-
1
-
-
84903579488
-
Influence of serum uric acid levels on prognosis and survival in amyotrophic lateral sclerosis: a meta-analysis
-
Abraham A, Drory VE (2014) Influence of serum uric acid levels on prognosis and survival in amyotrophic lateral sclerosis: a meta-analysis. J Neurol 261:1133-1138
-
(2014)
J Neurol
, vol.261
, pp. 1133-1138
-
-
Abraham, A.1
Drory, V.E.2
-
2
-
-
0029147825
-
No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease
-
Ahlskog JE, Uitti RJ, Low PA et al (1995) No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease. Mov Disord 10:566-573
-
(1995)
Mov Disord
, vol.10
, pp. 566-573
-
-
Ahlskog, J.E.1
Uitti, R.J.2
Low, P.A.3
-
3
-
-
0345060347
-
Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively
-
Alfinito PD, Wang SP, Manzino L et al (2003) Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. J Neurosci 23:10982-10987
-
(2003)
J Neurosci
, vol.23
, pp. 10982-10987
-
-
Alfinito, P.D.1
Wang, S.P.2
Manzino, L.3
-
4
-
-
84922590859
-
Relation between uric acid and Alzheimer's disease in elderly Jordanians
-
Al-Khateeb E, Althaher A, Al-Khateeb M et al (2015) Relation between uric acid and Alzheimer's disease in elderly Jordanians. J Alzheimers Dis 44:859-865
-
(2015)
J Alzheimers Dis
, vol.44
, pp. 859-865
-
-
Al-Khateeb, E.1
Althaher, A.2
Al-Khateeb, M.3
-
5
-
-
36048943239
-
Gout and risk of Parkinson disease: a prospective study
-
Alonso A, Rodriguez LA, Logroscino G et al (2007) Gout and risk of Parkinson disease: a prospective study. Neurology 69:1696-1700
-
(2007)
Neurology
, vol.69
, pp. 1696-1700
-
-
Alonso, A.1
Rodriguez, L.A.2
Logroscino, G.3
-
6
-
-
77955154086
-
The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms
-
Amaro S, Canovas D, Castellanos M et al (2010) The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms. Int J Stroke 5:325-328
-
(2010)
Int J Stroke
, vol.5
, pp. 325-328
-
-
Amaro, S.1
Canovas, D.2
Castellanos, M.3
-
7
-
-
0019787519
-
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis
-
Ames BN, Cathcart R, Schwiers E et al (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 78:6858-6862
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, pp. 6858-6862
-
-
Ames, B.N.1
Cathcart, R.2
Schwiers, E.3
-
8
-
-
70349487220
-
Serum uric acid levels in patients with Parkinson's disease: their relationship to treatment and disease duration
-
Andreadou E, Nikolaou C, Gournaras F et al (2009) Serum uric acid levels in patients with Parkinson's disease: their relationship to treatment and disease duration. Clin Neurol Neurosurg 111:724-728
-
(2009)
Clin Neurol Neurosurg
, vol.111
, pp. 724-728
-
-
Andreadou, E.1
Nikolaou, C.2
Gournaras, F.3
-
9
-
-
34447547493
-
Low plasma uric acid level in Parkinson's disease
-
Annanmaki T, Muuronen A, Murros K (2007) Low plasma uric acid level in Parkinson's disease. Mov Disord 22:1133-1137
-
(2007)
Mov Disord
, vol.22
, pp. 1133-1137
-
-
Annanmaki, T.1
Muuronen, A.2
Murros, K.3
-
10
-
-
33750984544
-
Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production
-
Arendash GW, Schleif W, Rezai-Zadeh K et al (2006) Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production. Neuroscience 142:941-952
-
(2006)
Neuroscience
, vol.142
, pp. 941-952
-
-
Arendash, G.W.1
Schleif, W.2
Rezai-Zadeh, K.3
-
11
-
-
67849083449
-
Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice
-
Arendash GW, Mori T, Cao C et al (2009) Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice. J Alzheimers Dis 17:661-680
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 661-680
-
-
Arendash, G.W.1
Mori, T.2
Cao, C.3
-
12
-
-
80055002811
-
Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease
-
Armentero MT, Pinna A, Ferré S et al (2011) Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease. Pharmacol Ther 132:280-299
-
(2011)
Pharmacol Ther
, vol.132
, pp. 280-299
-
-
Armentero, M.T.1
Pinna, A.2
Ferré, S.3
-
13
-
-
0034950069
-
Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
-
Ascherio A, Zhang SM, Hernan MA et al (2001) Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol 50:56-63
-
(2001)
Ann Neurol
, vol.50
, pp. 56-63
-
-
Ascherio, A.1
Zhang, S.M.2
Hernan, M.A.3
-
14
-
-
73549111772
-
Urate as a predictor of the rate of clinical decline in Parkinson disease
-
Ascherio A, LeWitt PA, Xu K et al (2009) Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol 66:1460-1468
-
(2009)
Arch Neurol
, vol.66
, pp. 1460-1468
-
-
Ascherio, A.1
LeWitt, P.A.2
Xu, K.3
-
15
-
-
84921985362
-
The PRO-ACT database: design, initial analyses, and predictive features
-
Atassi N, Berry J, Shui A et al (2014) The PRO-ACT database: design, initial analyses, and predictive features. Neurology 83:1719-1725
-
(2014)
Neurology
, vol.83
, pp. 1719-1725
-
-
Atassi, N.1
Berry, J.2
Shui, A.3
-
16
-
-
77649110090
-
The relationship between uric acid levels and Huntington's disease progression
-
Auinger P, Kieburtz K, McDermott MP (2010) The relationship between uric acid levels and Huntington's disease progression. Mov Disord 25:224-228
-
(2010)
Mov Disord
, vol.25
, pp. 224-228
-
-
Auinger, P.1
Kieburtz, K.2
McDermott, M.P.3
-
17
-
-
70449529633
-
The blood-brain barrier and immune function and dysfunction
-
Banks WA, Erickson MA (2009) The blood-brain barrier and immune function and dysfunction. Neurobiol Dis 37:26-32
-
(2009)
Neurobiol Dis
, vol.37
, pp. 26-32
-
-
Banks, W.A.1
Erickson, M.A.2
-
18
-
-
80054922215
-
Coffee and amyotrophic lateral sclerosis: a possible preventive role
-
Beghi E, Pupillo E, Messina P et al (2011) Coffee and amyotrophic lateral sclerosis: a possible preventive role. Am J Epidemiol 174:1002-1008
-
(2011)
Am J Epidemiol
, vol.174
, pp. 1002-1008
-
-
Beghi, E.1
Pupillo, E.2
Messina, P.3
-
19
-
-
64549104196
-
A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity
-
Belcastro V, Tozzi A, Tantucci M et al (2009) A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity. Exp Neurol 217:231-234
-
(2009)
Exp Neurol
, vol.217
, pp. 231-234
-
-
Belcastro, V.1
Tozzi, A.2
Tantucci, M.3
-
20
-
-
0034649444
-
Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study
-
Benedetti MD, Bower JH, Maraganore DM et al (2000) Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study. Neurology 55:1350-1358
-
(2000)
Neurology
, vol.55
, pp. 1350-1358
-
-
Benedetti, M.D.1
Bower, J.H.2
Maraganore, D.M.3
-
21
-
-
0000687128
-
Uric acid: friend or foe?
