Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17313-17335

  Ejlerskov, Patrick ^a,b   Rasmussen, Izabela ^a   Nielsen, Troels Tolstrup ^a,c   Bergström, Ann Louise ^d   Tohyama, Yumi ^e   Jensen, Poul Henning ^f   Vilhardt, Frederik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Rigshospitalet   (Denmark)

^d H LUNDBECK A S   (Denmark)

^e HIMEJI DOKKYO UNIVERSITY   (Japan)

^f AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGOSOMES; AUTOPHAGY; BASAL LEVELS; CYTOSOLIC; DEACETYLASE; MICROTUBULES; SYNUCLEIN; VESICULAR TRANSPORT;

NEURONS; POLYMERIZATION;

PHYSIOLOGY;

3 METHYLADENINE; ALPHA SYNUCLEIN; CELL PROTEIN; HISTONE DEACETYLASE 6; NERVE GROWTH FACTOR; PROTEIN RAB1A; PROTEIN RAB8; RAB PROTEIN; RAB27A PROTEIN; RAPAMYCIN; SHORT HAIRPIN RNA; TREHALOSE; TUBULIN POLYMERIZATION PROMOTING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; CELL DIFFERENTIATION; CELL FUNCTION; CELL FUSION; CELL MATURATION; CELL MOTILITY; CONTROLLED STUDY; DNA MODIFICATION; DOWN REGULATION; EXOCYTOSIS; EXOPHAGY; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; UPREGULATION;

Α-SYNUCLEIN; AUTOPHAGOSOMES; EXOPHAGY; HDAC6; P25Α; PARKINSON DISEASE; PROTEIN DEGRADATION; PROTEIN SECRETION; TRAFFICKING;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CELL DIFFERENTIATION; CYTOPLASMIC VESICLES; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASES; INCLUSION BODIES; LYSOSOMES; MEMBRANE FUSION; MICROTUBULE-ASSOCIATED PROTEINS; NERVE GROWTH FACTOR; NEURITES; PC12 CELLS; PHAGOSOMES; PROTEIN TRANSPORT; PROTEOLYSIS; RAB GTP-BINDING PROTEINS; RATS; RNA, SMALL INTERFERING; SECRETORY PATHWAY; SIROLIMUS; TOR SERINE-THREONINE KINASES; TREHALOSE;

EID: 84879052241     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.401174     Document Type: Article

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