Blocking of frizzled signaling with a homologous peptide fragment of Wnt3a/Wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction

Circulation

Volumn 124, Issue 15, 2011, Pages 1626-1635

  Laeremans, Hilde ^a   Hackeng, Tilman M ^a   Van Zandvoort, Marc A M J ^a   Thijssen, Victor L J L ^b   Janssen, Ben J A ^a   Ottenheijm, Harry C J ^a   Smits, Jos F M ^a   Blankesteijn, W Matthijs ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

heart failure; myocardial infarction; myofibroblasts; pharmacology; receptor blocker; Wnt frizzled pathway

Indexed keywords

FRIZZLED PROTEIN; FRIZZLED PROTEIN 1; FRIZZLED PROTEIN 2; FRIZZLED PROTEIN 4; FRIZZLED PROTEIN 5; PEPTIDE FRAGMENT; PROTEIN INHIBITOR; RHODAMINE; UM 206; UM 207; UNCLASSIFIED DRUG; WNT3A PROTEIN; WNT5A PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MIGRATION; CELL PROLIFERATION; DRUG EFFECT; DRUG HALF LIFE; HEART EJECTION FRACTION; HEART FAILURE; HEART HEMODYNAMICS; HEART INFARCTION; HEART VENTRICLE REMODELING; HEART VOLUME; HUMAN; HUMAN CELL; LUNG WEIGHT; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WOUND HEALING;

ANIMALS; CELL LINE, TRANSFORMED; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CRICETINAE; CRICETULUS; FIBROBLASTS; FRIZZLED RECEPTORS; HEART FAILURE; HUMANS; MALE; MICE; MYOCARDIAL INFARCTION; MYOCARDIUM; PEPTIDE FRAGMENTS; RATS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; VENTRICULAR REMODELING; WNT3A PROTEIN;

EID: 80054008597     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.976969     Document Type: Article

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