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Volumn 49, Issue 1, 2014, Pages 28-38

The Role of inflammatory and oxidative stress mechanisms in the pathogenesis of parkinson's disease: Focus on astrocytes

Author keywords

Inflammatory mediators; Oxidative stress; Parkinson's disease

Indexed keywords

GLUTAMIC ACID; PROSTAGLANDIN; PROTEIN S100B; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84894384733     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8483-x     Document Type: Review
Times cited : (266)

References (110)
  • 1
    • 0037110424 scopus 로고    scopus 로고
    • The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis
    • 1:CAS:528:DC%2BD38XmvVCltrs%3D 10.1016/S0022-510X(02)00207-1 12220687
    • Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M, Eisdorfer C (2002) The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci 202:13-23
    • (2002) J Neurol Sci , vol.202 , pp. 13-23
    • Minagar, A.1    Shapshak, P.2    Fujimura, R.3    Ownby, R.4    Heyes, M.5    Eisdorfer, C.6
  • 2
    • 0028012270 scopus 로고
    • Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
    • 1:CAS:528:DyaK2cXhvV2gtbo%3D 8301364
    • Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW (1994) Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14:846-856
    • (1994) J Neurosci , vol.14 , pp. 846-856
    • Balasingam, V.1    Tejada-Berges, T.2    Wright, E.3    Bouckova, R.4    Yong, V.W.5
  • 3
    • 58149181977 scopus 로고    scopus 로고
    • Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • 1:CAS:528:DC%2BD1cXhtlaisrjO 2759089 18981141
    • Hu X, Zhang D, Pang H, Caudle WM, Li Y, Gao H, Liu Y, Qian L, Wilson B, Di Monte DA, Ali SF, Zhang J, Block ML, Hong JS (2008) Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Immunol 181:7194-7204
    • (2008) J Immunol , vol.181 , pp. 7194-7204
    • Hu, X.1    Zhang, D.2    Pang, H.3    Caudle, W.M.4    Li, Y.5    Gao, H.6    Liu, Y.7    Qian, L.8    Wilson, B.9    Di Monte, D.A.10    Ali, S.F.11    Zhang, J.12    Block, M.L.13    Hong, J.S.14
  • 4
    • 47249142027 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease
    • 1:CAS:528:DC%2BD1cXns1ynu7g%3D 10.2174/138161208784480153 18537665
    • Asanuma M, Miyazaki I (2008) Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease. Curr Pharm Des 14:1428-1434
    • (2008) Curr Pharm des , vol.14 , pp. 1428-1434
    • Asanuma, M.1    Miyazaki, I.2
  • 5
    • 34547878297 scopus 로고    scopus 로고
    • Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
    • 1:CAS:528:DC%2BD2sXovFehs7g%3D 10.1038/sj.bjp.0707337 17592514
    • Esposito G, Scuderi C, Savani C, Steardo L Jr, De Filippis D, Cottone P, Iuvone T, Cuomo V, Steardo L (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151:1272-1279
    • (2007) Br J Pharmacol , vol.151 , pp. 1272-1279
    • Esposito, G.1    Scuderi, C.2    Savani, C.3    Steardo, Jr.L.4    De Filippis, D.5    Cottone, P.6    Iuvone, T.7    Cuomo, V.8    Steardo, L.9
  • 7
    • 60349132064 scopus 로고    scopus 로고
    • The role of neuroimmunomodulation in Alzheimer's disease
    • 1:CAS:528:DC%2BD1MXjs1OntLo%3D 10.1111/j.1749-6632.2008.03972.x 19236346
    • Maccioni RB, Rojo LE, Fernandez JA, Kuljis RO (2009) The role of neuroimmunomodulation in Alzheimer's disease. Ann N Y Acad Sci 1153:240-246
    • (2009) Ann N y Acad Sci , vol.1153 , pp. 240-246
    • Maccioni, R.B.1    Rojo, L.E.2    Fernandez, J.A.3    Kuljis, R.O.4
  • 8
    • 84859761962 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease and related disorders: A lesson from genetically manipulated mouse models of alpha-synucleinopathies
    • Sekiyama K, Sugama S, Fujita M, Sekigawa A, Takamatsu Y, Waragai M, Takenouchi T, Hashimoto M (2012) Neuroinflammation in Parkinson's disease and related disorders: a lesson from genetically manipulated mouse models of alpha-synucleinopathies. Parkinson's Dis 2012:271732
    • (2012) Parkinson's Dis , vol.2012 , pp. 271732
    • Sekiyama, K.1    Sugama, S.2    Fujita, M.3    Sekigawa, A.4    Takamatsu, Y.5    Waragai, M.6    Takenouchi, T.7    Hashimoto, M.8
  • 9
    • 77950651813 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
    • Tansey MG, Goldberg MS (2009) Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis
    • (2009) Neurobiol Dis
    • Tansey, M.G.1    Goldberg, M.S.2
  • 10
    • 72549110892 scopus 로고    scopus 로고
    • Potential neuroprotection mechanisms in PD: Focus on dopamine agonist pramipexole
    • 1:CAS:528:DC%2BD1MXhsVCrsLrO 10.1185/03007990903364954 19842998
    • Albrecht S, Buerger E (2009) Potential neuroprotection mechanisms in PD: focus on dopamine agonist pramipexole. Curr Med Res Opin 25:2977-2987
    • (2009) Curr Med Res Opin , vol.25 , pp. 2977-2987
    • Albrecht, S.1    Buerger, E.2
  • 11
    • 0033674667 scopus 로고    scopus 로고
    • R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition
    • 1:CAS:528:DC%2BD3cXotFCrsLc%3D 10.1006/exnr.2000.7517 11085911
    • Klegeris A, McGeer PL (2000) R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition. Exp Neurol 166:458-464
