Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors

GLIA

Volumn 18, Issue 2, 1996, Pages 152-180

  Fiebich, Bernd L ^a   Biber, Knut ^a   Lieb, Klaus ^a   Van Calker, Dietrich ^a   Berger, Mathias ^a   Bauer, Joachim ^a   Gebicke Haerter, Peter J ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Alzheimer's disease; CGS21680; Meloxicam; NSAIDs; Prostaglandin

Indexed keywords

ADENOSINE RECEPTOR; ADENYLATE CYCLASE; ANTISENSE OLIGONUCLEOTIDE; CYCLIC AMP; CYCLOOXYGENASE 2; ENZYME INHIBITOR; ISOENZYME; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYME INDUCTION; ENZYMOLOGY; GENETICS; METABOLISM; MICROGLIA; NORTHERN BLOTTING; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RAT; UPREGULATION;

ADENYLATE CYCLASE; ANIMALS; BLOTTING, NORTHERN; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INDUCTION; ENZYME INHIBITORS; ISOENZYMES; MICROGLIA; OLIGONUCLEOTIDES, ANTISENSE; POLYMERASE CHAIN REACTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RECEPTORS, PURINERGIC P1; UP-REGULATION;

EID: 0030268068     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-1136(199610)18:2<152::aid-glia7>3.0.co;2-2     Document Type: Article

References (46)

