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Volumn 16, Issue 4, 2010, Pages 455-462

Boosting endogenous neuroprotection in multiple sclerosis: The ASsociation of inosine and interferon β in relapsing-remitting multiple sclerosis (ASIIMS) trial

Author keywords

Endogenous neuroprotection; Inosine; Multiple sclerosis; Neurodegeneration; Uric acid

Indexed keywords

BETA INTERFERON; INOSINE; PLACEBO; URIC ACID; ANTIINFLAMMATORY AGENT; BETA1A INTERFERON; INTERFERON BETA SERINE; INTERFERON BETA-1B; NEUROPROTECTIVE AGENT;

EID: 77954673594     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458509360547     Document Type: Article
Times cited : (50)

References (48)
  • 2
    • 0027160479 scopus 로고
    • Towards the physiological function of uric acid
    • Becker BF. Towards the physiological function of uric acid. Free Radic Biol Med 1993;14:615-631.
    • (1993) Free Radic Biol. Med. , vol.14 , pp. 615-631
    • Becker, B.F.1
  • 3
    • 53049093018 scopus 로고    scopus 로고
    • Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity
    • Gonsette RE. Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity. J Neurol Sci 2008;274:48-53.
    • (2008) J. Neurol. Sci. , vol.274 , pp. 48-53
    • Gonsette, R.E.1
  • 4
    • 0031930043 scopus 로고    scopus 로고
    • Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis
    • Hooper DC, Spitsin S, Kean RB, et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A 1998;95:675-680.
    • (1998) Proc. Natl. Acad. Sci. U S A , vol.95 , pp. 675-680
    • Hooper, D.C.1    Spitsin, S.2    Kean, R.B.3
  • 5
    • 0034932843 scopus 로고    scopus 로고
    • Uric acid levels in patients with multiple sclerosis: Analysis in mono-and dizygotic twins
    • Spitsin S, Hooper DC, Mikheeva T, Koprowski H. Uric acid levels in patients with multiple sclerosis: analysis in mono-and dizygotic twins. Mult Scler 2001;7:165-166.
    • (2001) Mult Scler , vol.7 , pp. 165-166
    • Spitsin, S.1    Hooper, D.C.2    Mikheeva, T.3    Koprowski, H.4
  • 7
    • 33646814321 scopus 로고    scopus 로고
    • Uric acid in multiple sclerosis
    • Koch M, De Keyser J. Uric acid in multiple sclerosis. Neurol Res 2006;28:316-319.
    • (2006) Neurol. Res. , vol.28 , pp. 316-319
    • Koch, M.1    De Keyser, J.2
  • 8
    • 12644261423 scopus 로고    scopus 로고
    • Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis
    • Hooper DC, Bagasra O, Marini JC, et al. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A 1997;94:2528-2533.
    • (1997) Proc. Natl. Acad. Sci. U S A , vol.94 , pp. 2528-2533
    • Hooper, D.C.1    Bagasra, O.2    Marini, J.C.3
  • 9
    • 0019787519 scopus 로고
    • Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: A hypothesis
    • Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 1981;78:6858-6862.
    • (1981) Proc. Natl. Acad. Sci. U S A , vol.78 , pp. 6858-6862
    • Ames, B.N.1    Cathcart, R.2    Schwiers, E.3    Hochstein, P.4
  • 10
    • 0035116154 scopus 로고    scopus 로고
    • Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite
    • Koprowski H, Spitsin SV, Hooper DC. Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite. Ann Neurol 2001;49:139.
    • (2001) Ann. Neurol. , vol.49 , pp. 139
    • Koprowski, H.1    Spitsin, S.V.2    Hooper, D.C.3
  • 11
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis
    • McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121-127.
    • (2001) Ann. Neurol. , vol.50 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3
  • 12
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis
    • PRISMS Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis Study Group
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. Lancet 1998;352:1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 13
    • 0027418515 scopus 로고
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993;43:655-661.
    • (1993) , vol.43 , pp. 655-661
  • 14
