-
-
0034914206
-
A molecular chaperone complex at the lysosomal membrane is required for protein translocation
-
Agarraberes FA, Dice JF. A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci 2001;114(Pt 13):2491–2499.
-
(2001)
J Cell Sci
, vol.114
, pp. 2491-2499
-
-
Agarraberes, F.A.1
Dice, J.F.2
-
22
-
-
0029837453
-
A receptor for the selective uptake and degradation of proteins by lysosomes
-
Cuervo AM, Dice JF. A receptor for the selective uptake and degradation of proteins by lysosomes. Science 1996;273:501–503.
-
(1996)
Science
, vol.273
, pp. 501-503
-
-
Cuervo, A.M.1
Dice, J.F.2
-
23
-
-
51349130544
-
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
-
Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo AM. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol 2008;28:5747–5763.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5747-5763
-
-
Bandyopadhyay, U.1
Kaushik, S.2
Varticovski, L.3
Cuervo, A.M.4
-
24
-
-
77955989034
-
Identification of regulators of chaperone-mediated autophagy
-
Bandyopadhyay U, Sridhar S, Kaushik S, Kiffin R, Cuervo AM. Identification of regulators of chaperone-mediated autophagy. Mol Cell 2010;39:535–547.
-
(2010)
Mol Cell
, vol.39
, pp. 535-547
-
-
Bandyopadhyay, U.1
Sridhar, S.2
Kaushik, S.3
Kiffin, R.4
Cuervo, A.M.5
-
25
-
-
0034232418
-
Regulation of Lamp2a levels in the lysosomal membrane
-
Cuervo AM, Dice JF. Regulation of Lamp2a levels in the lysosomal membrane. Traffic 2000;1:570–583.
-
(2000)
Traffic
, vol.1
, pp. 570-583
-
-
Cuervo, A.M.1
Dice, J.F.2
-
26
-
-
0028848119
-
Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation
-
Cuervo AM, Knecht E, Terlecky SR, Dice JF. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am J Physiol 1995;269(5 Pt 1):C1200–C1208.
-
(1995)
Am J Physiol
, vol.269
, Issue.5
, pp. C1200-C1208
-
-
Cuervo, A.M.1
Knecht, E.2
Terlecky, S.R.3
Dice, J.F.4
-
27
-
-
0030923854
-
An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
-
Agarraberes FA, Terlecky SR, Dice JF. An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J Cell Biol 1997;137:825–834.
-
(1997)
J Cell Biol
, vol.137
, pp. 825-834
-
-
Agarraberes, F.A.1
Terlecky, S.R.2
Dice, J.F.3
-
28
-
-
84937520970
-
Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy
-
Arias E, Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM. Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy. Mol Cell 2015;59:270–284.
-
(2015)
Mol Cell
, vol.59
, pp. 270-284
-
-
Arias, E.1
Koga, H.2
Diaz, A.3
Mocholi, E.4
Patel, B.5
Cuervo, A.M.6
-
29
-
-
84878775231
-
Lipofuscin: formation, effects and role of macroautophagy
-
Hohn A, Grune T. Lipofuscin: formation, effects and role of macroautophagy. Redox Biol 2013;1:140–144.
-
(2013)
Redox Biol
, vol.1
, pp. 140-144
-
-
Hohn, A.1
Grune, T.2
-
30
-
-
0032568534
-
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci U S A 1998;95:6469–6473.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
31
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997;388:839–840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
32
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin MC, Kachergus J, Roumier C, et al. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004;364:1167–1169.
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
-
33
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045–2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
-
34
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Kruger R, Kuhn W, Muller T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 1998;18:106–108.
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
-
35
-
-
0242300619
-
alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton AB, Singleton A, Hague S, et al. alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003;302:841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Singleton, A.2
Hague, S.3
-
36
-
-
33746869343
-
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
-
Maraganore DM, de Andrade M, Elbaz A, et al. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA 2006;296:661–670.
-
(2006)
JAMA
, vol.296
, pp. 661-670
-
-
Maraganore, D.M.1
de Andrade, M.2
Elbaz, A.3
-
37
-
-
69149089036
-
Molecular pathogenesis of Parkinson disease: insights from genetic studies
-
Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Exp Rev Mol Med 2009;11:e22.
-
(2009)
Exp Rev Mol Med
, vol.11
-
-
Gasser, T.1
-
38
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
Simon-Sanchez J, Schulte C, Bras JM, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet 2009;41:1308–1312.
-
(2009)
Nat Genet
, vol.41
, pp. 1308-1312
-
-
Simon-Sanchez, J.1
Schulte, C.2
Bras, J.M.3
-
39
-
-
0033607801
-
Degradation of alpha-synuclein by proteasome
-
Bennett MC, Bishop JF, Leng Y, Chock PB, Chase TN, Mouradian MM. Degradation of alpha-synuclein by proteasome. J Biol Chem 1999;274:33855–33858.
-
(1999)
J Biol Chem
, vol.274
, pp. 33855-33858
-
-
Bennett, M.C.1
Bishop, J.F.2
Leng, Y.3
Chock, P.B.4
Chase, T.N.5
Mouradian, M.M.6
-
40
-
-
0034680913
-
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
-
Imai Y, Soda M, Takahashi R. Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 2000;275:35661–35664.
-
(2000)
J Biol Chem
, vol.275
, pp. 35661-35664
-
-
Imai, Y.1
Soda, M.2
Takahashi, R.3
-
41
-
-
0041589248
-
Alpha-Synuclein is degraded by both autophagy and the proteasome
-
Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 2003;278:25009–25013.
