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Volumn 25, Issue 3, 2014, Pages 128-137

New insights into IGF-1 signaling in the heart

Author keywords

Calcium; Cardiac progenitor stem cells; IGF 1R; Inter organelle communication

Indexed keywords

CALCIUM; CARDIAC PROGENITOR STEM CELLS; IGF-1R; INTER-ORGANELLE COMMUNICATION;

EID: 84894364992     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2013.12.002     Document Type: Review
Times cited : (195)

References (115)
  • 1
    • 0036782071 scopus 로고    scopus 로고
    • Structural biology of insulin and IGF1 receptors: implications for drug design
    • De Meyts P., Whittaker J. Structural biology of insulin and IGF1 receptors: implications for drug design. Nat. Rev. Drug Discov. 2002, 1:769-783.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 769-783
    • De Meyts, P.1    Whittaker, J.2
  • 3
    • 84861087862 scopus 로고    scopus 로고
    • The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances
    • Ungvari Z., Csiszar A. The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances. J. Gerontol. A: Biol. Sci. Med. Sci. 2012, 67:599-610.
    • (2012) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.67 , pp. 599-610
    • Ungvari, Z.1    Csiszar, A.2
  • 4
    • 84879409964 scopus 로고    scopus 로고
    • Regulation of cardiac autophagy by insulin-like growth factor 1
    • Troncoso R., et al. Regulation of cardiac autophagy by insulin-like growth factor 1. IUBMB Life 2013, 65:593-601.
    • (2013) IUBMB Life , vol.65 , pp. 593-601
    • Troncoso, R.1
  • 5
    • 84873848690 scopus 로고    scopus 로고
    • Myocardial ischemia-reperfusion injury: a neglected therapeutic target
    • Hausenloy D.J., Yellon D.M. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J. Clin. Invest. 2013, 123:92-100.
    • (2013) J. Clin. Invest. , vol.123 , pp. 92-100
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 6
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statistics--2013 update: a report from the American Heart Association
    • Go A.S., et al. Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation 2013, 127:e6-e245.
    • (2013) Circulation , vol.127
    • Go, A.S.1
  • 7
    • 84868706059 scopus 로고    scopus 로고
    • Human conditions of insulin-like growth factor-I (IGF-I) deficiency
    • Puche J.E., Castilla-Cortazar I. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J. Transl. Med. 2012, 10:224.
    • (2012) J. Transl. Med. , vol.10 , pp. 224
    • Puche, J.E.1    Castilla-Cortazar, I.2
  • 8
    • 0030061941 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and angiographically documented coronary artery disease
    • Spallarossa P., et al. Insulin-like growth factor-I and angiographically documented coronary artery disease. Am. J. Cardiol. 1996, 77:200-202.
    • (1996) Am. J. Cardiol. , vol.77 , pp. 200-202
    • Spallarossa, P.1
  • 9
    • 27744592942 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) I, -II, and IGF binding protein-3 and risk of ischemic stroke
    • Johnsen S.P., et al. Insulin-like growth factor (IGF) I, -II, and IGF binding protein-3 and risk of ischemic stroke. J. Clin. Endocrinol. Metab. 2005, 90:5937-5941.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 5937-5941
    • Johnsen, S.P.1
  • 10
    • 0142056143 scopus 로고    scopus 로고
    • Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study
    • Vasan R.S., et al. Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study. Ann. Intern. Med. 2003, 139:642-648.
    • (2003) Ann. Intern. Med. , vol.139 , pp. 642-648
    • Vasan, R.S.1
  • 11
    • 77958604010 scopus 로고    scopus 로고
    • Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: association with adiponectin
    • Watanabe S., et al. Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: association with adiponectin. Eur. J. Heart Fail. 2010, 12:1214-1222.
    • (2010) Eur. J. Heart Fail. , vol.12 , pp. 1214-1222
    • Watanabe, S.1
  • 12
    • 84863397956 scopus 로고    scopus 로고
    • Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy
    • Troncoso R., et al. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc. Res. 2012, 93:320-329.
    • (2012) Cardiovasc. Res. , vol.93 , pp. 320-329
    • Troncoso, R.1
  • 13
    • 33746324537 scopus 로고    scopus 로고
    • Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
    • Eisner V., et al. Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes. FEBS Lett. 2006, 580:4495-4500.
    • (2006) FEBS Lett. , vol.580 , pp. 4495-4500
    • Eisner, V.1
  • 14
    • 84863115697 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function
    • Zhang Y., et al. Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function. Hypertension 2012, 59:680-693.
