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Volumn 49, Issue 7, 2010, Pages 1212-1220

Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet

Author keywords

Amyloid; Adenosine receptors; Alzheimer's disease; Caffeine; Cholesterol; Endoplasmic reticulum stress; Free radicals; Oxidative stress; Tau

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; AMYLOID BETA PROTEIN; ANTIOXIDANT; CAFFEINE; CHOLESTEROL; FREE RADICAL; GLUTATHIONE; ISOPROSTANE; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR; TAU PROTEIN;

EID: 77956180469     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.07.007     Document Type: Article
Times cited : (150)

References (69)
  • 2
    • 0024299370 scopus 로고
    • Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
    • Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988, 240:622-630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 3
    • 28244461327 scopus 로고    scopus 로고
    • Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation
    • Levi O., Lutjohann D., Devir A., von B.K., Hartmann T., Michaelson D.M. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. J. Neurochem. 2005, 95:987-997.
    • (2005) J. Neurochem. , vol.95 , pp. 987-997
    • Levi, O.1    Lutjohann, D.2    Devir, A.3    von, B.K.4    Hartmann, T.5    Michaelson, D.M.6
  • 4
    • 0023764870 scopus 로고
    • Familial hypercholesterolemia and apolipoprotein E4
    • Eto M., Watanabe K., Chonan N., Ishii K. Familial hypercholesterolemia and apolipoprotein E4. Atherosclerosis 1988, 72:123-128.
    • (1988) Atherosclerosis , vol.72 , pp. 123-128
    • Eto, M.1    Watanabe, K.2    Chonan, N.3    Ishii, K.4
  • 5
    • 0027477297 scopus 로고
    • Apolipoprotein E polymorphism is associated with plasma cholesterol response in a 7-day hospitalization study for metabolic and dietary control in NIDDM
    • Murakami K., Shimizu M., Yamada N., Ishibashi S., Shimano H., Yazaki Y., Akanuma Y. Apolipoprotein E polymorphism is associated with plasma cholesterol response in a 7-day hospitalization study for metabolic and dietary control in NIDDM. Diab. Care 1993, 16:564-569.
    • (1993) Diab. Care , vol.16 , pp. 564-569
    • Murakami, K.1    Shimizu, M.2    Yamada, N.3    Ishibashi, S.4    Shimano, H.5    Yazaki, Y.6    Akanuma, Y.7
  • 6
    • 67749114631 scopus 로고    scopus 로고
    • Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later
    • Solomon A., Kivipelto M., Wolozin B., Zhou J., Whitmer R.A. Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement. Geriatr. Cognit. Disord. 2009, 28:75-80.
    • (2009) Dement. Geriatr. Cognit. Disord. , vol.28 , pp. 75-80
    • Solomon, A.1    Kivipelto, M.2    Wolozin, B.3    Zhou, J.4    Whitmer, R.A.5
  • 12
    • 75149118997 scopus 로고    scopus 로고
    • Role of oxidative stress in the progression of Alzheimer's disease
    • Sultana R., Butterfield D.A. Role of oxidative stress in the progression of Alzheimer's disease. J. Alzheimers Dis. 2010, 19:341-353.
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 341-353
    • Sultana, R.1    Butterfield, D.A.2
  • 14
    • 67650674085 scopus 로고    scopus 로고
    • Oxidative stress related changes in the brain of hypercholesterolemic rabbits
    • Aytan N., Jung T., Tamturk F., Grune T., Kartal-Ozer N. Oxidative stress related changes in the brain of hypercholesterolemic rabbits. Biofactors 2008, 33:225-236.
    • (2008) Biofactors , vol.33 , pp. 225-236
    • Aytan, N.1    Jung, T.2    Tamturk, F.3    Grune, T.4    Kartal-Ozer, N.5
  • 15
    • 0034302893 scopus 로고    scopus 로고
    • Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases
    • Greco A., Minghetti L., Levi G. Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases. Neurochem. Res. 2000, 25:1357-1364.
    • (2000) Neurochem. Res. , vol.25 , pp. 1357-1364
    • Greco, A.1    Minghetti, L.2    Levi, G.3
  • 16
    • 18844444191 scopus 로고    scopus 로고
    • Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity
    • Woltjer R.L., Nghiem W., Maezawa I., Milatovic D., Vaisar T., Montine K.S., Montine T.J. Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. J. Neurochem. 2005, 93:1047-1056.
    • (2005) J. Neurochem. , vol.93 , pp. 1047-1056
    • Woltjer, R.L.1    Nghiem, W.2    Maezawa, I.3    Milatovic, D.4    Vaisar, T.5    Montine, K.S.6    Montine, T.J.7
  • 19
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • Oyadomari S., Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004, 11:381-389.
    • (2004) Cell Death Differ. , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 20
    • 0028177562 scopus 로고
    • Induction of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
    • Sparks D.L., Scheff S.W., Hunsaker J.C., Liu H., Landers T., Gross D.R. Induction of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp. Neurol. 1994, 126:88-94.
    • (1994) Exp. Neurol. , vol.126 , pp. 88-94
    • Sparks, D.L.1    Scheff, S.W.2    Hunsaker, J.C.3    Liu, H.4    Landers, T.5    Gross, D.R.6
  • 21
    • 33749161414 scopus 로고    scopus 로고
    • Deposition of iron and beta-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets
    • Ghribi O., Golovko M.Y., Larsen B., Schrag M., Murphy E.J. Deposition of iron and beta-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. J. Neurochem. 2006, 99:438-449.
    • (2006) J. Neurochem. , vol.99 , pp. 438-449
    • Ghribi, O.1    Golovko, M.Y.2    Larsen, B.3    Schrag, M.4    Murphy, E.J.5
  • 22
    • 33746299216 scopus 로고    scopus 로고
    • High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus
    • Ghribi O., Larsen B., Schrag M., Herman M.M. High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp. Neurol. 2006, 200:460-467.
    • (2006) Exp. Neurol. , vol.200 , pp. 460-467
    • Ghribi, O.1    Larsen, B.2    Schrag, M.3    Herman, M.M.4
  • 23
    • 56949085688 scopus 로고    scopus 로고
    • Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease
    • Jaya Prasanthi R.P., Schommer E., Thomasson S., Thompson A., Feist G., Ghribi O. Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease. Mech. Ageing Dev. 2008, 129:649-655.
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 649-655
    • Jaya Prasanthi, R.P.1    Schommer, E.2    Thomasson, S.3    Thompson, A.4    Feist, G.5    Ghribi, O.6
  • 24
    • 56349160982 scopus 로고    scopus 로고
    • Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling
    • Sharma S., Prasanthi R.P.J., Schommer E., Feist G., Ghribi O. Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling. Neurobiol. Dis. 2008, 32:426-432.
    • (2008) Neurobiol. Dis. , vol.32 , pp. 426-432
    • Sharma, S.1    Prasanthi, R.P.J.2    Schommer, E.3    Feist, G.4    Ghribi, O.5
  • 30
    • 0000664818 scopus 로고
    • Body size and metabolism
    • Kleiber M. Body size and metabolism. Hilgardia 1932, 6:315-351.
    • (1932) Hilgardia , vol.6 , pp. 315-351
    • Kleiber, M.1
  • 32
    • 34249720541 scopus 로고    scopus 로고
    • Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats
    • Rush J.W., Quadrilatero J., Levy A.S., Ford R.J. Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Exp. Biol. Med. (Maywood. ) 2007, 232:814-822.
    • (2007) Exp. Biol. Med. (Maywood. ) , vol.232 , pp. 814-822
    • Rush, J.W.1    Quadrilatero, J.2    Levy, A.S.3    Ford, R.J.4
  • 34
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
    • McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 2001, 21:1249-1259.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.O.3    Aw, T.Y.4    Holbrook, N.J.5
  • 35
    • 33646166316 scopus 로고    scopus 로고
    • The role of the endoplasmic reticulum in the accumulation of beta-amyloid peptide in Alzheimer's disease
    • Ghribi O. The role of the endoplasmic reticulum in the accumulation of beta-amyloid peptide in Alzheimer's disease. Curr. Mol. Med. 2006, 6:119-133.
    • (2006) Curr. Mol. Med. , vol.6 , pp. 119-133
    • Ghribi, O.1
  • 37
    • 56349145099 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease: a reappraisal
    • Pratico D. Oxidative stress hypothesis in Alzheimer's disease: a reappraisal. Trends Pharmacol. Sci. 2008, 29:609-615.
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 609-615
    • Pratico, D.1
  • 40
    • 39749157595 scopus 로고    scopus 로고
    • Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from mild cognitive impairment
    • Bermejo P., Martin-Aragon S., Benedi J., Susin C., Felici E., Gil P., Ribera J.M., Villar A.M. Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from mild cognitive impairment. Free Radic. Res. 2008, 42:162-170.
    • (2008) Free Radic. Res. , vol.42 , pp. 162-170
    • Bermejo, P.1    Martin-Aragon, S.2    Benedi, J.3    Susin, C.4    Felici, E.5    Gil, P.6    Ribera, J.M.7    Villar, A.M.8
  • 43
    • 0034982557 scopus 로고    scopus 로고
    • Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein
    • Johnson R.J., Xiao G., Shanmugaratnam J., Fine R.E. Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein. Neurobiol. Aging 2001, 22:387-395.
    • (2001) Neurobiol. Aging , vol.22 , pp. 387-395
    • Johnson, R.J.1    Xiao, G.2    Shanmugaratnam, J.3    Fine, R.E.4
  • 45
    • 0035233820 scopus 로고    scopus 로고
    • Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1
    • Yoo B.C., Fountoulakis M., Dierssen M., Lubec G. Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1. J. Neural Transm. Suppl. 2001, 321-334.
    • (2001) J. Neural Transm. Suppl. , pp. 321-334
    • Yoo, B.C.1    Fountoulakis, M.2    Dierssen, M.3    Lubec, G.4
  • 48
    • 0029904160 scopus 로고    scopus 로고
    • Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species
    • Devasagayam T.P., Kamat J.P., Mohan H., Kesavan P.C. Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species. Biochim. Biophys. Acta 1996, 1282:63-70.
    • (1996) Biochim. Biophys. Acta , vol.1282 , pp. 63-70
    • Devasagayam, T.P.1    Kamat, J.P.2    Mohan, H.3    Kesavan, P.C.4
  • 49
    • 0034109403 scopus 로고    scopus 로고
    • Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation
    • Lee C. Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation. Clin. Chim. Acta 2000, 295:141-154.
    • (2000) Clin. Chim. Acta , vol.295 , pp. 141-154
    • Lee, C.1
  • 50
    • 0026033895 scopus 로고
    • Antioxidant behaviour of caffeine: efficient scavenging of hydroxyl radicals
    • Shi X., Dalal N.S., Jain A.C. Antioxidant behaviour of caffeine: efficient scavenging of hydroxyl radicals. Food Chem. Toxicol. 1991, 29:1-6.
    • (1991) Food Chem. Toxicol. , vol.29 , pp. 1-6
    • Shi, X.1    Dalal, N.S.2    Jain, A.C.3
  • 51
    • 0027157066 scopus 로고
    • 2+ release from the intracellular stores of hepatocytes is not mediated by ryanodine receptors
    • 2+ release from the intracellular stores of hepatocytes is not mediated by ryanodine receptors. Biochem. J. 1993, 291:799-801.
    • (1993) Biochem. J. , vol.291 , pp. 799-801
    • McNulty, T.J.1    Taylor, C.W.2
  • 52
    • 0030987603 scopus 로고    scopus 로고
    • Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells
    • Querfurth H.W., Jiang J., Geiger J.D., Selkoe D.J. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. J. Neurochem. 1997, 69:1580-1591.
    • (1997) J. Neurochem. , vol.69 , pp. 1580-1591
    • Querfurth, H.W.1    Jiang, J.2    Geiger, J.D.3    Selkoe, D.J.4
  • 54
    • 33847612208 scopus 로고
    • Adenosine 3β, 5β-phosphate in biological materials. I. Purification and properties of cyclic 3β, 5β-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3β, 5β-phosphate in human urine
    • Butcher R.W., Sutherland E.W. Adenosine 3β, 5β-phosphate in biological materials. I. Purification and properties of cyclic 3β, 5β-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3β, 5β-phosphate in human urine. J. Biol. Chem. 1962, 237:1244-1250.
    • (1962) J. Biol. Chem. , vol.237 , pp. 1244-1250
    • Butcher, R.W.1    Sutherland, E.W.2
  • 55
    • 0024365888 scopus 로고
    • Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment
    • Rudolphi K.A., Keil M., Fastbom J., Fredholm B.B. Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment. Neurosci. Lett. 1989, 103:275-280.
    • (1989) Neurosci. Lett. , vol.103 , pp. 275-280
    • Rudolphi, K.A.1    Keil, M.2    Fastbom, J.3    Fredholm, B.B.4
  • 56
    • 0242416171 scopus 로고    scopus 로고
    • A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation
    • Angulo E., Casado V., Mallol J., Canela E.I., Vinals F., Ferrer I., Lluis C., Franco R. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Brain Pathol. 2003, 13:440-451.
    • (2003) Brain Pathol. , vol.13 , pp. 440-451
    • Angulo, E.1    Casado, V.2    Mallol, J.3    Canela, E.I.4    Vinals, F.5    Ferrer, I.6    Lluis, C.7    Franco, R.8
  • 57
    • 0033562590 scopus 로고    scopus 로고
    • The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions
    • Svenningsson P., Nomikos G.G., Fredholm B.B. The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. J. Neurosci. 1999, 19:4011-4022.
    • (1999) J. Neurosci. , vol.19 , pp. 4011-4022
    • Svenningsson, P.1    Nomikos, G.G.2    Fredholm, B.B.3
  • 59
    • 0025709406 scopus 로고
    • Hippocampal adenosine A1 receptors are decreased in Alzheimer's disease
    • Kalaria R.N., Sromek S., Wilcox B.J., Unnerstall J.R. Hippocampal adenosine A1 receptors are decreased in Alzheimer's disease. Neurosci. Lett. 1990, 118:257-260.
    • (1990) Neurosci. Lett. , vol.118 , pp. 257-260
    • Kalaria, R.N.1    Sromek, S.2    Wilcox, B.J.3    Unnerstall, J.R.4
  • 60
    • 0027389045 scopus 로고
    • Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study
    • Ulas J., Brunner L.C., Nguyen L., Cotman C.W. Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. Neuroscience 1993, 52:843-854.
    • (1993) Neuroscience , vol.52 , pp. 843-854
    • Ulas, J.1    Brunner, L.C.2    Nguyen, L.3    Cotman, C.W.4
  • 61
    • 0027231677 scopus 로고
    • Differential alterations in adenosine A1 and kappa 1 opioid receptors in the striatum in Alzheimer's disease
    • Ikeda M., Mackay K.B., Dewar D., McCulloch J. Differential alterations in adenosine A1 and kappa 1 opioid receptors in the striatum in Alzheimer's disease. Brain Res. 1993, 616:211-217.
    • (1993) Brain Res. , vol.616 , pp. 211-217
    • Ikeda, M.1    Mackay, K.B.2    Dewar, D.3    McCulloch, J.4
  • 64
    • 0345168910 scopus 로고    scopus 로고
    • Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function
    • Rosin D.L., Hettinger B.D., Lee A., Linden J. Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function. Neurology 2003, 61:S12-S18.
    • (2003) Neurology , vol.61
    • Rosin, D.L.1    Hettinger, B.D.2    Lee, A.3    Linden, J.4
  • 65
    • 72449208698 scopus 로고    scopus 로고
    • Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway
    • Canas P.M., Porciuncula L.O., Cunha G.M., Silva C.G., Machado N.J., Oliveira J.M., Oliveira C.R., Cunha R.A. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J. Neurosci. 2009, 29:14741-14751.
    • (2009) J. Neurosci. , vol.29 , pp. 14741-14751
    • Canas, P.M.1    Porciuncula, L.O.2    Cunha, G.M.3    Silva, C.G.4    Machado, N.J.5    Oliveira, J.M.6    Oliveira, C.R.7    Cunha, R.A.8
  • 66
    • 14544288232 scopus 로고    scopus 로고
    • Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease
    • Xu K., Bastia E., Schwarzschild M. Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacol. Ther. 2005, 105:267-310.
    • (2005) Pharmacol. Ther. , vol.105 , pp. 267-310
    • Xu, K.1    Bastia, E.2    Schwarzschild, M.3
  • 67
    • 42649109113 scopus 로고    scopus 로고
    • Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease
    • Chen X., Gawryluk J.W., Wagener J.F., Ghribi O., Geiger J.D. Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J. Neuroinflammation 2008, 5:12.
    • (2008) J. Neuroinflammation , vol.5 , pp. 12
    • Chen, X.1    Gawryluk, J.W.2    Wagener, J.F.3    Ghribi, O.4    Geiger, J.D.5
  • 68
    • 54349106751 scopus 로고    scopus 로고
    • Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum
    • Chen X., Lan X., Roche I., Liu R., Geiger J.D. Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. J. Neurochem. 2008, 107:1147-1157.
    • (2008) J. Neurochem. , vol.107 , pp. 1147-1157
    • Chen, X.1    Lan, X.2    Roche, I.3    Liu, R.4    Geiger, J.D.5
  • 69
    • 77956180419 scopus 로고    scopus 로고
    • Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases
    • Chen X., Ghribi O., Geiger J.D., Liu R., Geiger J.D. Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J. Alzheimers Dis. 2010, 20(suppl 1):S127-S141.
    • (2010) J. Alzheimers Dis. , vol.20 , Issue.SUPPL. 1
    • Chen, X.1    Ghribi, O.2    Geiger, J.D.3    Liu, R.4    Geiger, J.D.5


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