    • 0020399170 scopus 로고
    • Tables of the number of patients required in clinical trials using the logrank test
    • Freedman LS. Tables of the number of patients required in clinical trials using the logrank test. Stat Med 1982;1:121-129.
    • (1982) Stat Med. , vol.1 , pp. 121-129
    • Freedman, L.S.1
  • 15
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-1452.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 16
    • 0032919071 scopus 로고    scopus 로고
    • Development of a multiple sclerosis functional composite as a clinical trial outcome measure
    • Cutter GR, Baier ML, Rudick RA, et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 1999;122:871-882.
    • (1999) Brain , vol.122 , pp. 871-882
    • Cutter, G.R.1    Baier, M.L.2    Rudick, R.A.3
  • 17
    • 0034353915 scopus 로고    scopus 로고
    • Semiparametric regression for the mean and rate functions of recurrent events
    • Lin D, Wei L, Yang I, Ying Z. Semiparametric regression for the mean and rate functions of recurrent events. J R Statist Soc Ser B 2000;62:711-730.
    • (2000) J. R Statist. Soc. Ser. B. , vol.62 , pp. 711-730
    • Lin, D.1    Wei, L.2    Yang, I.3    Ying, Z.4
  • 18
    • 21844474073 scopus 로고    scopus 로고
    • Serum uric acid, dehydroepiandrosterone sulphate, and apolipoprotein e genotype in benign vs. progressive multiple sclerosis
    • Ramsaransing GS, Heersema DJ, De Keyser J. Serum uric acid, dehydroepiandrosterone sulphate, and apolipoprotein e genotype in benign vs. progressive multiple sclerosis. Eur J Neurol 2005;12:514-518.
    • (2005) Eur. J. Neurol. , vol.12 , pp. 514-518
    • Ramsaransing, G.S.1    Heersema, D.J.2    De Keyser, J.3
  • 19
    • 0035078061 scopus 로고    scopus 로고
    • Uric acid levels in sera from patients with multiple sclerosis
    • Drulović J, Dujmovic I, Stojsavljević N, et al. Uric acid levels in sera from patients with multiple sclerosis. J Neurol 2001;248:121-126.
    • (2001) J. Neurol. , vol.248 , pp. 121-126
    • Drulović, J.1    Dujmovic, I.2    Stojsavljević, N.3
  • 20
    • 0036050889 scopus 로고    scopus 로고
    • Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction
    • Toncev G, Milicic B, Toncev S, Samardzic G. Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction. Eur J Neurol 2002;9:221-226.
    • (2002) Eur. J. Neurol. , vol.9 , pp. 221-226
    • Toncev, G.1    Milicic, B.2    Toncev, S.3    Samardzic, G.4
  • 21
    • 0036808782 scopus 로고    scopus 로고
    • Serum uric acid and multiple sclerosis
    • Sotgiu S, Pugliatti M, Sanna A, et al. Serum uric acid and multiple sclerosis. Neurol Sci 2002;23:183-188.
    • (2002) Neurol. Sci. , vol.23 , pp. 183-188
    • Sotgiu, S.1    Pugliatti, M.2    Sanna, A.3
  • 22
    • 53049110218 scopus 로고    scopus 로고
    • Serum levels of uric acid in patients with multiple sclerosis: A biological marker in clinical course and treatment of MS
    • P412
    • Deretzi G, Pelidou SH, Zacharakis G, Kyritsis AP. Serum levels of uric acid in patients with multiple sclerosis: a biological marker in clinical course and treatment of MS. Mult Scler 2003;9(Suppl 1):S100, P412.
    • (2003) Mult Scler , vol.9 , Issue.1 SUPPL. , pp. 100
    • Deretzi, G.1    Pelidou, S.H.2    Zacharakis, G.3    Kyritsis, A.P.4
  • 24
    • 41049089267 scopus 로고    scopus 로고
    • Variation of serum uric acid levels in multiple sclerosis during relapses and immunomodulatory treatment
    • Guerrero AL, Martín-Polo J, Laherrán E, et al. Variation of serum uric acid levels in multiple sclerosis during relapses and immunomodulatory treatment. Eur J Neurol 2008;15:394-397.
    • (2008) Eur. J. Neurol. , vol.15 , pp. 394-397
    • Guerrero, A.L.1    Martín-Polo, J.2    Laherrán, E.3
  • 25
    • 77954273373 scopus 로고    scopus 로고
    • Serum uric acid levels are decreased in patients with relapsing-remitting multiple sclerosis, in particular during relapses
