Altered levels of homocysteine and serum natural antioxidants links oxidative damage to Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 33, Issue 4, 2013, Pages 1051-1058

  Cankurtaran, Mustafa ^a   Yesil, Yusuf ^a   Kuyumcu, Mehmet Emin ^a   Oztürk, Zeynel Abidin ^b   Yavuz, Burcu Balam ^a   Halil, Meltem ^a   Ulger, Zekeriya ^a   Cankurtaran, Eylem Sahin ^c   Arioǧul, Servet ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

^c ANKARA ONCOLOGY EDUCATION AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Alzheimer's disease; antioxidant; elderly; homocysteine; oxidative stress; uric acid

Indexed keywords

ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; C REACTIVE PROTEIN; CHOLESTEROL; CREATININE; CYANOCOBALAMIN; FOLIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

AGED; ALBUMIN BLOOD LEVEL; ALZHEIMER DISEASE; ARTICLE; BILIRUBIN BLOOD LEVEL; BODY MASS; COGNITION; CROSS-SECTIONAL STUDY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 84873688769     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-121630     Document Type: Article

References (75)

1. Sato Y, Suzuki I, Nakamura T, Bernier F, Aoshima K, Oda Y (2012) Identification of a newplasma biomarker of Alzheimer disease using metabolomics technology. J Lipid Res 53, 567-576
2. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM (2007) Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 3, 186-191
3. Mudher A, Lovestone S (2002) Alzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci 25, 22-26
4. Christen Y (2000) Oxidative stress and Alzheimer disease. Am J Clin Nutr 71, 621S-629S.
5. Yavuz BB, Yavuz B, Halil M, Cankurtaran M, Ulger Z, Cankurtaran ES, Aytemir K, Ariogul S (2008) Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease. Int Psychogeriatr 20, 815-823
6. Reiter RJ (1995) Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 9, 526-533
7. Sayre LM, Perry G, Atwood CS, SmithMA(2000) The role of metals in neurodegenerative diseases. Cell Mol Biol (Noisyle-grand) 46, 731-741
8. Smith MA, Nunomura A, Zhu X, Takeda A, Perry G (2000) Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxid Redox Signal 2, 413-420
9. Zhu X, Raina AK, Lee HG, Casadesus G, Smith MA, Perry G (2004) Oxidative stress signalling in Alzheimer's disease. Brain Res 1000, 32-39
10. Ewing JF, Haber SN, Maines MD (1992) Normal and heatinduced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: Hyperthermia causes rapid induction of mRNA and protein. J Neurochem 58, 1140-1149
11. Becker BF (1993) Towards the physiological function of uric acid. Free Radic Biol Med 14, 615-631
12. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346, 476-483
13. Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Porcellini E, Licastro F (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 82, 636-643
14. Faraci FM, Lentz SR (2004) Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke 35, 345-347
15. Dwyer BE, Raina AK, Perry G, Smith MA (2004) Homocysteine and Alzheimer's disease: A modifiable risk? Free Radic Biol Med 36, 1471-1475
16. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state" A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198
17. Stähelin HB, MonschAU, SpiegelR(1997) Early diagnosis of dementia via a two-step screening and diagnostic procedure. Int Psychogeriatr 9(SUPPL1), 123-130
18. Rabe-Jabłónska J, BiénkiewiczW(1994) Anxiety disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association: Diagnostic and statistical manual of mental disorders (DMS-IV -options book]. Psychiatr Pol 28, 255-268
19. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944
20. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140, 566-572
21. Cohendy R, Rubenstein LZ, Eledjam JJ (2001) The Mini Nutritional Assessment-Short Form for preoperative nutritional evaluation of elderly patients. Aging (Milano) 13, 293-297
22. Kaiser MJ, Bauer JM, Ramsch C, Uter W, Guigoz Y, Cederholm T, Thomas DR, Anthony P, Charlton KE, Maggio M, Tsai AC, Grathwohl D, Vellas B, Sieber CC, Group M-I (2009) Validation of the mini nutritional assessment short-form (MNA-SF): A practical tool for identification of nutritional status. J Nutr Health Aging 13, 782-788
23. Yesil Y, Kuyumcu ME, Cankurtaran M, Uz B, Kara A, Kilic MK, Halil M, Ulger Z, Yavuz BB, Haznedaroglu IC, Ariogul S (2012) Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD). Arch Gerontol Geriatr 55, 257-260
24. Kivipelto M, Helkala EL, Hanninen T, Laakso MP, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A (2001) Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study. Neurology 56, 1683-1689
25. Kuyumcu ME, Yesil Y, Oztürk ZA, Halil M, Ulger Z, Yavuz BB, Cankurtaran M, Cinar E, Ariogul S (2012) Alzheimer's disease is associated with a low prevalence of hypertension. Dement Geriatr Cogn Disord 33, 6-10
