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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1464-1470

3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cells

(13) Xue, Danfeng a,b Wang, Quanxin c Chen, Ziheng a,b Cai, Lei c Bao, Li c Qi, Qiuyue c Liu, Lei a,b Wang, Xiaohui a Jin, Haijing a Wang, Jun a Wu, Hao a,b Liu, Hongwei c Chen, Quan a,b,d

a INSTITUTE OF ZOOLOGY (China)

b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES (China)

c INSTITUTE OF MICROBIOLOGY (China)

d NANKAI UNIVERSITY (China)

Author keywords

3 Anhydro 6 hydroxy ophiobolin A; Autophagy; ROS; Synuclein

Indexed keywords

3 ANHYDRO 6 HYDROXY OPHIOBOLIN A; ALPHA SYNUCLEIN; AUTOPHAGY PROTEIN 5; BECLIN 1; BECLIN 2; PROTEIN; REACTIVE OXYGEN METABOLITE; SESTERTERPENE; UNCLASSIFIED DRUG; 3-ANHYDRO-6-HYDROXYOPHIOBOLIN A;

ARTICLE; AUTOPHAGY; BIOLOGICAL ACTIVITY; BIPOLARIS ORYZAE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRISPR CAS SYSTEM; ENZYME ACTIVATION; HELA CELL LINE; HUMAN; HUMAN CELL; LEWY BODY; MITOCHONDRIAL MEMBRANE POTENTIAL; PC12 CELL LINE; PROTEIN DEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; ANIMAL; ASCOMYCETES; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN PROCESSING; RAT; STRUCTURE ACTIVITY RELATION;

ALPHA-SYNUCLEIN; ANIMALS; ASCOMYCOTA; AUTOPHAGY; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MOLECULAR CONFORMATION; PC12 CELLS; PROTEIN MODIFICATION, TRANSLATIONAL; PROTEOLYSIS; RATS; SESTERTERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925485842 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.02.030 Document Type: Article

Times cited : (14)

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