    • (2000) Exp Neurol , vol.166 , pp. 458-464
    • Klegeris, A.1    McGeer, P.L.2
  • 12
    • 49549103772 scopus 로고    scopus 로고
    • PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicity
    • 1:CAS:528:DC%2BD1cXhtVeis7%2FL 10.1016/j.npep.2008.04.003 2569970 18533255
    • Guillot TS, Richardson JR, Wang MZ, Li YJ, Taylor TN, Ciliax BJ, Zachrisson O, Mercer A, Miller GW (2008) PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicity. Neuropeptides 42:423-434
    • (2008) Neuropeptides , vol.42 , pp. 423-434
    • Guillot, T.S.1    Richardson, J.R.2    Wang, M.Z.3    Li, Y.J.4    Taylor, T.N.5    Ciliax, B.J.6    Zachrisson, O.7    Mercer, A.8    Miller, G.W.9
  • 13
    • 57449104707 scopus 로고    scopus 로고
    • Glial cells as players in parkinsonism: The "good", the "bad", and the "mysterious" glia
    • 1:CAS:528:DC%2BD1cXhsFWksbzJ
    • Mena MA, Garcia de Yebenes J (2008) Glial cells as players in parkinsonism: the "good", the "bad", and the "mysterious" glia. Neuroscientist Rev J Bringing Neurobiol Neurol Psychiatry 14:544-560
    • (2008) Neuroscientist Rev J Bringing Neurobiol Neurol Psychiatry , vol.14 , pp. 544-560
    • Mena, M.A.1    Garcia De Yebenes, J.2
  • 14
    • 76349084060 scopus 로고    scopus 로고
    • Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6)
    • 1:CAS:528:DC%2BC3cXhs1Ohu7s%3D 10.1016/j.jep.2009.12.012 20018235
    • Niranjan R, Kamat PK, Nath C, Shukla R (2010) Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). J Ethnopharmacol 127:625-630
    • (2010) J Ethnopharmacol , vol.127 , pp. 625-630
    • Niranjan, R.1    Kamat, P.K.2    Nath, C.3    Shukla, R.4
  • 16
    • 61449224570 scopus 로고    scopus 로고
    • Microglia: Gatekeepers of central nervous system immunology
    • 1:CAS:528:DC%2BD1MXivVarsbw%3D 10.1189/jlb.0608385 19028958
    • Tambuyzer BR, Ponsaerts P, Nouwen EJ (2009) Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol 85:352-370
    • (2009) J Leukoc Biol , vol.85 , pp. 352-370
    • Tambuyzer, B.R.1    Ponsaerts, P.2    Nouwen, E.J.3
  • 17
    • 79959586911 scopus 로고    scopus 로고
    • Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-κB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6
    • 1:CAS:528:DC%2BC3MXmsVymurg%3D 10.1007/s10571-011-9684-3 21461920
    • Niranjan R, Nath C, Shukla R (2011) Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-κB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6. Cell Mol Neurobiol 31:755-764
    • (2011) Cell Mol Neurobiol , vol.31 , pp. 755-764
    • Niranjan, R.1    Nath, C.2    Shukla, R.3
  • 18
    • 34547380204 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and Parkinson's disease: Are microglia pathogenic in either disorder?
    • 1:CAS:528:DC%2BD2sXhtVWqs77L 10.1016/S0074-7742(07)82012-5 17678964
    • Rogers J, Mastroeni D, Leonard B, Joyce J, Grover A (2007) Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int Rev Neurobiol 82:235-246
    • (2007) Int Rev Neurobiol , vol.82 , pp. 235-246
    • Rogers, J.1    Mastroeni, D.2    Leonard, B.3    Joyce, J.4    Grover, A.5
  • 19
    • 46749085399 scopus 로고    scopus 로고
    • Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism
    • 1:CAS:528:DC%2BD1cXosVOgtLk%3D 10.1016/j.neulet.2008.06.040 18582534
    • Brodacki B, Staszewski J, Toczylowska B, Kozlowska E, Drela N, Chalimoniuk M, Stepien A (2008) Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism. Neurosci Lett 441:158-162
    • (2008) Neurosci Lett , vol.441 , pp. 158-162
    • Brodacki, B.1    Staszewski, J.2    Toczylowska, B.3    Kozlowska, E.4    Drela, N.5    Chalimoniuk, M.6    Stepien, A.7
  • 20
    • 34248392684 scopus 로고    scopus 로고
    • Microglial activation and its implications in the brain diseases
    • 1:CAS:528:DC%2BD2sXltFejsro%3D 10.2174/092986707780597961 17504139
    • Dheen ST, Kaur C, Ling EA (2007) Microglial activation and its implications in the brain diseases. Curr Med Chem 14:1189-1197
    • (2007) Curr Med Chem , vol.14 , pp. 1189-1197
    • Dheen, S.T.1    Kaur, C.2    Ling, E.A.3
  • 21
    • 34250673610 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease
    • 10.1016/j.disamonth.2007.02.001 17586326
    • Khandhar SM, Marks WJ (2007) Epidemiology of Parkinson's disease. Dis Mon 53:200-205
    • (2007) Dis Mon , vol.53 , pp. 200-205
    • Khandhar, S.M.1    Marks, W.J.2
  • 23
    • 41549133855 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study
    • 1:CAS:528:DC%2BD1cXktlCkurw%3D 10.1016/j.jocn.2007.02.095 18343119
    • Etminan M, Carleton BC, Samii A (2008) Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study. J Clin Neurosci 15:576-577
    • (2008) J Clin Neurosci , vol.15 , pp. 576-577
    • Etminan, M.1    Carleton, B.C.2    Samii, A.3
  • 25
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
    • 1:CAS:528:DyaK1cXmtFGkt78%3D 9749582
    • Hirsch EC, Hunot S, Damier P, Faucheux B (1998) Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann Neurol 44:S115-S120
    • (1998) Ann Neurol , vol.44
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 26
    • 0036077851 scopus 로고    scopus 로고
