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Volumn 8, Issue 1, 2014, Pages

In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis

Author keywords

Alpha synuclein; Biomolecular reaction networks modeling; In silico experiments; Neurodegeneration; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; CHAPERONE; PROTEASOME;

EID: 84902546681     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-8-54     Document Type: Article
Times cited : (24)

References (47)
  • 6
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
    • 10.1016/S0140-6736(04)17104-3, 15451225
    • Ibáñez P, Bonnet A-M, Débarges B, Lohmann E, Tison F, Pollak P, Agid Y, Dürr A, Brice A. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 2004, 364:1169-1171. 10.1016/S0140-6736(04)17104-3, 15451225.
    • (2004) Lancet , vol.364 , pp. 1169-1171
    • Ibáñez, P.1    Bonnet, A.-M.2    Débarges, B.3    Lohmann, E.4    Tison, F.5    Pollak, P.6    Agid, Y.7    Dürr, A.8    Brice, A.9
  • 8
    • 65549102934 scopus 로고    scopus 로고
    • Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death
    • 10.1111/j.1471-4159.2009.06054.x, 19476547
    • Vekrellis K, Xilouri M, Emmanouilidou E, Stefanis L. Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death. J Neurochem 2009, 109:1348-1362. 10.1111/j.1471-4159.2009.06054.x, 19476547.
    • (2009) J Neurochem , vol.109 , pp. 1348-1362
    • Vekrellis, K.1    Xilouri, M.2    Emmanouilidou, E.3    Stefanis, L.4
  • 9
    • 4644340821 scopus 로고    scopus 로고
    • Neurobiology of alpha-synuclein
    • 10.1385/MN:30:1:001, 15247485
    • Vekrellis K, Rideout HJ, Stefanis L. Neurobiology of alpha-synuclein. Mol Neurobiol 2004, 30:1-21. 10.1385/MN:30:1:001, 15247485.
    • (2004) Mol Neurobiol , vol.30 , pp. 1-21
    • Vekrellis, K.1    Rideout, H.J.2    Stefanis, L.3
  • 10
    • 25444433798 scopus 로고    scopus 로고
    • Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein
    • 10.1016/j.jmb.2005.08.046, 16171820
    • Kaylor J, Bodner N, Edridge S, Yamin G, Hong D-P, Fink AL. Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein. J Mol Biol 2005, 353:357-372. 10.1016/j.jmb.2005.08.046, 16171820.
    • (2005) J Mol Biol , vol.353 , pp. 357-372
    • Kaylor, J.1    Bodner, N.2    Edridge, S.3    Yamin, G.4    Hong, D.-P.5    Fink, A.L.6
  • 12
    • 83055180511 scopus 로고    scopus 로고
    • Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy
    • Sultana Z, Paleologou KE, Al-Mansoori KM, Ardah MT, Singh N, Usmani S, Jiao H, Martin FL, Bharath MMS, Vali S, El-Agnaf OMA. Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy. Neuroscience 2011, 199:303-317.
    • (2011) Neuroscience , vol.199 , pp. 303-317
    • Sultana, Z.1    Paleologou, K.E.2    Al-Mansoori, K.M.3    Ardah, M.T.4    Singh, N.5    Usmani, S.6    Jiao, H.7    Martin, F.L.8    Bharath, M.M.S.9    Vali, S.10    El-Agnaf, O.M.A.11
  • 13
    • 69049112795 scopus 로고    scopus 로고
    • Modulation of alpha-synuclein aggregation by dopamine: a review
    • 10.1007/s11064-009-9986-8, 19444607
    • Leong SL, Cappai R, Barnham KJ, Pham CLL. Modulation of alpha-synuclein aggregation by dopamine: a review. Neurochem Res 2009, 34:1838-1846. 10.1007/s11064-009-9986-8, 19444607.
