Epicardium and myocardium separate from a common precursor pool by crosstalk between bone morphogenetic protein- and fibroblast growth factor-signaling pathways

Circulation Research

Volumn 105, Issue 5, 2009, Pages 431-441

  Van Wijk, Bram ^a   Van Den Berg, Gert ^a   Abu Issa, Radwan ^c   Barnett, Phil ^a   Van Der Velden, Saskia ^a   Schmidt, Martina ^a,b,d   Ruijter, Jan M ^a   Kirby, Margaret L ^e   Moorman, Antoon F M ^a   Van Den Hoff, Maurice J B ^a,b  

^a Heart Failure Research Center   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF MICHIGAN DEARBORN   (United States)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

BMP; Cardiovascular development; Epicardium; FGF; Proepicardium; Regeneration

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NUCLEIC ACID BINDING PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TBX18; UNCLASSIFIED DRUG; VELAFERMIN; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3,3' DIOCTADECYLINDOCARBOCYANINE; 3,3'-DIOCTADECYLINDOCARBOCYANINE; BONE MORPHOGENETIC PROTEIN 2; CARBOCYANINE; FIBROBLAST GROWTH FACTOR 2; FLUORESCENT DYE; MITOGEN ACTIVATED PROTEIN KINASE; NITRILE; PROTEIN KINASE INHIBITOR; RECOMBINANT PROTEIN; T BOX TRANSCRIPTION FACTOR; TBX18 PROTEIN, CHICKEN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; EPICARDIUM; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STIMULATION; THREE DIMENSIONAL IMAGING; ANIMAL; APOPTOSIS; CELL LINE; CELL PROLIFERATION; CHICK EMBRYO; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; HEART; IMAGE PROCESSING; METABOLISM; PERICARDIUM; PHENOTYPE; PHOSPHORYLATION; PRENATAL DEVELOPMENT;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEINS; BUTADIENES; CARBOCYANINES; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL PROLIFERATION; CHICK EMBRYO; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTORS; FLUORESCENT DYES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MICROSCOPY, FLUORESCENCE; MYOCARDIUM; NITRILES; PERICARDIUM; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; T-BOX DOMAIN PROTEINS;

EID: 70149105663     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.203083     Document Type: Article

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