    • The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma
    • 1:CAS:528:DC%2BD38XivVensbo%3D 10.1046/j.1471-4159.2002.00799.x 12067227
    • Castano A, Herrera AJ, Cano J, Machado A (2002) The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma. J Neurochem 81:150-157
    • (2002) J Neurochem , vol.81 , pp. 150-157
    • Castano, A.1    Herrera, A.J.2    Cano, J.3    Machado, A.4
  • 27
    • 33845204785 scopus 로고    scopus 로고
    • Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures
    • 1:CAS:528:DC%2BD28Xht12qtLnN 10.1016/j.lfs.2006.09.010 17049947
    • Tian YY, An LJ, Jiang L, Duan YL, Chen J, Jiang B (2006) Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures. Life Sci 80:193-199
    • (2006) Life Sci , vol.80 , pp. 193-199
    • Tian, Y.Y.1    An, L.J.2    Jiang, L.3    Duan, Y.L.4    Chen, J.5    Jiang, B.6
  • 28
    • 64549087544 scopus 로고    scopus 로고
    • Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not
    • 1:CAS:528:DC%2BD1MXkslyhtrc%3D 10.1016/j.ejphar.2009.03.026 19292984
    • Santiago M, Hernandez-Romero MC, Machado A, Cano J (2009) Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not. Eur J Pharmacol 609:58-64
    • (2009) Eur J Pharmacol , vol.609 , pp. 58-64
    • Santiago, M.1    Hernandez-Romero, M.C.2    Machado, A.3    Cano, J.4
  • 29
    • 0031469850 scopus 로고    scopus 로고
    • TNF-alpha expressed in the brain of transgenic mice lowers central tyroxine hydroxylase immunoreactivity and alters grooming behavior
    • 1:CAS:528:DyaK2sXotVyhur4%3D 10.1016/S0304-3940(97)00850-1 9464656
    • Aloe L, Fiore M (1997) TNF-alpha expressed in the brain of transgenic mice lowers central tyroxine hydroxylase immunoreactivity and alters grooming behavior. Neurosci Lett 238:65-68
    • (1997) Neurosci Lett , vol.238 , pp. 65-68
    • Aloe, L.1    Fiore, M.2
  • 30
    • 1942519702 scopus 로고    scopus 로고
    • Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid
    • 1:CAS:528:DC%2BD2cXjsFKktrg%3D 10.1111/j.1471-4159.2004.02359.x 15056291
    • Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparini L, Ongini E (2004) Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. J Neurochem 89:484-493
    • (2004) J Neurochem , vol.89 , pp. 484-493
    • Wenk, G.L.1    McGann-Gramling, K.2    Hauss-Wegrzyniak, B.3    Ronchetti, D.4    Maucci, R.5    Rosi, S.6    Gasparini, L.7    Ongini, E.8
  • 31
    • 4344691112 scopus 로고    scopus 로고
    • Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: A potential, new model of Parkinson's disease
    • 1:CAS:528:DC%2BD3sXksF2rt78%3D 10.2741/1158 12957870
    • Carvey PM, Chang Q, Lipton JW, Ling Z (2003) Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: a potential, new model of Parkinson's disease. Front Biosci 8:s826-s837
    • (2003) Front Biosci , vol.8
    • Carvey, P.M.1    Chang, Q.2    Lipton, J.W.3    Ling, Z.4
  • 32
    • 53749099718 scopus 로고    scopus 로고
    • Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease
    • 1:CAS:528:DC%2BD1cXht1Kns7nJ 10.1016/j.nbd.2008.06.011 18675359
    • Lane EL, Soulet D, Vercammen L, Cenci MA, Brundin P (2008) Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease. Neurobiol Dis 32:220-228
    • (2008) Neurobiol Dis , vol.32 , pp. 220-228
    • Lane, E.L.1    Soulet, D.2    Vercammen, L.3    Cenci, M.A.4    Brundin, P.5
  • 33
    • 0034050672 scopus 로고    scopus 로고
    • MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: Neuroprotective strategies
    • 10991672
    • Grunblatt E, Mandel S, Youdim MB (2000) MPTP and 6-hydroxydopamine- induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies. J Neurol 247(Suppl 2):II95-II102
    • (2000) J Neurol , vol.247 , Issue.SUPPL. 2
    • Grunblatt, E.1    Mandel, S.2    Youdim, M.B.3
  • 34
    • 47049122191 scopus 로고    scopus 로고
    • Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol
    • 10.1016/j.parkreldis.2008.04.012 2547123 18585085
    • Meredith GE, Totterdell S, Potashkin JA, Surmeier DJ (2008) Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol. Parkinsonism Relat Disord 14(Suppl 2):S112-S115
    • (2008) Parkinsonism Relat Disord , vol.14 , Issue.SUPPL. 2
    • Meredith, G.E.1    Totterdell, S.2    Potashkin, J.A.3    Surmeier, D.J.4
  • 35
    • 84755160782 scopus 로고    scopus 로고
    • Ability to delay neuropathological events associated with astrocytic MAO-B increase in a parkinsonian mouse model: Implications for early intervention on disease progression
    • Siddiqui A, Mallajosyula JK, Rane A, Andersen JK Ability to delay neuropathological events associated with astrocytic MAO-B increase in a parkinsonian mouse model: implications for early intervention on disease progression. Neurobiology of disease 40:444-448
    • Neurobiology of Disease , vol.40 , pp. 444-448
    • Siddiqui, A.1    Mallajosyula, J.K.2    Rane, A.3    Andersen, J.K.4
  • 36
    • 0036716889 scopus 로고    scopus 로고
    • MPTP: Insights into parkinsonian neurodegeneration
    • 1:CAS:528:DC%2BD38XmsVCit70%3D 10.1016/S0892-0362(02)00222-2 12200192
    • Speciale SG (2002) MPTP: insights into parkinsonian neurodegeneration. Neurotoxicol Teratol 24:607-620
