ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

Nature Cell Biology

Volumn 17, Issue 5, 2015, Pages 627-638

  D'Uva, Gabriele ^a   Aharonov, Alla ^a   Lauriola, Mattia ^a,b   Kain, David ^c   Yahalom Ronen, Yfat ^a   Carvalho, Silvia ^a   Weisinger, Karen ^a   Bassat, Elad ^a   Rajchman, Dana ^a   Yifa, Oren ^a   Lysenko, Marina ^a   Konfino, Tal ^c   Hegesh, Julius ^c   Brenner, Ori ^a   Neeman, Michal ^a   Yarden, Yosef ^a   Leor, Jonathan ^c   Sarig, Rachel ^c   Harvey, Richard P ^d,e   Tzahor, Eldad ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c SHEBA MEDICAL CENTER   (Israel)

^d VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; NEU DIFFERENTIATION FACTOR; PROTEIN KINASE B; CTNNB1 PROTEIN, MOUSE; ERBB2 PROTEIN, MOUSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMEGALY; CELL DEDIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; HEART FAILURE; HEART HYPERTROPHY; HEART INFARCTION; HEART MUSCLE CELL; HEART REGENERATION; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE REGENERATION; AGE; AGONISTS; ANIMAL; CELL CULTURE; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; REGENERATION; TIME; TIME LAPSE IMAGING;

MAMMALIA; MURINAE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BETA CATENIN; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOGEN SYNTHASE KINASE 3; MAGNETIC RESONANCE IMAGING; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NEUREGULIN-1; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; REGENERATION; SIGNAL TRANSDUCTION; TIME FACTORS; TIME-LAPSE IMAGING;

EID: 84928938582     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3149     Document Type: Article

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