    • (2009) Neurochem Res , vol.34 , pp. 1838-1846
    • Leong, S.L.1    Cappai, R.2    Barnham, K.J.3    Pham, C.L.L.4
  • 14
    • 65849127844 scopus 로고    scopus 로고
    • Abberant α-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    • 10.1371/journal.pone.0005515, 2677735, 19436756
    • Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L. Abberant α-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One 2009, 4:e5515. 10.1371/journal.pone.0005515, 2677735, 19436756.
    • (2009) PLoS One , vol.4
    • Xilouri, M.1    Vogiatzi, T.2    Vekrellis, K.3    Park, D.4    Stefanis, L.5
  • 16
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • 10.1074/jbc.M801992200, 2527094, 18566453
    • Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008, 283:23542-23556. 10.1074/jbc.M801992200, 2527094, 18566453.
    • (2008) J Biol Chem , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 17
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • 10.1126/science.1101738, 15333840
    • Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004, 305:1292-1295. 10.1126/science.1101738, 15333840.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 18
    • 77951976610 scopus 로고    scopus 로고
    • Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
    • 10.1016/j.neurobiolaging.2008.07.008, 18715677
    • Emmanouilidou E, Stefanis L, Vekrellis K. Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiol Aging 2010, 31:953-968. 10.1016/j.neurobiolaging.2008.07.008, 18715677.
    • (2010) Neurobiol Aging , vol.31 , pp. 953-968
    • Emmanouilidou, E.1    Stefanis, L.2    Vekrellis, K.3
  • 19
    • 0041589248 scopus 로고    scopus 로고
    • α-synuclein is degraded by both autophagy and the proteasome
    • 10.1074/jbc.M300227200, 12719433
    • Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. α-synuclein is degraded by both autophagy and the proteasome. J Biol Chem 2003, 278:25009-25013. 10.1074/jbc.M300227200, 12719433.
    • (2003) J Biol Chem , vol.278 , pp. 25009-25013
    • Webb, J.L.1    Ravikumar, B.2    Atkins, J.3    Skepper, J.N.4    Rubinsztein, D.C.5
  • 20
    • 67649966284 scopus 로고    scopus 로고
    • Modeling proteasome dynamics in Parkinson's disease
    • 10.1088/1478-3975/6/3/036005, 19411740
    • Sneppen K, Lizana L, Jensen MH, Pigolotti S, Otzen D. Modeling proteasome dynamics in Parkinson's disease. Phys Biol 2009, 6:036005. 10.1088/1478-3975/6/3/036005, 19411740.
    • (2009) Phys Biol , vol.6 , pp. 036005
    • Sneppen, K.1    Lizana, L.2    Jensen, M.H.3    Pigolotti, S.4    Otzen, D.5
  • 21
    • 50649112184 scopus 로고    scopus 로고
    • Alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis
    • 10.1074/jbc.M710560200, 18502751
    • Zhang N-Y, Tang Z, Liu C-W. alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis. J Biol Chem 2008, 283:20288-20298. 10.1074/jbc.M710560200, 18502751.
    • (2008) J Biol Chem , vol.283 , pp. 20288-20298
    • Zhang, N.-Y.1    Tang, Z.2    Liu, C.-W.3
  • 22
    • 1842424791 scopus 로고    scopus 로고
    • Proteasomal inhibition by alpha-synuclein filaments and oligomers
    • 10.1074/jbc.M306390200, 14711827
    • Lindersson E, Beedholm R, Højrup P, Moos T, Gai W, Hendil KB, Jensen PH. Proteasomal inhibition by alpha-synuclein filaments and oligomers. J Biol Chem 2004, 279:12924-12934. 10.1074/jbc.M306390200, 14711827.
    • (2004) J Biol Chem , vol.279 , pp. 12924-12934
    • Lindersson, E.1    Beedholm, R.2    Højrup, P.3    Moos, T.4    Gai, W.5    Hendil, K.B.6    Jensen, P.H.7
  • 23
    • 69049084725 scopus 로고    scopus 로고
    • A cellular model to monitor proteasome dysfunction by α-synuclein
    • Nonaka T, Hasegawa M. A cellular model to monitor proteasome dysfunction by α-synuclein. Biochemistry (Mosc) 2009, 48:8014-8022.