    • (2002) Neurotoxicol Teratol , vol.24 , pp. 607-620
    • Speciale, S.G.1
  • 37
    • 0032848686 scopus 로고    scopus 로고
    • Multiple antioxidants in the prevention and treatment of Parkinson's disease
    • 1:CAS:528:DyaK1MXmslGitb4%3D 10.1080/07315724.1999.10718878 10511322
    • Prasad KN, Cole WC, Kumar B (1999) Multiple antioxidants in the prevention and treatment of Parkinson's disease. J Am Coll Nutr 18:413-423
    • (1999) J Am Coll Nutr , vol.18 , pp. 413-423
    • Prasad, K.N.1    Cole, W.C.2    Kumar, B.3
  • 39
    • 34347357758 scopus 로고    scopus 로고
    • Inflammation in Parkinson's diseases and other neurodegenerative diseases: Cause and therapeutic implications
    • 1:CAS:528:DC%2BD2sXnsVWqsbs%3D 10.2174/138161207780858429 17584117
    • Wilms H, Zecca L, Rosenstiel P, Sievers J, Deuschl G, Lucius R (2007) Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Curr Pharm Des 13:1925-1928
    • (2007) Curr Pharm des , vol.13 , pp. 1925-1928
    • Wilms, H.1    Zecca, L.2    Rosenstiel, P.3    Sievers, J.4    Deuschl, G.5    Lucius, R.6
  • 42
    • 56449115830 scopus 로고    scopus 로고
    • Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability
    • 1:CAS:528:DC%2BD1cXhsVCms7nK 10.1016/j.nbd.2008.09.010 18930140
    • Pieper HC, Evert BO, Kaut O, Riederer PF, Waha A, Wullner U (2008) Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability. Neurobiol Dis 32:521-527
    • (2008) Neurobiol Dis , vol.32 , pp. 521-527
    • Pieper, H.C.1    Evert, B.O.2    Kaut, O.3    Riederer, P.F.4    Waha, A.5    Wullner, U.6
  • 43
    • 0033117048 scopus 로고    scopus 로고
    • IL-1 beta, IL-2, IL-6 and TNF-alpha production by peripheral blood mononuclear cells from patients with Parkinson's disease
    • 1:CAS:528:DyaK1MXjs1Ortr0%3D 10.1016/S0753-3322(99)80079-1 10349502
    • Bessler H, Djaldetti R, Salman H, Bergman M, Djaldetti M (1999) IL-1 beta, IL-2, IL-6 and TNF-alpha production by peripheral blood mononuclear cells from patients with Parkinson's disease. Biomed Pharmacother 53:141-145
    • (1999) Biomed Pharmacother , vol.53 , pp. 141-145
    • Bessler, H.1    Djaldetti, R.2    Salman, H.3    Bergman, M.4    Djaldetti, M.5
  • 44
    • 0034525420 scopus 로고    scopus 로고
    • Changes in cytokines and neurotrophins in Parkinson's disease
    • Nagatsu T, Mogi M, Ichinose H, Togari A (2000) Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Transm Suppl:277-290
    • (2000) J Neural Transm , Issue.SUPPL. , pp. 277-290
    • Nagatsu, T.1    Mogi, M.2    Ichinose, H.3    Togari, A.4
  • 45
    • 72149100983 scopus 로고    scopus 로고
    • Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice
    • 1:CAS:528:DC%2BD1MXhtlyhtbzM 10.1016/j.brainres.2009.07.030 19631617
    • Bian MJ, Li LM, Yu M, Fei J, Huang F (2009) Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice. Brain Res 1302:256-264
    • (2009) Brain Res , vol.1302 , pp. 256-264
    • Bian, M.J.1    Li, L.M.2    Yu, M.3    Fei, J.4    Huang, F.5
  • 46
    • 69349102568 scopus 로고    scopus 로고
    • Selective types of autophagy in yeast
    • 1:CAS:528:DC%2BD1MXhtV2rs7bM 10.1016/j.bbamcr.2009.02.006 19264099
    • Kraft C, Reggiori F, Peter M (2009) Selective types of autophagy in yeast. Biochim Biophys Acta 1793:1404-1412
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1404-1412
    • Kraft, C.1    Reggiori, F.2    Peter, M.3
  • 48
    • 0642377387 scopus 로고    scopus 로고
    • The interleukin-1 system: An attractive and viable therapeutic target in neurodegenerative disease
    • 1:CAS:528:DC%2BD3sXnvVyjt70%3D 10.2174/1568007033482742 14529361
    • Allan SM, Pinteaux E (2003) The interleukin-1 system: an attractive and viable therapeutic target in neurodegenerative disease. Curr Drug Targets CNS Neurol Disord 2:293-302
    • (2003) Curr Drug Targets CNS Neurol Disord , vol.2 , pp. 293-302
    • Allan, S.M.1    Pinteaux, E.2
  • 49
    • 79954435887 scopus 로고    scopus 로고
    • TNF: A key neuroinflammatory mediator of neurotoxicity and neurodegeneration in models of Parkinson's disease
    • McCoy MK, Ruhn KA, Blesch A, Tansey MG TNF: a key neuroinflammatory mediator of neurotoxicity and neurodegeneration in models of Parkinson's disease. Advances in experimental medicine and biology 691:539-540
    • Advances in Experimental Medicine and Biology , vol.691 , pp. 539-540
    • McCoy, M.K.1    Ruhn, K.A.2    Blesch, A.3    Tansey, M.G.4
  • 50
    • 0043173825 scopus 로고    scopus 로고
    • Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells
    • 1:CAS:528:DC%2BD3sXmt1Gjsrk%3D 10.1002/jnr.10663 12868068
    • Gomez-Santos C, Ferrer I, Santidrian AF, Barrachina M, Gil J, Ambrosio S (2003) Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J Neurosci Res 73:341-350
    • (2003) J Neurosci Res , vol.73 , pp. 341-350
    • Gomez-Santos, C.1    Ferrer, I.2    Santidrian, A.F.3    Barrachina, M.4    Gil, J.5    Ambrosio, S.6
  • 52
    • 38449109568 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: Is there sufficient evidence for mechanism-based interventional therapy?