-
Benzie I, Strain J (1996) Uric acid: friend or foe? Redox Rep 2:231-234
-
(1996)
Redox Rep
, vol.2
, pp. 231-234
-
-
Benzie, I.1
Strain, J.2
-
22
-
-
0042141599
-
A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson's disease
-
Bibbiani F, Oh JD, Petzer JP et al (2003) A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson's disease. Exp Neurol 184:285-294
-
(2003)
Exp Neurol
, vol.184
, pp. 285-294
-
-
Bibbiani, F.1
Oh, J.D.2
Petzer, J.P.3
-
23
-
-
0038113064
-
A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists
-
Blum D, Galas MC, Pintor A et al (2003) A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists. J Neurosci 23:5361-5369
-
(2003)
J Neurosci
, vol.23
, pp. 5361-5369
-
-
Blum, D.1
Galas, M.C.2
Pintor, A.3
-
24
-
-
38849159145
-
Metabolomic profiling to develop blood biomarkers for Parkinson's disease
-
Bogdanov M, Matson WR, Wang L et al (2008) Metabolomic profiling to develop blood biomarkers for Parkinson's disease. Brain 131:389-396
-
(2008)
Brain
, vol.131
, pp. 389-396
-
-
Bogdanov, M.1
Matson, W.R.2
Wang, L.3
-
25
-
-
33745144316
-
Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study
-
Bos MJ, Koudstaal PJ, Hofman A et al (2006) Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. Stroke 37:1503-1507
-
(2006)
Stroke
, vol.37
, pp. 1503-1507
-
-
Bos, M.J.1
Koudstaal, P.J.2
Hofman, A.3
-
26
-
-
0042305247
-
Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes
-
Brambilla R, Cottini L, Fumagalli M et al (2003) Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia 43:190-194
-
(2003)
Glia
, vol.43
, pp. 190-194
-
-
Brambilla, R.1
Cottini, L.2
Fumagalli, M.3
-
27
-
-
84874606434
-
Astrocyte signaling and neurodegeneration: new insights into CNS disorders
-
Brambilla L, Martorana F, Rossi D (2012) Astrocyte signaling and neurodegeneration: new insights into CNS disorders. Prion 7:28-36
-
(2012)
Prion
, vol.7
, pp. 28-36
-
-
Brambilla, L.1
Martorana, F.2
Rossi, D.3
-
28
-
-
0032510829
-
Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells
-
Brodie C, Blumberg PM, Jacobson KA (1998) Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells. FEBS Lett 429:139-142
-
(1998)
FEBS Lett
, vol.429
, pp. 139-142
-
-
Brodie, C.1
Blumberg, P.M.2
Jacobson, K.A.3
-
29
-
-
77954541590
-
Caffeine attenuates lipopolysaccharide-induced neuroinflammation
-
Brothers HM, Marchalant Y, Wenk GL (2010) Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neurosci Lett 480:97-100
-
(2010)
Neurosci Lett
, vol.480
, pp. 97-100
-
-
Brothers, H.M.1
Marchalant, Y.2
Wenk, G.L.3
-
30
-
-
33751503096
-
In vivo modulation of the Parkinsonian phenotype by Nrf2
-
Burton NC, Kensler TW, Guilarte TR (2006) In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology 27:1094-1100
-
(2006)
Neurotoxicology
, vol.27
, pp. 1094-1100
-
-
Burton, N.C.1
Kensler, T.W.2
Guilarte, T.R.3
-
31
-
-
84878706647
-
Ischemia modified albumin and plasma oxidative stress markers in Alzheimer's disease
-
Can M, Varlibas F, Guven B et al (2013) Ischemia modified albumin and plasma oxidative stress markers in Alzheimer's disease. Eur Neurol 69:377-380
-
(2013)
Eur Neurol
, vol.69
, pp. 377-380
-
-
Can, M.1
Varlibas, F.2
Guven, B.3
-
32
-
-
84873688769
-
Altered levels of homocysteine and serum natural antioxidants links oxidative damage to Alzheimer's disease
-
Cankurtaran M, Yesil Y, Kuyumcu ME et al (2012) Altered levels of homocysteine and serum natural antioxidants links oxidative damage to Alzheimer's disease. J Alzheimers Dis 33:1051-1058
-
(2012)
J Alzheimers Dis
, vol.33
, pp. 1051-1058
-
-
Cankurtaran, M.1
Yesil, Y.2
Kuyumcu, M.E.3
-
33
-
-
67849104997
-
Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice
-
Cao C, Cirrito JR, Lin X et al (2009) Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice. J Alzheimers Dis 17:681-697
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 681-697
-
-
Cao, C.1
Cirrito, J.R.2
Lin, X.3
-
34
-
-
84886089887
-
Uric acid is associated with the prevalence but not disease progression of multiple system atrophy in Chinese population
-
Cao B, Guo X, Chen K et al (2013) Uric acid is associated with the prevalence but not disease progression of multiple system atrophy in Chinese population. J Neurol 260:2511-2515
-
(2013)
J Neurol
, vol.260
, pp. 2511-2515
-
-
Cao, B.1
Guo, X.2
Chen, K.3
-
35
-
-
70450219517
-
Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease
-
Carta AR, Kachroo A, Schintu N et al (2009) Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease. J Neurochem 111:1478-1489
-
(2009)
J Neurochem
, vol.111
, pp. 1478-1489
-
-
Carta, A.R.1
Kachroo, A.2
Schintu, N.3
-
36
-
-
55949096514
-
SLC2A9 is a high-capacity urate transporter in humans
-
Caulfield MJ, Munroe PB, O'Neill D et al (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Med 5:e197
-
(2008)
PLoS Med
, vol.5
, pp. e197
-
-
Caulfield, M.J.1
Munroe, P.B.2
O'Neill, D.3
-
37
-
-
0036221193
-
Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke
-
Chamorro A, Obach V, Cervera A et al (2002) Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke 33:1048-1052
-
(2002)
Stroke
, vol.33
, pp. 1048-1052
-
-
Chamorro, A.1
Obach, V.2
Cervera, A.3
-
38
-
-
84898539374
-
Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial
-
Chamorro A, Amaro S, Castellanos M et al (2014) Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial. Lancet Neurol 13:453-460
-
(2014)
Lancet Neurol
, vol.13
, pp. 453-460
-
-
Chamorro, A.1
Amaro, S.2
Castellanos, M.3
-
39
-
-
0037090246
-
Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake
-
Checkoway H, Powers K, Smith-Weller T et al (2002) Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am J Epidemiol 155:732-738
-
(2002)
Am J Epidemiol
, vol.155
, pp. 732-738
-
-
Checkoway, H.1
Powers, K.2
Smith-Weller, T.3
-
40
-
-
0034977186
-
Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism
-
Chen Y, Vartiainen NE, Ying W et al (2001a) Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J Neurochem 77:1601-1610
-
(2001)
J Neurochem
, vol.77
, pp. 1601-1610
-
-
Chen, Y.1
Vartiainen, N.E.2
Ying, W.3
-
41
-
-
0035874345
-
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease
-
Chen JF, Xu K, Petzer JP et al (2001b) Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci 21:RC143
-
(2001)
J Neurosci
, vol.21
, pp. RC143
-
-
Chen, J.F.1
Xu, K.2
Petzer, J.P.3
-
42
-
-
33845296450
-
Valproate protects dopaminergic neurons in midbrain neuron/ glia cultures by stimulating the release of neurotrophic factors from astrocytes
-
Chen PS, Peng GS, Li G et al (2006) Valproate protects dopaminergic neurons in midbrain neuron/ glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry 11:1116-1125
-
(2006)
Mol Psychiatry
, vol.11
, pp. 1116-1125
-
-
Chen, P.S.1
Peng, G.S.2
Li, G.3
-
43
-
-
65249166556
-
Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study
-
Chen H, Mosley TH, Alonso A et al (2009a) Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol 169:1064-1069
-
(2009)
Am J Epidemiol
, vol.169
, pp. 1064-1069
-
-
Chen, H.1
Mosley, T.H.2
Alonso, A.3
-
44
-
-
62449132771
-
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte
-
Chen PC, Vargas MR, Pani AK et al (2009b) Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte. Proc Natl Acad Sci U S A 106:2933-2938
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 2933-2938
-
-
Chen, P.C.1
Vargas, M.R.2
Pani, A.K.3
-
45
-
-
77956180419
-
Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases
-
Chen X, Ghribi O, Geiger JD (2010) Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J Alzheimers Dis 20:S127-S141
-
(2010)
J Alzheimers Dis
, vol.20
, pp. S127-S141
-
-
Chen, X.1
Ghribi, O.2
Geiger, J.D.3
-
46
-
-
84871954612
-
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration
-
Chen X, Burdett TC, Desjardins CA et al (2013) Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A 110:300-305
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 300-305
-
-
Chen, X.1
Burdett, T.C.2
Desjardins, C.A.3
-
47
-
-
84899449984
-
Serum uric acid levels in patients with Alzheimer's disease:a meta-analysis
-
Chen X, Guo X, Huang R et al (2014) Serum uric acid levels in patients with Alzheimer's disease:a meta-analysis. PLoS One 9:e94084
-
(2014)
PLoS One
, vol.9
, pp. e94084
-
-
Chen, X.1
Guo, X.2
Huang, R.3
-
48
-
-
20244362093
-
CGS 21680 attenuates symptoms of Huntington's disease in a transgenic mouse model
-
Chou SY, Lee YC, Chen HM et al (2005) CGS 21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. J Neurochem 93:310-320
-
(2005)
J Neurochem
, vol.93
, pp. 310-320
-
-
Chou, S.Y.1
Lee, Y.C.2
Chen, H.M.3
-
50
-
-
0028036368
-
Uric acid is reduced in the substantia nigra in Parkinson's disease:effect on dopamine oxidation
-
Church WH, Ward VL (1994) Uric acid is reduced in the substantia nigra in Parkinson's disease:effect on dopamine oxidation. Brain Res Bull 33:419-425
-
(1994)
Brain Res Bull
, vol.33
, pp. 419-425
-
-
Church, W.H.1
Ward, V.L.2
-
51
-
-
84861006456
-
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease
-
Cipriani S, Desjardins CA, Burdett TC et al (2012a) Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease. PLoS One 7:e37331
-
(2012)
PLoS One
, vol.7
, pp. e37331
-
-
Cipriani, S.1
Desjardins, C.A.2
Burdett, T.C.3
-
52
-
-
84866261719
-
Protection of dopaminergic cells by urate requires its accumulation in astrocytes
-
Cipriani S, Desjardins CA, Burdett TC et al (2012b) Protection of dopaminergic cells by urate requires its accumulation in astrocytes. J Neurochem 123:172-181
-
(2012)
J Neurochem
, vol.123
, pp. 172-181
-
-
Cipriani, S.1
Desjardins, C.A.2
Burdett, T.C.3
-
53
-
-
16344372309
-
Neuroprotection by adenosine in the brain: from A(1) receptor activation to A (2A) receptor blockade
-
Cunha RA (2005) Neuroprotection by adenosine in the brain: from A(1) receptor activation to A (2A) receptor blockade. Purinergic Signal 1:111-134
-
(2005)
Purinergic Signal
, vol.1
, pp. 111-134
-
-
Cunha, R.A.1
-
54
-
-
0020960991
-
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines
-
Daly JW, Butts-Lamb P, Padgett W (1983) Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cell Mol Neurobiol 3:69-80
-
(1983)
Cell Mol Neurobiol
, vol.3
, pp. 69-80
-
-
Daly, J.W.1
Butts-Lamb, P.2
Padgett, W.3
-
55
-
-
0029795479
-
Observations on serum uric acid levels and the risk of idiopathic Parkinson's disease
-
Davis JW, Grandinetti A, Waslien CI et al (1996) Observations on serum uric acid levels and the risk of idiopathic Parkinson's disease. Am J Epidemiol 144:480-484
-
(1996)
Am J Epidemiol
, vol.144
, pp. 480-484
-
-
Davis, J.W.1
Grandinetti, A.2
Waslien, C.I.3
-
56
-
-
27644540928
-
Serum uric acid levels and the risk of Parkinson disease
-
de Lau LM, Koudstaal PJ, Hofman A et al (2005) Serum uric acid levels and the risk of Parkinson disease. Ann Neurol 58:797-800
-
(2005)
Ann Neurol
, vol.58
, pp. 797-800
-
-
De Lau, L.M.1
Koudstaal, P.J.2
Hofman, A.3
-
57
-
-
84922269921
-
Elevation of striatal urate in experimental models of Parkinson's disease: a compensatory mechanism triggered by dopaminergic nigrostriatal degeneration?
