α-Synuclein interacts with glucocerebrosidase providing a molecular link between Parkinson and gaucher diseases

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28080-28088

  Yap, Thai Leong ^a   Gruschus, James M ^a   Velayati, Arash ^b   Westbroek, Wendy ^b   Goldin, Ehud ^b   Moaven, Nima ^b   Sidransky, Ellen ^b   Lee, Jennifer C ^a,c  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c Building 50 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONDURITOLS; DISSOCIATION CONSTANT; GAUCHER DISEASE; GENETIC RISKS; GENETIC STUDIES; GLUCOCEREBROSIDASE; HUMAN TISSUES; IMMUNOPRECIPITATIONS; INTERACTION SITE; LYSOSOMAL STORAGE DISORDER; MOLECULAR LINKS; MOLECULAR MECHANISM; MUTANT ENZYMES; NEURONAL CELL CULTURE; NON-COVALENT INTERACTION; PARKINSON DISEASE; PRESYNAPTIC; PROTEIN-PROTEIN INTERACTIONS; SOLUTION CONDITIONS; SYNUCLEIN; WILD TYPES;

ANIMAL CELL CULTURE; DISSOCIATION; ENZYMES; FLUORESCENCE; GENES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; RESONANCE; SODIUM CHLORIDE; TISSUE;

ASSOCIATION REACTIONS;

ALPHA SYNUCLEIN; GLUCOSYLCERAMIDASE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISSOCIATION CONSTANT; GAUCHER DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYSOSOME; MUTANT; NERVE CELL CULTURE; PARKINSON DISEASE; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; STATIC ELECTRICITY; WILD TYPE;

ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; ENZYME INHIBITORS; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; HYDROGEN-ION CONCENTRATION; INOSITOL; LYSOSOMES; MULTIPROTEIN COMPLEXES; MUTATION, MISSENSE; PARKINSON DISEASE;

EID: 79959925894     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.237859     Document Type: Article

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