    • (2012) Hypertension , vol.59 , pp. 680-693
    • Zhang, Y.1
  • 15
    • 84856960026 scopus 로고    scopus 로고
    • The potential effects of IGF-1 and GH on patients with chronic heart failure
    • Perkel D., et al. The potential effects of IGF-1 and GH on patients with chronic heart failure. J. Cardiovasc. Pharmacol. Ther. 2012, 17:72-78.
    • (2012) J. Cardiovasc. Pharmacol. Ther. , vol.17 , pp. 72-78
    • Perkel, D.1
  • 16
    • 84859902396 scopus 로고    scopus 로고
    • Growth factors, nutrient signaling, and cardiovascular aging
    • Fontana L., et al. Growth factors, nutrient signaling, and cardiovascular aging. Circ. Res. 2012, 110:1139-1150.
    • (2012) Circ. Res. , vol.110 , pp. 1139-1150
    • Fontana, L.1
  • 18
    • 0033906634 scopus 로고    scopus 로고
    • Structure and function of the type 1 insulin-like growth factor receptor
    • Adams T.E., et al. Structure and function of the type 1 insulin-like growth factor receptor. Cell. Mol. Life Sci. 2000, 57:1050-1093.
    • (2000) Cell. Mol. Life Sci. , vol.57 , pp. 1050-1093
    • Adams, T.E.1
  • 19
    • 0038326122 scopus 로고
    • Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors
    • Jacobs S., et al. Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. Proc. Natl. Acad. Sci. U.S.A. 1983, 80:1228-1231.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , pp. 1228-1231
    • Jacobs, S.1
  • 20
    • 84872832228 scopus 로고    scopus 로고
    • Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors
    • Ibarra C., et al. Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors. Circ. Res. 2013, 112:236-245.
    • (2013) Circ. Res. , vol.112 , pp. 236-245
    • Ibarra, C.1
  • 21
    • 0030803878 scopus 로고    scopus 로고
    • Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes
    • Foncea R., et al. Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes. J. Biol. Chem. 1997, 272:19115-19124.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19115-19124
    • Foncea, R.1
  • 22
    • 0034978399 scopus 로고    scopus 로고
    • The three dimensional structure of the type I insulin-like growth factor receptor
    • Ward C.W., et al. The three dimensional structure of the type I insulin-like growth factor receptor. Mol. Pathol. 2001, 54:125-132.
    • (2001) Mol. Pathol. , vol.54 , pp. 125-132
    • Ward, C.W.1
  • 23
    • 55049090844 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy
    • Kim J., et al. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol. Endocrinol. 2008, 22:2531-2543.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 2531-2543
    • Kim, J.1
  • 24
    • 0343517544 scopus 로고    scopus 로고
    • Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes
    • Foncea R., et al. Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes. Biochem. Biophys. Res. Commun. 2000, 273:736-744.
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 736-744
    • Foncea, R.1
  • 25
    • 0035844282 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor I receptors utilize different G protein signaling components
    • Dalle S., et al. Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J. Biol. Chem. 2001, 276:15688-15695.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15688-15695
    • Dalle, S.1
  • 26
    • 0034723183 scopus 로고    scopus 로고
    • Association of heterotrimeric G(i) with the insulin-like growth factor-I receptor. Release of G(betagamma) subunits upon receptor activation
    • Hallak H., et al. Association of heterotrimeric G(i) with the insulin-like growth factor-I receptor. Release of G(betagamma) subunits upon receptor activation. J. Biol. Chem. 2000, 275:2255-2258.
    • (2000) J. Biol. Chem. , vol.275 , pp. 2255-2258
    • Hallak, H.1
  • 27
    • 0035831492 scopus 로고    scopus 로고
    • Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma-dependent mitogen-activated protein kinase activation and growth
    • Kuemmerle J.F., Murthy K.S. Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma-dependent mitogen-activated protein kinase activation and growth. J. Biol. Chem. 2001, 276:7187-7194.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7187-7194
    • Kuemmerle, J.F.1    Murthy, K.S.2
  • 28
    • 0028982925 scopus 로고
    • G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor
    • Luttrell L.M., et al. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J. Biol. Chem. 1995, 270:16495-16498.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16495-16498
    • Luttrell, L.M.1
  • 29
    • 1542289963 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
    • Ibarra C., et al. Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. J. Biol. Chem. 2004, 279:7554-7565.
    • (2004) J. Biol. Chem. , vol.279 , pp. 7554-7565
    • Ibarra, C.1
  • 30
    • 84858228729 scopus 로고    scopus 로고
    • G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function
    • Tadevosyan A., et al. G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function. J. Physiol. 2012, 590:1313-1330.