-
(2003)
J Biol Chem
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztein, D.C.5
-
42
-
-
1442275729
-
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway
-
Lee HJ, Khoshaghideh F, Patel S, Lee SJ. Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci 2004;24:1888–1896.
-
(2004)
J Neurosci
, vol.24
, pp. 1888-1896
-
-
Lee, H.J.1
Khoshaghideh, F.2
Patel, S.3
Lee, S.J.4
-
43
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004;305:1292–1295.
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
44
-
-
53049098471
-
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008;283:23542–23556.
-
(2008)
J Biol Chem
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
Xilouri, M.2
Vekrellis, K.3
Stefanis, L.4
-
45
-
-
84862598619
-
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway
-
Klucken J, Poehler AM, Ebrahimi-Fakhari D, et al. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy 2012;8:754–766.
-
(2012)
Autophagy
, vol.8
, pp. 754-766
-
-
Klucken, J.1
Poehler, A.M.2
Ebrahimi-Fakhari, D.3
-
46
-
-
68449089023
-
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein
-
Yu WH, Dorado B, Figueroa HY, et al. Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. Am J Pathol 2009;175:736–747.
-
(2009)
Am J Pathol
, vol.175
, pp. 736-747
-
-
Yu, W.H.1
Dorado, B.2
Figueroa, H.Y.3
-
47
-
-
84869041395
-
Development and characterization of a new Parkinson's disease model resulting from impaired autophagy
-
Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, Savitt JM. Development and characterization of a new Parkinson's disease model resulting from impaired autophagy. J Neurosci 2012;32:16503–16509.
-
(2012)
J Neurosci
, vol.32
, pp. 16503-16509
-
-
Ahmed, I.1
Liang, Y.2
Schools, S.3
Dawson, V.L.4
Dawson, T.M.5
Savitt, J.M.6
-
48
-
-
84861595545
-
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain
-
Friedman LG, Lachenmayer ML, Wang J, et al. Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain. J Neurosci 2012;32:7585–7593.
-
(2012)
J Neurosci
, vol.32
, pp. 7585-7593
-
-
Friedman, L.G.1
Lachenmayer, M.L.2
Wang, J.3
-
49
-
-
80051534540
-
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
-
Zimprich A, Benet-Pages A, Struhal W, et al. A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet 2011;89:168–175.
-
(2011)
Am J Hum Genet
, vol.89
, pp. 168-175
-
-
Zimprich, A.1
Benet-Pages, A.2
Struhal, W.3
-
50
-
-
84900460616
-
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy
-
Zavodszky E, Seaman MN, Moreau K, et al. Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat Commun 2014;5:3828.
-
(2014)
Nat Commun
, vol.5
, pp. 3828
-
-
Zavodszky, E.1
Seaman, M.N.2
Moreau, K.3
-
51
-
-
84906503242
-
VPS35 dysfunction impairs lysosomal degradation of alpha-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
-
Miura E, Hasegawa T, Konno M, et al. VPS35 dysfunction impairs lysosomal degradation of alpha-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease. Neurobiol Dis 2014;71:1–13.
-
(2014)
Neurobiol Dis
, vol.71
, pp. 1-13
-
-
Miura, E.1
Hasegawa, T.2
Konno, M.3
-
52
-
-
84920740324
-
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein
-
Dhungel N, Eleuteri S, Li LB, et al. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein. Neuron 2015;85:76–87.
-
(2015)
Neuron
, vol.85
, pp. 76-87
-
-
Dhungel, N.1
Eleuteri, S.2
Li, L.B.3
-
53
-
-
33749133430
-
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
-
Ramirez A, Heimbach A, Grundemann J, et al. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet 2006;38:1184–1191.
-
(2006)
Nat Genet
, vol.38
, pp. 1184-1191
-
-
Ramirez, A.1
Heimbach, A.2
Grundemann, J.3
-
54
-
-
84929654352
-
The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms
-
Park JS, Blair NF, Sue CM. The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms. Mov Disord 2015;30:770–779.
-
(2015)
Mov Disord
, vol.30
, pp. 770-779
-
-
Park, J.S.1
Blair, N.F.2
Sue, C.M.3
-
55
-
-
84929353414
-
alpha-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal parkinsonism protein Atp13a2
-
Kett LR, Stiller B, Bernath MM, et al. alpha-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal parkinsonism protein Atp13a2. J Neurosci 2015;35:5724–5742.
-
(2015)
J Neurosci
, vol.35
, pp. 5724-5742
-
-
Kett, L.R.1
Stiller, B.2
Bernath, M.M.3
-
56
-
-
38849174979
-
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente M, Talloczy Z, Kaushik S, et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 2008;118:777–788.
-
(2008)
J Clin Invest
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
-
57
-
-
84878230429
-
Lewy body-like alpha-synuclein aggregates resist degradation and impair macroautophagy
-
Tanik SA, Schultheiss CE, Volpicelli-Daley LA, Brunden KR, Lee VM. Lewy body-like alpha-synuclein aggregates resist degradation and impair macroautophagy. J Biol Chem 2013;288:15194–15210.
-
(2013)
J Biol Chem
, vol.288
, pp. 15194-15210
-
-
Tanik, S.A.1
Schultheiss, C.E.2
Volpicelli-Daley, L.A.3
Brunden, K.R.4
Lee, V.M.5
-
58
-
-
84885363886
-
Polo-like kinase 2 regulates selective autophagic alpha-synuclein clearance and suppresses its toxicity in vivo
-
Oueslati A, Schneider BL, Aebischer P, Lashuel HA. Polo-like kinase 2 regulates selective autophagic alpha-synuclein clearance and suppresses its toxicity in vivo. Proc Natl Acad Sci U S A 2013;110:E3945–E3954.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E3945-E3954
-
-
Oueslati, A.1
Schneider, B.L.2
Aebischer, P.3
Lashuel, H.A.4
-
59
-
-
84901361843
-
Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease
-
Tenreiro S, Reimao-Pinto MM, Antas P, et al. Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. PLoS Genet 2014;10:e1004302.