    • P888
    • Tsakiri A, Tsiantoulas D, Frederiksen J. Serum uric acid levels are decreased in patients with relapsing-remitting multiple sclerosis, in particular during relapses. Mult Scler 2008;14(Suppl 1):S289, P888.
    • (2008) Mult Scler , vol.14 , Issue.1 SUPPL. , pp. 289
    • Tsakiri, A.1    Tsiantoulas, D.2    Frederiksen, J.3
  • 26
    • 0034490274 scopus 로고    scopus 로고
    • Increase in serum levels of uric acid, an endogenous antioxidant, under treatment with glatiramer acetate for multiple sclerosis
    • Constantinescu CS, Freitag P, Kappos L. Increase in serum levels of uric acid, an endogenous antioxidant, under treatment with glatiramer acetate for multiple sclerosis. Mult Scler 2000;6:378-381.
    • (2000) Mult Scler , vol.6 , pp. 378-381
    • Constantinescu, C.S.1    Freitag, P.2    Kappos, L.3
  • 27
    • 77954263357 scopus 로고    scopus 로고
    • Treatment with interferon beta 1b (Betaferon) and serum uric acid levels: Two year follow-up
    • P305
    • Toncev G, Drakulic M, Knezevic Z. Treatment with interferon beta 1b (Betaferon) and serum uric acid levels: two year follow-up. Mult Scler 2007;13(Suppl 2):S90, P305.
    • (2007) Mult Scler , vol.13 , Issue.2 SUPPL. , pp. 90
    • Toncev, G.1    Drakulic, M.2    Knezevic, Z.3
  • 28
    • 77954263059 scopus 로고    scopus 로고
    • Increase of serum uric acid levels in multiple sclerosis during treatment with natalizumab
    • P888
    • Handouk Y, Angeleri VA, Danni M, De Riso S, Provinciali L. Increase of serum uric acid levels in multiple sclerosis during treatment with natalizumab. Mult Scler 2008;14(Suppl 1):S281, P888.
    • (2008) Mult Scler , vol.14 , Issue.1 SUPPL. , pp. 281
    • Handouk, Y.1    Angeleri, V.A.2    Danni, M.3    De Riso, S.4    Provinciali, L.5
  • 30
    • 0028036368 scopus 로고
    • Uric acid is reduced in the substantia nigra in Parkinson's disease: Effect on dopamine oxidation
    • Church WH, Ward VL. Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. Brain Res Bull 1994;33:419-425.
    • (1994) Brain Res. Bull. , vol.33 , pp. 419-425
    • Church, W.H.1    Ward, V.L.2
  • 32
    • 0032531735 scopus 로고    scopus 로고
    • Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
    • Hensley K, Maidt ML, Yu Z, Sang H, Markesbery WR, Floyd RA. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neurosci 1998;18:8126-8132.
    • (1998) J. Neurosci. , vol.18 , pp. 8126-8132
    • Hensley, K.1    Maidt, M.L.2    Yu, Z.3    Sang, H.4    Markesbery, W.R.5    Floyd, R.A.6
  • 33
    • 0026554440 scopus 로고
    • Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex
    • Beal MF, Matson WR, Storey E, et al. Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex. J Neurol Sci 1992;108:80-87.
    • (1992) J. Neurol. Sci. , vol.108 , pp. 80-87
    • Beal, M.F.1    Matson, W.R.2    Storey, E.3
  • 34
    • 0026647212 scopus 로고
    • Measurement of low-molecular-weight antioxidants, uric acid, tyrosine and tryptophan in plaques and white matter from patients with multiple sclerosis
    • Langemann H, Kabiersch A, Newcombe J. Measurement of low-molecular-weight antioxidants, uric acid, tyrosine and tryptophan in plaques and white matter from patients with multiple sclerosis. Eur Neurol 1992;32:248-252.
    • (1992) Eur. Neurol. , vol.32 , pp. 248-252
    • Langemann, H.1    Kabiersch, A.2    Newcombe, J.3
  • 35
    • 56349160121 scopus 로고    scopus 로고
    • Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression
    • van Horssen J, Schreibelt G, Drexhage J, et al. Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression. Free Radic Biol Med 2008;45:1729-1737.
    • (2008) Free Radic Biol. Med. , vol.45 , pp. 1729-1737
    • Van Horssen, J.1    Schreibelt, G.2    Drexhage, J.3
  • 36
    • 33751540077 scopus 로고    scopus 로고
    • Interferon-beta and neuroprotection in multiple sclerosis-facts, hopes and phantasies