    • (2012) J. Physiol. , vol.590 , pp. 1313-1330
    • Tadevosyan, A.1
  • 31
    • 84879816153 scopus 로고    scopus 로고
    • Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca in adult cardiac myocytes
    • Merlen C., et al. Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca in adult cardiac myocytes. J. Mol. Cell. Cardiol. 2013, 62C:189-202.
    • (2013) J. Mol. Cell. Cardiol. , vol.62 C , pp. 189-202
    • Merlen, C.1
  • 32
    • 77954619980 scopus 로고    scopus 로고
    • Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression
    • Tadevosyan A., et al. Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J. Biol. Chem. 2010, 285:22338-22349.
    • (2010) J. Biol. Chem. , vol.285 , pp. 22338-22349
    • Tadevosyan, A.1
  • 33
    • 77957774460 scopus 로고    scopus 로고
    • Nuclear beta-adrenergic receptors modulate gene expression in adult rat heart
    • Vaniotis G., et al. Nuclear beta-adrenergic receptors modulate gene expression in adult rat heart. Cell. Signal. 2011, 23:89-98.
    • (2011) Cell. Signal. , vol.23 , pp. 89-98
    • Vaniotis, G.1
  • 34
    • 77950286813 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
    • Nikolaev V.O., et al. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science 2010, 327:1653-1657.
    • (2010) Science , vol.327 , pp. 1653-1657
    • Nikolaev, V.O.1
  • 35
    • 66149091985 scopus 로고    scopus 로고
    • Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart
    • Lyon A.R., et al. Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:6854-6859.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 6854-6859
    • Lyon, A.R.1
  • 36
    • 84872833596 scopus 로고    scopus 로고
    • Membrane receptor neighborhoods: snuggling up to the nucleus
    • Bers D.M. Membrane receptor neighborhoods: snuggling up to the nucleus. Circ. Res. 2013, 112:224-226.
    • (2013) Circ. Res. , vol.112 , pp. 224-226
    • Bers, D.M.1
  • 37
    • 84865560018 scopus 로고    scopus 로고
    • Nuclear inositol 1,4,5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy
    • Arantes L.A., et al. Nuclear inositol 1,4,5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy. J. Mol. Cell. Cardiol. 2012, 53:475-486.
    • (2012) J. Mol. Cell. Cardiol. , vol.53 , pp. 475-486
    • Arantes, L.A.1
  • 38
    • 84864320581 scopus 로고    scopus 로고
    • Plasticity of surface structures and beta(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure
    • Lyon A.R., et al. Plasticity of surface structures and beta(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ. Heart Fail. 2012, 5:357-365.
    • (2012) Circ. Heart Fail. , vol.5 , pp. 357-365
    • Lyon, A.R.1
  • 39
    • 84862908305 scopus 로고    scopus 로고
    • Cardiomyocyte death: mechanisms and translational implications
    • Chiong M., et al. Cardiomyocyte death: mechanisms and translational implications. Cell Death Dis. 2011, 2:e244.
    • (2011) Cell Death Dis. , vol.2
    • Chiong, M.1
  • 40
    • 0035940387 scopus 로고    scopus 로고
    • In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein
    • Mehrhof F.B., et al. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 2001, 104:2088-2094.
    • (2001) Circulation , vol.104 , pp. 2088-2094
    • Mehrhof, F.B.1
  • 41
    • 33746840153 scopus 로고    scopus 로고
    • IGF-I mediated survival pathways in normal and malignant cells
    • Kurmasheva R.T., Houghton P.J. IGF-I mediated survival pathways in normal and malignant cells. Biochim. Biophys. Acta 2006, 1766:1-22.
    • (2006) Biochim. Biophys. Acta , vol.1766 , pp. 1-22
    • Kurmasheva, R.T.1    Houghton, P.J.2
  • 42
    • 0033305250 scopus 로고    scopus 로고
    • Effects of Igf1 gene deletion on postnatal growth patterns
    • Wang J., et al. Effects of Igf1 gene deletion on postnatal growth patterns. Endocrinology 1999, 140:3391-3394.
    • (1999) Endocrinology , vol.140 , pp. 3391-3394
    • Wang, J.1
  • 43
    • 23944456384 scopus 로고    scopus 로고
    • Skeletal muscle hypertrophy and atrophy signaling pathways
    • Glass D.J. Skeletal muscle hypertrophy and atrophy signaling pathways. Int. J. Biochem. Cell Biol. 2005, 37:1974-1984.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 1974-1984
    • Glass, D.J.1
  • 44
    • 18944402728 scopus 로고    scopus 로고
    • Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation
    • Song Y.H., et al. Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation. J. Investig. Med. 2005, 53:135-142.
