Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Saraswati, Sarika ^a   Alfaro, Maria P ^a   Thorne, Curtis A ^b   Atkinson, James ^a,c   Lee, Ethan ^b   Young, Pampee P ^a,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE IALPHA; PYRVINIUM EMBONATE; AXIN PROTEIN; BETA CATENIN; DKK3 PROTEIN, HUMAN; MYC PROTEIN; REPRESSOR PROTEIN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR RESPONSE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; HEART INFARCTION; HEART MUSCLE; HISTOLOGY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; TISSUE REPAIR; TREATMENT RESPONSE; WOUND HEALING; ANIMAL; CELL STRAIN HEK293; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION; GENETICS; HEART; HEART VENTRICLE REMODELING; IMMUNOBLOTTING; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALIA; MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CASEIN KINASE IALPHA; CELL PROLIFERATION; ENZYME ACTIVATION; GENE EXPRESSION; HEART; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MYOCARDIAL INFARCTION; MYOCARDIUM; PROTO-ONCOGENE PROTEINS C-MYC; PYRVINIUM COMPOUNDS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VENTRICULAR REMODELING; WNT PROTEINS; WOUND HEALING;

EID: 78649747488     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015521     Document Type: Article

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