    • (2009) Biochemistry (Mosc) , vol.48 , pp. 8014-8022
    • Nonaka, T.1    Hasegawa, M.2
  • 24
    • 78049299130 scopus 로고    scopus 로고
    • Modelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration
    • 10.1371/journal.pone.0013175, 2950841, 20949132
    • Proctor CJ, Tangeman PJ, Ardley HC. Modelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration. PLoS One 2010, 5:e13175. 10.1371/journal.pone.0013175, 2950841, 20949132.
    • (2010) PLoS One , vol.5
    • Proctor, C.J.1    Tangeman, P.J.2    Ardley, H.C.3
  • 25
    • 80054755695 scopus 로고    scopus 로고
    • Pathological roles of α-synuclein in neurological disorders
    • 10.1016/S1474-4422(11)70213-7, 22014436
    • Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L. Pathological roles of α-synuclein in neurological disorders. Lancet Neurol 2011, 10:1015-1025. 10.1016/S1474-4422(11)70213-7, 22014436.
    • (2011) Lancet Neurol , vol.10 , pp. 1015-1025
    • Vekrellis, K.1    Xilouri, M.2    Emmanouilidou, E.3    Rideout, H.J.4    Stefanis, L.5
  • 27
    • 0035800097 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease
    • Volles MJ, Lee SJ, Rochet JC, Shtilerman MD, Ding TT, Kessler JC, Lansbury PT. Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry (Mosc) 2001, 40:7812-7819.
    • (2001) Biochemistry (Mosc) , vol.40 , pp. 7812-7819
    • Volles, M.J.1    Lee, S.J.2    Rochet, J.C.3    Shtilerman, M.D.4    Ding, T.T.5    Kessler, J.C.6    Lansbury, P.T.7
  • 28
    • 54749104651 scopus 로고    scopus 로고
    • Controlling the mass action of alpha-synuclein in Parkinson's disease
    • 10.1111/j.1471-4159.2008.05612.x, 18691382
    • Kim C, Lee S-J. Controlling the mass action of alpha-synuclein in Parkinson's disease. J Neurochem 2008, 107:303-316. 10.1111/j.1471-4159.2008.05612.x, 18691382.
    • (2008) J Neurochem , vol.107 , pp. 303-316
    • Kim, C.1    Lee, S.-J.2
  • 29
    • 84884155816 scopus 로고    scopus 로고
    • Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity
    • 10.1016/j.neurobiolaging.2013.06.006, 23891486
    • Melachroinou K, Xilouri M, Emmanouilidou E, Masgrau R, Papazafiri P, Stefanis L, Vekrellis K. Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity. Neurobiol Aging 2013, 34:2853-2865. 10.1016/j.neurobiolaging.2013.06.006, 23891486.
    • (2013) Neurobiol Aging , vol.34 , pp. 2853-2865
    • Melachroinou, K.1    Xilouri, M.2    Emmanouilidou, E.3    Masgrau, R.4    Papazafiri, P.5    Stefanis, L.6    Vekrellis, K.7
  • 31
    • 9444266171 scopus 로고    scopus 로고
    • Cell Designer: a process diagram editor for gene-regulatory and biochemical networks
    • Funahashi A, Morohashi M, Kitano H, Tanimura N. Cell Designer: a process diagram editor for gene-regulatory and biochemical networks. BIOSILICO 2003, 1:159-162.
    • (2003) BIOSILICO , vol.1 , pp. 159-162
    • Funahashi, A.1    Morohashi, M.2    Kitano, H.3    Tanimura, N.4
  • 33
    • 53049108584 scopus 로고    scopus 로고
    • Mathematical approach to understand the kinetics of alpha-synuclein aggregation: relevance to Parkinson's disease
    • 10.1016/j.compbiomed.2008.08.008, 18823621
    • Bharathi P, Nagabhushan P, Rao KSJ. Mathematical approach to understand the kinetics of alpha-synuclein aggregation: relevance to Parkinson's disease. Comput Biol Med 2008, 38:1084-1093. 10.1016/j.compbiomed.2008.08.008, 18823621.