    • (2005) J. Investig. Med. , vol.53 , pp. 135-142
    • Song, Y.H.1
  • 45
    • 0032579211 scopus 로고    scopus 로고
    • Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes
    • Lavandero S., et al. Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes. FEBS Lett. 1998, 422:193-196.
    • (1998) FEBS Lett. , vol.422 , pp. 193-196
    • Lavandero, S.1
  • 46
    • 77957053174 scopus 로고    scopus 로고
    • The IP3 receptor regulates cardiac hypertrophy in response to select stimuli
    • Nakayama H., et al. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ. Res. 2010, 107:659-666.
    • (2010) Circ. Res. , vol.107 , pp. 659-666
    • Nakayama, H.1
  • 47
    • 84877923964 scopus 로고    scopus 로고
    • Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72
    • Ham Y.M., Mahoney S.J. Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72. Exp. Cell Res. 2013, 319:1451-1462.
    • (2013) Exp. Cell Res. , vol.319 , pp. 1451-1462
    • Ham, Y.M.1    Mahoney, S.J.2
  • 48
    • 10744223902 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway
    • McMullen J.R., et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J. Biol. Chem. 2004, 279:4782-4793.
    • (2004) J. Biol. Chem. , vol.279 , pp. 4782-4793
    • McMullen, J.R.1
  • 49
    • 0033228631 scopus 로고    scopus 로고
    • Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice
    • Delaughter M.C., et al. Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice. FASEB J. 1999, 13:1923-1929.
    • (1999) FASEB J. , vol.13 , pp. 1923-1929
    • Delaughter, M.C.1
  • 50
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi A.M., et al. Autophagy in human health and disease. N. Engl. J. Med. 2013, 368:1845-1846.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1845-1846
    • Choi, A.M.1
  • 51
    • 84885580133 scopus 로고    scopus 로고
    • Cardiovascular autophagy: Concepts, controversies and perspectives
    • Lavandero S., et al. Cardiovascular autophagy: Concepts, controversies and perspectives. Autophagy 2013, 9:1455-1466.
    • (2013) Autophagy , vol.9 , pp. 1455-1466
    • Lavandero, S.1
  • 52
    • 35848961242 scopus 로고    scopus 로고
    • Myocyte autophagy in heart disease: friend or foe?
    • Rothermel B.A., Hill J.A. Myocyte autophagy in heart disease: friend or foe?. Autophagy 2007, 3:632-634.
    • (2007) Autophagy , vol.3 , pp. 632-634
    • Rothermel, B.A.1    Hill, J.A.2
  • 53
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
    • Matsui Y., et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 2007, 100:914-922.
    • (2007) Circ. Res. , vol.100 , pp. 914-922
    • Matsui, Y.1
  • 54
    • 34447133404 scopus 로고    scopus 로고
    • Cardiac autophagy is a maladaptive response to hemodynamic stress
    • Zhu H., et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J. Clin. Invest. 2007, 117:1782-1793.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1782-1793
    • Zhu, H.1
  • 55
    • 77958611244 scopus 로고    scopus 로고
    • Long-term IGF-I exposure decreases autophagy and cell viability
    • Bitto A., et al. Long-term IGF-I exposure decreases autophagy and cell viability. PLoS ONE 2010, 5:e12592.
    • (2010) PLoS ONE , vol.5
    • Bitto, A.1
  • 56
    • 33747863220 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells
    • Jia G., et al. Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells. Immunol. Cell Biol. 2006, 84:448-454.
    • (2006) Immunol. Cell Biol. , vol.84 , pp. 448-454
    • Jia, G.1
  • 57
    • 42749094854 scopus 로고    scopus 로고
    • Insulin signaling pathways and cardiac growth
    • DeBosch B.J., Muslin A.J. Insulin signaling pathways and cardiac growth. J. Mol. Cell. Cardiol. 2008, 44:855-864.
    • (2008) J. Mol. Cell. Cardiol. , vol.44 , pp. 855-864
    • DeBosch, B.J.1    Muslin, A.J.2
  • 58
    • 83455238338 scopus 로고    scopus 로고
    • Optimization of cardiac metabolism in heart failure
    • Nagoshi T., et al. Optimization of cardiac metabolism in heart failure. Curr. Pharm. Des. 2011, 17:3846-3853.
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 3846-3853
    • Nagoshi, T.1
  • 59
    • 79953742344 scopus 로고    scopus 로고
    • Akt2: a critical regulator of cardiomyocyte survival and metabolism
    • Muslin A.J. Akt2: a critical regulator of cardiomyocyte survival and metabolism. Pediatr. Cardiol. 2011, 32:317-322.