-
De Luca MA, Cauli O, Morelli M et al (2014) Elevation of striatal urate in experimental models of Parkinson's disease: a compensatory mechanism triggered by dopaminergic nigrostriatal degeneration? J Neurochem 131:284-289
-
(2014)
J Neurochem
, vol.131
, pp. 284-289
-
-
De Luca, M.A.1
Cauli, O.2
Morelli, M.3
-
59
-
-
56049092243
-
Gout and the risk of Parkinson's disease: a cohort study
-
De Vera M, Rahman MM, Rankin J et al (2008) Gout and the risk of Parkinson's disease: a cohort study. Arthritis Rheum 59:1549-1554
-
(2008)
Arthritis Rheum
, vol.59
, pp. 1549-1554
-
-
De Vera, M.1
Rahman, M.M.2
Rankin, J.3
-
60
-
-
57049083981
-
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
-
Dehghan A, Kottgen A, Yang Q et al (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372:1953-1961
-
(2008)
Lancet
, vol.372
, pp. 1953-1961
-
-
Dehghan, A.1
Kottgen, A.2
Yang, Q.3
-
61
-
-
34248392684
-
Microglial activation and its implications in the brain diseases
-
Dheen ST, Kaur C, Ling EA (2007) Microglial activation and its implications in the brain diseases. Curr Med Chem 14:1189-1197
-
(2007)
Curr Med Chem
, vol.14
, pp. 1189-1197
-
-
Dheen, S.T.1
Kaur, C.2
Ling, E.A.3
-
62
-
-
84858332372
-
Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis
-
D'Hooghe MB, Haentjens P, Nagels G et al (2012) Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis. Eur J Neurol 19:616-624
-
(2012)
Eur J Neurol
, vol.19
, pp. 616-624
-
-
D'Hooghe, M.B.1
Haentjens, P.2
Nagels, G.3
-
63
-
-
33847745017
-
Astroglia-mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity
-
Du Y, Chen CP, Tseng CY et al (2007) Astroglia-mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity. Glia 55:463-472
-
(2007)
Glia
, vol.55
, pp. 463-472
-
-
Du, Y.1
Chen, C.P.2
Tseng, C.Y.3
-
64
-
-
0036270262
-
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
-
Duan W, Ladenheim B, Cutler RG et al (2002) Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J Neurochem 80:101-110
-
(2002)
J Neurochem
, vol.80
, pp. 101-110
-
-
Duan, W.1
Ladenheim, B.2
Cutler, R.G.3
-
65
-
-
79551626268
-
Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease
-
Ellrichmann G, Petrasch-Parwez E, Lee DH et al (2011) Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease. PLoS One 6:e16172
-
(2011)
PLoS One
, vol.6
, pp. e16172
-
-
Ellrichmann, G.1
Petrasch-Parwez, E.2
Lee, D.H.3
-
66
-
-
84856034604
-
Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier
-
Erickson MA, Dohi K, Banks WA (2012) Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier. Neuroimmunomodulation 19:121-130
-
(2012)
Neuroimmunomodulation
, vol.19
, pp. 121-130
-
-
Erickson, M.A.1
Dohi, K.2
Banks, W.A.3
-
67
-
-
77956196113
-
Caffeine as a protective factor in dementia and Alzheimer's disease
-
Eskelinen MH, Kivipelto M (2010) Caffeine as a protective factor in dementia and Alzheimer's disease. J Alzheimers Dis 20:S167-S174
-
(2010)
J Alzheimers Dis
, vol.20
, pp. S167-S174
-
-
Eskelinen, M.H.1
Kivipelto, M.2
-
68
-
-
58849083195
-
Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study
-
Eskelinen MH, Ngandu T, Tuomilehto J et al (2009) Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis 16:85-91
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 85-91
-
-
Eskelinen, M.H.1
Ngandu, T.2
Tuomilehto, J.3
-
69
-
-
60149091497
-
Serum uric acid and cognitive function and dementia
-
Euser SM, Hofman A, Westendorp RG et al (2009) Serum uric acid and cognitive function and dementia. Brain 132:377-382
-
(2009)
Brain
, vol.132
, pp. 377-382
-
-
Euser, S.M.1
Hofman, A.2
Westendorp, R.G.3
-
70
-
-
79955864999
-
Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson's disease
-
Facheris MF, Hicks AA, Minelli C et al (2011) Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson's disease. J Mol Neurosci 43:246-250
-
(2011)
J Mol Neurosci
, vol.43
, pp. 246-250
-
-
Facheris, M.F.1
Hicks, A.A.2
Minelli, C.3
-
71
-
-
0032924712
-
Nutritional and occupational factors influencing the risk of Parkinson's disease: a case-control study in southeastern Sweden
-
Fall PA, Fredrikson M, Axelson O et al (1999) Nutritional and occupational factors influencing the risk of Parkinson's disease: a case-control study in southeastern Sweden. Mov Disord 14:28-37
-
(1999)
Mov Disord
, vol.14
, pp. 28-37
-
-
Fall, P.A.1
Fredrikson, M.2
Axelson, O.3
-
72
-
-
0030268068
-
Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors
-
Fiebich BL, Biber K, Lieb K et al (1996) Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors. Glia 18:152-160
-
(1996)
Glia
, vol.18
, pp. 152-160
-
-
Fiebich, B.L.1
Biber, K.2
Lieb, K.3
-
73
-
-
0032432275
-
Protein kinase C-mediated regulation of inducible nitric oxide synthase expression in cultured microglial cells
-
Fiebich BL, Butcher RD, Gebicke-Haerter PJ (1998) Protein kinase C-mediated regulation of inducible nitric oxide synthase expression in cultured microglial cells. J Neuroimmunol 92:170-178
-
(1998)
J Neuroimmunol
, vol.92
, pp. 170-178
-
-
Fiebich, B.L.1
Butcher, R.D.2
Gebicke-Haerter, P.J.3
-
74
-
-
77956198871
-
Mitochondria and the link between neuroinflammation and neurodegeneration
-
Filippo MD, Chiasserini D, Tozzi A et al (2010) Mitochondria and the link between neuroinflammation and neurodegeneration. J Alzheimers Dis 20:S369-S379
-
(2010)
J Alzheimers Dis
, vol.20
, pp. S369-S379
-
-
Filippo, M.D.1
Chiasserini, D.2
Tozzi, A.3
-
75
-
-
0942298557
-
Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage
-
Fink JS, Kalda A, Ryu H et al (2004) Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage. J Neurochem 88:538-544
-
(2004)
J Neurochem
, vol.88
, pp. 538-544
-
-
Fink, J.S.1
Kalda, A.2
Ryu, H.3
-
76
-
-
0345561561
-
Actions of caffeine in the brain with special reference to factors that contribute to its widespread use
-
Fredholm BB, Battig K, Holmen J et al (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51:83-133
-
(1999)
Pharmacol Rev
, vol.51
, pp. 83-133
-
-
Fredholm, B.B.1
Battig, K.2
Holmen, J.3
-
77
-
-
77049092091
-
Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms
-
Fujishita K, Ozawa T, Shibata K et al (2009) Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms. Cell Mol Neurobiol 29:1121-1129
-
(2009)
Cell Mol Neurobiol
, vol.29
, pp. 1121-1129
-
-
Fujishita, K.1
Ozawa, T.2
Shibata, K.3
-
78
-
-
0028321498
-
CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil
-
Gao Y, Phillis JW (1994) CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci 55:PL61-PL65
-
(1994)
Life Sci
, vol.55
, pp. PL61-PL65
-
-
Gao, Y.1
Phillis, J.W.2
-
79
-
-
41349103415
-
Diet, urate, and Parkinson's disease risk in men
-
Gao X, Chen H, Choi HK et al (2008) Diet, urate, and Parkinson's disease risk in men. Am J Epidemiol 167:831-838
-
(2008)
Am J Epidemiol
, vol.167
, pp. 831-838
-
-
Gao, X.1
Chen, H.2
Choi, H.K.3
-
80
-
-
30744472146
-
In vivo imaging of microglial activation with [11C] (R)-PK11195 PET in idiopathic Parkinson's disease
-
Gerhard A, Pavese N, Hotton G et al (2006) In vivo imaging of microglial activation with [11C] (R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 21:404-412
-
(2006)
Neurobiol Dis
, vol.21
, pp. 404-412
-
-
Gerhard, A.1
Pavese, N.2
Hotton, G.3
-
81
-
-
84868654616
-
Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson's disease: linking to Akt/GSK3beta signaling pathway
-
Gong L, Zhang QL, Zhang N et al (2012) Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson's disease: linking to Akt/GSK3beta signaling pathway. J Neurochem 123:876-885
-
(2012)
J Neurochem
, vol.123
, pp. 876-885
-
-
Gong, L.1
Zhang, Q.L.2
Zhang, N.3
-
82
-
-
77954673594
-
Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of Inosine and Interferon beta in relapsing- remitting Multiple Sclerosis (ASIIMS) trial
-
Gonsette RE, Sindic C, D'Hooghe MB et al (2010) Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of Inosine and Interferon beta in relapsing- remitting Multiple Sclerosis (ASIIMS) trial. Mult Scler 16:455-462
-
(2010)
Mult Scler
, vol.16
, pp. 455-462
-
-
Gonsette, R.E.1
Sindic, C.2
D'Hooghe, M.B.3
-
83
-
-
84886412353
-
Genetic variability related to serum uric acid concentration and risk of Parkinson's disease
-
Gonzalez-Aramburu I, Sanchez-Juan P, Jesus S et al (2013) Genetic variability related to serum uric acid concentration and risk of Parkinson's disease. Mov Disord 28:1737-1740
-
(2013)
Mov Disord
, vol.28
, pp. 1737-1740
-
-
Gonzalez-Aramburu, I.1
Sanchez-Juan, P.2
Jesus, S.3
-
84
-
-
84890214544
-
A3 Adenosine receptors mediate oligodendrocyte death and ischemic damage to optic nerve
-
Gonzalez-Fernandez E, Sanchez-Gomez MV, Perez-Samartin A et al (2014) A3 Adenosine receptors mediate oligodendrocyte death and ischemic damage to optic nerve. Glia 62(2):199-216