    • 1:CAS:528:DC%2BD1cXhs1Cht7Y%3D 10.2741/2713 17981581
    • Tansey MG, Frank-Cannon TC, McCoy MK, Lee JK, Martinez TN, McAlpine FE, Ruhn KA, Tran TA (2008) Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy? Front Biosci 13:709-717
    • (2008) Front Biosci , vol.13 , pp. 709-717
    • Tansey, M.G.1    Frank-Cannon, T.C.2    McCoy, M.K.3    Lee, J.K.4    Martinez, T.N.5    McAlpine, F.E.6    Ruhn, K.A.7    Tran, T.A.8
  • 53
    • 0038051266 scopus 로고    scopus 로고
    • The role of glial reaction and inflammation in Parkinson's disease
    • 1:CAS:528:DC%2BD3sXmtVCku7c%3D 10.1111/j.1749-6632.2003.tb07478.x 12846989
    • Hirsch EC, Breidert T, Rousselet E, Hunot S, Hartmann A, Michel PP (2003) The role of glial reaction and inflammation in Parkinson's disease. Ann N Y Acad Sci 991:214-228
    • (2003) Ann N y Acad Sci , vol.991 , pp. 214-228
    • Hirsch, E.C.1    Breidert, T.2    Rousselet, E.3    Hunot, S.4    Hartmann, A.5    Michel, P.P.6
  • 55
    • 26844435700 scopus 로고    scopus 로고
    • Tumour necrosis factor antagonists: Infliximab, adalimumab and etanercept
    • 1:STN:280:DC%2BD2MrmsVWitw%3D%3D 16240851
    • Breedveld FC (2005) Tumour necrosis factor antagonists: infliximab, adalimumab and etanercept. Ned Tijdschr Geneeskd 149:2273-2277
    • (2005) Ned Tijdschr Geneeskd , vol.149 , pp. 2273-2277
    • Breedveld, F.C.1
  • 57
    • 48849100711 scopus 로고    scopus 로고
    • The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury
    • 1:CAS:528:DC%2BD1cXpvFGmtrY%3D 10.1016/j.brainres.2008.06.024 18598679
    • Li B, Guo YS, Sun MM, Dong H, Wu SY, Wu DX, Li CY (2008) The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury. Brain Res 1226:199-208
    • (2008) Brain Res , vol.1226 , pp. 199-208
    • Li, B.1    Guo, Y.S.2    Sun, M.M.3    Dong, H.4    Wu, S.Y.5    Wu, D.X.6    Li, C.Y.7
  • 58
    • 27744462871 scopus 로고    scopus 로고
    • Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease
    • 1:CAS:528:DC%2BD2MXht1Wqt77I 10.1523/JNEUROSCI.3591-05.2005 16267225
    • Liang X, Wang Q, Hand T, Wu L, Breyer RM, Montine TJ, Andreasson K (2005) Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 25:10180-10187
    • (2005) J Neurosci , vol.25 , pp. 10180-10187
    • Liang, X.1    Wang, Q.2    Hand, T.3    Wu, L.4    Breyer, R.M.5    Montine, T.J.6    Andreasson, K.7
  • 62
    • 0037107175 scopus 로고    scopus 로고
    • The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice
    • 1:CAS:528:DC%2BD38Xnt12ksbs%3D 12223557
    • Parish CL, Finkelstein DI, Tripanichkul W, Satoskar AR, Drago J, Horne MK (2002) The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice. J Neurosci 22:8034-8041
    • (2002) J Neurosci , vol.22 , pp. 8034-8041
    • Parish, C.L.1    Finkelstein, D.I.2    Tripanichkul, W.3    Satoskar, A.R.4    Drago, J.5    Horne, M.K.6
  • 63
    • 0032498945 scopus 로고    scopus 로고
    • Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: A postmortem neuropathologic study of 100 cases
    • 1:STN:280:DyaK1c7mvFSgsQ%3D%3D 10.1001/archpsyc.55.3.205 9510214
    • Purohit DP, Perl DP, Haroutunian V, Powchik P, Davidson M, Davis KL (1998) Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases. Arch Gen Psychiatry 55:205-211
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 205-211
    • Purohit, D.P.1    Perl, D.P.2    Haroutunian, V.3    Powchik, P.4    Davidson, M.5    Davis, K.L.6
  • 65
    • 84862762387 scopus 로고    scopus 로고
    • Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: Implications for multiple system atrophy
    • 1:CAS:528:DC%2BC38XovFarsrw%3D 10.1007/s00401-012-0977-5 3377902 22491959
    • Stefanova N, Kaufmann WA, Humpel C, Poewe W, Wenning GK (2012) Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. Acta Neuropathol 124:51-65
    • (2012) Acta Neuropathol , vol.124 , pp. 51-65
    • Stefanova, N.1    Kaufmann, W.A.2    Humpel, C.3    Poewe, W.4    Wenning, G.K.5
  • 66
    • 33947640544 scopus 로고    scopus 로고
    • On the relation of oxidative stress to neuroinflammation: Lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    • 1:CAS:528:DC%2BD28XhtVKntb7E 10.1089/ars.2006.8.2075 17034351
    • Hensley K, Mhatre M, Mou S, Pye QN, Stewart C, West M, Williamson KS (2006) On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Antioxid Redox Signal 8:2075-2087
    • (2006) Antioxid Redox Signal , vol.8 , pp. 2075-2087
    • Hensley, K.1    Mhatre, M.2    Mou, S.3    Pye, Q.N.4    Stewart, C.5    West, M.6    Williamson, K.S.7
  • 67
    • 0036753450 scopus 로고    scopus 로고
    • Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