    • (2011) Pediatr. Cardiol. , vol.32 , pp. 317-322
    • Muslin, A.J.1
  • 60
    • 0030693249 scopus 로고    scopus 로고
    • Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting
    • Bailyes E.M., et al. Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem. J. 1997, 327:209-215.
    • (1997) Biochem. J. , vol.327 , pp. 209-215
    • Bailyes, E.M.1
  • 61
    • 33748744723 scopus 로고    scopus 로고
    • Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
    • Slaaby R., et al. Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. J. Biol. Chem. 2006, 281:25869-25874.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25869-25874
    • Slaaby, R.1
  • 62
    • 0027502045 scopus 로고
    • Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity
    • Soos M.A., et al. Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 1993, 290:419-426.
    • (1993) Biochem. J. , vol.290 , pp. 419-426
    • Soos, M.A.1
  • 63
    • 84864390304 scopus 로고    scopus 로고
    • Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2
    • Pierre-Eugene C., et al. Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2. PLoS ONE 2012, 7:e41992.
    • (2012) PLoS ONE , vol.7
    • Pierre-Eugene, C.1
  • 64
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • Belfiore A., et al. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr. Rev. 2009, 30:586-623.
    • (2009) Endocr. Rev. , vol.30 , pp. 586-623
    • Belfiore, A.1
  • 65
    • 0031965286 scopus 로고    scopus 로고
    • Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia
    • Federici M., et al. Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia. Diabetes 1998, 47:87-92.
    • (1998) Diabetes , vol.47 , pp. 87-92
    • Federici, M.1
  • 66
    • 0031727326 scopus 로고    scopus 로고
    • Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity
    • Federici M., et al. Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity. J. Clin. Endocrinol. Metab. 1998, 83:2911-2915.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2911-2915
    • Federici, M.1
  • 67
    • 0442326249 scopus 로고    scopus 로고
    • Insulin-like growth factor I has a direct effect on glucose and protein metabolism, but no effect on lipid metabolism in type 1 diabetes
    • Simpson H.L., et al. Insulin-like growth factor I has a direct effect on glucose and protein metabolism, but no effect on lipid metabolism in type 1 diabetes. J. Clin. Endocrinol. Metab. 2004, 89:425-432.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 425-432
    • Simpson, H.L.1
  • 68
    • 0028123307 scopus 로고
    • Insulin-like growth factor-1 therapy in diabetes: physiologic basis, clinical benefits, and risks
    • Kolaczynski J.W., Caro J.F. Insulin-like growth factor-1 therapy in diabetes: physiologic basis, clinical benefits, and risks. Ann. Intern. Med. 1994, 120:47-55.
    • (1994) Ann. Intern. Med. , vol.120 , pp. 47-55
    • Kolaczynski, J.W.1    Caro, J.F.2
  • 69
    • 21244476778 scopus 로고    scopus 로고
    • Insulin resistance and type 2 diabetes mellitus: is there a therapeutic role for IGF-1?
    • Moses A.C. Insulin resistance and type 2 diabetes mellitus: is there a therapeutic role for IGF-1?. Endocr. Dev. 2005, 9:121-134.
    • (2005) Endocr. Dev. , vol.9 , pp. 121-134
    • Moses, A.C.1
  • 70
    • 84857595431 scopus 로고    scopus 로고
    • Heart smart insulin-like growth factor 1
    • Marsh S.A., Davidoff A.J. Heart smart insulin-like growth factor 1. Hypertension 2012, 59:550-551.
    • (2012) Hypertension , vol.59 , pp. 550-551
    • Marsh, S.A.1    Davidoff, A.J.2
  • 71
    • 84868454231 scopus 로고    scopus 로고
    • Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling
    • Scharin Tang M., et al. Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling. Growth Horm. IGF Res. 2012, 22:206-211.
    • (2012) Growth Horm. IGF Res. , vol.22 , pp. 206-211
    • Scharin Tang, M.1
  • 72
    • 79951938474 scopus 로고    scopus 로고
    • Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
    • Guevara-Aguirre J., et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci. Transl. Med. 2011, 3:70ra13.
    • (2011) Sci. Transl. Med. , vol.3
    • Guevara-Aguirre, J.1
  • 73
    • 67349260154 scopus 로고    scopus 로고
    • IGF-I replacement therapy in children with congenital IGF-I deficiency (Laron syndrome) maintains heart dimension and function
    • Scheinowitz M., et al. IGF-I replacement therapy in children with congenital IGF-I deficiency (Laron syndrome) maintains heart dimension and function. Growth Horm. IGF Res. 2009, 19:280-282.