-
(2014)
Glia
, vol.62
, Issue.2
, pp. 199-216
-
-
Gonzalez-Fernandez, E.1
Sanchez-Gomez, M.V.2
Perez-Samartin, A.3
-
85
-
-
65649126049
-
Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization
-
Guerreiro S, Ponceau A, Toulorge D et al (2009) Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization. J Neurochem 109:1118-1128
-
(2009)
J Neurochem
, vol.109
, pp. 1118-1128
-
-
Guerreiro, S.1
Ponceau, A.2
Toulorge, D.3
-
86
-
-
36949000863
-
Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice
-
Haberman F, Tang SC, Arumugam TV et al (2007) Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice. Neuromolecular Med 9:315-323
-
(2007)
Neuromolecular Med
, vol.9
, pp. 315-323
-
-
Haberman, F.1
Tang, S.C.2
Arumugam, T.V.3
-
87
-
-
84872687901
-
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
-
Hauser DN, Hastings TG (2013) Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism. Neurobiol Dis 51:35-42
-
(2013)
Neurobiol Dis
, vol.51
, pp. 35-42
-
-
Hauser, D.N.1
Hastings, T.G.2
-
89
-
-
9544227379
-
Diet and Parkinson's disease. II: a possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study
-
Hellenbrand W, Boeing H, Robra BP et al (1996) Diet and Parkinson's disease. II: a possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study. Neurology 47:644-650
-
(1996)
Neurology
, vol.47
, pp. 644-650
-
-
Hellenbrand, W.1
Boeing, H.2
Robra, B.P.3
-
90
-
-
0028363784
-
Stimulation of reactive astrogliosis in vivo by extracellular adenosine diphosphate or an adenosine A2 receptor agonist
-
Hindley S, Herman MA, Rathbone MP (1994) Stimulation of reactive astrogliosis in vivo by extracellular adenosine diphosphate or an adenosine A2 receptor agonist. J Neurosci Res 38:399-406
-
(1994)
J Neurosci Res
, vol.38
, pp. 399-406
-
-
Hindley, S.1
Herman, M.A.2
Rathbone, M.P.3
-
91
-
-
0031930043
-
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis
-
Hooper DC, Spitsin S, Kean RB et al (1998) Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A 95:675-680
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 675-680
-
-
Hooper, D.C.1
Spitsin, S.2
Kean, R.B.3
-
92
-
-
0034038044
-
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis
-
Hooper DC, Scott GS, Zborek A et al (2000) Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis. FASEB J 14:691-698
-
(2000)
FASEB J
, vol.14
, pp. 691-698
-
-
Hooper, D.C.1
Scott, G.S.2
Zborek, A.3
-
93
-
-
33745491875
-
Serum uric acid and risk of ischemic stroke: the ARIC Study
-
Hozawa A, Folsom AR, Ibrahim H et al (2006) Serum uric acid and risk of ischemic stroke: the ARIC Study. Atherosclerosis 187:401-407
-
(2006)
Atherosclerosis
, vol.187
, pp. 401-407
-
-
Hozawa, A.1
Folsom, A.R.2
Ibrahim, H.3
-
94
-
-
38049053106
-
Coffee and tea consumption and the risk of Parkinson's disease
-
Hu G, Bidel S, Jousilahti P et al (2007) Coffee and tea consumption and the risk of Parkinson's disease. Mov Disord 22:2242-2248
-
(2007)
Mov Disord
, vol.22
, pp. 2242-2248
-
-
Hu, G.1
Bidel, S.2
Jousilahti, P.3
-
95
-
-
33750940225
-
Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation
-
Huang QY, Wei C, Yu L et al (2006) Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. J Neurosci 26:11371-11378
-
(2006)
J Neurosci
, vol.26
, pp. 11371-11378
-
-
Huang, Q.Y.1
Wei, C.2
Yu, L.3
-
96
-
-
79959352258
-
A new drug design targeting the adenosinergic system for Huntington's disease
-
Huang NK, Lin JH, Lin JT et al (2011) A new drug design targeting the adenosinergic system for Huntington's disease. PLoS One 6:e20934
-
(2011)
PLoS One
, vol.6
, pp. e20934
-
-
Huang, N.K.1
Lin, J.H.2
Lin, J.T.3
-
97
-
-
0029294575
-
Inducible nitric oxide synthase gene expression in brain following cerebral ischemia
-
Iadecola C, Zhang F, Xu S et al (1995) Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 15:378-384
-
(1995)
J Cereb Blood Flow Metab
, vol.15
, pp. 378-384
-
-
Iadecola, C.1
Zhang, F.2
Xu, S.3
-
98
-
-
0036020950
-
Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease
-
Ikeda K, Kurokawa M, Aoyama S et al (2002) Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease. J Neurochem 80:262-270
-
(2002)
J Neurochem
, vol.80
, pp. 262-270
-
-
Ikeda, K.1
Kurokawa, M.2
Aoyama, S.3
-
99
-
-
84862985282
-
Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study
-
Ikeda K, Hirayama T, Takazawa T et al (2012) Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study. Intern Med 51:1501-1508
-
(2012)
Intern Med
, vol.51
, pp. 1501-1508
-
-
Ikeda, K.1
Hirayama, T.2
Takazawa, T.3
-
100
-
-
45449092100
-
Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity
-
Imamura K, Takeshima T, Nakaso K et al (2008) Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity. Neurosci Lett 440:97-102
-
(2008)
Neurosci Lett
, vol.440
, pp. 97-102
-
-
Imamura, K.1
Takeshima, T.2
Nakaso, K.3
-
101
-
-
77955608828
-
Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1
-
Innamorato NG, Jazwa A, Rojo AI et al (2010) Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. PLoS One 5:e11838
-
(2010)
PLoS One
, vol.5
, pp. e11838
-
-
Innamorato, N.G.1
Jazwa, A.2
Rojo, A.I.3
-
103
-
-
33947307990
-
Nrf2-mediated protection against 6-hydroxydopamine
-
Jakel RJ, Townsend JA, Kraft AD et al (2007) Nrf2-mediated protection against 6-hydroxydopamine. Brain Res 1144:192-201
-
(2007)
Brain Res
, vol.1144
, pp. 192-201
-
-
Jakel, R.J.1
Townsend, J.A.2
Kraft, A.D.3
-
104
-
-
0037378026
-
Oxidative stress in Parkinson's disease
-
Jenner P (2003) Oxidative stress in Parkinson's disease. Ann Neurol 53:S26-S36
-
(2003)
Ann Neurol
, vol.53
, pp. S26-S36
-
-
Jenner, P.1
-
105
-
-
84871660499
-
Low serum uric acid concentration in Parkinson's disease in southern Spain
-
Jesus S, Perez I, Caceres-Redondo MT et al (2012) Low serum uric acid concentration in Parkinson's disease in southern Spain. Eur J Neurol 20:208-210
-
(2012)
Eur J Neurol
, vol.20
, pp. 208-210
-
-
Jesus, S.1
Perez, I.2
Caceres-Redondo, M.T.3
-
106
-
-
77950199824
-
Attenuated variants of Lesch-Nyhan disease
-
Jinnah HA, Ceballos-Picot I, Torres RJ et al (2010) Attenuated variants of Lesch-Nyhan disease. Brain 133:671-689
-
(2010)
Brain
, vol.133
, pp. 671-689
-
-
Jinnah, H.A.1
Ceballos-Picot, I.2
Torres, R.J.3
-
107
-
-
8444243293
-
Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence
-
Joghataie MT, Roghani M, Negahdar F et al (2004) Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence. Parkinsonism Relat Disord 10:465-468
-
(2004)
Parkinsonism Relat Disord
, vol.10
, pp. 465-468
-
-
Joghataie, M.T.1
Roghani, M.2
Negahdar, F.3
-
108
-
-
70449552850
-
Metabolomic profiling in LRRK2-related Parkinson's disease
-
Johansen KK, Wang L, Aasly JO et al (2009) Metabolomic profiling in LRRK2-related Parkinson's disease. PLoS One 4:e7551
-
(2009)
PLoS One
, vol.4
, pp. e7551
-
-
Johansen, K.K.1
Wang, L.2
Aasly, J.O.3
-
109
-
-
0034025513
-
Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells
-
Jones DC, Gunasekar PG, Borowitz JL et al (2000) Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells. J Neurochem 74:2296-2304
-
(2000)
J Neurochem
, vol.74
, pp. 2296-2304
-
-
Jones, D.C.1
Gunasekar, P.G.2
Borowitz, J.L.3
-
110
-
-
84867777145
-
The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases
-
Joshi G, Johnson JA (2012) The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent Pat CNS Drug Discov 7:218-229
-
(2012)
Recent Pat CNS Drug Discov
, vol.7
, pp. 218-229
-
-
Joshi, G.1
Johnson, J.A.2
-
111
-
-
77952545692
-
Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration
-
Kachroo A, Irizarry MC, Schwarzschild MA (2010) Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration. Exp Neurol 223:657-661
-
(2010)
Exp Neurol
, vol.223
, pp. 657-661
-
-
Kachroo, A.1
Irizarry, M.C.2
Schwarzschild, M.A.3
-
112
-
-
84980053533
-
Clinical outcomes and serum uric acid levels in elderly patients with amyotrophic lateral sclerosis aged ≥ 70 years
-
Kataoka H, Kiriyama T, Kobayashi Y et al (2013) Clinical outcomes and serum uric acid levels in elderly patients with amyotrophic lateral sclerosis aged ≥ 70 years. Am J Neurodegener Dis 2:140-144
-
(2013)
Am J Neurodegener Dis
, vol.2
, pp. 140-144
-
-
Kataoka, H.1
Kiriyama, T.2
Kobayashi, Y.3
-
113
-
-
77952807424
-
The evolutionary fate of the genes encoding the purine catabolic enzymes in hominoids, birds, and reptiles
-
Keebaugh AC, Thomas JW (2010) The evolutionary fate of the genes encoding the purine catabolic enzymes in hominoids, birds, and reptiles. Mol Biol Evol 27:1359-1369
-
(2010)
Mol Biol Evol
, vol.27
, pp. 1359-1369
-
-
Keebaugh, A.C.1
Thomas, J.W.2
-
114
-
-
69549116245
-
Low uric acid levels in serum of patients with ALS: further evidence for oxidative stress?
