Development: Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size

Science Signaling

Volumn 4, Issue 196, 2011, Pages

  Xin, Mei ^a   Kim, Yuri ^a   Sutherland, Lillian B ^a   Qi, Xiaoxia ^a   McAnally, John ^a   Schwartz, Robert J ^b,c   Richardson, James A ^a,d   Bassel Duby, Rhonda ^a   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b EAST TEXAS MEDICAL CENTER   (United States)

^c University of Houston   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SOMATOMEDIN; YAP PROTEIN, MOUSE;

ARTICLE; ENGINEERING; FIBROBLAST; INFORMATION SCIENCE; MOUSE; NOISE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TELEPHONE; 129 MOUSE; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DNA MICROARRAY; FEMALE; FETUS HEART; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART MUSCLE CELL; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MOUSE MUTANT; NEWBORN; ORGAN SIZE; PRENATAL DEVELOPMENT; RAT; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE; WESTERN BLOTTING;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANIMALS, NEWBORN; BETA CATENIN; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; FEMALE; FETAL HEART; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED ICR; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SIZE; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SOMATOMEDINS;

EID: 80054965145     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002278     Document Type: Article

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39. Acknowledgments: We are grateful to L. Lum for providing IWR1 small-molecule inhibitor. We thank T. Carroll, B. Johnson, D. Patrick, C. Grueter, E. Small, R. Frost, and M. Murakami for sharing insightful discussions. We thank C. Nolen and G. Vitug for technical support. We also thank J. Cabrera for graphics. Funding: M.X. was supported by a Beginning Grant-in-Aid from the American Heart Association. Work in the laboratory of E.N.O. was supported by grants from the NIH, the Robert A. Welch Foundation (grant I-0025), the American Heart Association: Jon Holden DeHaan Foundation, the Donald W. Reynolds Center for Clinical Cardiovascular Research, and the Fondation Leducq TransAtlantic Network of Excellence in Cardiovascular Research Program. Author contributions: M.X., R.B.-D., and E.N.O. designed the study and wrote the paper; M.X., R.B.-D., E.N.O., and J.A.R. interpreted the data; M.X., Y.K., L.B.S., X.Q., and J.M. performed the experiments; and R.J.S. provided the Nkx-KI-Cre mouse line. Competing interests: The authors declare that they have no competing interests.