    • (2009) Growth Horm. IGF Res. , vol.19 , pp. 280-282
    • Scheinowitz, M.1
  • 74
    • 78649719816 scopus 로고    scopus 로고
    • Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice
    • Panici J.A., et al. Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J. 2010, 24:5073-5079.
    • (2010) FASEB J. , vol.24 , pp. 5073-5079
    • Panici, J.A.1
  • 75
    • 22144444220 scopus 로고    scopus 로고
    • Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span
    • Sonntag W.E., et al. Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology 2005, 146:2920-2932.
    • (2005) Endocrinology , vol.146 , pp. 2920-2932
    • Sonntag, W.E.1
  • 76
    • 79955477628 scopus 로고    scopus 로고
    • Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation
    • Groban L., et al. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Horm. IGF Res. 2011, 21:81-88.
    • (2011) Growth Horm. IGF Res. , vol.21 , pp. 81-88
    • Groban, L.1
  • 77
    • 50449083011 scopus 로고    scopus 로고
    • Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
    • Li Q., et al. Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction. Rejuvenation Res. 2008, 11:725-733.
    • (2008) Rejuvenation Res. , vol.11 , pp. 725-733
    • Li, Q.1
  • 78
    • 84855171399 scopus 로고    scopus 로고
    • IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a
    • Hua Y., et al. IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a. J. Cell. Mol. Med. 2012, 16:83-95.
    • (2012) J. Cell. Mol. Med. , vol.16 , pp. 83-95
    • Hua, Y.1
  • 79
    • 84859077841 scopus 로고    scopus 로고
    • Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging
    • Bailey-Downs L.C., et al. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J. Gerontol. A: Biol. Sci. Med. Sci. 2012, 67:313-329.
    • (2012) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.67 , pp. 313-329
    • Bailey-Downs, L.C.1
  • 80
    • 84866240614 scopus 로고    scopus 로고
    • Myocardial dysfunction in sepsis: a large, unsolved puzzle
    • Fernandes C.J., de Assuncao M.S. Myocardial dysfunction in sepsis: a large, unsolved puzzle. Crit. Care Res. Pract. 2012, 2012:896430.
    • Crit. Care Res. Pract. , vol.2012 , pp. 896430
    • Fernandes, C.J.1    de Assuncao, M.S.2
  • 81
    • 34249326963 scopus 로고    scopus 로고
    • Mechanisms of sepsis-induced cardiac dysfunction
    • Rudiger A., Singer M. Mechanisms of sepsis-induced cardiac dysfunction. Crit. Care Med. 2007, 35:1599-1608.
    • (2007) Crit. Care Med. , vol.35 , pp. 1599-1608
    • Rudiger, A.1    Singer, M.2
  • 82
    • 82055162875 scopus 로고    scopus 로고
    • Sepsis-induced cardiomyopathy
    • Romero-Bermejo F.J., et al. Sepsis-induced cardiomyopathy. Curr. Cardiol. Rev. 2011, 7:163-183.
    • (2011) Curr. Cardiol. Rev. , vol.7 , pp. 163-183
    • Romero-Bermejo, F.J.1
  • 83
    • 46849115103 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance
    • Ashare A., et al. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am. J. Respir. Crit. Care Med. 2008, 178:149-157.
    • (2008) Am. J. Respir. Crit. Care Med. , vol.178 , pp. 149-157
    • Ashare, A.1
  • 84
    • 41649085155 scopus 로고    scopus 로고
    • Survival and cellular immune functions in septic mice treated with growth hormone (GH) and insulin-like growth factor-I (IGF-I)
    • Schmitz D., et al. Survival and cellular immune functions in septic mice treated with growth hormone (GH) and insulin-like growth factor-I (IGF-I). Growth Horm. IGF Res. 2008, 18:245-252.
    • (2008) Growth Horm. IGF Res. , vol.18 , pp. 245-252
    • Schmitz, D.1
  • 85
    • 67749122387 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of insulin-like growth factor I (IGF-1) rescues lipopolysaccharide-induced cardiac dysfunction and activation of stress signaling in murine cardiomyocytes
    • Zhao P., et al. Cardiac-specific overexpression of insulin-like growth factor I (IGF-1) rescues lipopolysaccharide-induced cardiac dysfunction and activation of stress signaling in murine cardiomyocytes. Shock 2009, 32:100-107.
    • (2009) Shock , vol.32 , pp. 100-107
    • Zhao, P.1
  • 86
    • 65549162587 scopus 로고    scopus 로고
    • Local insulin-like growth factor I prevents sepsis-induced muscle atrophy
    • Nystrom G., et al. Local insulin-like growth factor I prevents sepsis-induced muscle atrophy. Metabolism 2009, 58:787-797.
