Cardiac-specific overexpression of cyclin-dependent kinase 2 increases smaller mononuclear cardiomyocytes

Circulation Research

Volumn 88, Issue 4, 2001, Pages 443-450

  Liao, Hai Sun ^a   Kang, Peter M ^a   Nagashima, Hirotaka ^a   Yamasaki, Naohito ^a   Usheva, Anny ^a   Ding, Bo ^a   Lorell, Beverly H ^a   Izumo, Seigo ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cardiomyocyte regeneration; Cell cycle; Cyclin dependent kinase

Indexed keywords

CELL NUCLEUS ANTIGEN; CYCLIN A; CYCLIN DEPENDENT KINASE 2; GENE PRODUCT; MYOSIN HEAVY CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ECHOCARDIOGRAPHY; GENE OVEREXPRESSION; HEART MUSCLE CELL; HEART VENTRICLE PRESSURE; HEART WEIGHT; HUMAN; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0035793914     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.88.4.443     Document Type: Article

References (58)

1. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development
2. Formation of binucleated myocardial cells in the neonatal rat: An index for growth hypertrophy
3. Cardiomyocyte DNA synthesis and binucleation during murine development
4. Myocardial cell hypertrophy or hyperplasia
5. Survey of studies examining mammalian cardiomyocyte DNA synthesis
6. Acquisition of multiple nuclei and the activity of DNA polymerase α and reinitiation of DNA replication in terminally differentiated adult cardiac muscle cells in culture
7. Post-injury DNA synthesis, mitosis and ultrastructural reorganization of adult frog cardiac myocytes: An electron microscopic-autoradiographic study
8. Autoradiographic study on the synthesis of DNA, RNA, and proteins in normal cardiac muscle cells and those changed by experimental injury
9. DNA synthesis in atrial myocytes of rats with aortic stenosis
10. Response of the adult newt ventricle to injury
11. Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts
12. Cell cycle checkpoints: Preventing an identity crisis
13. Cyclins and cancer
14. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age
15. Principles of CDK regulation
16. Cell cycle checkpoints
17. G1 phase progression: Cycling on cue
18. The cdk2 kinase is required for the G1-to-S transition in mammalian cells
19. Distinct roles for cyclin-dependent kinases in cell cycle control
20. Mitosis in transition
21. Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo
22. Adenovirus EIA represses cardiac gene transcription and reactivates DNA synthesis in ventricular myocytes, via alternative pocket protein- and p300-binding domains
23. Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription
24. Induction of DNA synthesis and apoptosis in cardiac myocytes by EIA oncoprotein
25. The c-myc proto-oncogene regulates cardiac development in transgenic mice
26. Transgenic animals as a tool for studying the effect of the c-myc proto-oncogene on cardiac development
27. Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice
28. Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice
29. Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes
30. Tissue-specific regulation of the α-myosin heavy chain gene promoter in transgenic mice
31. Isolation and characterization of the mouse cardiac myosin heavy chain genes
32. Cyclins and cyclin-dependent kinases are differentially regulated during terminal differentiation of C2C12 muscle cells
33. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells: An in vitro model of load-induced cardiac hypertrophy
34. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
35. Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation
36. Inhibition of cardiac myocyte division in c-myc transgenic mice
37. A simple, rapid, and sensitive DNA assay procedure
38. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin
39. Transthoracic echocardiography in models of cardiac disease in the mouse
40. Assessment of cardiomyocyte DNA synthesis during hypertrophy in adult mice
41. Cyclin-dependent regulation of G1 in mammalian fibroblasts
42. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
43. Acceleration of the G1/S phase transition by expression of cyclius D1 and E with an inducible system
44. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
45. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
46. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
47. Altered expression of cell cycle proteins and prolonged duration of cardiac myocyte hyperplasia in p27KIPI knockout mice
48. Cardiac-specific deletion of ALK3, the type IA receptor from bone morphogenetic proteins, unmasks an essential, myocyte-autonomous role in the mid-gestation heart
49. Insulin-like growth factor-receptor and its ligand regulate the reentry of adult ventricular myocytes into the cell cycle
50. Regenerative capacities of normal and cirrhotic livers following 70% hepatectomy in rats and the effect of alpha-tocopherol on cirrhotic regeneration
51. p27 kipl alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation
52. Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1
53. Size control in animal development
54. Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells
55. Differential and dramatic changes of cyclin-dependent kinase activities in cardiomyocytes during the neonatal period
56. Role of G1 phase cyclins and cyclin-dependent kinases during cardiomyocyte hypertrophic growth in rats
57. Transgenic mice in cardiovascular research
58. Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy