-
1
-
-
0037110424
-
The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis
-
1:CAS:528:DC%2BD38XmvVCltrs%3D 10.1016/S0022-510X(02)00207-1 12220687
-
Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M, Eisdorfer C (2002) The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci 202:13-23
-
(2002)
J Neurol Sci
, vol.202
, pp. 13-23
-
-
Minagar, A.1
Shapshak, P.2
Fujimura, R.3
Ownby, R.4
Heyes, M.5
Eisdorfer, C.6
-
2
-
-
0028012270
-
Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
-
1:CAS:528:DyaK2cXhvV2gtbo%3D 8301364
-
Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW (1994) Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14:846-856
-
(1994)
J Neurosci
, vol.14
, pp. 846-856
-
-
Balasingam, V.1
Tejada-Berges, T.2
Wright, E.3
Bouckova, R.4
Yong, V.W.5
-
3
-
-
58149181977
-
Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
-
1:CAS:528:DC%2BD1cXhtlaisrjO 2759089 18981141
-
Hu X, Zhang D, Pang H, Caudle WM, Li Y, Gao H, Liu Y, Qian L, Wilson B, Di Monte DA, Ali SF, Zhang J, Block ML, Hong JS (2008) Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Immunol 181:7194-7204
-
(2008)
J Immunol
, vol.181
, pp. 7194-7204
-
-
Hu, X.1
Zhang, D.2
Pang, H.3
Caudle, W.M.4
Li, Y.5
Gao, H.6
Liu, Y.7
Qian, L.8
Wilson, B.9
Di Monte, D.A.10
Ali, S.F.11
Zhang, J.12
Block, M.L.13
Hong, J.S.14
-
4
-
-
47249142027
-
Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease
-
1:CAS:528:DC%2BD1cXns1ynu7g%3D 10.2174/138161208784480153 18537665
-
Asanuma M, Miyazaki I (2008) Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease. Curr Pharm Des 14:1428-1434
-
(2008)
Curr Pharm des
, vol.14
, pp. 1428-1434
-
-
Asanuma, M.1
Miyazaki, I.2
-
5
-
-
34547878297
-
Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
-
1:CAS:528:DC%2BD2sXovFehs7g%3D 10.1038/sj.bjp.0707337 17592514
-
Esposito G, Scuderi C, Savani C, Steardo L Jr, De Filippis D, Cottone P, Iuvone T, Cuomo V, Steardo L (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151:1272-1279
-
(2007)
Br J Pharmacol
, vol.151
, pp. 1272-1279
-
-
Esposito, G.1
Scuderi, C.2
Savani, C.3
Steardo, Jr.L.4
De Filippis, D.5
Cottone, P.6
Iuvone, T.7
Cuomo, V.8
Steardo, L.9
-
6
-
-
84866312659
-
Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases
-
Wight RD, Tull CA, Deel MW, Stroope BL, Eubanks AG, Chavis JA, Drew PD, Hensley LL Resveratrol effects on astrocyte function: relevance to neurodegenerative diseases. Biochemical and biophysical research communications 426:112-115
-
Biochemical and Biophysical Research Communications
, vol.426
, pp. 112-115
-
-
Wight, R.D.1
Tull, C.A.2
Deel, M.W.3
Stroope, B.L.4
Eubanks, A.G.5
Chavis, J.A.6
Drew, P.D.7
Hensley, L.L.8
-
7
-
-
60349132064
-
The role of neuroimmunomodulation in Alzheimer's disease
-
1:CAS:528:DC%2BD1MXjs1OntLo%3D 10.1111/j.1749-6632.2008.03972.x 19236346
-
Maccioni RB, Rojo LE, Fernandez JA, Kuljis RO (2009) The role of neuroimmunomodulation in Alzheimer's disease. Ann N Y Acad Sci 1153:240-246
-
(2009)
Ann N y Acad Sci
, vol.1153
, pp. 240-246
-
-
Maccioni, R.B.1
Rojo, L.E.2
Fernandez, J.A.3
Kuljis, R.O.4
-
8
-
-
84859761962
-
Neuroinflammation in Parkinson's disease and related disorders: A lesson from genetically manipulated mouse models of alpha-synucleinopathies
-
Sekiyama K, Sugama S, Fujita M, Sekigawa A, Takamatsu Y, Waragai M, Takenouchi T, Hashimoto M (2012) Neuroinflammation in Parkinson's disease and related disorders: a lesson from genetically manipulated mouse models of alpha-synucleinopathies. Parkinson's Dis 2012:271732
-
(2012)
Parkinson's Dis
, vol.2012
, pp. 271732
-
-
Sekiyama, K.1
Sugama, S.2
Fujita, M.3
Sekigawa, A.4
Takamatsu, Y.5
Waragai, M.6
Takenouchi, T.7
Hashimoto, M.8
-
9
-
-
77950651813
-
Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
-
Tansey MG, Goldberg MS (2009) Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis
-
(2009)
Neurobiol Dis
-
-
Tansey, M.G.1
Goldberg, M.S.2
-
10
-
-
72549110892
-
Potential neuroprotection mechanisms in PD: Focus on dopamine agonist pramipexole
-
1:CAS:528:DC%2BD1MXhsVCrsLrO 10.1185/03007990903364954 19842998
-
Albrecht S, Buerger E (2009) Potential neuroprotection mechanisms in PD: focus on dopamine agonist pramipexole. Curr Med Res Opin 25:2977-2987
-
(2009)
Curr Med Res Opin
, vol.25
, pp. 2977-2987
-
-
Albrecht, S.1
Buerger, E.2
-
11
-
-
0033674667
-
R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition
-
1:CAS:528:DC%2BD3cXotFCrsLc%3D 10.1006/exnr.2000.7517 11085911
-
Klegeris A, McGeer PL (2000) R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition. Exp Neurol 166:458-464
-
(2000)
Exp Neurol
, vol.166
, pp. 458-464
-
-
Klegeris, A.1
McGeer, P.L.2
-
12
-
-
49549103772
-
PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicity
-
1:CAS:528:DC%2BD1cXhtVeis7%2FL 10.1016/j.npep.2008.04.003 2569970 18533255
-
Guillot TS, Richardson JR, Wang MZ, Li YJ, Taylor TN, Ciliax BJ, Zachrisson O, Mercer A, Miller GW (2008) PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicity. Neuropeptides 42:423-434
-
(2008)
Neuropeptides
, vol.42
, pp. 423-434
-
-
Guillot, T.S.1
Richardson, J.R.2
Wang, M.Z.3
Li, Y.J.4
Taylor, T.N.5
Ciliax, B.J.6
Zachrisson, O.7
Mercer, A.8
Miller, G.W.9
-
14
-
-
76349084060
-
Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6)
-
1:CAS:528:DC%2BC3cXhs1Ohu7s%3D 10.1016/j.jep.2009.12.012 20018235
-
Niranjan R, Kamat PK, Nath C, Shukla R (2010) Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). J Ethnopharmacol 127:625-630
-
(2010)
J Ethnopharmacol
, vol.127
, pp. 625-630
-
-
Niranjan, R.1
Kamat, P.K.2
Nath, C.3
Shukla, R.4
-
15
-
-
38549164060
-
Glial dysfunction in parkin null mice: Effects of aging
-
1:CAS:528:DC%2BD1cXhtFejtLg%3D 10.1523/JNEUROSCI.4609-07.2008 18199761
-
Solano RM, Casarejos MJ, Menendez-Cuervo J, Rodriguez-Navarro JA, Garcia de Yebenes J, Mena MA (2008) Glial dysfunction in parkin null mice: effects of aging. J Neurosci 28:598-611
-
(2008)
J Neurosci
, vol.28
, pp. 598-611
-
-
Solano, R.M.1
Casarejos, M.J.2
Menendez-Cuervo, J.3
Rodriguez-Navarro, J.A.4
Garcia De Yebenes, J.5
Mena, M.A.6
-
16
-
-
61449224570
-
Microglia: Gatekeepers of central nervous system immunology
-
1:CAS:528:DC%2BD1MXivVarsbw%3D 10.1189/jlb.0608385 19028958
-
Tambuyzer BR, Ponsaerts P, Nouwen EJ (2009) Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol 85:352-370
-
(2009)
J Leukoc Biol
, vol.85
, pp. 352-370
-
-
Tambuyzer, B.R.1
Ponsaerts, P.2
Nouwen, E.J.3
-
17
-
-
79959586911
-
Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-κB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6
-
1:CAS:528:DC%2BC3MXmsVymurg%3D 10.1007/s10571-011-9684-3 21461920
-
Niranjan R, Nath C, Shukla R (2011) Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-κB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6. Cell Mol Neurobiol 31:755-764
-
(2011)
Cell Mol Neurobiol
, vol.31
, pp. 755-764
-
-
Niranjan, R.1
Nath, C.2
Shukla, R.3
-
18
-
-
34547380204
-
Neuroinflammation in Alzheimer's disease and Parkinson's disease: Are microglia pathogenic in either disorder?
-
1:CAS:528:DC%2BD2sXhtVWqs77L 10.1016/S0074-7742(07)82012-5 17678964
-
Rogers J, Mastroeni D, Leonard B, Joyce J, Grover A (2007) Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int Rev Neurobiol 82:235-246
-
(2007)
Int Rev Neurobiol
, vol.82
, pp. 235-246
-
-
Rogers, J.1
Mastroeni, D.2
Leonard, B.3
Joyce, J.4
Grover, A.5
-
19
-
-
46749085399
-
Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism
-
1:CAS:528:DC%2BD1cXosVOgtLk%3D 10.1016/j.neulet.2008.06.040 18582534
-
Brodacki B, Staszewski J, Toczylowska B, Kozlowska E, Drela N, Chalimoniuk M, Stepien A (2008) Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism. Neurosci Lett 441:158-162
-
(2008)
Neurosci Lett
, vol.441
, pp. 158-162
-
-
Brodacki, B.1
Staszewski, J.2
Toczylowska, B.3
Kozlowska, E.4
Drela, N.5
Chalimoniuk, M.6
Stepien, A.7
-
20
-
-
34248392684
-
Microglial activation and its implications in the brain diseases
-
1:CAS:528:DC%2BD2sXltFejsro%3D 10.2174/092986707780597961 17504139
-
Dheen ST, Kaur C, Ling EA (2007) Microglial activation and its implications in the brain diseases. Curr Med Chem 14:1189-1197
-
(2007)
Curr Med Chem
, vol.14
, pp. 1189-1197
-
-
Dheen, S.T.1
Kaur, C.2
Ling, E.A.3
-
21
-
-
34250673610
-
Epidemiology of Parkinson's disease
-
10.1016/j.disamonth.2007.02.001 17586326
-
Khandhar SM, Marks WJ (2007) Epidemiology of Parkinson's disease. Dis Mon 53:200-205
-
(2007)
Dis Mon
, vol.53
, pp. 200-205
-
-
Khandhar, S.M.1
Marks, W.J.2
-
22
-
-
33746894717
-
Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease
-
10.1002/mds.20856
-
Ton TG, Heckbert SR, Longstreth WT Jr, Rossing MA, Kukull WA, Franklin GM, Swanson PD, Smith-Weller T, Checkoway H (2006) Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease. Mov Disord Off J Mov Disord Soc 21:964-969
-
(2006)
Mov Disord off J Mov Disord Soc
, vol.21
, pp. 964-969
-
-
Ton, T.G.1
Heckbert, S.R.2
Longstreth, Jr.W.T.3
Rossing, M.A.4
Kukull, W.A.5
Franklin, G.M.6
Swanson, P.D.7
Smith-Weller, T.8
Checkoway, H.9
-
23
-
-
41549133855
-
Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study
-
1:CAS:528:DC%2BD1cXktlCkurw%3D 10.1016/j.jocn.2007.02.095 18343119
-
Etminan M, Carleton BC, Samii A (2008) Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study. J Clin Neurosci 15:576-577
-
(2008)
J Clin Neurosci
, vol.15
, pp. 576-577
-
-
Etminan, M.1
Carleton, B.C.2
Samii, A.3
-
24
-
-
41849084193
-
What is the harm-benefit ratio of Cox-2 inhibitors?
-
10.1093/ije/dym296 18263647
-
van Staa TP, Smeeth L, Persson I, Parkinson J, Leufkens HG (2008) What is the harm-benefit ratio of Cox-2 inhibitors? Int J Epidemiol 37:405-413
-
(2008)
Int J Epidemiol
, vol.37
, pp. 405-413
-
-
Van Staa, T.P.1
Smeeth, L.2
Persson, I.3
Parkinson, J.4
Leufkens, H.G.5
-
25
-
-
0031715925
-
Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
-
1:CAS:528:DyaK1cXmtFGkt78%3D 9749582
-
Hirsch EC, Hunot S, Damier P, Faucheux B (1998) Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann Neurol 44:S115-S120
-
(1998)
Ann Neurol
, vol.44
-
-
Hirsch, E.C.1
Hunot, S.2
Damier, P.3
Faucheux, B.4
-
26
-
-
0036077851
-
The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma
-
1:CAS:528:DC%2BD38XivVensbo%3D 10.1046/j.1471-4159.2002.00799.x 12067227
-
Castano A, Herrera AJ, Cano J, Machado A (2002) The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma. J Neurochem 81:150-157
-
(2002)
J Neurochem
, vol.81
, pp. 150-157
-
-
Castano, A.1
Herrera, A.J.2
Cano, J.3
Machado, A.4
-
27
-
-
33845204785
-
Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures
-
1:CAS:528:DC%2BD28Xht12qtLnN 10.1016/j.lfs.2006.09.010 17049947
-
Tian YY, An LJ, Jiang L, Duan YL, Chen J, Jiang B (2006) Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures. Life Sci 80:193-199
-
(2006)
Life Sci
, vol.80
, pp. 193-199
-
-
Tian, Y.Y.1
An, L.J.2
Jiang, L.3
Duan, Y.L.4
Chen, J.5
Jiang, B.6
-
28
-
-
64549087544
-
Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not
-
1:CAS:528:DC%2BD1MXkslyhtrc%3D 10.1016/j.ejphar.2009.03.026 19292984
-
Santiago M, Hernandez-Romero MC, Machado A, Cano J (2009) Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not. Eur J Pharmacol 609:58-64
-
(2009)
Eur J Pharmacol
, vol.609
, pp. 58-64
-
-
Santiago, M.1
Hernandez-Romero, M.C.2
Machado, A.3
Cano, J.4
-
29
-
-
0031469850
-
TNF-alpha expressed in the brain of transgenic mice lowers central tyroxine hydroxylase immunoreactivity and alters grooming behavior
-
1:CAS:528:DyaK2sXotVyhur4%3D 10.1016/S0304-3940(97)00850-1 9464656
-
Aloe L, Fiore M (1997) TNF-alpha expressed in the brain of transgenic mice lowers central tyroxine hydroxylase immunoreactivity and alters grooming behavior. Neurosci Lett 238:65-68
-
(1997)
Neurosci Lett
, vol.238
, pp. 65-68
-
-
Aloe, L.1
Fiore, M.2
-
30
-
-
1942519702
-
Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid
-
1:CAS:528:DC%2BD2cXjsFKktrg%3D 10.1111/j.1471-4159.2004.02359.x 15056291
-
Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparini L, Ongini E (2004) Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. J Neurochem 89:484-493
-
(2004)
J Neurochem
, vol.89
, pp. 484-493
-
-
Wenk, G.L.1
McGann-Gramling, K.2
Hauss-Wegrzyniak, B.3
Ronchetti, D.4
Maucci, R.5
Rosi, S.6
Gasparini, L.7
Ongini, E.8
-
31
-
-
4344691112
-
Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: A potential, new model of Parkinson's disease
-
1:CAS:528:DC%2BD3sXksF2rt78%3D 10.2741/1158 12957870
-
Carvey PM, Chang Q, Lipton JW, Ling Z (2003) Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: a potential, new model of Parkinson's disease. Front Biosci 8:s826-s837
-
(2003)
Front Biosci
, vol.8
-
-
Carvey, P.M.1
Chang, Q.2
Lipton, J.W.3
Ling, Z.4
-
32
-
-
53749099718
-
Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease
-
1:CAS:528:DC%2BD1cXht1Kns7nJ 10.1016/j.nbd.2008.06.011 18675359
-
Lane EL, Soulet D, Vercammen L, Cenci MA, Brundin P (2008) Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease. Neurobiol Dis 32:220-228
-
(2008)
Neurobiol Dis
, vol.32
, pp. 220-228
-
-
Lane, E.L.1
Soulet, D.2
Vercammen, L.3
Cenci, M.A.4
Brundin, P.5
-
33
-
-
0034050672
-
MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: Neuroprotective strategies
-
10991672
-
Grunblatt E, Mandel S, Youdim MB (2000) MPTP and 6-hydroxydopamine- induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies. J Neurol 247(Suppl 2):II95-II102
-
(2000)
J Neurol
, vol.247
, Issue.SUPPL. 2
-
-
Grunblatt, E.1
Mandel, S.2
Youdim, M.B.3
-
34
-
-
47049122191
-
Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol
-
10.1016/j.parkreldis.2008.04.012 2547123 18585085
-
Meredith GE, Totterdell S, Potashkin JA, Surmeier DJ (2008) Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol. Parkinsonism Relat Disord 14(Suppl 2):S112-S115
-
(2008)
Parkinsonism Relat Disord
, vol.14
, Issue.SUPPL. 2
-
-
Meredith, G.E.1
Totterdell, S.2
Potashkin, J.A.3
Surmeier, D.J.4
-
35
-
-
84755160782
-
Ability to delay neuropathological events associated with astrocytic MAO-B increase in a parkinsonian mouse model: Implications for early intervention on disease progression
-
Siddiqui A, Mallajosyula JK, Rane A, Andersen JK Ability to delay neuropathological events associated with astrocytic MAO-B increase in a parkinsonian mouse model: implications for early intervention on disease progression. Neurobiology of disease 40:444-448
-
Neurobiology of Disease
, vol.40
, pp. 444-448
-
-
Siddiqui, A.1
Mallajosyula, J.K.2
Rane, A.3
Andersen, J.K.4
-
36
-
-
0036716889
-
MPTP: Insights into parkinsonian neurodegeneration
-
1:CAS:528:DC%2BD38XmsVCit70%3D 10.1016/S0892-0362(02)00222-2 12200192
-
Speciale SG (2002) MPTP: insights into parkinsonian neurodegeneration. Neurotoxicol Teratol 24:607-620
-
(2002)
Neurotoxicol Teratol
, vol.24
, pp. 607-620
-
-
Speciale, S.G.1
-
37
-
-
0032848686
-
Multiple antioxidants in the prevention and treatment of Parkinson's disease
-
1:CAS:528:DyaK1MXmslGitb4%3D 10.1080/07315724.1999.10718878 10511322
-
Prasad KN, Cole WC, Kumar B (1999) Multiple antioxidants in the prevention and treatment of Parkinson's disease. J Am Coll Nutr 18:413-423
-
(1999)
J Am Coll Nutr
, vol.18
, pp. 413-423
-
-
Prasad, K.N.1
Cole, W.C.2
Kumar, B.3
-
38
-
-
58149234727
-
Neuromodulation in a minipig MPTP model of Parkinson disease
-
10.1080/02688690802448285 19085346
-
Bjarkam CR, Nielsen MS, Glud AN, Rosendal F, Mogensen P, Bender D, Doudet D, Moller A, Sorensen JC (2008) Neuromodulation in a minipig MPTP model of Parkinson disease. Br J Neurosurg 22(Suppl 1):S9-S12
-
(2008)
Br J Neurosurg
, vol.22
, Issue.SUPPL. 1
-
-
Bjarkam, C.R.1
Nielsen, M.S.2
Glud, A.N.3
Rosendal, F.4
Mogensen, P.5
Bender, D.6
Doudet, D.7
Moller, A.8
Sorensen, J.C.9
-
39
-
-
34347357758
-
Inflammation in Parkinson's diseases and other neurodegenerative diseases: Cause and therapeutic implications
-
1:CAS:528:DC%2BD2sXnsVWqsbs%3D 10.2174/138161207780858429 17584117
-
Wilms H, Zecca L, Rosenstiel P, Sievers J, Deuschl G, Lucius R (2007) Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Curr Pharm Des 13:1925-1928
-
(2007)
Curr Pharm des
, vol.13
, pp. 1925-1928
-
-
Wilms, H.1
Zecca, L.2
Rosenstiel, P.3
Sievers, J.4
Deuschl, G.5
Lucius, R.6
-
40
-
-
33847400898
-
The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats
-
1:CAS:528:DC%2BD2sXislKhs7g%3D 10.1016/j.ejphar.2006.12.032 17320073
-
Reksidler AB, Lima MM, Zanata SM, Machado HB, da Cunha C, Andreatini R, Tufik S, Vital MA (2007) The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats. Eur J Pharmacol 560:163-175
-
(2007)
Eur J Pharmacol
, vol.560
, pp. 163-175
-
-
Reksidler, A.B.1
Lima, M.M.2
Zanata, S.M.3
Machado, H.B.4
Da Cunha, C.5
Andreatini, R.6
Tufik, S.7
Vital, M.A.8
-
41
-
-
79955599480
-
Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism
-
Ros-Bernal F, Hunot S, Herrero MT, Parnadeau S, Corvol JC, Lu L, Alvarez-Fischer D, Carrillo-de Sauvage MA, Saurini F, Coussieu C, Kinugawa K, Prigent A, Hoglinger G, Hamon M, Tronche F, Hirsch EC, Vyas S Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism. Proc Natl Acad Sci USA 108:6632-6637
-
Proc Natl Acad Sci USA
, vol.108
, pp. 6632-6637
-
-
Ros-Bernal, F.1
Hunot, S.2
Herrero, M.T.3
Parnadeau, S.4
Corvol, J.C.5
Lu, L.6
Alvarez-Fischer, D.7
Sauvage Ma, C.8
Saurini, F.9
Coussieu, C.10
Kinugawa, K.11
Prigent, A.12
Hoglinger, G.13
Hamon, M.14
Tronche, F.15
Hirsch, E.C.16
Vyas, S.17
-
42
-
-
56449115830
-
Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability
-
1:CAS:528:DC%2BD1cXhsVCms7nK 10.1016/j.nbd.2008.09.010 18930140
-
Pieper HC, Evert BO, Kaut O, Riederer PF, Waha A, Wullner U (2008) Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability. Neurobiol Dis 32:521-527
-
(2008)
Neurobiol Dis
, vol.32
, pp. 521-527
-
-
Pieper, H.C.1
Evert, B.O.2
Kaut, O.3
Riederer, P.F.4
Waha, A.5
Wullner, U.6
-
43
-
-
0033117048
-
IL-1 beta, IL-2, IL-6 and TNF-alpha production by peripheral blood mononuclear cells from patients with Parkinson's disease
-
1:CAS:528:DyaK1MXjs1Ortr0%3D 10.1016/S0753-3322(99)80079-1 10349502
-
Bessler H, Djaldetti R, Salman H, Bergman M, Djaldetti M (1999) IL-1 beta, IL-2, IL-6 and TNF-alpha production by peripheral blood mononuclear cells from patients with Parkinson's disease. Biomed Pharmacother 53:141-145
-
(1999)
Biomed Pharmacother
, vol.53
, pp. 141-145
-
-
Bessler, H.1
Djaldetti, R.2
Salman, H.3
Bergman, M.4
Djaldetti, M.5
-
44
-
-
0034525420
-
Changes in cytokines and neurotrophins in Parkinson's disease
-
Nagatsu T, Mogi M, Ichinose H, Togari A (2000) Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Transm Suppl:277-290
-
(2000)
J Neural Transm
, Issue.SUPPL.
, pp. 277-290
-
-
Nagatsu, T.1
Mogi, M.2
Ichinose, H.3
Togari, A.4
-
45
-
-
72149100983
-
Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice
-
1:CAS:528:DC%2BD1MXhtlyhtbzM 10.1016/j.brainres.2009.07.030 19631617
-
Bian MJ, Li LM, Yu M, Fei J, Huang F (2009) Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice. Brain Res 1302:256-264
-
(2009)
Brain Res
, vol.1302
, pp. 256-264
-
-
Bian, M.J.1
Li, L.M.2
Yu, M.3
Fei, J.4
Huang, F.5
-
46
-
-
69349102568
-
Selective types of autophagy in yeast
-
1:CAS:528:DC%2BD1MXhtV2rs7bM 10.1016/j.bbamcr.2009.02.006 19264099
-
Kraft C, Reggiori F, Peter M (2009) Selective types of autophagy in yeast. Biochim Biophys Acta 1793:1404-1412
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 1404-1412
-
-
Kraft, C.1
Reggiori, F.2
Peter, M.3
-
47
-
-
67349283932
-
Interleukin-6 serum levels in patients with Parkinson's disease
-
1:CAS:528:DC%2BD1MXhvVCqsLk%3D 10.1007/s11064-009-9921-z 19214748
-
Hofmann KW, Schuh AF, Saute J, Townsend R, Fricke D, Leke R, Souza DO, Portela LV, Chaves ML, Rieder CR (2009) Interleukin-6 serum levels in patients with Parkinson's disease. Neurochem Res 34:1401-1404
-
(2009)
Neurochem Res
, vol.34
, pp. 1401-1404
-
-
Hofmann, K.W.1
Schuh, A.F.2
Saute, J.3
Townsend, R.4
Fricke, D.5
Leke, R.6
Souza, D.O.7
Portela, L.V.8
Chaves, M.L.9
Rieder, C.R.10
-
48
-
-
0642377387
-
The interleukin-1 system: An attractive and viable therapeutic target in neurodegenerative disease
-
1:CAS:528:DC%2BD3sXnvVyjt70%3D 10.2174/1568007033482742 14529361
-
Allan SM, Pinteaux E (2003) The interleukin-1 system: an attractive and viable therapeutic target in neurodegenerative disease. Curr Drug Targets CNS Neurol Disord 2:293-302
-
(2003)
Curr Drug Targets CNS Neurol Disord
, vol.2
, pp. 293-302
-
-
Allan, S.M.1
Pinteaux, E.2
-
50
-
-
0043173825
-
Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells
-
1:CAS:528:DC%2BD3sXmt1Gjsrk%3D 10.1002/jnr.10663 12868068
-
Gomez-Santos C, Ferrer I, Santidrian AF, Barrachina M, Gil J, Ambrosio S (2003) Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J Neurosci Res 73:341-350
-
(2003)
J Neurosci Res
, vol.73
, pp. 341-350
-
-
Gomez-Santos, C.1
Ferrer, I.2
Santidrian, A.F.3
Barrachina, M.4
Gil, J.5
Ambrosio, S.6
-
51
-
-
84863380403
-
Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions
-
1:CAS:528:DC%2BC38XkslCmtrs%3D 10.1523/JNEUROSCI.4628-11.2012
-
Ramirez SH, Hasko J, Skuba A, Fan S, Dykstra H, McCormick R, Reichenbach N, Krizbai I, Mahadevan A, Zhang M, Tuma R, Son YJ, Persidsky Y (2012) Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J Neurosci Off J Soc Neurosci 32:4004-4016
-
(2012)
J Neurosci off J Soc Neurosci
, vol.32
, pp. 4004-4016
-
-
Ramirez, S.H.1
Hasko, J.2
Skuba, A.3
Fan, S.4
Dykstra, H.5
McCormick, R.6
Reichenbach, N.7
Krizbai, I.8
Mahadevan, A.9
Zhang, M.10
Tuma, R.11
Son, Y.J.12
Persidsky, Y.13
-
52
-
-
38449109568
-
Neuroinflammation in Parkinson's disease: Is there sufficient evidence for mechanism-based interventional therapy?
-
1:CAS:528:DC%2BD1cXhs1Cht7Y%3D 10.2741/2713 17981581
-
Tansey MG, Frank-Cannon TC, McCoy MK, Lee JK, Martinez TN, McAlpine FE, Ruhn KA, Tran TA (2008) Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy? Front Biosci 13:709-717
-
(2008)
Front Biosci
, vol.13
, pp. 709-717
-
-
Tansey, M.G.1
Frank-Cannon, T.C.2
McCoy, M.K.3
Lee, J.K.4
Martinez, T.N.5
McAlpine, F.E.6
Ruhn, K.A.7
Tran, T.A.8
-
53
-
-
0038051266
-
The role of glial reaction and inflammation in Parkinson's disease
-
1:CAS:528:DC%2BD3sXmtVCku7c%3D 10.1111/j.1749-6632.2003.tb07478.x 12846989
-
Hirsch EC, Breidert T, Rousselet E, Hunot S, Hartmann A, Michel PP (2003) The role of glial reaction and inflammation in Parkinson's disease. Ann N Y Acad Sci 991:214-228
-
(2003)
Ann N y Acad Sci
, vol.991
, pp. 214-228
-
-
Hirsch, E.C.1
Breidert, T.2
Rousselet, E.3
Hunot, S.4
Hartmann, A.5
Michel, P.P.6
-
54
-
-
77955577063
-
Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes
-
Sriram K, Lin GX, Jefferson AM, Roberts JR, Chapman RS, Chen BT, Soukup JM, Ghio AJ, Antonini JM Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. Arch Toxicol 84:521-540
-
Arch Toxicol
, vol.84
, pp. 521-540
-
-
Sriram, K.1
Lin, G.X.2
Jefferson, A.M.3
Roberts, J.R.4
Chapman, R.S.5
Chen, B.T.6
Soukup, J.M.7
Ghio, A.J.8
Antonini, J.M.9
-
55
-
-
26844435700
-
Tumour necrosis factor antagonists: Infliximab, adalimumab and etanercept
-
1:STN:280:DC%2BD2MrmsVWitw%3D%3D 16240851
-
Breedveld FC (2005) Tumour necrosis factor antagonists: infliximab, adalimumab and etanercept. Ned Tijdschr Geneeskd 149:2273-2277
-
(2005)
Ned Tijdschr Geneeskd
, vol.149
, pp. 2273-2277
-
-
Breedveld, F.C.1
-
56
-
-
58149354213
-
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase
-
1:CAS:528:DC%2BD1cXhsVarurbL 10.1523/JNEUROSCI.3568-08.2008 19005069
-
Cheret C, Gervais A, Lelli A, Colin C, Amar L, Ravassard P, Mallet J, Cumano A, Krause KH, Mallat M (2008) Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci 28:12039-12051
-
(2008)
J Neurosci
, vol.28
, pp. 12039-12051
-
-
Cheret, C.1
Gervais, A.2
Lelli, A.3
Colin, C.4
Amar, L.5
Ravassard, P.6
Mallet, J.7
Cumano, A.8
Krause, K.H.9
Mallat, M.10
-
57
-
-
48849100711
-
The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury
-
1:CAS:528:DC%2BD1cXpvFGmtrY%3D 10.1016/j.brainres.2008.06.024 18598679
-
Li B, Guo YS, Sun MM, Dong H, Wu SY, Wu DX, Li CY (2008) The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury. Brain Res 1226:199-208
-
(2008)
Brain Res
, vol.1226
, pp. 199-208
-
-
Li, B.1
Guo, Y.S.2
Sun, M.M.3
Dong, H.4
Wu, S.Y.5
Wu, D.X.6
Li, C.Y.7
-
58
-
-
27744462871
-
Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease
-
1:CAS:528:DC%2BD2MXht1Wqt77I 10.1523/JNEUROSCI.3591-05.2005 16267225
-
Liang X, Wang Q, Hand T, Wu L, Breyer RM, Montine TJ, Andreasson K (2005) Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 25:10180-10187
-
(2005)
J Neurosci
, vol.25
, pp. 10180-10187
-
-
Liang, X.1
Wang, Q.2
Hand, T.3
Wu, L.4
Breyer, R.M.5
Montine, T.J.6
Andreasson, K.7
-
59
-
-
84864819509
-
Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI
-
10.1136/jnnp-2012-303023 22807559
-
Sethi V, Yousry TA, Muhlert N, Ron M, Golay X, Wheeler-Kingshott C, Miller DH, Chard DT (2012) Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI. J Neurol Neurosurg Psychiatry 83:877-882
-
(2012)
J Neurol Neurosurg Psychiatry
, vol.83
, pp. 877-882
-
-
Sethi, V.1
Yousry, T.A.2
Muhlert, N.3
Ron, M.4
Golay, X.5
Wheeler-Kingshott, C.6
Miller, D.H.7
Chard, D.T.8
-
60
-
-
79951954218
-
Anti-inflammatory actions of a taurine analogue, ethane beta-sultam, in phagocytic cells, in vivo and in vitro
-
Ward RJ, Lallemand F, de Witte P, Crichton RR, Piette J, Tipton K, Hemmings K, Pitard A, Page M, Della Corte L, Taylor D, Dexter D Anti-inflammatory actions of a taurine analogue, ethane beta-sultam, in phagocytic cells, in vivo and in vitro. Biochem Pharmacol 81:743-751
-
Biochem Pharmacol
, vol.81
, pp. 743-751
-
-
Ward, R.J.1
Lallemand, F.2
De Witte, P.3
Crichton, R.R.4
Piette, J.5
Tipton, K.6
Hemmings, K.7
Pitard, A.8
Page, M.9
Della Corte, L.10
Taylor, D.11
Dexter, D.12
-
61
-
-
13444266079
-
IL-1 beta-dependent regulation of C/EBP delta transcriptional activity
-
1:CAS:528:DC%2BD2MXhtVKhtb8%3D 10.1016/j.bbrc.2005.01.002 15694370
-
Svotelis A, Doyon G, Bernatchez G, Desilets A, Rivard N, Asselin C (2005) IL-1 beta-dependent regulation of C/EBP delta transcriptional activity. Biochem Biophys Res Commun 328:461-470
-
(2005)
Biochem Biophys Res Commun
, vol.328
, pp. 461-470
-
-
Svotelis, A.1
Doyon, G.2
Bernatchez, G.3
Desilets, A.4
Rivard, N.5
Asselin, C.6
-
62
-
-
0037107175
-
The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice
-
1:CAS:528:DC%2BD38Xnt12ksbs%3D 12223557
-
Parish CL, Finkelstein DI, Tripanichkul W, Satoskar AR, Drago J, Horne MK (2002) The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice. J Neurosci 22:8034-8041
-
(2002)
J Neurosci
, vol.22
, pp. 8034-8041
-
-
Parish, C.L.1
Finkelstein, D.I.2
Tripanichkul, W.3
Satoskar, A.R.4
Drago, J.5
Horne, M.K.6
-
63
-
-
0032498945
-
Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: A postmortem neuropathologic study of 100 cases
-
1:STN:280:DyaK1c7mvFSgsQ%3D%3D 10.1001/archpsyc.55.3.205 9510214
-
Purohit DP, Perl DP, Haroutunian V, Powchik P, Davidson M, Davis KL (1998) Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases. Arch Gen Psychiatry 55:205-211
-
(1998)
Arch Gen Psychiatry
, vol.55
, pp. 205-211
-
-
Purohit, D.P.1
Perl, D.P.2
Haroutunian, V.3
Powchik, P.4
Davidson, M.5
Davis, K.L.6
-
64
-
-
6444243168
-
Temporal gene expression patterns in G93A/SOD1 mouse
-
1:CAS:528:DC%2BD2cXnvV2qt7s%3D 10.1080/14660820410017091
-
Chen LC, Smith A, Ben Y, Zukic B, Ignacio S, Moore D, Lee N (2004) Temporal gene expression patterns in G93A/SOD1 mouse. Amyotroph Lateral Scler Other Mot Neuron Disord 5:164-171
-
(2004)
Amyotroph Lateral Scler Other Mot Neuron Disord
, vol.5
, pp. 164-171
-
-
Chen, L.C.1
Smith, A.2
Ben, Y.3
Zukic, B.4
Ignacio, S.5
Moore, D.6
Lee, N.7
-
65
-
-
84862762387
-
Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: Implications for multiple system atrophy
-
1:CAS:528:DC%2BC38XovFarsrw%3D 10.1007/s00401-012-0977-5 3377902 22491959
-
Stefanova N, Kaufmann WA, Humpel C, Poewe W, Wenning GK (2012) Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. Acta Neuropathol 124:51-65
-
(2012)
Acta Neuropathol
, vol.124
, pp. 51-65
-
-
Stefanova, N.1
Kaufmann, W.A.2
Humpel, C.3
Poewe, W.4
Wenning, G.K.5
-
66
-
-
33947640544
-
On the relation of oxidative stress to neuroinflammation: Lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
-
1:CAS:528:DC%2BD28XhtVKntb7E 10.1089/ars.2006.8.2075 17034351
-
Hensley K, Mhatre M, Mou S, Pye QN, Stewart C, West M, Williamson KS (2006) On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Antioxid Redox Signal 8:2075-2087
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 2075-2087
-
-
Hensley, K.1
Mhatre, M.2
Mou, S.3
Pye, Q.N.4
Stewart, C.5
West, M.6
Williamson, K.S.7
-
67
-
-
0036753450
-
Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
-
1:CAS:528:DC%2BD38XotVCiurs%3D 10.1016/S0197-4580(02)00021-0 12392782
-
Klegeris A, McGeer PL (2002) Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiol Aging 23:787-794
-
(2002)
Neurobiol Aging
, vol.23
, pp. 787-794
-
-
Klegeris, A.1
McGeer, P.L.2
-
68
-
-
77953953898
-
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
-
1:CAS:528:DC%2BD1MXht1GkurvF
-
Choi SH, Bosetti F (2009) Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging (Albany NY) 1:234-244
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 234-244
-
-
Choi, S.H.1
Bosetti, F.2
-
69
-
-
0030909616
-
Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
-
1:CAS:528:DyaK2sXisValtb4%3D 9092596
-
Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746-2755
-
(1997)
J Neurosci
, vol.17
, pp. 2746-2755
-
-
Nogawa, S.1
Zhang, F.2
Ross, M.E.3
Iadecola, C.4
-
70
-
-
1842714301
-
Neuroinflammation, COX-2, and ALS - A dual role?
-
1:CAS:528:DC%2BD2cXjtVChtrw%3D 10.1016/j.expneurol.2003.12.009 15081582
-
Consilvio C, Vincent AM, Feldman EL (2004) Neuroinflammation, COX-2, and ALS - a dual role? Exp Neurol 187:1-10
-
(2004)
Exp Neurol
, vol.187
, pp. 1-10
-
-
Consilvio, C.1
Vincent, A.M.2
Feldman, E.L.3
-
71
-
-
0038641723
-
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
-
1:CAS:528:DC%2BD3sXjs1yitbc%3D 10.1073/pnas.0837397100 12702778
-
Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S (2003) Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci USA 100:5473-5478
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5473-5478
-
-
Teismann, P.1
Tieu, K.2
Choi, D.K.3
Wu, D.C.4
Naini, A.5
Hunot, S.6
Vila, M.7
Jackson-Lewis, V.8
Przedborski, S.9
-
72
-
-
4444333049
-
Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
-
1:CAS:528:DC%2BD2cXotFajt7k%3D 15453089
-
Minghetti L (2004) Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 63:901-910
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 901-910
-
-
Minghetti, L.1
-
73
-
-
36849012987
-
Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro
-
1:CAS:528:DC%2BD2sXhsVSmtLfO 10.1007/s00109-007-0233-y 17639288
-
Iuvone T, Esposito G, De Filippis D, Bisogno T, Petrosino S, Scuderi C, Di Marzo V, Steardo L (2007) Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro. J Mol Med 85:1379-1392
-
(2007)
J Mol Med
, vol.85
, pp. 1379-1392
-
-
Iuvone, T.1
Esposito, G.2
De Filippis, D.3
Bisogno, T.4
Petrosino, S.5
Scuderi, C.6
Di Marzo, V.7
Steardo, L.8
-
74
-
-
21044442392
-
Prostaglandins and cyclooxygenases in glial cells during brain inflammation
-
1:CAS:528:DC%2BD2MXlsFels7k%3D 10.2174/1568010054022051 16101543
-
Tzeng SF, Hsiao HY, Mak OT (2005) Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allergy 4:335-340
-
(2005)
Curr Drug Targets Inflamm Allergy
, vol.4
, pp. 335-340
-
-
Tzeng, S.F.1
Hsiao, H.Y.2
Mak, O.T.3
-
75
-
-
33847101490
-
Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
1:CAS:528:DC%2BD2sXit1Kju74%3D 10.1016/j.brainres.2006.12.054 17275793
-
Yasuda Y, Shinagawa R, Yamada M, Mori T, Tateishi N, Fujita S (2007) Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Res 1138:196-202
-
(2007)
Brain Res
, vol.1138
, pp. 196-202
-
-
Yasuda, Y.1
Shinagawa, R.2
Yamada, M.3
Mori, T.4
Tateishi, N.5
Fujita, S.6
-
76
-
-
41149111376
-
Liver X receptor beta (LXRbeta): A link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia
-
1:CAS:528:DC%2BD1cXitl2lsrY%3D 10.1073/pnas.0711599105 18238900
-
Kim HJ, Fan X, Gabbi C, Yakimchuk K, Parini P, Warner M, Gustafsson JA (2008) Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci USA 105:2094-2099
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2094-2099
-
-
Kim, H.J.1
Fan, X.2
Gabbi, C.3
Yakimchuk, K.4
Parini, P.5
Warner, M.6
Gustafsson, J.A.7
-
77
-
-
62549125971
-
Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration
-
1:CAS:528:DC%2BD1MXjsV2mtbg%3D 10.1016/j.jneuroim.2009.01.016 19201037
-
Sugama S, Takenouchi T, Kitani H, Fujita M, Hashimoto M (2009) Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration. J Neuroimmunol 208:104-114
-
(2009)
J Neuroimmunol
, vol.208
, pp. 104-114
-
-
Sugama, S.1
Takenouchi, T.2
Kitani, H.3
Fujita, M.4
Hashimoto, M.5
-
78
-
-
59249099095
-
Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice
-
1:CAS:528:DC%2BD1MXhsFKlu7Y%3D 10.1016/j.yexmp.2008.10.004 19027004
-
Aoki E, Yano R, Yokoyama H, Kato H, Araki T (2009) Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahyropyridine)-induced apoptosis in nigral neurons of mice. Exp Mol Pathol 86:57-64
-
(2009)
Exp Mol Pathol
, vol.86
, pp. 57-64
-
-
Aoki, E.1
Yano, R.2
Yokoyama, H.3
Kato, H.4
Araki, T.5
-
79
-
-
66549092773
-
Interactions between cortical rhythms and spiking activity of single basal ganglia neurons in the normal and parkinsonian state
-
10.1093/cercor/bhn171 18842667
-
Gatev P, Wichmann T (2009) Interactions between cortical rhythms and spiking activity of single basal ganglia neurons in the normal and parkinsonian state. Cereb Cortex 19:1330-1344
-
(2009)
Cereb Cortex
, vol.19
, pp. 1330-1344
-
-
Gatev, P.1
Wichmann, T.2
-
81
-
-
47349104402
-
Glial reactions in Parkinson's disease
-
10.1002/mds.21751 18044695
-
McGeer PL, McGeer EG (2008) Glial reactions in Parkinson's disease. Mov Disord 23:474-483
-
(2008)
Mov Disord
, vol.23
, pp. 474-483
-
-
McGeer, P.L.1
McGeer, E.G.2
-
82
-
-
34447328426
-
Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: Microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb
-
1:CAS:528:DC%2BD2sXotVWlsr0%3D 10.1016/j.exger.2007.04.010 17592750
-
Vroon A, Drukarch B, Bol JG, Cras P, Breve JJ, Allan SM, Relton JK, Hoogland PV, Van Dam AM (2007) Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb. Exp Gerontol 42:762-771
-
(2007)
Exp Gerontol
, vol.42
, pp. 762-771
-
-
Vroon, A.1
Drukarch, B.2
Bol, J.G.3
Cras, P.4
Breve, J.J.5
Allan, S.M.6
Relton, J.K.7
Hoogland, P.V.8
Van Dam, A.M.9
-
83
-
-
0023897535
-
Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain
-
1:CAS:528:DyaL1cXkvVOltL0%3D 10.1097/00005072-198807000-00006 2898510
-
Schneider JS, Denaro FJ (1988) Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain. J Neuropathol Exp Neurol 47:452-458
-
(1988)
J Neuropathol Exp Neurol
, vol.47
, pp. 452-458
-
-
Schneider, J.S.1
Denaro, F.J.2
-
84
-
-
34249085348
-
Pathogenesis of Parkinson's disease: Oxidative stress, environmental impact factors and inflammatory processes
-
1:CAS:528:DC%2BD1cXlvFGluro%3D 10.1007/s12264-007-0018-x 17592536
-
Yuan H, Zheng JC, Liu P, Zhang SF, Xu JY, Bai LM (2007) Pathogenesis of Parkinson's disease: oxidative stress, environmental impact factors and inflammatory processes. Neurosci Bull 23:125-130
-
(2007)
Neurosci Bull
, vol.23
, pp. 125-130
-
-
Yuan, H.1
Zheng, J.C.2
Liu, P.3
Zhang, S.F.4
Xu, J.Y.5
Bai, L.M.6
-
85
-
-
69149111021
-
Antioxidants in complex treatment of Parkinson's disease
-
1:STN:280:DC%2BD28njtlSjsg%3D%3D 17069058
-
Katunina EA, Malykhina EA, Kuznetsov NV, Avakian GN, Gusev E, Nerobkova LN, Voronina TA, Barskov IV (2006) Antioxidants in complex treatment of Parkinson's disease. Zh Nevrol Psikhiatr Im S S Korsakova 106:22-28
-
(2006)
Zh Nevrol Psikhiatr im S S Korsakova
, vol.106
, pp. 22-28
-
-
Katunina, E.A.1
Malykhina, E.A.2
Kuznetsov, N.V.3
Avakian, G.N.4
Gusev, E.5
Nerobkova, L.N.6
Voronina, T.A.7
Barskov, I.V.8
-
86
-
-
57649155208
-
Oxidative stress in Parkinson's disease: A mechanism of pathogenic and therapeutic significance
-
1:CAS:528:DC%2BD1MXhsVaqtbs%3D 10.1196/annals.1427.023 2745097 19076434
-
Zhou C, Huang Y, Przedborski S (2008) Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 1147:93-104
-
(2008)
Ann N y Acad Sci
, vol.1147
, pp. 93-104
-
-
Zhou, C.1
Huang, Y.2
Przedborski, S.3
-
87
-
-
0037378026
-
Oxidative stress in Parkinson's disease
-
1:CAS:528:DC%2BD3sXjtFGitLs%3D 10.1002/ana.10483 12666096 discussion S36-28
-
Jenner P (2003) Oxidative stress in Parkinson's disease. Ann Neurol 53(Suppl 3):S26-S36, discussion S36-28
-
(2003)
Ann Neurol
, vol.53
, Issue.SUPPL. 3
-
-
Jenner, P.1
-
88
-
-
33750967645
-
Hypertrophic pachymeningitis in rheumatoid arthritis after adalimumab administration
-
1:CAS:528:DC%2BD28Xhtlemu7%2FM 16981287
-
Ahmed M, Luggen M, Herman JH, Weiss KL, Decourten-Myers G, Quinlan JG, Khanna D (2006) Hypertrophic pachymeningitis in rheumatoid arthritis after adalimumab administration. J Rheumatol 33:2344-2346
-
(2006)
J Rheumatol
, vol.33
, pp. 2344-2346
-
-
Ahmed, M.1
Luggen, M.2
Herman, J.H.3
Weiss, K.L.4
Decourten-Myers, G.5
Quinlan, J.G.6
Khanna, D.7
-
89
-
-
33751416459
-
Oxidative stress in human diseases
-
1:CAS:528:DC%2BD28XhtlahtrzI 10.1016/S0003-4509(06)75334-2 17119468
-
Favier A (2006) Oxidative stress in human diseases. Ann Pharm Fr 64:390-396
-
(2006)
Ann Pharm Fr
, vol.64
, pp. 390-396
-
-
Favier, A.1
-
90
-
-
31744436120
-
Divergent role of calcium on Abeta- and MPTP-induced cell death in SK-N-SH neuroblastoma
-
1:CAS:528:DC%2BD28XhtFSgtrc%3D 10.1016/j.lfs.2005.06.036 16212983
-
Lee WS, Tsai WJ, Yeh PH, Wei BL, Chiou WF (2006) Divergent role of calcium on Abeta- and MPTP-induced cell death in SK-N-SH neuroblastoma. Life Sci 78:1268-1275
-
(2006)
Life Sci
, vol.78
, pp. 1268-1275
-
-
Lee, W.S.1
Tsai, W.J.2
Yeh, P.H.3
Wei, B.L.4
Chiou, W.F.5
-
91
-
-
71049157158
-
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species
-
1:CAS:528:DC%2BD1MXhsFaitbzI 10.1016/j.neuro.2009.07.016 2789857 19660496
-
Ortiz-Ortiz MA, Moran JM, Bravosanpedro JM, Gonzalez-Polo RA, Niso-Santano M, Anantharam V, Kanthasamy AG, Soler G, Fuentes JM (2009) Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species. Neurotoxicology 30:1008-1018
-
(2009)
Neurotoxicology
, vol.30
, pp. 1008-1018
-
-
Ortiz-Ortiz, M.A.1
Moran, J.M.2
Bravosanpedro, J.M.3
Gonzalez-Polo, R.A.4
Niso-Santano, M.5
Anantharam, V.6
Kanthasamy, A.G.7
Soler, G.8
Fuentes, J.M.9
-
92
-
-
33847667547
-
Mitochondrial dysfunction in Parkinson's disease
-
1:CAS:528:DC%2BD2sXisl2rsbY%3D 10.1016/j.mito.2006.12.002 17300997
-
Fukae J, Mizuno Y, Hattori N (2007) Mitochondrial dysfunction in Parkinson's disease. Mitochondrion 7:58-62
-
(2007)
Mitochondrion
, vol.7
, pp. 58-62
-
-
Fukae, J.1
Mizuno, Y.2
Hattori, N.3
-
93
-
-
0038051345
-
Mitochondria, oxidative damage, and inflammation in Parkinson's disease
-
1:CAS:528:DC%2BD3sXmtVCku78%3D 10.1111/j.1749-6632.2003.tb07470.x 12846981
-
Beal MF (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann N Y Acad Sci 991:120-131
-
(2003)
Ann N y Acad Sci
, vol.991
, pp. 120-131
-
-
Beal, M.F.1
-
94
-
-
77149143852
-
Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration
-
Jung BD, Shin EJ, Nguyen XK, Jin CH, Bach JH, Park SJ, Nah SY, Wie MB, Bing G, Kim HC Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration. Neurochem Int 56:229-244
-
Neurochem Int
, vol.56
, pp. 229-244
-
-
Jung, B.D.1
Shin, E.J.2
Nguyen, X.K.3
Ch, J.4
Bach, J.H.5
Park, S.J.6
Nah, S.Y.7
Wie, M.B.8
Bing, G.9
Kim, H.C.10
-
95
-
-
79251543343
-
Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice
-
Akundi RS, Huang Z, Eason J, Pandya JD, Zhi L, Cass WA, Sullivan PG, Bueler H Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PloS one 6:e16038
-
PloS One
, vol.6
-
-
Akundi, R.S.1
Huang, Z.2
Eason, J.3
Pandya, J.D.4
Zhi, L.5
Cass, W.A.6
Sullivan, P.G.7
Bueler, H.8
-
96
-
-
33847005101
-
Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
-
1:CAS:528:DC%2BD2sXjt1Grs7w%3D 10.1111/j.1471-4159.2006.04327.x 17254027
-
Hunter RL, Dragicevic N, Seifert K, Choi DY, Liu M, Kim HC, Cass WA, Sullivan PG, Bing G (2007) Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J Neurochem 100:1375-1386
-
(2007)
J Neurochem
, vol.100
, pp. 1375-1386
-
-
Hunter, R.L.1
Dragicevic, N.2
Seifert, K.3
Choi, D.Y.4
Liu, M.5
Kim, H.C.6
Cass, W.A.7
Sullivan, P.G.8
Bing, G.9
-
97
-
-
84860715199
-
Effects of obovatol on GSH depleted glia-mediated neurotoxicity and oxidative damage
-
Lee M, Kwon BM, Suk K, McGeer E, McGeer PL Effects of obovatol on GSH depleted glia-mediated neurotoxicity and oxidative damage. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology 7:173-186
-
Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology
, vol.7
, pp. 173-186
-
-
Lee, M.1
Kwon, B.M.2
Suk, K.3
McGeer, E.4
McGeer, P.L.5
-
98
-
-
80053634031
-
The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
-
Drouin-Ouellet J, Gibrat C, Bousquet M, Calon F, Kriz J, Cicchetti F The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration. Journal of neuroinflammation 8:137
-
Journal of Neuroinflammation
, vol.8
, pp. 137
-
-
Drouin-Ouellet, J.1
Gibrat, C.2
Bousquet, M.3
Calon, F.4
Kriz, J.5
Cicchetti, F.6
-
99
-
-
77957943337
-
The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6
-
Niranjan R, Nath C, Shukla R The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6. Free radical research 44:1304-1316
-
Free Radical Research
, vol.44
, pp. 1304-1316
-
-
Niranjan, R.1
Nath, C.2
Shukla, R.3
-
100
-
-
77957048035
-
Astrocytes and therapeutics for Parkinson's disease
-
1:CAS:528:DC%2BC3cXht1SqsLnL
-
Rappold PM, Tieu K (2010) Astrocytes and therapeutics for Parkinson's disease. Neurother J Am Soc Exp Neuro Ther 7:413-423
-
(2010)
Neurother J Am Soc Exp Neuro Ther
, vol.7
, pp. 413-423
-
-
Rappold, P.M.1
Tieu, K.2
-
101
-
-
79953856393
-
Astrocytes in Parkinson's disease and DJ-1
-
1:CAS:528:DC%2BC3MXls1Oju7o%3D 10.1111/j.1471-4159.2011.07217.x 3076520 21413989
-
Hauser DN, Cookson MR (2011) Astrocytes in Parkinson's disease and DJ-1. J Neurochem 117:357-358
-
(2011)
J Neurochem
, vol.117
, pp. 357-358
-
-
Hauser, D.N.1
Cookson, M.R.2
-
102
-
-
84870281028
-
The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6
-
Niranjan R, Rajasekar N, Nath C, Shukla R (2012) The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6. Chemico-biological interactions
-
(2012)
Chemico-biological Interactions
-
-
Niranjan, R.1
Rajasekar, N.2
Nath, C.3
Shukla, R.4
-
103
-
-
84863442753
-
Astrocyte-derived GDNF is a potent inhibitor of microglial activation
-
1:CAS:528:DC%2BC38XhtVShtLvM 10.1016/j.nbd.2012.04.014 22579772
-
Rocha SM, Cristovao AC, Campos FL, Fonseca CP, Baltazar G (2012) Astrocyte-derived GDNF is a potent inhibitor of microglial activation. Neurobiol Dis 47:407-415
-
(2012)
Neurobiol Dis
, vol.47
, pp. 407-415
-
-
Rocha, S.M.1
Cristovao, A.C.2
Campos, F.L.3
Fonseca, C.P.4
Baltazar, G.5
-
104
-
-
84864672251
-
Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6
-
1:CAS:528:DC%2BC38XhtFant7fF 10.3109/10715762.2012.697626 22656125
-
Niranjan R, Nath C, Shukla R (2012) Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6. Free Radic Res 46:1167-1177
-
(2012)
Free Radic Res
, vol.46
, pp. 1167-1177
-
-
Niranjan, R.1
Nath, C.2
Shukla, R.3
-
105
-
-
77957943337
-
The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6
-
1:CAS:528:DC%2BC3cXht1yjsrrF 10.3109/10715762.2010.501080 20815783
-
Niranjan R, Nath C, Shukla R (2010) The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6. Free Radic Res 44:1304-1316
-
(2010)
Free Radic Res
, vol.44
, pp. 1304-1316
-
-
Niranjan, R.1
Nath, C.2
Shukla, R.3
-
106
-
-
84860322835
-
Genomic analysis of reactive astrogliosis
-
1:CAS:528:DC%2BC38XmvFehs70%3D 10.1523/JNEUROSCI.6221-11.2012
-
Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA (2012) Genomic analysis of reactive astrogliosis. J Neurosci Off J Soc Neurosci 32:6391-6410
-
(2012)
J Neurosci off J Soc Neurosci
, vol.32
, pp. 6391-6410
-
-
Zamanian, J.L.1
Xu, L.2
Foo, L.C.3
Nouri, N.4
Zhou, L.5
Giffard, R.G.6
Barres, B.A.7
-
107
-
-
84863319545
-
Neuroinflammation alters voltage-dependent conductance in striatal astrocytes
-
1:CAS:528:DC%2BC38Xht1GjtLfN 10.1152/jn.01182.2011 22457466
-
Karpuk N, Burkovetskaya M, Kielian T (2012) Neuroinflammation alters voltage-dependent conductance in striatal astrocytes. J Neurophysiol 108:112-123
-
(2012)
J Neurophysiol
, vol.108
, pp. 112-123
-
-
Karpuk, N.1
Burkovetskaya, M.2
Kielian, T.3
-
108
-
-
80053576812
-
Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155
-
10.1002/glia.21233 3241213 22170100
-
Tarassishin L, Loudig O, Bauman A, Shafit-Zagardo B, Suh HS, Lee SC (2011) Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155. Glia 59:1911-1922
-
(2011)
Glia
, vol.59
, pp. 1911-1922
-
-
Tarassishin, L.1
Loudig, O.2
Bauman, A.3
Shafit-Zagardo, B.4
Suh, H.S.5
Lee, S.C.6
-
109
-
-
84855572413
-
Cobalt(II) beta-ketoaminato complexes as novel inhibitors of neuroinflammation
-
1:CAS:528:DC%2BC38Xks1Gluw%3D%3D 10.1016/j.ejphar.2011.11.038 22173130
-
Madeira JM, Beloukhina N, Boudreau K, Boettcher TA, Gurley L, Walker DG, McNeil WS, Klegeris A (2012) Cobalt(II) beta-ketoaminato complexes as novel inhibitors of neuroinflammation. Eur J Pharmacol 676:81-88
-
(2012)
Eur J Pharmacol
, vol.676
, pp. 81-88
-
-
Madeira, J.M.1
Beloukhina, N.2
Boudreau, K.3
Boettcher, T.A.4
Gurley, L.5
Walker, D.G.6
McNeil, W.S.7
Klegeris, A.8
-
110
-
-
68849097924
-
Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1
-
1:CAS:528:DC%2BD1MXpvFOltrk%3D
-
Waak J, Weber SS, Waldenmaier A, Gorner K, Alunni-Fabbroni M, Schell H, Vogt-Weisenhorn D, Pham TT, Reumers V, Baekelandt V, Wurst W, Kahle PJ (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J Off Publ Fed Am Soc Exp Biol 23:2478-2489
-
(2009)
FASEB J off Publ Fed Am Soc Exp Biol
, vol.23
, pp. 2478-2489
-
-
Waak, J.1
Weber, S.S.2
Waldenmaier, A.3
Gorner, K.4
Alunni-Fabbroni, M.5
Schell, H.6
Vogt-Weisenhorn, D.7
Pham, T.T.8
Reumers, V.9
Baekelandt, V.10
Wurst, W.11
Kahle, P.J.12
|