    • (2008) Comput Biol Med , vol.38 , pp. 1084-1093
    • Bharathi, P.1    Nagabhushan, P.2    Rao, K.S.J.3
  • 35
    • 0001144902 scopus 로고    scopus 로고
    • Efficient exact stochastic simulation of chemical systems with many species and many channels
    • Gibson MA, Bruck J. Efficient exact stochastic simulation of chemical systems with many species and many channels. J Phys Chem A 2000, 104:1876-1889.
    • (2000) J Phys Chem A , vol.104 , pp. 1876-1889
    • Gibson, M.A.1    Bruck, J.2
  • 36
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • Gillespie DT. Exact stochastic simulation of coupled chemical reactions. J Phys Chem 1977, 81:2340-2361.
    • (1977) J Phys Chem , vol.81 , pp. 2340-2361
    • Gillespie, D.T.1
  • 39
    • 33846997878 scopus 로고    scopus 로고
    • Presynaptic α-synuclein aggregates, Not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    • 10.1523/JNEUROSCI.4564-06.2007, 17287515
    • Kramer ML, Schulz-Schaeffer WJ. Presynaptic α-synuclein aggregates, Not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007, 27:1405-1410. 10.1523/JNEUROSCI.4564-06.2007, 17287515.
    • (2007) J Neurosci , vol.27 , pp. 1405-1410
    • Kramer, M.L.1    Schulz-Schaeffer, W.J.2
  • 42
    • 77954531383 scopus 로고    scopus 로고
    • Comparison of different algorithms for simultaneous estimation of multiple parameters in kinetic metabolic models
    • Baker SM, Schallau K, Junker BH. Comparison of different algorithms for simultaneous estimation of multiple parameters in kinetic metabolic models. J Integr Bioinforma 2010, 7(3):133.
    • (2010) J Integr Bioinforma , vol.7 , Issue.3 , pp. 133
    • Baker, S.M.1    Schallau, K.2    Junker, B.H.3
  • 43
    • 0242574982 scopus 로고    scopus 로고
    • Parameter estimation in biochemical pathways: a comparison of global optimization methods
    • 10.1101/gr.1262503, 403766, 14559783
    • Moles CG, Mendes P, Banga JR. Parameter estimation in biochemical pathways: a comparison of global optimization methods. Genome Res 2003, 13:2467-2474. 10.1101/gr.1262503, 403766, 14559783.
    • (2003) Genome Res , vol.13 , pp. 2467-2474
    • Moles, C.G.1    Mendes, P.2    Banga, J.R.3
  • 44
    • 0002651837 scopus 로고
    • An overview of evolutionary algorithms for parameter optimization
    • Bäck T, Schwefel H-P. An overview of evolutionary algorithms for parameter optimization. Evol Comput 1993, 1:1-23.
    • (1993) Evol Comput , vol.1 , pp. 1-23
    • Bäck, T.1    Schwefel, H.-P.2
  • 45
    • 0034266683 scopus 로고    scopus 로고
    • Stochastic ranking for constrained evolutionary optimization
    • Runarsson TP, Yao X. Stochastic ranking for constrained evolutionary optimization. IEEE Trans Evol Comput 2000, 4:284-294.
    • (2000) IEEE Trans Evol Comput , vol.4 , pp. 284-294
    • Runarsson, T.P.1    Yao, X.2
  • 47
    • 33947623106 scopus 로고    scopus 로고
    • SBMLeditor: effective creation of models in the Systems Biology Markup language (SBML)
    • Rodriguez N, Donizelli M, le Novère N. SBMLeditor: effective creation of models in the Systems Biology Markup language (SBML). BMC Bioinforma 2007, 8:79.
    • (2007) BMC Bioinforma , vol.8 , pp. 79
    • Rodriguez, N.1    Donizelli, M.2    le Novère, N.3


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