    • (2009) Metabolism , vol.58 , pp. 787-797
    • Nystrom, G.1
  • 87
    • 36949021815 scopus 로고    scopus 로고
    • Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy
    • Philippou A., et al. Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy. J. Musculoskelet. Neuronal Interact. 2007, 7:208-218.
    • (2007) J. Musculoskelet. Neuronal Interact. , vol.7 , pp. 208-218
    • Philippou, A.1
  • 88
    • 67349215109 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and bone: lessons from mice and men
    • Kawai M., Rosen C.J. Insulin-like growth factor-I and bone: lessons from mice and men. Pediatr. Nephrol. 2009, 24:1277-1285.
    • (2009) Pediatr. Nephrol. , vol.24 , pp. 1277-1285
    • Kawai, M.1    Rosen, C.J.2
  • 89
    • 33645222277 scopus 로고    scopus 로고
    • Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain
    • Aberg N.D., et al. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci. World J. 2006, 6:53-80.
    • (2006) Sci. World J. , vol.6 , pp. 53-80
    • Aberg, N.D.1
  • 90
    • 84873806643 scopus 로고    scopus 로고
    • Regenerating new heart with stem cells
    • Anversa P., et al. Regenerating new heart with stem cells. J. Clin. Invest. 2013, 123:62-70.
    • (2013) J. Clin. Invest. , vol.123 , pp. 62-70
    • Anversa, P.1
  • 91
    • 84875793723 scopus 로고    scopus 로고
    • New cells in old hearts
    • Bostrom P., Frisen J. New cells in old hearts. N. Engl. J. Med. 2013, 368:1358-1360.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1358-1360
    • Bostrom, P.1    Frisen, J.2
  • 92
    • 84872611623 scopus 로고    scopus 로고
    • Mammalian heart renewal by pre-existing cardiomyocytes
    • Senyo S.E., et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 2013, 493:433-436.
    • (2013) Nature , vol.493 , pp. 433-436
    • Senyo, S.E.1
  • 93
    • 84878850858 scopus 로고    scopus 로고
    • Cardiac stem cell therapy and the promise of heart regeneration
    • Garbern J.C., Lee R.T. Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell 2013, 12:689-698.
    • (2013) Cell Stem Cell , vol.12 , pp. 689-698
    • Garbern, J.C.1    Lee, R.T.2
  • 94
    • 34547699399 scopus 로고    scopus 로고
    • Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
    • Hsieh P.C., et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat. Med. 2007, 13:970-974.
    • (2007) Nat. Med. , vol.13 , pp. 970-974
    • Hsieh, P.C.1
  • 95
    • 79953903083 scopus 로고    scopus 로고
    • Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair
    • Loffredo F.S., et al. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell 2011, 8:389-398.
    • (2011) Cell Stem Cell , vol.8 , pp. 389-398
    • Loffredo, F.S.1
  • 96
    • 77958108078 scopus 로고    scopus 로고
    • Protein therapeutics for cardiac regeneration after myocardial infarction
    • Segers V.F., Lee R.T. Protein therapeutics for cardiac regeneration after myocardial infarction. J. Cardiovasc. Transl. Res. 2010, 3:469-477.
    • (2010) J. Cardiovasc. Transl. Res. , vol.3 , pp. 469-477
    • Segers, V.F.1    Lee, R.T.2
  • 97
    • 70450242953 scopus 로고    scopus 로고
    • The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor
    • Yu X.Y., et al. The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor. Mol. Cell. Biochem. 2009, 332:25-32.
    • (2009) Mol. Cell. Biochem. , vol.332 , pp. 25-32
    • Yu, X.Y.1
  • 98
    • 10744228523 scopus 로고    scopus 로고
    • Adult cardiac stem cells are multipotent and support myocardial regeneration
    • Beltrami A.P., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003, 114:763-776.
    • (2003) Cell , vol.114 , pp. 763-776
    • Beltrami, A.P.1
  • 99
    • 78650790879 scopus 로고    scopus 로고
    • C-kitpos GATA-4 high rat cardiac stem cells foster adult cardiomyocyte survival through IGF-1 paracrine signalling
    • Kawaguchi N., et al. c-kitpos GATA-4 high rat cardiac stem cells foster adult cardiomyocyte survival through IGF-1 paracrine signalling. PLoS ONE 2010, 5:e14297.
    • (2010) PLoS ONE , vol.5
    • Kawaguchi, N.1
  • 100
    • 79958779464 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration
    • D'Amario D., et al. Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration. Circ. Res. 2011, 108:1467-1481.