-
(2014)
PLoS Genet
, vol.10
-
-
Tenreiro, S.1
Reimao-Pinto, M.M.2
Antas, P.3
-
60
-
-
84909592222
-
Interplay between sumoylation and phosphorylation for protection against alpha-synuclein inclusions
-
Shahpasandzadeh H, Popova B, Kleinknecht A, Fraser PE, Outeiro TF, Braus GH. Interplay between sumoylation and phosphorylation for protection against alpha-synuclein inclusions. J Biol Chem 2014;289:31224–31240.
-
(2014)
J Biol Chem
, vol.289
, pp. 31224-31240
-
-
Shahpasandzadeh, H.1
Popova, B.2
Kleinknecht, A.3
Fraser, P.E.4
Outeiro, T.F.5
Braus, G.H.6
-
61
-
-
80054732644
-
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway
-
Tofaris GK, Kim HT, Hourez R, Jung JW, Kim KP, Goldberg AL. Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway. Proc Natl Acad Sci U S A 2011;108:17004–17009.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17004-17009
-
-
Tofaris, G.K.1
Kim, H.T.2
Hourez, R.3
Jung, J.W.4
Kim, K.P.5
Goldberg, A.L.6
-
62
-
-
81755185877
-
alpha-Synuclein fate is determined by USP9X-regulated monoubiquitination
-
Rott R, Szargel R, Haskin J, et al. alpha-Synuclein fate is determined by USP9X-regulated monoubiquitination. Proc Natl Acad Sci U S A 2011;108:18666–18671.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 18666-18671
-
-
Rott, R.1
Szargel, R.2
Haskin, J.3
-
63
-
-
80054026084
-
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of alpha-synuclein
-
Ebrahimi-Fakhari D, Cantuti-Castelvetri I, Fan Z, et al. Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of alpha-synuclein. J Neurosci 2011;31:14508–14520.
-
(2011)
J Neurosci
, vol.31
, pp. 14508-14520
-
-
Ebrahimi-Fakhari, D.1
Cantuti-Castelvetri, I.2
Fan, Z.3
-
64
-
-
84859600567
-
Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies
-
Vekrellis K, Stefanis L. Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies. Exp Opin Ther Targets 2012;16:421–432.
-
(2012)
Exp Opin Ther Targets
, vol.16
, pp. 421-432
-
-
Vekrellis, K.1
Stefanis, L.2
-
65
-
-
79954631518
-
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
-
Alvarez-Erviti L, Seow Y, Schapira AH, et al. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis 2011;42:360–367.
-
(2011)
Neurobiol Dis
, vol.42
, pp. 360-367
-
-
Alvarez-Erviti, L.1
Seow, Y.2
Schapira, A.H.3
-
66
-
-
84865307818
-
Exosomal cell-to-cell transmission of alpha synuclein oligomers
-
Danzer KM, Kranich LR, Ruf WP, et al. Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener 2012;7:42.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 42
-
-
Danzer, K.M.1
Kranich, L.R.2
Ruf, W.P.3
-
67
-
-
84881147729
-
Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein
-
Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ. Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein. Exp Mol Med 2013;45:e22.
-
(2013)
Exp Mol Med
, vol.45
-
-
Lee, H.J.1
Cho, E.D.2
Lee, K.W.3
Kim, J.H.4
Cho, S.G.5
Lee, S.J.6
-
68
-
-
84922364789
-
Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment
-
Poehler AM, Xiang W, Spitzer P, et al. Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment. Autophagy 2014;10:2171–2192.
-
(2014)
Autophagy
, vol.10
, pp. 2171-2192
-
-
Poehler, A.M.1
Xiang, W.2
Spitzer, P.3
-
69
-
-
84879052241
-
Tubulin polymerization-promoting protein (TPPP/p25alpha) promotes unconventional secretion of alpha-synuclein through exophagy by impairing autophagosome-lysosome fusion
-
Ejlerskov P, Rasmussen I, Nielsen TT, et al. Tubulin polymerization-promoting protein (TPPP/p25alpha) promotes unconventional secretion of alpha-synuclein through exophagy by impairing autophagosome-lysosome fusion. J Biol Chem 2013;288:17313–17335.
-
(2013)
J Biol Chem
, vol.288
, pp. 17313-17335
-
-
Ejlerskov, P.1
Rasmussen, I.2
Nielsen, T.T.3
-
70
-
-
84899964982
-
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha-Synuclein externalization via exosomes
-
Kong SM, Chan BK, Park JS, et al. Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha-Synuclein externalization via exosomes. Hum Mol Genet 2014;23:2816–2833.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 2816-2833
-
-
Kong, S.M.1
Chan, B.K.2
Park, J.S.3
-
71
-
-
84909952796
-
ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein
-
Tsunemi T, Hamada K, Krainc D. ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein. J Neurosci 2014;34:15281–15287.
-
(2014)
J Neurosci
, vol.34
, pp. 15281-15287
-
-
Tsunemi, T.1
Hamada, K.2
Krainc, D.3
-
72
-
-
0031036896
-
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
-
Anglade P, Vyas S, Javoy-Agid F, et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 1997;12:25–31.