1. Adams, J., Callaço-Moraes, Y., and De Belleroche, J. (1996) Cyclooxygenase-2 induction in cerebral cortex: An intracellular response to synaptic excitation. J. Neurochem., 66:6-13.
2. Appleby, S.B., Ristimaki, A., Neilson, K., Narko, K., and Hla, T. (1994) Structure of the human cyclooxygenase-2 gene. Biochem. J., 302:723-727.
3. Apte, R.N., Oppenheim, J.J., and Durum, S.K. (1989) Beta-endorphin regulates interleukin 1 production and release by murine bone marrow macrophages. Int. Immunol., 1:465-470.
4. Bauer, J., Strauss, S., Volk, B., and Berger, M. (1991) Interleukin-6-mediated events in Alzheimer's disease pathology. Immunol. Today, 12:422.
5. Bauer, M.K.A., Lieb, K., Schulze-Osthoff, K., Berger, M., Gebicke-Haerter, P.J., Bauer, J., and Fiebich, B.L. (1996) Expression and regulation of cyclooxygenase-2 in rat microglia. Eur. J. Biochem., (submitted).
6. Breder, C.D., Dewitt, D., and Kraig, R.P. (1995) Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol., 355: 296-315.
7. Breitner, J.C.S. (1996) The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu. Rev. Med., 47:401-411.
8. Breitner, J.C.S., Welsh, K.A., Helms, M.J., Gaskell, P.C., Gau, B.A., Roses, A.D., Pericak-Vance, M.A., and Saunders, A.M. (1995) Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. Neurobiol. Aging, 16:523-530.
9. Brown, D.R., Schmidt, B., and Kretzschmar, H.A. (1996) Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature, 380:345-347.
10. Cao, C.Y., Matsumura, K., Yamagata, K., and Watanabe, Y. (1995) Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res., 697:187-196.
11. Crofford, L.J., Wilder, R.L., Ristimaki, A.P., Sano, H., Remmers, E.F., Epps, H.R., and Hla, T. (1994) Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteriods. J. Clin. Invest. 93:1095-1101.
12. Dickson, D.W., Mattiace, L.A., Kure, K., Hutchins, K., Lyman, W.D., and Brosnan, C.F. (1991) Biology of disease: Microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab. Invest., 64:135-156.
13. Dickson, D.W., Lee, S.C., Mattiace, L.A., Yen, S., and Brosnan, C.F. (1993) Microglia in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia, 7:75-83.
14. Feng, L., Sun, W., Xia, Y., Tang, W.W., Chanmugam, P., Soyoola, E., Wilson, C.B., and Hwang, D. (1993) Cloning two isoforms of rat cyclooxygenase: Differential regulation of their expression. Arch. Biochem. Biophys., 307:361-368.
15. 2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells. J. Neurochem., 66:1426-1431
16. 2b receptor signalling is altered by stimulation of bradykinin or interleukin receptors in astroglioma cells. Neurochem Int., 25:99-102.
17. Fredholm, B.B., Abbracchio, M.P., Burnstock, G., Daly, J.W., Harden, K.T., Jacobson, K.A., Leff, P., and Williams, M. (1994) VI. Nomenclature and classification of purinoceptors. Pharmacol Rev., 46:143-156.
18. Gebicke-Haerter, P.J., Bauer, J., Schobert, A., and Northoff, H. (1989) Lipopolysaccharide-free conditions in primary astrocyte cultures allow growth and isolation of microglial cells. J. Neurosci., 9:183-194.
19. 2-receptors are required to stimulate microglia proliferation. Neurochem. Int., 29:37-42.
20. Gebicke-Haerter, P.J., van Calker, D., Nörenberg, W., and Illes, P. (1996b) Molecular mechanisms of microglial activation. Neurochem. Int., 29:1-12.
21. Griffin, W.S.T., Sheng, J.G., Roberts, G.W., and Mrak, R.E., (1995) Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution. J. Neuropathol. Exp. Neurol., 276-281.
22. Giulian, D., Corpuz, M., Richmond, B., and Wendt, E. (1996) Activated microglia are the principal glial source of thromboxane in the central nervous system. Neurochem. Int., 29:65-76.
23. Huell, M., Strauss, S., Volk, B., Berger, M., and Bauer, J. (1995) Interleukin-6 is present in early stages of plaque formation and is restricted to brains of Alzheimer's disease patients. Acta Neuropathol., 89:544-551.
24. Kujubu, D.A. and Herschman, H.R. (1992) Dexamethasone inhibits mitogen induction of theTIS10 prostaglandin synthase/cyclooxygenase gene. J. Biol. Chem., 267:7991-7994.
25. McGeer, P.L., Walker, D.G., Akijama, H., Yasuhara, O., and McGeer, E.G. (1994) Involvement of microglia in Alzheimer's disease. Neuropathol. Appl. Neurobiol., 20:191-192.
26. Meda, L., Cassatella, M.A., Szendrei, G.I., Otvos, L.J., Baron, P., Villalba, M., Ferrari, D., and Rossi, F. (1995) Activation of microglial cells by β-amyloid protein and interferon-gamma. Nature, 374: 647-650.
27. Minghetti, L. and Levi, G. (1995) Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures. J. Neurochem., 65:2690-2698.
28. Minghetti, L., Polazzi, E., Nicolini, A., Créminon, C., and Levi, G. (1996) Interferon-gamma and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells inhibiting cyclooxygenase-2 expression. J. Neurochem., 66:1963-1970.
29. Mrak, R.E., Sheng, J.G., and Griffin, W.S.T. (1995) Glial cytokines in Alzheimer's disease: Review and pathogenic implications. Hum. Pathol., 26:816-823.
30. Myatt, L., Langdon, G., and Brockman, D.E. (1994) Identification and changes in concentrations of prostaglandin H synthase (PGHS) isoforms in rat myometrium at parturition. Prostaglandins, 48:285-296.
31. Noble, S. and Balfour, J.A. (1996) Meloxicam. Drugs, 51:424-430.
32. Musing, R. and Ullrich, V. (1992) Regulation of cyclooxygenase and thromboxane synthase in human monocytes. Eur. J. Biochem., 206:131-136.
33. Nusing, R.M., Klein, T., Pfeilschifter, J., and Ullrich, V. (1996) Effect of cyclic AMP and prostaglandin E2 on the induction of nitric oxide-and prostanoid-forming pathways in cultured rat mesangial cells. Biochem. J., 313:617-623.
34. O'Banion, M.K., Winn, V.D., and Young, D.A. (1992) cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. USA., 89:4888-4892.
35. Pairet, M. and Engelhardt, G. (1996) Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: Possible physiological and therapeutic implications. Fundam. Clin. Pharmacol., 10:1-15.
36. Perry, V.H. and Gordon, S. (1991) Macrophages and the nervous system. Int. Rev. Cytol., 125:203-244.
37. Planas, A.M., Soriano, M.A., Rodriguez-Farré, E., and Ferrer, I. (1995) Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain. Neurosci. Lett., 200:187-190.
38. Probst, A., Brunnschweiler, H., Lautenschläger, C., and Ullrich, J. (1987) A special type of senile plaque, possibly an initial stage. Acta Neuropathol., 74:133-141.
39. Rich, J., Rasmusson, D.X., Folstein, M.F., Carson, K.A., Kawas, C., and Brandt, J. (1995) Nonsteroidal anti-inflammatory drugs in Alzheimer's disease. Neurology, 45:51-55.
40. Rogers, J., Kirby, L.C., Hempelman, S.R., Berry, D.L., McGeer, P.L., Kaszniak, A.W., Zalinski, J., Cofield, M., Mansukhani, L., and Wilson, P. (1993) Clinical trial of indomethacin in Alzheimer's disease. Neurology, 43:1609-1611.
41. Rudolphi, K.A., Schubert, P., Parkinson, F.E., and Fredholm, B.B. (1992) Neuroprotective role of adenosine in cerebral ischemia T.I.P.S., 13:439-445.
42. Salvemini, D., Misko, T.P., Masferrer, J.L., Seibert, K., Currie, M.G., and Needleman, P. (1993) Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. USA, 90:7240-7244.
43. Sirois, J., Levy, L.O., Simmons, D.L., and Richards, J.S. (1993) Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles: Induction in vivo and in vitro. J. Biol. Chem., 268:12199-12206.
44. van Calker, D., Müller, M., and Hamprecht, B. (1979) Adenosine regulates via two different types of receptors the accumulation of cyclic AMP in cultured brain cells. J. Neurochem., 33:999-1005.
45. Verheij, M., Koomen, G.C.M., van Mourik, J.A., and Dewit, L. (1994) Radiation reduces cyclooxygenase activity in cultured human endothelial cells at low doses. Prostaglandins, 48:351-366.
46. Yamagata, K., Andreasson, K.I., Kaufmann, W.E., Barnes, C.A., and Worley, P.F. (1993) Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids. Neuron, 11:371-386.