    • Kieseier BC, Hartung HP. Interferon-beta and neuroprotection in multiple sclerosis-facts, hopes and phantasies. Exp Neurol 2007;203:1-4.
    • (2007) Exp. Neurol. , vol.203 , pp. 1-4
    • Kieseier, B.C.1    Hartung, H.P.2
  • 37
    • 59349090559 scopus 로고    scopus 로고
    • Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity
    • Schwartz M, London A, Shechter R. Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: the role of innate immunity. Neuroscience 2009;158:1133-1142.
    • (2009) Neuroscience , vol.158 , pp. 1133-1142
    • Schwartz, M.1    London, A.2    Shechter, R.3
  • 38
    • 60849102769 scopus 로고    scopus 로고
    • Immunoglobulins and complement in postmortem multiple sclerosis tissue
    • Barnett MH, Parratt JD, Cho ES, Prineas JW. Immunoglobulins and complement in postmortem multiple sclerosis tissue. Ann Neurol 2009;65:32-46.
    • (2009) Ann. Neurol. , vol.65 , pp. 32-46
    • Barnett, M.H.1    Parratt, J.D.2    Cho, E.S.3    Prineas, J.W.4
  • 39
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009;284:13291-13295.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 40
    • 67650178847 scopus 로고    scopus 로고
    • The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection
    • Vamos E, Pardutz A, Klivenyi P, Toldi J, Vecsei L. The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection. J Neurol Sci 2009;283:21-27.
    • (2009) J. Neurol. Sci. , vol.283 , pp. 21-27
    • Vamos, E.1    Pardutz, A.2    Klivenyi, P.3    Toldi, J.4    Vecsei, L.5
  • 41
    • 0037226838 scopus 로고    scopus 로고
    • Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases
    • Aboul-Enein F, Rauschka H, Kornek B, et al. Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. J Neuropathol Exp Neurol 2003;62:25-33.
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 25-33
    • Aboul-Enein, F.1    Rauschka, H.2    Kornek, B.3
  • 42
    • 41649097176 scopus 로고    scopus 로고
    • Increased expression of endoplasmic reticulum stress-related signalling pathway molecules in multiple sclerosis lesions
    • Mhâille AN, McQuaid S, Windebank A, et al. Increased expression of endoplasmic reticulum stress-related signalling pathway molecules in multiple sclerosis lesions. J Neuropathol Exp Neurol 2008;67:200-211.
    • (2008) J. Neuropathol. Exp. Neurol. , vol.67 , pp. 200-211
    • Mhâille, A.N.1    McQuaid, S.2    Windebank, A.3
  • 43
    • 52949104790 scopus 로고    scopus 로고
    • The endocannabinoid system and multiple sclerosis
    • Baker D, Pryce G. The endocannabinoid system and multiple sclerosis. Curr Pharm des 2008;14:2326-2336.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 2326-2336
    • Baker, D.1    Pryce, G.2
  • 44
    • 0034747982 scopus 로고    scopus 로고
    • Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease
    • Spitsin S, Hooper DC, Leist T, et al. Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease. Mult Scler 2001;7:313-319.
    • (2001) Mult Scler , vol.7 , pp. 313-319
    • Spitsin, S.1    Hooper, D.C.2    Leist, T.3
  • 45
    • 42149097449 scopus 로고    scopus 로고
    • Inosine in the treatment of multiple sclerosis: An open-label study in 32 patients
    • poster P06.151
    • Toncev G, Milicic B, Perovic S, Toncev S, Zlatic G, Knecevic Z. Inosine in the treatment of multiple sclerosis: an open-label study in 32 patients. Neurology 2005;94(Suppl 1):A385, poster P06.151.
    • (2005) Neurology , vol.94 , Issue.1 SUPPL.
    • Toncev, G.1    Milicic, B.2    Perovic, S.3    Toncev, S.4    Zlatic, G.5    Knecevic, Z.6
  • 47
    • 1642264093 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy
    • Gilgun-Sherki Y, Melamed E, Offen D. The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. J Neurol 2004;251:261-268.
    • (2004) J. Neurol. , vol.251 , pp. 261-268
    • Gilgun-Sherki, Y.1    Melamed, E.2    Offen, D.3


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