-
(1997)
Histol Histopathol
, vol.12
, pp. 25-31
-
-
Anglade, P.1
Vyas, S.2
Javoy-Agid, F.3
-
73
-
-
0242499488
-
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases
-
Zhu JH, Guo F, Shelburne J, Watkins S, Chu CT. Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol 2003;13:473–481.
-
(2003)
Brain Pathol
, vol.13
, pp. 473-481
-
-
Zhu, J.H.1
Guo, F.2
Shelburne, J.3
Watkins, S.4
Chu, C.T.5
-
74
-
-
68149123529
-
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions
-
Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 2009;35:385–398.
-
(2009)
Neurobiol Dis
, vol.35
, pp. 385-398
-
-
Chu, Y.1
Dodiya, H.2
Aebischer, P.3
Olanow, C.W.4
Kordower, J.H.5
-
75
-
-
77956855813
-
Pathogenic lysosomal depletion in Parkinson's disease
-
Dehay B, Bove J, Rodriguez-Muela N, et al. Pathogenic lysosomal depletion in Parkinson's disease. J Neurosci 2010;30:12535–12544.
-
(2010)
J Neurosci
, vol.30
, pp. 12535-12544
-
-
Dehay, B.1
Bove, J.2
Rodriguez-Muela, N.3
-
76
-
-
77949504405
-
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
-
Crews L, Spencer B, Desplats P, et al. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One 2010;5:e9313.
-
(2010)
PLoS One
, vol.5
-
-
Crews, L.1
Spencer, B.2
Desplats, P.3
-
77
-
-
65849127844
-
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
-
Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L. Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One 2009;4:e5515.
-
(2009)
PLoS One
, vol.4
-
-
Xilouri, M.1
Vogiatzi, T.2
Vekrellis, K.3
Park, D.4
Stefanis, L.5
-
78
-
-
79953202481
-
Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy
-
Choubey V, Safiulina D, Vaarmann A, et al. Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy. J Biol Chem 2011;286:10814–10824.
-
(2011)
J Biol Chem
, vol.286
, pp. 10814-10824
-
-
Choubey, V.1
Safiulina, D.2
Vaarmann, A.3
-
79
-
-
0035894855
-
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
-
Stefanis L, Larsen KE, Rideout HJ, Sulzer D, Greene LA. Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J Neurosci 2001;21:9549–9560.
-
(2001)
J Neurosci
, vol.21
, pp. 9549-9560
-
-
Stefanis, L.1
Larsen, K.E.2
Rideout, H.J.3
Sulzer, D.4
Greene, L.A.5
-
80
-
-
70350550208
-
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
-
Spencer B, Potkar R, Trejo M, et al. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 2009;29:13578–13588.
-
(2009)
J Neurosci
, vol.29
, pp. 13578-13588
-
-
Spencer, B.1
Potkar, R.2
Trejo, M.3
-
81
-
-
77957189194
-
alpha-Synuclein impairs macroautophagy: implications for Parkinson's disease
-
Winslow AR, Chen CW, Corrochano S, et al. alpha-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol 2010;190:1023–1037.
-
(2010)
J Cell Biol
, vol.190
, pp. 1023-1037
-
-
Winslow, A.R.1
Chen, C.W.2
Corrochano, S.3
-
82
-
-
84894350781
-
HMGB1 is involved in autophagy inhibition caused by SNCA/alpha-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B
-
Song JX, Lu JH, Liu LF, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/alpha-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy 2014;10:144–154.
-
(2014)
Autophagy
, vol.10
, pp. 144-154
-
-
Song, J.X.1
Lu, J.H.2
Liu, L.F.3
-
83
-
-
84911001724
-
Overexpression of human E46K mutant alpha-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway
-
Yan JQ, Yuan YH, Gao YN, et al. Overexpression of human E46K mutant alpha-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway. Mol Neurobiol 2014;50:685–701.
-
(2014)
Mol Neurobiol
, vol.50
, pp. 685-701
-
-
Yan, J.Q.1
Yuan, Y.H.2
Gao, Y.N.3
-
84
-
-
84921456454
-
A53T human alpha-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration
-
Chen L, Xie Z, Turkson S, Zhuang X. A53T human alpha-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci 2015;35:890–905.
-
(2015)
J Neurosci
, vol.35
, pp. 890-905
-
-
Chen, L.1
Xie, Z.2
Turkson, S.3
Zhuang, X.4
-
85
-
-
84989360055
-
Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons
-
Koch JC, Bitow F, Haack J, et al. Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons. Cell Death Dis 2015;6:e1811.
-
(2015)
Cell Death Dis
, vol.6
-
-
Koch, J.C.1
Bitow, F.2
Haack, J.3
-
86
-
-
84919468220
-
Formation of alpha-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes
-
Volpicelli-Daley LA, Gamble KL, Schultheiss CE, Riddle DM, West AB, Lee VM. Formation of alpha-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. Mol Biol Cell 2014;25:4010–4023.
-
(2014)
Mol Biol Cell
, vol.25
, pp. 4010-4023
-
-
Volpicelli-Daley, L.A.1
Gamble, K.L.2
Schultheiss, C.E.3
Riddle, D.M.4
West, A.B.5
Lee, V.M.6
-
87
-
-
85012106645
-
Role of alpha- and beta-synucleins in the axonal pathology of Parkinson's disease and related synucleinopathies
-
Sekigawa A, Takamatsu Y, Sekiyama K, Hashimoto M. Role of alpha- and beta-synucleins in the axonal pathology of Parkinson's disease and related synucleinopathies. Biomolecules 2015;5:1000–1011.