26. Karaman Y (2010) Relationship between blood pressure and Alzheimer's Disease. Akad Geriatri 2, 77-87
27. Migliore L, Petrozzi L, Lucetti C, Gambaccini G, Bernardini S, Scarpato R, Trippi F, Barale R, Frenzilli G, Rodilla V, Bonuccelli U (2002) Oxidative damage and cytogenetic analysis in leukocytes of Parkinson's disease patients. Neurology 58, 1809-1815
28. Markesbery WR, Lovell MA (2006) DNA oxidation in Alzheimer's disease. Antioxid Redox Signal 8, 2039-2045
29. Zhu X, Smith MA, Honda K, Aliev G,Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G (2007) Vascular oxidative stress in Alzheimer disease. J Neurol Sci 257, 240-246
30. Adunsky A, Arinzon Z, Fidelman Z, Krasniansky I, Arad M, Gepstein R (2005) Plasma homocysteine levels and cognitive status in long-Term stay geriatric patients: A cross-sectional study. Arch Gerontol Geriatr 40, 129-138
31. Ho PI, Collins SC, Dhitavat S, Ortiz D, Ashline D, Rogers E, Shea TB (2001) Homocysteine potentiates beta-Amyloid neurotoxicity: Role of oxidative stress. J Neurochem 78, 249-253
32. Streck EL, Vieira PS, Wannmacher CM, Dutra-Filho CS, Wajner M, Wyse AT (2003) In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus. Metab Brain Dis 18, 147-154
33. Fuso A, Nicolia V, Cavallaro RA, Ricceri L, D'Anselmi F, Coluccia P, Calamandrei G, Scarpa S (2008) Bvitamin deprivation induces hyperhomocysteinemia and brain S-Adenosylhomocysteine, depletes brain Sadenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Mol Cell Neurosci 37, 731-746
34. Troen AM, Shea-Budgell M, Shukitt-Hale B, Smith DE, Selhub J, Rosenberg IH (2008) B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A 105, 12474-12479
35. Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H (2002) Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilinmediated generation of amyloid beta-protein. J Biol Chem 277, 12915-12920
36. Zhuo JM, Portugal GS, Kruger WD, Wang H, Gould TJ, Pratico D (2010) Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. Curr Alzheimer Res 7, 140-149
37. Pacheco-Quinto J, Rodriguez de Turco EB, DeRosa S, Howard A, Cruz-Sanchez F, Sambamurti K, Refolo L, Petanceska S, Pappolla MA (2006) Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiol Dis 22, 651-656
38. Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T (2007) Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci 27, 2751-2759
39. Gallucci M, Zanardo A, De Valentin L, Vianello A (2004) Homocysteine in Alzheimer disease and vascular dementia. Arch Gerontol Geriatr SUPPL9, 195-200
40. Genedani S, Rasio G, Cortelli P, Antonelli F, Guidolin D, Galantucci M, Fuxe K, Agnati LF (2004) Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in Alzheimer's disease patients and in Parkinson's disease patients. Neurotox Res 6, 327-332
41. Mizrahi EH, Bowirrat A, Jacobsen DW, Korczyn AD, Traore F, Petot GJ, Lerner AJ, Debanne SM, Adunsky A, Dibello PM, Friedland RP (2004) Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel. J Neurol Sci 227, 109-113
42. Quadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M, Lucca U (2004) Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 80, 114-122
43. Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, Kölsch H, Weller M, Jessen F (2010) Sadenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis 7, 373-378
44. Trojanowski JQ, Vandeerstichele H, Korecka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter WZ,WeinerMW, Jack CR, JagustW, Toga AW, Lee VM, Shaw LM, Initiative AsDN (2010) Update on the biomarker core of the Alzheimer's disease neuroimaging initiative subjects. Alzheimers Dement 6, 230-238
45. Tucker KL, Hannan MT, Qiao N, Jacques PF, Selhub J, Cupples LA, Kiel DP (2005) Low plasma vitamin B12 is associated with lower BMD: The Framingham osteoporosis study. J Bone Miner Res 20, 152-158
46. Haan MN, Miller JW, Aiello AE, Whitmer RA, Jagust WJ, Mungas DM, Allen LH, Green R (2007) Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: Results from the Sacramento Area Latino study on aging. Am J Clin Nutr 85, 511-517
47. Annerbo S, Kivipelto M, Lokk J (2009) A prospective study on the development of Alzheimer's disease with regard to thyroid-stimulating hormone and homocysteine. Dement Geriatr Cogn Disord 28, 275-280
48. Kuszczyk M, Gordon-Krajcer W, Lazarewicz JW (2009) Homocysteine-induced acute excitotoxicity in cerebellar granule cells in vitro is accompanied by PP2A-mediated dephosphorylation of tau. Neurochem Int 55, 174-180
49. HuangT,Yuan G, Zhang Z, Zou Z, LiD(2008) Cardiovascular pathogenesis in hyperhomocysteinemia. Asia Pac J Clin Nutr 17, 8-16