    • (2011) Circ. Res. , vol.108 , pp. 1467-1481
    • D'Amario, D.1
  • 101
    • 0038298232 scopus 로고    scopus 로고
    • Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells
    • Wetterau L.A., et al. Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. J. Clin. Endocrinol. Metab. 2003, 88:3354-3359.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 3354-3359
    • Wetterau, L.A.1
  • 102
    • 21144458217 scopus 로고    scopus 로고
    • Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function
    • Linke A., et al. Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:8966-8971.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 8966-8971
    • Linke, A.1
  • 103
    • 26244460357 scopus 로고    scopus 로고
    • Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    • Urbanek K., et al. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ. Res. 2005, 97:663-673.
    • (2005) Circ. Res. , vol.97 , pp. 663-673
    • Urbanek, K.1
  • 104
    • 48049109419 scopus 로고    scopus 로고
    • Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function
    • Rota M., et al. Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ. Res. 2008, 103:107-116.
    • (2008) Circ. Res. , vol.103 , pp. 107-116
    • Rota, M.1
  • 105
    • 33744501240 scopus 로고    scopus 로고
    • Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction
    • Davis M.E., et al. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:8155-8160.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 8155-8160
    • Davis, M.E.1
  • 106
    • 84860780047 scopus 로고    scopus 로고
    • Ischemia-reperfusion injury and pregnancy initiate time-dependent and robust signs of up-regulation of cardiac progenitor cells
    • Genead R., et al. Ischemia-reperfusion injury and pregnancy initiate time-dependent and robust signs of up-regulation of cardiac progenitor cells. PLoS ONE 2012, 7:e36804.
    • (2012) PLoS ONE , vol.7
    • Genead, R.1
  • 107
    • 84882759023 scopus 로고    scopus 로고
    • Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair
    • Ellison G.M., et al. Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell 2013, 154:827-842.
    • (2013) Cell , vol.154 , pp. 827-842
    • Ellison, G.M.1
  • 108
    • 70350127170 scopus 로고    scopus 로고
    • Spontaneous calcium oscillations regulate human cardiac progenitor cell growth
    • Ferreira-Martins J., et al. Spontaneous calcium oscillations regulate human cardiac progenitor cell growth. Circ. Res. 2009, 105:764-774.
    • (2009) Circ. Res. , vol.105 , pp. 764-774
    • Ferreira-Martins, J.1
  • 109
    • 78149334458 scopus 로고    scopus 로고
    • Factors released from embryonic stem cells stimulate c-kit-FLK-1(+ve) progenitor cells and enhance neovascularization
    • Fatma S., et al. Factors released from embryonic stem cells stimulate c-kit-FLK-1(+ve) progenitor cells and enhance neovascularization. Antioxid. Redox Signal. 2010, 13:1857-1865.
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 1857-1865
    • Fatma, S.1
  • 110
    • 70749095115 scopus 로고    scopus 로고
    • Enhanced mesenchymal cell engraftment by IGF-1 improves left ventricular function in rats undergoing myocardial infarction
    • Enoki C., et al. Enhanced mesenchymal cell engraftment by IGF-1 improves left ventricular function in rats undergoing myocardial infarction. Int. J. Cardiol. 2010, 138:9-18.
    • (2010) Int. J. Cardiol. , vol.138 , pp. 9-18
    • Enoki, C.1
  • 111
    • 39549105786 scopus 로고    scopus 로고
    • Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction
    • Hahn J.Y., et al. Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J. Am. Coll. Cardiol. 2008, 51:933-943.
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 933-943
    • Hahn, J.Y.1
  • 112
    • 77957241580 scopus 로고    scopus 로고
    • The proliferating role of insulin and insulin-like growth factors in cancer
    • Gallagher E.J., LeRoith D. The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol. Metab. 2010, 21:610-618.
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 610-618
    • Gallagher, E.J.1    LeRoith, D.2
  • 113
    • 77953202134 scopus 로고    scopus 로고
    • Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy
    • Huynh K., et al. Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy. Diabetes 2010, 59:1512-1520.
    • (2010) Diabetes , vol.59 , pp. 1512-1520
    • Huynh, K.1
  • 114
    • 77953386141 scopus 로고    scopus 로고
    • Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
    • Vinciguerra M., et al. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging 2010, 2:43-62.
    • (2010) Aging , vol.2 , pp. 43-62
    • Vinciguerra, M.1
  • 115
    • 84855860714 scopus 로고    scopus 로고
    • MIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart
    • Vinciguerra M., et al. mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart. Aging Cell 2012, 11:139-149.
    • (2012) Aging Cell , vol.11 , pp. 139-149
    • Vinciguerra, M.1


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