-
(2015)
Biomolecules
, vol.5
, pp. 1000-1011
-
-
Sekigawa, A.1
Takamatsu, Y.2
Sekiyama, K.3
Hashimoto, M.4
-
88
-
-
84863877366
-
Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes
-
Schwarz L, Goldbaum O, Bergmann M, Probst-Cousin S, Richter-Landsberg C. Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes. J Mol Neurosci 2012;47:256–266.
-
(2012)
J Mol Neurosci
, vol.47
, pp. 256-266
-
-
Schwarz, L.1
Goldbaum, O.2
Bergmann, M.3
Probst-Cousin, S.4
Richter-Landsberg, C.5
-
89
-
-
84866533589
-
Alteration of autophagosomal proteins in the brain of multiple system atrophy
-
Tanji K, Odagiri S, Maruyama A, et al. Alteration of autophagosomal proteins in the brain of multiple system atrophy. Neurobiol Dis 2013;49:190–198.
-
(2013)
Neurobiol Dis
, vol.49
, pp. 190-198
-
-
Tanji, K.1
Odagiri, S.2
Maruyama, A.3
-
90
-
-
84866444893
-
Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy
-
Chiba Y, Takei S, Kawamura N, et al. Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy. Neuropathol Appl Neurobiol 2012;38:559–571.
-
(2012)
Neuropathol Appl Neurobiol
, vol.38
, pp. 559-571
-
-
Chiba, Y.1
Takei, S.2
Kawamura, N.3
-
91
-
-
78149469728
-
Chaperone-mediated autophagy markers in Parkinson disease brains
-
Alvarez-Erviti L, Rodriguez-Oroz MC, Cooper JM, et al. Chaperone-mediated autophagy markers in Parkinson disease brains. Arch Neurol 2010;67:1464–1472.
-
(2010)
Arch Neurol
, vol.67
, pp. 1464-1472
-
-
Alvarez-Erviti, L.1
Rodriguez-Oroz, M.C.2
Cooper, J.M.3
-
92
-
-
77951541740
-
Lysosomal degradation of alpha-synuclein in vivo
-
Mak SK, McCormack AL, Manning-Bog AB, Cuervo AM, Di Monte DA. Lysosomal degradation of alpha-synuclein in vivo. J Biol Chem 2010;285:13621–13629.
-
(2010)
J Biol Chem
, vol.285
, pp. 13621-13629
-
-
Mak, S.K.1
McCormack, A.L.2
Manning-Bog, A.B.3
Cuervo, A.M.4
Di Monte, D.A.5
-
93
-
-
84937677490
-
VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson's disease
-
Tang FL, Erion JR, Tian Y, et al. VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson's disease. J Neurosci 2015;35:10613–10628.
-
(2015)
J Neurosci
, vol.35
, pp. 10613-10628
-
-
Tang, F.L.1
Erion, J.R.2
Tian, Y.3
-
94
-
-
58149215720
-
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy
-
Yang Q, She H, Gearing M, et al. Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 2009;323:124–127.
-
(2009)
Science
, vol.323
, pp. 124-127
-
-
Yang, Q.1
She, H.2
Gearing, M.3
-
95
-
-
84929705440
-
Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease
-
Murphy KE, Gysbers AM, Abbott SK, et al. Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease. Mov Disord 2015;30:1639–1647.
-
(2015)
Mov Disord
, vol.30
, pp. 1639-1647
-
-
Murphy, K.E.1
Gysbers, A.M.2
Abbott, S.K.3
-
96
-
-
84894528843
-
Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease
-
Murphy KE, Gysbers AM, Abbott SK, et al. Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease. Brain 2014;137(Pt 3):834–848.
-
(2014)
Brain
, vol.137
, pp. 834-848
-
-
Murphy, K.E.1
Gysbers, A.M.2
Abbott, S.K.3
-
97
-
-
84875876495
-
Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease
-
Alvarez-Erviti L, Seow Y, Schapira AH, Rodriguez-Oroz MC, Obeso JA, Cooper JM. Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease. Cell Death Dis 2013;4:e545.
-
(2013)
Cell Death Dis
, vol.4
-
-
Alvarez-Erviti, L.1
Seow, Y.2
Schapira, A.H.3
Rodriguez-Oroz, M.C.4
Obeso, J.A.5
Cooper, J.M.6
-
98
-
-
84908352032
-
Targeted suppression of chaperone-mediated autophagy by miR-320a promotes alpha-synuclein aggregation
-
Li G, Yang H, Zhu D, Huang H, Liu G, Lun P. Targeted suppression of chaperone-mediated autophagy by miR-320a promotes alpha-synuclein aggregation. Int J Mol Sci 2014;15:15845–15857.
-
(2014)
Int J Mol Sci
, vol.15
, pp. 15845-15857
-
-
Li, G.1
Yang, H.2
Zhu, D.3
Huang, H.4
Liu, G.5
Lun, P.6
-
99
-
-
85017330629
-
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease
-
Rothaug M, Stroobants S, Schweizer M, et al. LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease. Acta Neuropathol Commun 2015;3:6.
-
(2015)
Acta Neuropathol Commun
, vol.3
, pp. 6
-
-
Rothaug, M.1
Stroobants, S.2
Schweizer, M.3
-
100
-
-
3042760943
-
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts
-
Eskelinen EL, Schmidt CK, Neu S, et al. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell 2004;15:3132–3145.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 3132-3145
-
-
Eskelinen, E.L.1
Schmidt, C.K.2
Neu, S.3
-
101
-
-
67650087652
-
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
-
Neumann J, Bras J, Deas E, et al. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain 2009;132(Pt 7):1783–1794.