-
Keizman D, Ish-Shalom M, Berliner S et al (2009) Low uric acid levels in serum of patients with ALS: further evidence for oxidative stress? J Neurol Sci 285:95-99
-
(2009)
J Neurol Sci
, vol.285
, pp. 95-99
-
-
Keizman, D.1
Ish-Shalom, M.2
Berliner, S.3
-
115
-
-
33646203803
-
Decreased plasma antioxidants in patients with Alzheimer's disease
-
Kim TS, Pae CU, Yoon SJ et al (2006) Decreased plasma antioxidants in patients with Alzheimer's disease. Int J Geriatr Psychiatry 21:344-348
-
(2006)
Int J Geriatr Psychiatry
, vol.21
, pp. 344-348
-
-
Kim, T.S.1
Pae, C.U.2
Yoon, S.J.3
-
116
-
-
67651056502
-
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
-
Kolz M, Johnson T, Sanna S et al (2009) Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 5:e1000504
-
(2009)
PLoS Genet
, vol.5
, pp. e1000504
-
-
Kolz, M.1
Johnson, T.2
Sanna, S.3
-
119
-
-
0029294575
-
Inducible nitric oxide synthase gene expression in brain following cerebral ischemia
-
Ladecola C, Zhang F, Xu S et al (1995) Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 15:378-384
-
(1995)
J Cereb Blood Flow Metab
, vol.15
, pp. 378-384
-
-
Ladecola, C.1
Zhang, F.2
Xu, S.3
-
120
-
-
6644228387
-
Case-control study of markers of oxidative stress and metabolism of blood iron in Parkinson's disease
-
Larumbe Ilundain R, Ferrer Valls JV, Vines Rueda JJ et al (2001) Case-control study of markers of oxidative stress and metabolism of blood iron in Parkinson's disease. Rev Esp Salud Publica 75:43-53
-
(2001)
Rev Esp Salud Publica
, vol.75
, pp. 43-53
-
-
Larumbe Ilundain, R.1
Ferrer Valls, J.V.2
Vines Rueda, J.J.3
-
121
-
-
84902082985
-
Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology
-
Laurent C, Eddarkaoui S, Derisbourg M et al (2014) Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology. Neurobiol Aging 35:2079-2090
-
(2014)
Neurobiol Aging
, vol.35
, pp. 2079-2090
-
-
Laurent, C.1
Eddarkaoui, S.2
Derisbourg, M.3
-
122
-
-
84906766601
-
Adenosine receptors and Huntington's disease
-
Lee CF, Chern Y (2014) Adenosine receptors and Huntington's disease. Int Rev Neurobiol 119:195-232
-
(2014)
Int Rev Neurobiol
, vol.119
, pp. 195-232
-
-
Lee, C.F.1
Chern, Y.2
-
123
-
-
79960592809
-
Uric acid as a potential disease modifier in patients with multiple system atrophy
-
Lee JE, Song SK, Sohn YH et al (2011) Uric acid as a potential disease modifier in patients with multiple system atrophy. Mov Disord 26:1533-1536
-
(2011)
Mov Disord
, vol.26
, pp. 1533-1536
-
-
Lee, J.E.1
Song, S.K.2
Sohn, Y.H.3
-
124
-
-
0026045483
-
Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia
-
Lekieffre D, Callebert J, Plotkine M et al (1991) Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia. Brain Res 565:353-357
-
(1991)
Brain Res
, vol.565
, pp. 353-357
-
-
Lekieffre, D.1
Callebert, J.2
Plotkine, M.3
-
125
-
-
0035830550
-
Adenosine enhances glial glutamate efflux via A2a adenosine receptors
-
Li XX, Nomura T, Aihara H et al (2001) Adenosine enhances glial glutamate efflux via A2a adenosine receptors. Life Sci 68:1343-1350
-
(2001)
Life Sci
, vol.68
, pp. 1343-1350
-
-
Li, X.X.1
Nomura, T.2
Aihara, H.3
-
126
-
-
37349008492
-
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
-
Li S, Sanna S, Maschio A et al (2007) The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 3:e194
-
(2007)
PLoS Genet
, vol.3
, pp. e194
-
-
Li, S.1
Sanna, S.2
Maschio, A.3
-
127
-
-
70349466534
-
Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation
-
Li XZ, Bai LM, Yang YP et al (2009) Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation. Neurosci Res 65:252-258
-
(2009)
Neurosci Res
, vol.65
, pp. 252-258
-
-
Li, X.Z.1
Bai, L.M.2
Yang, Y.P.3
-
128
-
-
0033136194
-
Brain iNOS: current understanding and clinical implications
-
Licinio J, Prolo P, McCann SM et al (1999) Brain iNOS: current understanding and clinical implications. Mol Med Today 5:225-232
-
(1999)
Mol Med Today
, vol.5
, pp. 225-232
-
-
Licinio, J.1
Prolo, P.2
McCann, S.M.3
-
129
-
-
0036725818
-
Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging
-
Lindsay J, Laurin D, Verreault R et al (2002) Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156:445-453
-
(2002)
Am J Epidemiol
, vol.156
, pp. 445-453
-
-
Lindsay, J.1
Laurin, D.2
Verreault, R.3
-
130
-
-
84860836541
-
Regulation of uric acid excretion by the kidney
-
Lipkowitz MS (2012) Regulation of uric acid excretion by the kidney. Curr Rheumatol Rep 14:179-188
-
(2012)
Curr Rheumatol Rep
, vol.14
, pp. 179-188
-
-
Lipkowitz, M.S.1
-
131
-
-
84896719369
-
Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions
-
Machado-Filho JA, Correia AO, Montenegro AB et al (2014) Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions. Behav Brain Res 264:116-125
-
(2014)
Behav Brain Res
, vol.264
, pp. 116-125
-
-
Machado-Filho, J.A.1
Correia, A.O.2
Montenegro, A.B.3
-
132
-
-
0027155160
-
Hypouricemia, abnormal renal tubular urate transport, and plasma natriuretic factor(s) in patients with Alzheimer's disease
-
Maesaka JK, Wolf-Klein G, Piccione JM et al (1993) Hypouricemia, abnormal renal tubular urate transport, and plasma natriuretic factor(s) in patients with Alzheimer's disease. J Am Geriatr Soc 41:501-506
-
(1993)
J Am Geriatr Soc
, vol.41
, pp. 501-506
-
-
Maesaka, J.K.1
Wolf-Klein, G.2
Piccione, J.M.3
-
134
-
-
84872360567
-
Caffeine and alcohol intakes have no association with risk of multiple sclerosis
-
Massa J, O'Reilly EJ, Munger KL et al (2012) Caffeine and alcohol intakes have no association with risk of multiple sclerosis. Mult Scler 19:53-58
-
(2012)
Mult Scler
, vol.19
, pp. 53-58
-
-
Massa, J.1
O'Reilly, E.J.2
Munger, K.L.3
-
135
-
-
84887851711
-
Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes
-
Matos M, Augusto E, Agostinho P et al (2013) Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes. J Neurosci 33:18492-18502
-
(2013)
J Neurosci
, vol.33
, pp. 18492-18502
-
-
Matos, M.1
Augusto, E.2
Agostinho, P.3
-
136
-
-
0020351568
-
Blood-brain barrier transport of caffeine: doserelated restriction of adenine transport
-
McCall AL, Millington WR, Wurtman RJ (1982) Blood-brain barrier transport of caffeine: doserelated restriction of adenine transport. Life Sci 31:2709-2715
-
(1982)
Life Sci
, vol.31
, pp. 2709-2715
-
-
McCall, A.L.1
Millington, W.R.2
Wurtman, R.J.3
-
137
-
-
0036906924
-
Design and analysis of two-period studies of potentially disease-modifying treatments
-
McDermott MP, Hall WJ, Oakes D et al (2002) Design and analysis of two-period studies of potentially disease-modifying treatments. Control Clin Trials 23:635-649
-
(2002)
Control Clin Trials
, vol.23
, pp. 635-649
-
-
McDermott, M.P.1
Hall, W.J.2
Oakes, D.3
-
138
-
-
47349104402
-
Glial reactions in Parkinson's disease
-
McGeer PL, McGeer EG (2008) Glial reactions in Parkinson's disease. Mov Disord 23:474-483
-
(2008)
Mov Disord
, vol.23
, pp. 474-483
-
-
McGeer, P.L.1
McGeer, E.G.2
-
139
-
-
67649395906
-
Selective adenosine A2a receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischaemia
-
Melani A, Cipriani S, Vannucchi MG et al (2009) Selective adenosine A2a receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischaemia. Brain 132:1480-1495
-
(2009)
Brain
, vol.132
, pp. 1480-1495
-
-
Melani, A.1
Cipriani, S.2
Vannucchi, M.G.3
-
141
-
-
78650609433
-
A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease
-
Mievis S, Blum D, Ledent C (2011) A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease. Neurobiol Dis 41:570-576
-
(2011)
Neurobiol Dis
, vol.41
, pp. 570-576
-
-
Mievis, S.1
Blum, D.2
Ledent, C.3
-
142
-
-
34247880388
-
Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration
-
Minghetti L, Greco A, Potenza RL et al (2007) Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration. J Neuropathol Exp Neurol 66:363-371
-
(2007)
J Neuropathol Exp Neurol
, vol.66
, pp. 363-371
-
-
Minghetti, L.1
Greco, A.2
Potenza, R.L.3
-
143
-
-
84923089659
-
Presence and progression of non-motor symptoms in relation to uric acid in de novo Parkinson's disease
-
Moccia M, Picillo M, Erro R et al (2014) Presence and progression of non-motor symptoms in relation to uric acid in de novo Parkinson's disease. Eur J Neurol 22:93-98
-
(2014)
Eur J Neurol
, vol.22
, pp. 93-98
-
-
Moccia, M.1
Picillo, M.2
Erro, R.3
-
145
-
-
77955353133
-
Pathophysiological roles for purines: adenosine, caffeine and urate
-
Morelli M, Carta AR, Kachroo A et al (2010) Pathophysiological roles for purines: adenosine, caffeine and urate. Prog Brain Res 183:183-208
-
(2010)
Prog Brain Res
, vol.183
, pp. 183-208
-
-
Morelli, M.1
Carta, A.R.2
Kachroo, A.3
-
147
-
-
84926419210
-
Associated Inosine to interferon: results of a clinical trial in multiple sclerosis
-
Munoz Garcia D, Midaglia L, Martinez Vilela J et al (2015) Associated Inosine to interferon: results of a clinical trial in multiple sclerosis. Acta Neurol Scand. 131:405-410
-
(2015)
Acta Neurol Scand
, vol.131
, pp. 405-410
-
-
Munoz Garcia, D.1
Midaglia, L.2
Martinez Vilela, J.3
-
148
-
-
79957959973
-
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
-
Neymotin A, Calingasan NY, Wille E et al (2011) Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med 51:88-96
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 88-96
-
-
Neymotin, A.1
Calingasan, N.Y.2
Wille, E.3
-
149
-
-
84894384733
-
The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes
-
Niranjan R (2013) The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes. Mol Neurobiol 49:28-38
-
(2013)
Mol Neurobiol
, vol.49
, pp. 28-38
-
-
Niranjan, R.1
-
150
-
-
1642504355
-
ATP- and adenosine-mediated signaling in the central nervous system: adenosine stimulates glutamate release from astrocytes via A2a adenosine receptors
-
Nishizaki T (2004) ATP- and adenosine-mediated signaling in the central nervous system: adenosine stimulates glutamate release from astrocytes via A2a adenosine receptors. J Pharmacol Sci 94:100-102
-
(2004)
J Pharmacol Sci
, vol.94
, pp. 100-102
-
-
Nishizaki, T.1
-
151
-
-
0036097513
-
Loss of urate oxidase activity in hominoids and its evolutionary implications
-
Oda M, Satta Y, Takenaka O et al (2002) Loss of urate oxidase activity in hominoids and its evolutionary implications. Mol Biol Evol 19:640-653
-
(2002)
Mol Biol Evol
, vol.19
, pp. 640-653
-
-
Oda, M.1
Satta, Y.2
Takenaka, O.3
-
152
-
-
77956906686
-
Plasma urate and Parkinson's disease in women
-
O'Reilly EJ, Gao X, Weisskopf MG et al (2010) Plasma urate and Parkinson's disease in women. Am J Epidemiol 172:666-670
-
(2010)
Am J Epidemiol
, vol.172
, pp. 666-670
-
-
O'Reilly, E.J.1
Gao, X.2
Weisskopf, M.G.3
-
153
-
-
0000116599
-
The origin of man
-
Orowan E (1955) The origin of man. Nature 175:683-684
-
(1955)
Nature
, vol.175
, pp. 683-684
-
-
Orowan, E.1
-
154
-
-
0030727329
-
Adenosine receptor blockade and nitric oxide synthase inhibition in the retina: impact upon post-ischemic hyperemia and the electroretinogram
-
Ostwald P, Park SS, Toledano AY et al (1997) Adenosine receptor blockade and nitric oxide synthase inhibition in the retina: impact upon post-ischemic hyperemia and the electroretinogram. Vision Res 37:3453-3461
-
(1997)
Vision Res
, vol.37
, pp. 3453-3461
-
-
Ostwald, P.1
Park, S.S.2
Toledano, A.Y.3
-
156
-
-
84867330990
-
Uric acid levels predict survival in men with amyotrophic lateral sclerosis
-
Paganoni S, Zhang M, Quiroz Zarate A et al (2012) Uric acid levels predict survival in men with amyotrophic lateral sclerosis. J Neurol 259:1923-1928
-
(2012)
J Neurol
, vol.259
, pp. 1923-1928
-
-
Paganoni, S.1
Zhang, M.2
Quiroz Zarate, A.3
-
157
-
-
84893841038
-
Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial
-
Parkinson's-Study-Group, Schwarzschild MA, Ascherio A et al (2014) Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol 71:141-150
-
(2014)
JAMA Neurol
, vol.71
, pp. 141-150
-
-
Schwarzschild, M.A.1
Ascherio, A.2
-
158
-
-
14544287564
-
KW-6002 protects from MPTP induced dopaminergic toxicity in the mouse
-
Pierri M, Vaudano E, Sager T et al (2005) KW-6002 protects from MPTP induced dopaminergic toxicity in the mouse. Neuropharmacology 48:517-524
-
(2005)
Neuropharmacology
, vol.48
, pp. 517-524
-
-
Pierri, M.1
Vaudano, E.2
Sager, T.3
-
159
-
-
84901485155
-
Adenosine A2A receptor antagonists in Parkinson's disease: progress in clinical trials from the newly approved istradefylline to drugs in early development and those already discontinued
-
Pinna A (2014) Adenosine A2A receptor antagonists in Parkinson's disease: progress in clinical trials from the newly approved istradefylline to drugs in early development and those already discontinued. CNS Drugs 28:455-474
-
(2014)
CNS Drugs
, vol.28
, pp. 455-474
-
-
Pinna, A.1
-
160
-
-
73449102471
-
A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug
-
Pinna A, Tronci E, Schintu N et al (2010) A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58:613-623
-
(2010)
Neuropharmacology
, vol.58
, pp. 613-623
-
-
Pinna, A.1
Tronci, E.2
Schintu, N.3
-
161
-
-
5644239560
-
Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia
-
Polidori MC, Mattioli P, Aldred S et al (2004) Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord 18:265-270
-
(2004)
Dement Geriatr Cogn Disord
, vol.18
, pp. 265-270
-
-
Polidori, M.C.1
Mattioli, P.2
Aldred, S.3
-
162
-
-
0036522987
-
Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum
-
Popoli P, Pintor A, Domenici MR et al (2002) Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum. J Neurosci 22:1967-1975
-
(2002)
J Neurosci
, vol.22
, pp. 1967-1975
-
-
Popoli, P.1
Pintor, A.2
Domenici, M.R.3
-
164
-
-
84866103728
-
Caffeine for treatment of Parkinson disease: a randomized controlled trial
-
Postuma RB, Lang AE, Munhoz RP et al (2012) Caffeine for treatment of Parkinson disease: a randomized controlled trial. Neurology 79:651-658
-
(2012)
Neurology
, vol.79
, pp. 651-658
-
-
Postuma, R.B.1
Lang, A.E.2
Munhoz, R.P.3
-
165
-
-
84873711954
-
Effects of chronic caffeine intake in a mouse model of amyotrophic lateral sclerosis
-
Potenza RL, Armida M, Ferrante A et al (2013) Effects of chronic caffeine intake in a mouse model of amyotrophic lateral sclerosis. J Neurosci Res 91:585-592
-
(2013)
J Neurosci Res
, vol.91
, pp. 585-592
-
-
Potenza, R.L.1
Armida, M.2
Ferrante, A.3
-
166
-
-
77956180469
-
Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet
-
Prasanthi JR, Dasari B, Marwarha G et al (2010) Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med 49:1212-1220
-
(2010)
Free Radic Biol Med
, vol.49
, pp. 1212-1220
-
-
Prasanthi, J.R.1
Dasari, B.2
Marwarha, G.3
-
167
-
-
36949057849
-
Similar functions of uric acid and ascorbate in man?
-
Proctor P (1970) Similar functions of uric acid and ascorbate in man? Nature 228:868
-
(1970)
Nature
, vol.228
, pp. 868
-
-
Proctor, P.1
-
168
-
-
0024456653
-
Effect of deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group
-
PSG (1989a) Effect of deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group. N Engl J Med 321:1364-1371
-
(1989)
N Engl J Med
, vol.321
, pp. 1364-1371
-
-
-
169
-
-
0024457355
-
DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group
-
PSG (1989b) DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group. Arch Neurol 46:1052-1060
-
(1989)
Arch Neurol
, vol.46
, pp. 1052-1060
-
-
-
170
-
-
0027530638
-
Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
-
PSG (1993) Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 328:176-183
-
(1993)
N Engl J Med
, vol.328
, pp. 176-183
-
-
-
171
-
-
35148882113
-
Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
-
PSG (2007) Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 69:1480-1490
-
(2007)
Neurology
, vol.69
, pp. 1480-1490
-
-
-
172
-
-
70350139868
-
The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices
-
Pugliese AM, Traini C, Cipriani S et al (2009) The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Br J Pharmacol 157:818-830
-
(2009)
Br J Pharmacol
, vol.157
, pp. 818-830
-
-
Pugliese, A.M.1
Traini, C.2
Cipriani, S.3
-
173
-
-
0042662816
-
A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease
-
Ragonese P, Salemi G, Morgante L et al (2003) A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease. Neuroepidemiology 22:297-304
-
(2003)
Neuroepidemiology
, vol.22
, pp. 297-304
-
-
Ragonese, P.1
Salemi, G.2
Morgante, L.3
-
174
-
-
84856327256
-
Astrocyte mediated protection of fetal cerebral cortical neurons from rotenone and paraquat
-
Rathinam ML, Watts LT, Narasimhan M et al (2012) Astrocyte mediated protection of fetal cerebral cortical neurons from rotenone and paraquat. Environ Toxicol Pharmacol 33:353-360
-
(2012)
Environ Toxicol Pharmacol
, vol.33
, pp. 353-360
-
-
Rathinam, M.L.1
Watts, L.T.2
Narasimhan, M.3
-
175
-
-
0042591280
-
Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease
-
Rinaldi P, Polidori MC, Metastasio A et al (2003) Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging 24:915-919
-
(2003)
Neurobiol Aging
, vol.24
, pp. 915-919
-
-
Rinaldi, P.1
Polidori, M.C.2
Metastasio, A.3
-
176
-
-
33845804424
-
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke
-
Romanos E, Planas AM, Amaro S et al (2007) Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab 27:14-20
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 14-20
-
-
Romanos, E.1
Planas, A.M.2
Amaro, S.3
-
177
-
-
0034738134
-
Association of coffee and caffeine intake with the risk of Parkinson disease
-
Ross GW, Abbott RD, Petrovitch H et al (2000) Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA 283:2674-2679
-
(2000)
JAMA
, vol.283
, pp. 2674-2679
-
-
Ross, G.W.1
Abbott, R.D.2
Petrovitch, H.3
-
179
-
-
28244434101
-
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia
-
Saura J, Angulo E, Ejarque A et al (2005) Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. J Neurochem 95:919-929
-
(2005)
J Neurochem
, vol.95
, pp. 919-929
-
-
Saura, J.1
Angulo, E.2
Ejarque, A.3
-
180
-
-
84876034737
-
3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4] triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)- mediated neuroprotective effects
-
Scatena A, Fornai F, Trincavelli ML et al (2011) 3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4] triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)- mediated neuroprotective effects. ACS Chem Neurosci 2:526-535
-
(2011)
ACS Chem Neurosci
, vol.2
, pp. 526-535
-
-
Scatena, A.1
Fornai, F.2
Trincavelli, M.L.3
-
181
-
-
0344306440
-
Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease
-
Schwarzschild MA, Xu K, Oztas E et al (2003) Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease. Neurology 61:S55-S61
-
(2003)
Neurology
, vol.61
, pp. S55-S61
-
-
Schwarzschild, M.A.1
Xu, K.2
Oztas, E.3
-
182
-
-
33750171348
-
Targeting adenosine A2A receptors in Parkinson's disease
-
Schwarzschild MA, Agnati L, Fuxe K et al (2006) Targeting adenosine A2A receptors in Parkinson's disease. Trends Neurosci 29:647-654
-
(2006)
Trends Neurosci
, vol.29
, pp. 647-654
-
-
Schwarzschild, M.A.1
Agnati, L.2
Fuxe, K.3
-
183
-
-
45149122797
-
Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
-
Schwarzschild MA, Schwid SR, Marek K et al (2008) Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch Neurol 65:716-723
-
(2008)
Arch Neurol
, vol.65
, pp. 716-723
-
-
Schwarzschild, M.A.1
Schwid, S.R.2
Marek, K.3
-
185
-
-
0037058925
-
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors
-
Scott GS, Spitsin SV, Kean RB et al (2002) Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. Proc Natl Acad Sci U S A 99:16303-16308
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16303-16308
-
-
Scott, G.S.1
Spitsin, S.V.2
Kean, R.B.3
-
186
-
-
14744272784
-
Uric acid protects against secondary damage after spinal cord injury
-
Scott GS, Cuzzocrea S, Genovese T et al (2005) Uric acid protects against secondary damage after spinal cord injury. Proc Natl Acad Sci U S A 102:3483-3488
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 3483-3488
-
-
Scott, G.S.1
Cuzzocrea, S.2
Genovese, T.3
-
187
-
-
0023772209
-
Effect of aminophylline on postischemic edema and brain damage in cats
-
Seida M, Wagner HG, Vass K et al (1988) Effect of aminophylline on postischemic edema and brain damage in cats. Stroke 19:1275-1282
-
(1988)
Stroke
, vol.19
, pp. 1275-1282
-
-
Seida, M.1
Wagner, H.G.2
Vass, K.3
-
188
-
-
0037072889
-
The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes
-
Serra PA, Sciola L, Delogu MR et al (2002) The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes. J Biol Chem 277:34451-34461
-
(2002)
J Biol Chem
, vol.277
, pp. 34451-34461
-
-
Serra, P.A.1
Sciola, L.2
Delogu, M.R.3
-
190
-
-
84913533374
-
Mendelian randomization of serum urate and parkinson disease progression
-
Simon KC, Eberly S, Gao X et al (2014) Mendelian randomization of serum urate and parkinson disease progression. Ann Neurol 76:862-868
-
(2014)
Ann Neurol
, vol.76
, pp. 862-868
-
-
Simon, K.C.1
Eberly, S.2
Gao, X.3
-
191
-
-
84879480610
-
Association between caffeine intake and age at onset in Huntington's disease
-
Simonin C, Duru C, Salleron J et al (2013) Association between caffeine intake and age at onset in Huntington's disease. Neurobiol Dis 58:179-182
-
(2013)
Neurobiol Dis
, vol.58
, pp. 179-182
-
-
Simonin, C.1
Duru, C.2
Salleron, J.3
-
192
-
-
77953187009
-
Uric acid transport and disease
-
So A, Thorens B (2010) Uric acid transport and disease. J Clin Invest 120:1791-1799
-
(2010)
J Clin Invest
, vol.120
, pp. 1791-1799
-
-
So, A.1
Thorens, B.2
-
193
-
-
84862821537
-
Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease
-
Sonsalla PK, Wong LY, Harris SL et al (2012) Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease. Exp Neurol 234:482-487
-
(2012)
Exp Neurol
, vol.234
, pp. 482-487
-
-
Sonsalla, P.K.1
Wong, L.Y.2
Harris, S.L.3
-
194
-
-
77952467640
-
Different roles of radical scavengers-ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
-
Spasojevic I, Stevic Z, Nikolic-Kokic A et al (2010) Different roles of radical scavengers-ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Redox Rep 15:81-86
-
(2010)
Redox Rep
, vol.15
, pp. 81-86
-
-
Spasojevic, I.1
Stevic, Z.2
Nikolic-Kokic, A.3
-
195
-
-
0034747982
-
Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease
-
Spitsin S, Hooper DC, Leist T et al (2001) Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease. Mult Scler 7:313-319
-
(2001)
Mult Scler
, vol.7
, pp. 313-319
-
-
Spitsin, S.1
Hooper, D.C.2
Leist, T.3
-
196
-
-
0037028061
-
Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials
-
Stevens B, Porta S, Haak LL et al (2002) Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron 36:855-868
-
(2002)
Neuron
, vol.36
, pp. 855-868
-
-
Stevens, B.1
Porta, S.2
Haak, L.L.3
-
197
-
-
84955754860
-
Phase-3 clinical trial of the adenosine 2a antagonist preladenant, given as monotherapy, in patients with Parkinson's disease
-
Stocchi F, Rascol O, Hauser R et al (2014) Phase-3 clinical trial of the adenosine 2a antagonist preladenant, given as monotherapy, in patients with Parkinson's disease. Neurology 82:S7.004
-
(2014)
Neurology
, vol.82
, pp. S7.004
-
-
Stocchi, F.1
Rascol, O.2
Hauser, R.3
-
198
-
-
70349331090
-
Adenosine receptors and neurological disease: neuroprotection and neurodegeneration
-
Stone TW, Ceruti S, Abbracchio MP (2009) Adenosine receptors and neurological disease: neuroprotection and neurodegeneration. Handb Exp Pharmacol 193:535-587
-
(2009)
Handb Exp Pharmacol
, vol.193
, pp. 535-587
-
-
Stone, T.W.1
Ceruti, S.2
Abbracchio, M.P.3
-
199
-
-
0025822057
-
The effects of caffeine on ischemic neuronal injury as determined by magnetic resonance imaging and histopathology
-
Sutherland GR, Peeling J, Lesiuk HJ et al (1991) The effects of caffeine on ischemic neuronal injury as determined by magnetic resonance imaging and histopathology. Neuroscience 42:171-182
-
(1991)
Neuroscience
, vol.42
, pp. 171-182
-
-
Sutherland, G.R.1
Peeling, J.2
Lesiuk, H.J.3
-
200
-
-
84908212164
-
Roles of glial cells in neuroinflammation and neurodegeneration
-
Takeuchi H (2013) Roles of glial cells in neuroinflammation and neurodegeneration. Clin Exp Neuroimmunol 4:2-16
-
(2013)
Clin Exp Neuroimmunol
, vol.4
, pp. 2-16
-
-
Takeuchi, H.1
-
201
-
-
10744228352
-
Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: a study in ethnic Chinese
-
Tan EK, Tan C, Fook-Chong SM et al (2003) Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: a study in ethnic Chinese. J Neurol Sci 216:163-167
-
(2003)
J Neurol Sci
, vol.216
, pp. 163-167
-
-
Tan, E.K.1
Tan, C.2
Fook-Chong, S.M.3
-
202
-
-
39049183204
-
Therapeutic value of serum uric acid levels increasing in the treatment of multiple sclerosis
-
Toncev G (2006) Therapeutic value of serum uric acid levels increasing in the treatment of multiple sclerosis. Vojnosanit Pregl 63:879-882
-
(2006)
Vojnosanit Pregl
, vol.63
, pp. 879-882
-
-
Toncev, G.1
-
203
-
-
58149379610
-
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
-
Vargas MR, Johnson DA, Sirkis DW et al (2008) Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J Neurosci 28:13574-13581
-
(2008)
J Neurosci
, vol.28
, pp. 13574-13581
-
-
Vargas, M.R.1
Johnson, D.A.2
Sirkis, D.W.3
-
204
-
-
41349103917
-
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
-
Vitart V, Rudan I, Hayward C et al (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40:437-442
-
(2008)
Nat Genet
, vol.40
, pp. 437-442
-
-
Vitart, V.1
Rudan, I.2
Hayward, C.3
-
205
-
-
0028268303
-
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia
-
Von Lubitz DK, Lin RC, Melman N et al (1994) Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. Eur J Pharmacol 256:161-167
-
(1994)
Eur J Pharmacol
, vol.256
, pp. 161-167
-
-
Von Lubitz, D.K.1
Lin, R.C.2
Melman, N.3
-
206
-
-
0036713048
-
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
-
Watanabe S, Kang DH, Feng L et al (2002) Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 40:355-360
-
(2002)
Hypertension
, vol.40
, pp. 355-360
-
-
Watanabe, S.1
Kang, D.H.2
Feng, L.3
-
207
-
-
34548021226
-
Plasma urate and risk of Parkinson's disease
-
Weisskopf MG, O'Reilly E, Chen H et al (2007) Plasma urate and risk of Parkinson's disease. Am J Epidemiol 166:561-567
-
(2007)
Am J Epidemiol
, vol.166
, pp. 561-567
-
-
Weisskopf, M.G.1
O'Reilly, E.2
Chen, H.3
-
208
-
-
84875535930
-
Caffeine consumption and risk of dyskinesia in CALMPD
-
Wills AM, Eberly S, Tennis M et al (2013) Caffeine consumption and risk of dyskinesia in CALMPD. Mov Disord 28:380-383
-
(2013)
Mov Disord
, vol.28
, pp. 380-383
-
-
Wills, A.M.1
Eberly, S.2
Tennis, M.3
-
209
-
-
77951957859
-
Higher serum uric acid associated with decreased Parkinson's disease prevalence in a large community-based survey
-
Winquist A, Steenland K, Shankar A (2010) Higher serum uric acid associated with decreased Parkinson's disease prevalence in a large community-based survey. Mov Disord 25:932-936
-
(2010)
Mov Disord
, vol.25
, pp. 932-936
-
-
Winquist, A.1
Steenland, K.2
Shankar, A.3
-
210
-
-
80052683178
-
Increased cerebrospinal fluid production as a possible mechanism underlying caffeine's protective effect against Alzheimer's disease
-
Wostyn P, Van Dam D, Audenaert K et al (2011) Increased cerebrospinal fluid production as a possible mechanism underlying caffeine's protective effect against Alzheimer's disease. Int J Alzheimers Dis 2011:617420
-
(2011)
Int J Alzheimers Dis
, vol.2011
, pp. 617420
-
-
Wostyn, P.1
Van Dam, D.2
Audenaert, K.3
-
211
-
-
0026592267
-
Two independent mutational events in the loss of urate oxidase during hominoid evolution
-
Wu XW, Muzny DM, Lee CC et al (1992) Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol 34:78-84
-
(1992)
J Mol Evol
, vol.34
, pp. 78-84
-
-
Wu, X.W.1
Muzny, D.M.2
Lee, C.C.3
-
212
-
-
33845899095
-
Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine- induced dyskinesia in hemiparkinsonian mice
-
Xiao D, Bastia E, Xu YH et al (2006) Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine- induced dyskinesia in hemiparkinsonian mice. J Neurosci 26:13548-13555
-
(2006)
J Neurosci
, vol.26
, pp. 13548-13555
-
-
Xiao, D.1
Bastia, E.2
Xu, Y.H.3
-
213
-
-
14544288232
-
Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease
-
Xu K, Bastia E, Schwarzschild M (2005) Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacol Ther 105:267-310
-
(2005)
Pharmacol Ther
, vol.105
, pp. 267-310
-
-
Xu, K.1
Bastia, E.2
Schwarzschild, M.3
-
214
-
-
84898720683
-
Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology
-
Yadav V, Bever C Jr, Bowen J et al (2014) Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology. Neurology 82:1083-1092
-
(2014)
Neurology
, vol.82
, pp. 1083-1092
-
-
Yadav, V.1
Bever, C.2
Bowen, J.3
-
215
-
-
33947517977
-
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease
-
Yamamoto N, Sawada H, Izumi Y et al (2007) Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease. J Biol Chem 282:4364-4372
-
(2007)
J Biol Chem
, vol.282
, pp. 4364-4372
-
-
Yamamoto, N.1
Sawada, H.2
Izumi, Y.3
-
216
-
-
84866251649
-
Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis
-
Yao SQ, Li ZZ, Huang QY et al (2012) Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis. J Neurochem 123:100-112
-
(2012)
J Neurochem
, vol.123
, pp. 100-112
-
-
Yao, S.Q.1
Li, Z.Z.2
Huang, Q.Y.3
-
217
-
-
4344648152
-
Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma
-
Yeum KJ, Russell RM, Krinsky NI et al (2004) Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys 430:97-103
-
(2004)
Arch Biochem Biophys
, vol.430
, pp. 97-103
-
-
Yeum, K.J.1
Russell, R.M.2
Krinsky, N.I.3
-
218
-
-
0346232735
-
Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo
-
Yu ZF, Bruce-Keller AJ, Goodman Y et al (1998) Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J Neurosci Res 53:613-625
-
(1998)
J Neurosci Res
, vol.53
, pp. 613-625
-
-
Yu, Z.F.1
Bruce-Keller, A.J.2
Goodman, Y.3
-
219
-
-
41849085227
-
Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms
-
Yu L, Shen HY, Coelho JE et al (2008) Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Ann Neurol 63:338-346
-
(2008)
Ann Neurol
, vol.63
, pp. 338-346
-
-
Yu, L.1
Shen, H.Y.2
Coelho, J.E.3
-
220
-
-
80053221873
-
Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice
-
Zeitlin R, Patel S, Burgess S et al (2011) Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice. Brain Res 1417:127-136
-
(2011)
Brain Res
, vol.1417
, pp. 127-136
-
-
Zeitlin, R.1
Patel, S.2
Burgess, S.3
-
221
-
-
84903511459
-
Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity
-
Zhang N, Shu HY, Huang T et al (2014) Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity. PLoS One 9:e100286
-
(2014)
PLoS One
, vol.9
, pp. e100286
-
-
Zhang, N.1
Shu, H.Y.2
Huang, T.3
-
222
-
-
85027954954
-
Serum uric acid level is associated with the prevalence but not with survival of amyotrophic lateral sclerosis in a Chinese population
-
Zheng Z, Guo X, Wei Q et al (2014) Serum uric acid level is associated with the prevalence but not with survival of amyotrophic lateral sclerosis in a Chinese population. Metab Brain Dis 29:771-775
-
(2014)
Metab Brain Dis
, vol.29
, pp. 771-775
-
-
Zheng, Z.1
Guo, X.2
Wei, Q.3
-
223
-
-
84655161553
-
Protective effects of urate against 6-OHDA-induced cell injury in PC12 cells through antioxidant action
-
Zhu TG, Wang XX, Luo WF et al (2012) Protective effects of urate against 6-OHDA-induced cell injury in PC12 cells through antioxidant action. Neurosci Lett 506:175-179
-
(2012)
Neurosci Lett
, vol.506
, pp. 175-179
-
-
Zhu, T.G.1
Wang, X.X.2
Luo, W.F.3
-
224
-
-
79953781989
-
An exploratory study of serum urate levels in patients with amyotrophic lateral sclerosis
-
Zoccolella S, Simone IL, Capozzo R et al (2011) An exploratory study of serum urate levels in patients with amyotrophic lateral sclerosis. J Neurol 258:238-243
-
(2011)
J Neurol
, vol.258
, pp. 238-243
-
-
Zoccolella, S.1
Simone, I.L.2
Capozzo, R.3
|