50. Cito A, Porcelli B, Coppola MG, Mangiavacchi P, Cortelazzo A, Terzuoli L (2010) Analysis of serum levels of homocysteine and oxidative stress markers in patients with Alzheimer disease. Biomed Pharmacother, in Press. doi: 10.1016/j.biopha.2010.09.0188
51. Li L, Cao D, Desmond R, Rahman A, Lah JJ, Levey AI, Zamrini E (2008) Cognitive performance and plasma levels of homocysteine, vitamin B12, folate and lipids in patients with Alzheimer disease. Dement Geriatr Cogn Disord 26, 384-390
52. Ariogul S, Cankurtaran M, Dagli N, Khalil M,YavuzB(2005) Vitamin B12, folate, homocysteine and dementia: Are they really related? Arch Gerontol Geriatr 40, 139-146
53. Choi HK, Liu S, Curhan G (2005) Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: The Third National Health and Nutrition Examination Survey. Arthritis Rheum 52, 283-289
54. Gao X, Qi L, Qiao N, Choi HK, Curhan G, Tucker KL, AscherioA(2007) Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women. Hypertension 50, 306-312
55. Gao X, Chen H, Choi HK, Curhan G, Schwarzschild MA, Ascherio A (2008) Diet, urate, and Parkinson's disease risk in men. Am J Epidemiol 167, 831-838
56. Maxwell SR, Thomason H, Sandler D, Leguen C, Baxter MA, Thorpe GH, Jones AF, Barnett AH (1997) Antioxidant status in patients with uncomplicated insulin-dependent and noninsulin-dependent diabetes mellitus. Eur J Clin Invest 27, 484-490
57. Davies KJ, Sevanian A, Muakkassah-Kelly SF, Hochstein P (1986) Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid. Biochem J 235, 747-754
58. Waugh WH (2008) Inhibition of iron-catalyzed oxidations by attainable uric acid and ascorbic acid levels: Therapeutic implications for Alzheimer's disease and late cognitive impairment. Gerontology 54, 238-243
59. Bos MJ,Koudstaal PJ, Hofman A,Witteman JC, BretelerMM (2006) Uric acid is a risk factor for myocardial infarction and stroke: The Rotterdam study. Stroke 37, 1503-1507
60. Fang J, Alderman MH (2000) Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 283, 2404-2410
61. Hayden MR, Tyagi SC (2004) Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutr Metab (Lond) 1, 10
62. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, TuckML(2008) Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular reninangiotensin system. J Hypertens 26, 269-275
63. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, Wamsley A, Sheikh-Hamad D, Lan HY, Feng L, Johnson RJ (2003) Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-Activated protein kinase and cyclooxygenase-2. Hypertension 41, 1287-1293
64. Kang DH, Park SK, Lee IK, Johnson RJ (2005) Uric acidinduced C-reactive protein expression: Implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 16, 3553-3562
65. Rao GN, Corson MA, Berk BC (1991) Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression. J Biol Chem 266, 8604-8608
66. Euser SM, Hofman A, Westendorp RG, Breteler MM (2009) Serum uric acid and cognitive function and dementia. Brain 132, 377-382
67. Polidori MC, Mecocci P (2002) Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimers Dis 4, 517-522
68. Kim TS, Pae CU, Yoon SJ, JangWY, Lee NJ, Kim JJ, Lee SJ, Lee C, Paik IH, LeeCU(2006) Decreased plasma antioxidants in patients with Alzheimer's disease. Int J Geriatr Psychiatry 21, 344-348
69. Ahlskog JE, Uitti RJ, Low PA, Tyce GM, Nickander KK, Petersen RC,Kokmen E (1995) No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease. Mov Disord 10, 566-573
70. Irizarry MC, Raman R, Schwarzschild MA, Becerra LM, Thomas RG, Peterson RC, Ascherio A, Aisen PS (2009) Plasma urate and progression of mild cognitive impairment. Neurodegener Dis 6, 23-28
71. Rinaldi P, Polidori MC, Metastasio A, Mariani E, Mattioli P, Cherubini A, Catani M, Cecchetti R, Senin U, Mecocci P (2003) Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging 24, 915-919
72. Schretlen DJ, Inscore AB, Jinnah HA, Rao V, Gordon B, Pearlson GD (2007) Serum uric acid and cognitive function in community-dwelling older adults. Neuropsychology 21, 136-140
73. Di Giuseppe D, Ulivelli M, Bartalini S, Battistini S, Cerase A, Passero S, Summa D, Frosali S, Priora R, Margaritis A, Di Simplicio P (2010) Regulation of redox forms of plasma thiols by albumin in multiple sclerosis after fasting and methionine loading test. Amino Acids 38, 1461-1471
74. Delimaris I, Georgopoulos S, Kroupis C, Zachari A, Liberi M, Bastounis E, Dionyssiou-Asteriou A (2008) Serum oxidizability, total antioxidant status and albumin serum levels in patients with aneurysmal or arterial occlusive disease. Clin Biochem 41, 706-711
75. Peng F,YangY, Liu J, JiangY, Zhu C, Deng X, Hu X, Chen X, Zhong X (2012) Low antioxidant status of serum uric acid, bilirubin and albumin in patients with neuromyelitis optica Eur J Neurol 19, 277-283