-
(2009)
Brain
, vol.132
, pp. 1783-1794
-
-
Neumann, J.1
Bras, J.2
Deas, E.3
-
102
-
-
79956199921
-
Acid beta-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter alpha-synuclein processing
-
Cullen V, Sardi SP, Ng J, et al. Acid beta-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter alpha-synuclein processing. Ann Neurol 2011;69:940–953.
-
(2011)
Ann Neurol
, vol.69
, pp. 940-953
-
-
Cullen, V.1
Sardi, S.P.2
Ng, J.3
-
103
-
-
71049138581
-
Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism
-
Manning-Bog AB, Schule B, Langston JW. Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism. Neurotoxicology 2009;30:1127–1132.
-
(2009)
Neurotoxicology
, vol.30
, pp. 1127-1132
-
-
Manning-Bog, A.B.1
Schule, B.2
Langston, J.W.3
-
104
-
-
84875967929
-
Loss of beta-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells
-
Dermentzaki G, Dimitriou E, Xilouri M, Michelakakis H, Stefanis L. Loss of beta-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells. PLoS One 2013;8:e60674.
-
(2013)
PLoS One
, vol.8
-
-
Dermentzaki, G.1
Dimitriou, E.2
Xilouri, M.3
Michelakakis, H.4
Stefanis, L.5
-
105
-
-
84870671394
-
Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage
-
Cleeter MW, Chau KY, Gluck C, et al. Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage. Neurochem Int 2013;62:1–7.
-
(2013)
Neurochem Int
, vol.62
, pp. 1-7
-
-
Cleeter, M.W.1
Chau, K.Y.2
Gluck, C.3
-
106
-
-
79952619654
-
Accumulation and distribution of alpha-synuclein and ubiquitin in the CNS of Gaucher disease mouse models
-
Xu YH, Sun Y, Ran H, Quinn B, Witte D, Grabowski GA. Accumulation and distribution of alpha-synuclein and ubiquitin in the CNS of Gaucher disease mouse models. Mol Genet Metab 2011;102:436–447.
-
(2011)
Mol Genet Metab
, vol.102
, pp. 436-447
-
-
Xu, Y.H.1
Sun, Y.2
Ran, H.3
Quinn, B.4
Witte, D.5
Grabowski, G.A.6
-
107
-
-
84922266926
-
Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation
-
Fishbein I, Kuo YM, Giasson BI, Nussbaum RL. Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation. Brain 2014;137(Pt 12):3235–3247.
-
(2014)
Brain
, vol.137
, pp. 3235-3247
-
-
Fishbein, I.1
Kuo, Y.M.2
Giasson, B.I.3
Nussbaum, R.L.4
-
108
-
-
84912058317
-
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease
-
Woodard CM, Campos BA, Kuo SH, et al. iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Rep 2014;9:1173–1182.
-
(2014)
Cell Rep
, vol.9
, pp. 1173-1182
-
-
Woodard, C.M.1
Campos, B.A.2
Kuo, S.H.3
-
109
-
-
84902201548
-
iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis
-
Schondorf DC, Aureli M, McAllister FE, et al. iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nat Commun 2014;5:4028.
-
(2014)
Nat Commun
, vol.5
, pp. 4028
-
-
Schondorf, D.C.1
Aureli, M.2
McAllister, F.E.3
-
110
-
-
84907360500
-
Glucocerebrosidase depletion enhances cell-to-cell transmission of alpha-synuclein
-
Bae EJ, Yang NY, Song M, et al. Glucocerebrosidase depletion enhances cell-to-cell transmission of alpha-synuclein. Nat Commun 2014;5:4755.
-
(2014)
Nat Commun
, vol.5
, pp. 4755
-
-
Bae, E.J.1
Yang, N.Y.2
Song, M.3
-
111
-
-
84965185844
-
Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and alpha-synuclein aggregation
-
Bae EJ, Yang NY, Lee C, et al. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and alpha-synuclein aggregation. Exp Mol Med 2015;47:e153.
-
(2015)
Exp Mol Med
, vol.47
-
-
Bae, E.J.1
Yang, N.Y.2
Lee, C.3
-
112
-
-
79959925894
-
{alpha}-Synuclein interacts with glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases
-
Yap TL, Gruschus JM, Velayati A, et al. {alpha}-Synuclein interacts with glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases. J Biol Chem 2011;286:28080–28088.
-
(2011)
J Biol Chem
, vol.286
, pp. 28080-28088
-
-
Yap, T.L.1
Gruschus, J.M.2
Velayati, A.3
-
113
-
-
79960009804
-
Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies
-
Mazzulli JR, Xu YH, Sun Y, et al. Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011;146:37–52.
-
(2011)
Cell
, vol.146
, pp. 37-52
-
-
Mazzulli, J.R.1
Xu, Y.H.2
Sun, Y.3
-
114
-
-
84867036900
-
Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains
-
Gegg ME, Burke D, Heales SJ, et al. Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains. Ann Neurol 2012;72:455–463.
-
(2012)
Ann Neurol
, vol.72
, pp. 455-463
-
-
Gegg, M.E.1
Burke, D.2
Heales, S.J.3
-
115
-
-
84874487118
-
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
-
Sardi SP, Clarke J, Viel C, et al. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies. Proc Natl Acad Sci U S A 2013;110:3537–3542.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 3537-3542
-
-
Sardi, S.P.1
Clarke, J.2
Viel, C.3
-
116
-
-
84908282747
-
LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance
-
Rothaug M, Zunke F, Mazzulli JR, et al. LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance. Proc Natl Acad Sci U S A 2014;111:15573–15578.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 15573-15578
-
-
Rothaug, M.1
Zunke, F.2
Mazzulli, J.R.3
-
117
-
-
84858276817
-
Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease
-
Michelakakis H, Xiromerisiou G, Dardiotis E, et al. Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease. Mov Disord 2012;27:400–405.