    • 1:CAS:528:DC%2BD38XotVCiurs%3D 10.1016/S0197-4580(02)00021-0 12392782
    • Klegeris A, McGeer PL (2002) Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiol Aging 23:787-794
    • (2002) Neurobiol Aging , vol.23 , pp. 787-794
    • Klegeris, A.1    McGeer, P.L.2
  • 68
    • 77953953898 scopus 로고    scopus 로고
    • Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
    • 1:CAS:528:DC%2BD1MXht1GkurvF
    • Choi SH, Bosetti F (2009) Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging (Albany NY) 1:234-244
    • (2009) Aging (Albany NY) , vol.1 , pp. 234-244
    • Choi, S.H.1    Bosetti, F.2
  • 69
    • 0030909616 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
    • 1:CAS:528:DyaK2sXisValtb4%3D 9092596
    • Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746-2755
    • (1997) J Neurosci , vol.17 , pp. 2746-2755
    • Nogawa, S.1    Zhang, F.2    Ross, M.E.3    Iadecola, C.4
  • 70
    • 1842714301 scopus 로고    scopus 로고
    • Neuroinflammation, COX-2, and ALS - A dual role?
    • 1:CAS:528:DC%2BD2cXjtVChtrw%3D 10.1016/j.expneurol.2003.12.009 15081582
    • Consilvio C, Vincent AM, Feldman EL (2004) Neuroinflammation, COX-2, and ALS - a dual role? Exp Neurol 187:1-10
    • (2004) Exp Neurol , vol.187 , pp. 1-10
    • Consilvio, C.1    Vincent, A.M.2    Feldman, E.L.3
  • 72
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • 1:CAS:528:DC%2BD2cXotFajt7k%3D 15453089
    • Minghetti L (2004) Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 63:901-910
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 901-910
    • Minghetti, L.1
  • 73
    • 36849012987 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro
    • 1:CAS:528:DC%2BD2sXhsVSmtLfO 10.1007/s00109-007-0233-y 17639288
    • Iuvone T, Esposito G, De Filippis D, Bisogno T, Petrosino S, Scuderi C, Di Marzo V, Steardo L (2007) Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro. J Mol Med 85:1379-1392
    • (2007) J Mol Med , vol.85 , pp. 1379-1392
    • Iuvone, T.1    Esposito, G.2    De Filippis, D.3    Bisogno, T.4    Petrosino, S.5    Scuderi, C.6    Di Marzo, V.7    Steardo, L.8
  • 74
    • 21044442392 scopus 로고    scopus 로고
    • Prostaglandins and cyclooxygenases in glial cells during brain inflammation
    • 1:CAS:528:DC%2BD2MXlsFels7k%3D 10.2174/1568010054022051 16101543
    • Tzeng SF, Hsiao HY, Mak OT (2005) Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allergy 4:335-340
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 335-340
    • Tzeng, S.F.1    Hsiao, H.Y.2    Mak, O.T.3
  • 75
    • 33847101490 scopus 로고    scopus 로고
    • Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • 1:CAS:528:DC%2BD2sXit1Kju74%3D 10.1016/j.brainres.2006.12.054 17275793
    • Yasuda Y, Shinagawa R, Yamada M, Mori T, Tateishi N, Fujita S (2007) Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Res 1138:196-202
    • (2007) Brain Res , vol.1138 , pp. 196-202
    • Yasuda, Y.1    Shinagawa, R.2    Yamada, M.3    Mori, T.4    Tateishi, N.5    Fujita, S.6
  • 76
    • 41149111376 scopus 로고    scopus 로고
    • Liver X receptor beta (LXRbeta): A link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia
    • 1:CAS:528:DC%2BD1cXitl2lsrY%3D 10.1073/pnas.0711599105 18238900
    • Kim HJ, Fan X, Gabbi C, Yakimchuk K, Parini P, Warner M, Gustafsson JA (2008) Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci USA 105:2094-2099
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2094-2099
    • Kim, H.J.1    Fan, X.2    Gabbi, C.3    Yakimchuk, K.4    Parini, P.5    Warner, M.6    Gustafsson, J.A.7
  • 77
    • 62549125971 scopus 로고    scopus 로고
    • Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration
    • 1:CAS:528:DC%2BD1MXjsV2mtbg%3D 10.1016/j.jneuroim.2009.01.016 19201037
    • Sugama S, Takenouchi T, Kitani H, Fujita M, Hashimoto M (2009) Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration. J Neuroimmunol 208:104-114
    • (2009) J Neuroimmunol , vol.208 , pp. 104-114
    • Sugama, S.1    Takenouchi, T.2    Kitani, H.3    Fujita, M.4    Hashimoto, M.5
  • 78
    • 59249099095 scopus 로고    scopus 로고
    • Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice
    • 1:CAS:528:DC%2BD1MXhsFKlu7Y%3D 10.1016/j.yexmp.2008.10.004 19027004
    • Aoki E, Yano R, Yokoyama H, Kato H, Araki T (2009) Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahyropyridine)-induced apoptosis in nigral neurons of mice. Exp Mol Pathol 86:57-64
    • (2009) Exp Mol Pathol , vol.86 , pp. 57-64
    • Aoki, E.1    Yano, R.2    Yokoyama, H.3    Kato, H.4    Araki, T.5
  • 79
    • 66549092773 scopus 로고    scopus 로고
