Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo

PLoS Genetics

Volumn 8, Issue 5, 2012, Pages

  Misra, Chaitali ^a   Sachan, Nita ^b,f   McNally, Caryn Rothrock ^b   Koenig, Sara N ^a   Nichols, Haley A ^b   Guggilam, Anuradha ^a   Lucchesi, Pamela A ^a   Pu, William T ^c   Srivastava, Deepak ^d,e   Garg, Vidu ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f INDIAN SCHOOL OF BUSINESS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D2; TRANSCRIPTION FACTOR GATA 4; CCND2 PROTEIN, MOUSE; GATA4 PROTEIN, MOUSE; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR 5; TRANSCRIPTION FACTOR TBX5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CELL PROLIFERATION; CONGENITAL HEART DISEASE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONAL TISSUE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE FUNCTION; GENE MUTATION; GENE TARGETING; GENETIC CODE; HEART ATRIUM SEPTUM DEFECT; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART VALVE STENOSIS; HETEROZYGOSITY; HOMOZYGOSITY; IN VIVO STUDY; MOUSE; MOUSE MUTANT; MUTATIONAL ANALYSIS; MUTATOR GENE; NONHUMAN; NULL ALLELE; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; TRANSCRIPTION FACTOR GATA 4 GENE; ANIMAL; CONGENITAL HEART MALFORMATION; CYTOLOGY; EMBRYO DEVELOPMENT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART ATRIUM SEPTUM; HEART VENTRICLE; HUMAN; METABOLISM; MUTATION; PATHOPHYSIOLOGY;

MUS;

ANIMALS; ATRIAL SEPTUM; CELL PROLIFERATION; CYCLIN D2; EMBRYONIC DEVELOPMENT; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; HEART VENTRICLES; HUMANS; MICE; MICE, MUTANT STRAINS; MUTATION; MYOCYTES, CARDIAC; T-BOX DOMAIN PROTEINS;

EID: 84863681671     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002690     Document Type: Article

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