-
(2012)
Mov Disord
, vol.27
, pp. 400-405
-
-
Michelakakis, H.1
Xiromerisiou, G.2
Dardiotis, E.3
-
118
-
-
79959841853
-
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease
-
Do CB, Tung JY, Dorfman E, et al. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet 2011;7:e1002141.
-
(2011)
PLoS Genet
, vol.7
-
-
Do, C.B.1
Tung, J.Y.2
Dorfman, E.3
-
119
-
-
84876104005
-
The role of SCARB2 as susceptibility factor in Parkinson's disease
-
Hopfner F, Schulte EC, Mollenhauer B, et al. The role of SCARB2 as susceptibility factor in Parkinson's disease. Mov Disord 2013;28:538–540.
-
(2013)
Mov Disord
, vol.28
, pp. 538-540
-
-
Hopfner, F.1
Schulte, E.C.2
Mollenhauer, B.3
-
120
-
-
84860233638
-
Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese
-
Chen S, Zhang Y, Chen W, et al. Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese. Neurosci Lett 2012;516:21–23.
-
(2012)
Neurosci Lett
, vol.516
, pp. 21-23
-
-
Chen, S.1
Zhang, Y.2
Chen, W.3
-
121
-
-
84875245748
-
Is Parkinson disease associated with lysosomal integral membrane protein type-2?: challenges in interpreting association data
-
Maniwang E, Tayebi N, Sidransky E. Is Parkinson disease associated with lysosomal integral membrane protein type-2?: challenges in interpreting association data. Mol Genet Metab 2013;108:269–271.
-
(2013)
Mol Genet Metab
, vol.108
, pp. 269-271
-
-
Maniwang, E.1
Tayebi, N.2
Sidransky, E.3
-
122
-
-
84877351078
-
TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity
-
Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Bjorklund A. TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proc Natl Acad Sci U S A 2013;110:E1817–E1826.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E1817-E1826
-
-
Decressac, M.1
Mattsson, B.2
Weikop, P.3
Lundblad, M.4
Jakobsson, J.5
Bjorklund, A.6
-
123
-
-
84925597891
-
Genetic and chemical activation of TFEB mediates clearance of aggregated alpha-synuclein
-
Kilpatrick K, Zeng Y, Hancock T, Segatori L. Genetic and chemical activation of TFEB mediates clearance of aggregated alpha-synuclein. PLoS One 2015;10:e0120819.
-
(2015)
PLoS One
, vol.10
-
-
Kilpatrick, K.1
Zeng, Y.2
Hancock, T.3
Segatori, L.4
-
124
-
-
34247161367
-
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
-
Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007;282:5641–5652.
-
(2007)
J Biol Chem
, vol.282
, pp. 5641-5652
-
-
Sarkar, S.1
Davies, J.E.2
Huang, Z.3
Tunnacliffe, A.4
Rubinsztein, D.C.5
-
125
-
-
84925485842
-
3-anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of alpha-synuclein in PC12 cells
-
Xue D, Wang Q, Chen Z, et al. 3-anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of alpha-synuclein in PC12 cells. Bioorg Med Chem Lett 2015;25:1464–1470.
-
(2015)
Bioorg Med Chem Lett
, vol.25
, pp. 1464-1470
-
-
Xue, D.1
Wang, Q.2
Chen, Z.3
-
126
-
-
84929448327
-
Treatment with trehalose prevents behavioral and neurochemical deficits produced in an AAV alpha-synuclein rat model of Parkinson's disease
-
May 14., [Epub ahead of print]
-
He Q, Koprich JB, Wang Y, et al. Treatment with trehalose prevents behavioral and neurochemical deficits produced in an AAV alpha-synuclein rat model of Parkinson's disease. Mol Neurobiol 2015 May 14. doi: 10.1007/s12035-015-9173-7. [Epub ahead of print]
-
(2015)
Mol Neurobiol
-
-
He, Q.1
Koprich, J.B.2
Wang, Y.3
-
127
-
-
84881250979
-
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of alpha-synuclein in Parkinson's disease models
-
Hebron ML, Lonskaya I, Moussa CE. Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of alpha-synuclein in Parkinson's disease models. Hum Mol Genet 2013;22:3315–3328.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 3315-3328
-
-
Hebron, M.L.1
Lonskaya, I.2
Moussa, C.E.3
-
128
-
-
84899894003
-
c-Abl phosphorylates alpha-synuclein and regulates its degradation: implication for alpha-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
-
Mahul-Mellier AL, Fauvet B, Gysbers A, et al. c-Abl phosphorylates alpha-synuclein and regulates its degradation: implication for alpha-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet 2014;23:2858–2879.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 2858-2879
-
-
Mahul-Mellier, A.L.1
Fauvet, B.2
Gysbers, A.3
-
129
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey UB, Nie Z, Batlevi Y, et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007;447:859–863.
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
-
130
-
-
65249125897
-
p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum
-
Zhang XD, Wang Y, Wang Y, et al. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy 2009;5:339–350.
-
(2009)
Autophagy
, vol.5
, pp. 339-350
-
-
Zhang, X.D.1
Wang, Y.2
Wang, Y.3
-
131
-
-
84859702745
-
Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy
-
Cartier AE, Ubhi K, Spencer B, et al. Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. PLoS One 2012;7:e34713.