    • Interactions between cortical rhythms and spiking activity of single basal ganglia neurons in the normal and parkinsonian state
    • 10.1093/cercor/bhn171 18842667
    • Gatev P, Wichmann T (2009) Interactions between cortical rhythms and spiking activity of single basal ganglia neurons in the normal and parkinsonian state. Cereb Cortex 19:1330-1344
    • (2009) Cereb Cortex , vol.19 , pp. 1330-1344
    • Gatev, P.1    Wichmann, T.2
  • 81
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • 10.1002/mds.21751 18044695
    • McGeer PL, McGeer EG (2008) Glial reactions in Parkinson's disease. Mov Disord 23:474-483
    • (2008) Mov Disord , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 82
    • 34447328426 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: Microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb
    • 1:CAS:528:DC%2BD2sXotVWlsr0%3D 10.1016/j.exger.2007.04.010 17592750
    • Vroon A, Drukarch B, Bol JG, Cras P, Breve JJ, Allan SM, Relton JK, Hoogland PV, Van Dam AM (2007) Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb. Exp Gerontol 42:762-771
    • (2007) Exp Gerontol , vol.42 , pp. 762-771
    • Vroon, A.1    Drukarch, B.2    Bol, J.G.3    Cras, P.4    Breve, J.J.5    Allan, S.M.6    Relton, J.K.7    Hoogland, P.V.8    Van Dam, A.M.9
  • 83
    • 0023897535 scopus 로고
    • Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain
    • 1:CAS:528:DyaL1cXkvVOltL0%3D 10.1097/00005072-198807000-00006 2898510
    • Schneider JS, Denaro FJ (1988) Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain. J Neuropathol Exp Neurol 47:452-458
    • (1988) J Neuropathol Exp Neurol , vol.47 , pp. 452-458
    • Schneider, J.S.1    Denaro, F.J.2
  • 84
    • 34249085348 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Oxidative stress, environmental impact factors and inflammatory processes
    • 1:CAS:528:DC%2BD1cXlvFGluro%3D 10.1007/s12264-007-0018-x 17592536
    • Yuan H, Zheng JC, Liu P, Zhang SF, Xu JY, Bai LM (2007) Pathogenesis of Parkinson's disease: oxidative stress, environmental impact factors and inflammatory processes. Neurosci Bull 23:125-130
    • (2007) Neurosci Bull , vol.23 , pp. 125-130
    • Yuan, H.1    Zheng, J.C.2    Liu, P.3    Zhang, S.F.4    Xu, J.Y.5    Bai, L.M.6
  • 86
    • 57649155208 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease: A mechanism of pathogenic and therapeutic significance
    • 1:CAS:528:DC%2BD1MXhsVaqtbs%3D 10.1196/annals.1427.023 2745097 19076434
    • Zhou C, Huang Y, Przedborski S (2008) Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 1147:93-104
    • (2008) Ann N y Acad Sci , vol.1147 , pp. 93-104
    • Zhou, C.1    Huang, Y.2    Przedborski, S.3
  • 87
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease
    • 1:CAS:528:DC%2BD3sXjtFGitLs%3D 10.1002/ana.10483 12666096 discussion S36-28
    • Jenner P (2003) Oxidative stress in Parkinson's disease. Ann Neurol 53(Suppl 3):S26-S36, discussion S36-28
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3
    • Jenner, P.1
  • 89
    • 33751416459 scopus 로고    scopus 로고
    • Oxidative stress in human diseases
    • 1:CAS:528:DC%2BD28XhtlahtrzI 10.1016/S0003-4509(06)75334-2 17119468
    • Favier A (2006) Oxidative stress in human diseases. Ann Pharm Fr 64:390-396
    • (2006) Ann Pharm Fr , vol.64 , pp. 390-396
    • Favier, A.1
  • 90
    • 31744436120 scopus 로고    scopus 로고
    • Divergent role of calcium on Abeta- and MPTP-induced cell death in SK-N-SH neuroblastoma
    • 1:CAS:528:DC%2BD28XhtFSgtrc%3D 10.1016/j.lfs.2005.06.036 16212983
    • Lee WS, Tsai WJ, Yeh PH, Wei BL, Chiou WF (2006) Divergent role of calcium on Abeta- and MPTP-induced cell death in SK-N-SH neuroblastoma. Life Sci 78:1268-1275
    • (2006) Life Sci , vol.78 , pp. 1268-1275
    • Lee, W.S.1    Tsai, W.J.2    Yeh, P.H.3    Wei, B.L.4    Chiou, W.F.5
  • 92
    • 33847667547 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease
    • 1:CAS:528:DC%2BD2sXisl2rsbY%3D 10.1016/j.mito.2006.12.002 17300997
    • Fukae J, Mizuno Y, Hattori N (2007) Mitochondrial dysfunction in Parkinson's disease. Mitochondrion 7:58-62
    • (2007) Mitochondrion , vol.7 , pp. 58-62
    • Fukae, J.1    Mizuno, Y.2    Hattori, N.3
  • 93
    • 0038051345 scopus 로고    scopus 로고
    • Mitochondria, oxidative damage, and inflammation in Parkinson's disease
    • 1:CAS:528:DC%2BD3sXmtVCku78%3D 10.1111/j.1749-6632.2003.tb07470.x 12846981
    • Beal MF (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann N Y Acad Sci 991:120-131
    • (2003) Ann N y Acad Sci , vol.991 , pp. 120-131
    • Beal, M.F.1
  • 95
    • 79251543343 scopus 로고    scopus 로고
    • Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice
    • Akundi RS, Huang Z, Eason J, Pandya JD, Zhi L, Cass WA, Sullivan PG, Bueler H Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PloS one 6:e16038
    • PloS One , vol.6
    • Akundi, R.S.1    Huang, Z.2    Eason, J.3    Pandya, J.D.4    Zhi, L.5    Cass, W.A.6    Sullivan, P.G.7    Bueler, H.8
  • 96
    • 33847005101 scopus 로고    scopus 로고
    • Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
    • 1:CAS:528:DC%2BD2sXjt1Grs7w%3D 10.1111/j.1471-4159.2006.04327.x 17254027
    • Hunter RL, Dragicevic N, Seifert K, Choi DY, Liu M, Kim HC, Cass WA, Sullivan PG, Bing G (2007) Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J Neurochem 100:1375-1386
    • (2007) J Neurochem , vol.100 , pp. 1375-1386
    • Hunter, R.L.1    Dragicevic, N.2    Seifert, K.3    Choi, D.Y.4    Liu, M.5    Kim, H.C.6    Cass, W.A.7    Sullivan, P.G.8    Bing, G.9
  • 99
    • 77957943337 scopus 로고    scopus 로고
    • The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6
    • Niranjan R, Nath C, Shukla R The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6. Free radical research 44:1304-1316
    • Free Radical Research , vol.44 , pp. 1304-1316
    • Niranjan, R.1    Nath, C.2    Shukla, R.3
  • 100
    • 77957048035 scopus 로고    scopus 로고
    • Astrocytes and therapeutics for Parkinson's disease
    • 1:CAS:528:DC%2BC3cXht1SqsLnL
    • Rappold PM, Tieu K (2010) Astrocytes and therapeutics for Parkinson's disease. Neurother J Am Soc Exp Neuro Ther 7:413-423
    • (2010) Neurother J Am Soc Exp Neuro Ther , vol.7 , pp. 413-423
    • Rappold, P.M.1    Tieu, K.2
  • 101
    • 79953856393 scopus 로고    scopus 로고
    • Astrocytes in Parkinson's disease and DJ-1
    • 1:CAS:528:DC%2BC3MXls1Oju7o%3D 10.1111/j.1471-4159.2011.07217.x 3076520 21413989
    • Hauser DN, Cookson MR (2011) Astrocytes in Parkinson's disease and DJ-1. J Neurochem 117:357-358
    • (2011) J Neurochem , vol.117 , pp. 357-358
    • Hauser, D.N.1    Cookson, M.R.2
  • 102
    • 84870281028 scopus 로고    scopus 로고
    • The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6
    • Niranjan R, Rajasekar N, Nath C, Shukla R (2012) The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6. Chemico-biological interactions
    • (2012) Chemico-biological Interactions
    • Niranjan, R.1    Rajasekar, N.2    Nath, C.3    Shukla, R.4
  • 103
    • 84863442753 scopus 로고    scopus 로고
    • Astrocyte-derived GDNF is a potent inhibitor of microglial activation
    • 1:CAS:528:DC%2BC38XhtVShtLvM 10.1016/j.nbd.2012.04.014 22579772
    • Rocha SM, Cristovao AC, Campos FL, Fonseca CP, Baltazar G (2012) Astrocyte-derived GDNF is a potent inhibitor of microglial activation. Neurobiol Dis 47:407-415
    • (2012) Neurobiol Dis , vol.47 , pp. 407-415
    • Rocha, S.M.1    Cristovao, A.C.2    Campos, F.L.3    Fonseca, C.P.4    Baltazar, G.5
  • 104
    • 84864672251 scopus 로고    scopus 로고
    • Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6
    • 1:CAS:528:DC%2BC38XhtFant7fF 10.3109/10715762.2012.697626 22656125
    • Niranjan R, Nath C, Shukla R (2012) Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6. Free Radic Res 46:1167-1177
    • (2012) Free Radic Res , vol.46 , pp. 1167-1177
    • Niranjan, R.1    Nath, C.2    Shukla, R.3
  • 105
    • 77957943337 scopus 로고    scopus 로고
    • The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6
    • 1:CAS:528:DC%2BC3cXht1yjsrrF 10.3109/10715762.2010.501080 20815783
    • Niranjan R, Nath C, Shukla R (2010) The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6. Free Radic Res 44:1304-1316
    • (2010) Free Radic Res , vol.44 , pp. 1304-1316
    • Niranjan, R.1    Nath, C.2    Shukla, R.3
  • 107
    • 84863319545 scopus 로고    scopus 로고
    • Neuroinflammation alters voltage-dependent conductance in striatal astrocytes
    • 1:CAS:528:DC%2BC38Xht1GjtLfN 10.1152/jn.01182.2011 22457466
    • Karpuk N, Burkovetskaya M, Kielian T (2012) Neuroinflammation alters voltage-dependent conductance in striatal astrocytes. J Neurophysiol 108:112-123
    • (2012) J Neurophysiol , vol.108 , pp. 112-123
    • Karpuk, N.1    Burkovetskaya, M.2    Kielian, T.3
  • 108
    • 80053576812 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155
    • 10.1002/glia.21233 3241213 22170100
    • Tarassishin L, Loudig O, Bauman A, Shafit-Zagardo B, Suh HS, Lee SC (2011) Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155. Glia 59:1911-1922
    • (2011) Glia , vol.59 , pp. 1911-1922
    • Tarassishin, L.1    Loudig, O.2    Bauman, A.3    Shafit-Zagardo, B.4    Suh, H.S.5    Lee, S.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.