Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Zhang, Ning ^a   Shu, Hai Yang ^a   Huang, Tingting ^a   Zhang, Qi Lin ^a   Li, Da ^a   Zhang, Guan Qun ^a   Peng, Xiao Yan ^a   Liu, Chun Feng ^a   Luo, Wei Feng ^a   Hu, Li Fang ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA GLUTAMATE CYSTEINE LIGASE CATALYTIC SUBUNIT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; OXIDOPAMINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; URATE; NEUROPROTECTIVE AGENT; URIC ACID;

ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG ACCUMULATION; GENE EXPRESSION; GENE SILENCING; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NEUROPROTECTION; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; ACTIVE TRANSPORT; BIOLOGICAL MODEL; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN TRANSPORT; RNA INTERFERENCE; TOXICITY; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE; CELL LINE, TUMOR; DOPAMINERGIC NEURONS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYDROGEN PEROXIDE; MODELS, BIOLOGICAL; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDOPAMINE; PROTEIN TRANSPORT; PROTEOLYSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UBIQUITINATION; URIC ACID;

EID: 84903511459     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100286     Document Type: Article

References (32)

1. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, et al. (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417: 447-452. (Pubitemid 34563537)
2. Church WH, Ward VL (1994) Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. Brain Res Bull 33: 419-425.
3. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, et al. (2008) Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch Neurol 65: 716-723. (Pubitemid 351831449)
4. Annanmaki T, Pessala-Driver A, Hokkanen L, Murros K (2008) Uric acid associates with cognition in Parkinson's disease. Parkinsonism Relat Disord 14: 576-578.
5. Gong L, Zhang QL, Zhang N, Hua WY, Huang YX, et al. (2012) Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson's disease: linking to Akt/GSK3beta signaling pathway. J Neurochem 123: 876-885.
6. Guerreiro S, Ponceau A, Toulorge D, Martin E, Alvarez-Fischer D, et al. (2009) Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization. J Neurochem 109: 1118-1128.
7. Zhu TG, Wang XX, Luo WF, Zhang QL, Huang TT, et al. (2012) Protective effects of urate against 6-OHDA-induced cell injury in PC12 cells through antioxidant action. Neurosci Lett 506: 175-179.
8. Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, et al. (2007) Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol 66: 75-85. (Pubitemid 46066791)
9. Ansari N, Khodagholi F, Amini M (2011) 2-Ethoxy-4,5-diphenyl-1,3-oxazine- 6-one activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. Eur J Pharmacol 658: 84-90.
10. Jakel RJ, Townsend JA, Kraft AD, Johnson JA (2007) Nrf2-mediated protection against 6-hydroxydopamine. Brain Res 1144: 192-201. (Pubitemid 46440842)
11. Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, et al. (2009) Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci U S A 106: 2933-2938.
12. Crawford GD, Jr., Le WD, Smith RG, Xie WJ, Stefani E, et al. (1992) A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J Neurosci 12: 3392-3398.
13. Mahajan M, Kaur S, Mahajan S, Kant R (2009) Uric acid a better scavenger of free radicals than vitamin C in rheumatoid arthritis. Indian J Clin Biochem 24: 205-207.
14. Stewart D, Killeen E, Naquin R, Alam S, Alam J (2003) Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem 278: 2396-2402. (Pubitemid 36801313)
15. Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, et al. (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8: 379-391. (Pubitemid 36504013)
16. Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, et al. (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24: 7130-7139. (Pubitemid 39014439)
17. Zhang DD (2006) Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38: 769-789.
18. Yu J, Zhao Y, Li B, Sun L, Huo H (2012) 17beta-estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation. J Biochem Mol Toxicol 26: 264-269.
19. Cipriani S, Desjardins CA, Burdett TC, Xu Y, Xu K, et al. (2012) Protection of dopaminergic cells by urate requires its accumulation in astrocytes. J Neurochem 123: 172-181.
20. Spector R, Johanson C (2006) Micronutrient and urate transport in choroid plexus and kidney: implications for drug therapy. Pharm Res 23: 2515-2524. (Pubitemid 44691598)
21. Du Y, Chen CP, Tseng CY, Eisenberg Y, Firestein BL (2007) Astroglia-mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity. Glia 55: 463-472. (Pubitemid 46383176)
22. Gunjima K, Tomiyama R, Takakura K, Yamada T, Hashida K, et al. (2014) 3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway. J Cell Biochem 115: 151-160.
23. Tobon-Velasco JC, Vazquez-Victorio G, Macias-Silva M, Cuevas E, Ali SF, et al. (2012) S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Free Radic Biol Med 53: 1024-1040.
24. Furukawa M, Xiong Y (2005) BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 25: 162-171. (Pubitemid 40039808)
25. Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M (2004) Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24: 10941-10953. (Pubitemid 39603148)
26. Li Y, Paonessa JD, Zhang Y (2012) Mechanism of chemical activation of Nrf2. PLoS One 7: e35122.
27. Aoyama K, Matsumura N, Watabe M, Wang F, Kikuchi-Utsumi K, et al. (2011) Caffeine and uric acid mediate glutathione synthesis for neuroprotection. Neuroscience 181: 206-215.
28. Tobon-Velasco JC, Limon-Pacheco JH, Orozco-Ibarra M, Macias-Silva M, Vazquez-Victorio G, et al. (2013) 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-kappaB factors. Toxicology 304: 109-119.
29. Yeum KJ, Russell RM, Krinsky NI, Aldini G (2004) Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys 430: 97-103. (Pubitemid 39119784)
30. Proctor P (1970) Similar functions of uric acid and ascorbate in man? Nature 228: 868.
31. Sautin YY, Johnson RJ (2008) Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids 27: 608-619. (Pubitemid 351948591)
32. Dimitroula HV, Hatzitolios AI, Karvounis HI (2008) The role of uric acid in stroke: the issue remains unresolved. Neurologist 14: 238-242.