-
(2012)
PLoS One
, vol.7
-
-
Cartier, A.E.1
Ubhi, K.2
Spencer, B.3
-
132
-
-
77955023765
-
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
-
Rothenberg C, Srinivasan D, Mah L, et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 2010;19:3219–3232.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3219-3232
-
-
Rothenberg, C.1
Srinivasan, D.2
Mah, L.3
-
133
-
-
77957674939
-
Ubiquilin at a crossroads in protein degradation pathways
-
Rothenberg C, Monteiro MJ. Ubiquilin at a crossroads in protein degradation pathways. Autophagy 2010;6:979–980.
-
(2010)
Autophagy
, vol.6
, pp. 979-980
-
-
Rothenberg, C.1
Monteiro, M.J.2
-
134
-
-
33645829816
-
Consequences of the selective blockage of chaperone-mediated autophagy
-
Massey AC, Kaushik S, Sovak G, Kiffin R, Cuervo AM. Consequences of the selective blockage of chaperone-mediated autophagy. Proc Natl Acad Sci U S A 2006;103:5805–5810.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5805-5810
-
-
Massey, A.C.1
Kaushik, S.2
Sovak, G.3
Kiffin, R.4
Cuervo, A.M.5
-
135
-
-
48249091611
-
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy
-
Kaushik S, Massey AC, Mizushima N, Cuervo AM. Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell 2008;19:2179–2192.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 2179-2192
-
-
Kaushik, S.1
Massey, A.C.2
Mizushima, N.3
Cuervo, A.M.4
-
136
-
-
41949125675
-
Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus
-
Wang Y, Singh R, Massey AC, et al. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem 2008;283:4766–4777.
-
(2008)
J Biol Chem
, vol.283
, pp. 4766-4777
-
-
Wang, Y.1
Singh, R.2
Massey, A.C.3
-
137
-
-
79960330523
-
A photoconvertible fluorescent reporter to track chaperone-mediated autophagy
-
Koga H, Martinez-Vicente M, Macian F, Verkhusha VV, Cuervo AM. A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. Nat Commun 2011;2:386.
-
(2011)
Nat Commun
, vol.2
, pp. 386
-
-
Koga, H.1
Martinez-Vicente, M.2
Macian, F.3
Verkhusha, V.V.4
Cuervo, A.M.5
-
138
-
-
51349095898
-
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
-
Zhang C, Cuervo AM. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 2008;14:959–965.
-
(2008)
Nat Med
, vol.14
, pp. 959-965
-
-
Zhang, C.1
Cuervo, A.M.2
-
139
-
-
84879962810
-
Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration
-
Xilouri M, Brekk OR, Landeck N, et al. Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration. Brain 2013;136(Pt 7):2130–2146.
-
(2013)
Brain
, vol.136
, pp. 2130-2146
-
-
Xilouri, M.1
Brekk, O.R.2
Landeck, N.3
-
140
-
-
84902546681
-
In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis
-
Ouzounoglou E, Kalamatianos D, Emmanouilidou E, et al. In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis. BMC Syst Biol 2014;8:54.
-
(2014)
BMC Syst Biol
, vol.8
, pp. 54
-
-
Ouzounoglou, E.1
Kalamatianos, D.2
Emmanouilidou, E.3
-
141
-
-
84879121285
-
Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
-
Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol 2013;9:374–382.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 374-382
-
-
Anguiano, J.1
Garner, T.P.2
Mahalingam, M.3
Das, B.C.4
Gavathiotis, E.5
Cuervo, A.M.6
-
142
-
-
79961083395
-
CNS expression of glucocerebrosidase corrects {alpha}-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
-
Sardi SP, Clarke J, Kinnecom C, et al. CNS expression of glucocerebrosidase corrects {alpha}-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy. Proc Natl Acad Sci U S A 2011;108:12101–12106.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 12101-12106
-
-
Sardi, S.P.1
Clarke, J.2
Kinnecom, C.3
-
143
-
-
84907486116
-
Development of targeted therapies for Parkinson's disease and related synucleinopathies
-
Sybertz E, Krainc D. Development of targeted therapies for Parkinson's disease and related synucleinopathies. J Lipid Res 2014;55:1996–2003.
-
(2014)
J Lipid Res
, vol.55
, pp. 1996-2003
-
-
Sybertz, E.1
Krainc, D.2
-
144
-
-
33947376087
-
Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-beta-glucosidase
-
Steet R, Chung S, Lee WS, Pine CW, Do H, Kornfeld S. Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-beta-glucosidase. Biochem Pharmacol 2007;73:1376–1383.
-
(2007)
Biochem Pharmacol
, vol.73
, pp. 1376-1383
-
-
Steet, R.1
Chung, S.2
Lee, W.S.3
Pine, C.W.4
Do, H.5
Kornfeld, S.6
-
145
-
-
33748801230
-
The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms
-
Steet RA, Chung S, Wustman B, Powe A, Do H, Kornfeld SA. The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms. Proc Natl Acad Sci U S A 2006;103:13813–13818.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13813-13818
-
-
Steet, R.A.1
Chung, S.2
Wustman, B.3
Powe, A.4
Do, H.5
Kornfeld, S.A.6
-
146
-
-
84919876441
-
A GCase chaperone improves motor function in a mouse model of synucleinopathy
-
Richter F, Fleming SM, Watson M, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics 2014;11:840–856.
-
(2014)
Neurotherapeutics
, vol.11
, pp. 840-856
-
-
Richter, F.1
Fleming, S.M.2
Watson, M.3
-
147
-
-
84899819100
-
Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
-
McNeill A, Magalhaes J, Shen C, et al. Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain 2014;137(Pt 5):1481–1495.
-
(2014)
Brain
, vol.137
, pp. 1481-1495
-
-
McNeill, A.1
Magalhaes, J.2
Shen, C.3
|