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Volumn 14, Issue 5, 2000, Pages 691-698

Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood- CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis

Author keywords

Autoimmunity; Blood brain barrier; Demyelinating diseases; Encephalomyelitis; Multiple Sclerosis; Uric acid

Indexed keywords

URIC ACID;

EID: 0034038044     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.5.691     Document Type: Article
Times cited : (344)

References (49)
  • 3
    • 0028868821 scopus 로고
    • Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis
    • Okuda, Y., Sakoda, S., Fujimura, H., and Yanagihara, T. (1995) Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis. J. Neuroimmunol. 62, 103-112
    • (1995) J. Neuroimmunol. , vol.62 , pp. 103-112
    • Okuda, Y.1    Sakoda, S.2    Fujimura, H.3    Yanagihara, T.4
  • 5
    • 0030560858 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis
    • Cross, A. H., Keeling, R. M., Goorha, S., San, M., Rodi, C., Wyatt, P. S., Manning, P. T., and Misko, T. P. (1996) Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis. J. Neuroimmunol. 71, 145-153
    • (1996) J. Neuroimmunol. , vol.71 , pp. 145-153
    • Cross, A.H.1    Keeling, R.M.2    Goorha, S.3    San, M.4    Rodi, C.5    Wyatt, P.S.6    Manning, P.T.7    Misko, T.P.8
  • 7
    • 0026326187 scopus 로고
    • A requirement for the intercellular messenger nitric oxide in long-term potentiation
    • Schuman, E. M., and Madison, D. V. (1991) A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science 254, 1503-1506
    • (1991) Science , vol.254 , pp. 1503-1506
    • Schuman, E.M.1    Madison, D.V.2
  • 8
    • 0027752805 scopus 로고
    • The L-arginine nitric oxide pathway
    • Moncada, S., and Higgs, A. (1993) The L-arginine nitric oxide pathway. N. Engl. J. Med. 329, 2002-2012
    • (1993) N. Engl. J. Med. , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 9
    • 0031030722 scopus 로고    scopus 로고
    • Nitric oxide inhibits the secretion of T-helper 1 and T-helper 2-associated cytokines in activated human T cells
    • Bauer, H., Jung, T., Tsikas, D., Stichtenoth, D. O., Frohlich, J. C., and Neumann, C. (1997) Nitric oxide inhibits the secretion of T-helper 1 and T-helper 2-associated cytokines in activated human T cells. Immunology 90, 205-211
    • (1997) Immunology , vol.90 , pp. 205-211
    • Bauer, H.1    Jung, T.2    Tsikas, D.3    Stichtenoth, D.O.4    Frohlich, J.C.5    Neumann, C.6
  • 10
    • 0031179511 scopus 로고    scopus 로고
    • Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-γ-activated macrophages and microglial cells
    • Alberati-Giani, D., Malherbe, P., Ricciardi-Castagnoli, P., Köhler, C., Denis-Donini, S., and Cesura, A. M. (1997) Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-γ-activated macrophages and microglial cells. J. Immunol. 159, 419L-426L
    • (1997) J. Immunol. , vol.159
    • Alberati-Giani, D.1    Malherbe, P.2    Ricciardi-Castagnoli, P.3    Köhler, C.4    Denis-Donini, S.5    Cesura, A.M.6
  • 11
    • 0025874048 scopus 로고
    • Peroxynitrite induced lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
    • Radi, R., Beckman, J. S., Bush, K. M., and Freeman, B. A. (1991) Peroxynitrite induced lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys. 288, 481-487
    • (1991) Arch. Biochem. Biophys. , vol.288 , pp. 481-487
    • Radi, R.1    Beckman, J.S.2    Bush, K.M.3    Freeman, B.A.4
  • 12
    • 0025730414 scopus 로고
    • Peroxynitrite oxidation of sulfhydryls: The cytotoxic potential of superoxide and nitric oxide
    • Radi, R., Beckman, J. S., Bush, K. M., and Freeman, B. A. (1991) Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266, 4244-4250
    • (1991) J. Biol. Chem. , vol.266 , pp. 4244-4250
    • Radi, R.1    Beckman, J.S.2    Bush, K.M.3    Freeman, B.A.4
  • 14
    • 0028373681 scopus 로고
    • Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry
    • Beckman, J. S., Ye, Y. Z., Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., and White C. R. (1994) Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol. Chem. 375, 81-88
    • (1994) Biol. Chem. , vol.375 , pp. 81-88
    • Beckman, J.S.1    Ye, Y.Z.2    Anderson, P.G.3    Chen, J.4    Accavitti, M.A.5    Tarpey, M.M.6    White, C.R.7
  • 16
    • 0032146352 scopus 로고    scopus 로고
    • Peroxynitrite formation within the central nervous system in active multiple sclerosis
    • Cross, A. H., Maning, P. T., Keeling, R. M., Schmidt, R. E., and Misko, T. P. (1998) Peroxynitrite formation within the central nervous system in active multiple sclerosis. J. Neuroimmunol. 88, 45-56
    • (1998) J. Neuroimmunol. , vol.88 , pp. 45-56
    • Cross, A.H.1    Maning, P.T.2    Keeling, R.M.3    Schmidt, R.E.4    Misko, T.P.5
  • 17
    • 0030787471 scopus 로고    scopus 로고
    • Extensive peroxynitrite activity during progressive stages of central nervous system inflammation
    • van der Veen, R. C., Hinton, D. R., Incardonna, F., and Hofman, F. M. (1997) Extensive peroxynitrite activity during progressive stages of central nervous system inflammation. J. Neuroimmunol. 77, 1-7
    • (1997) J. Neuroimmunol. , vol.77 , pp. 1-7
    • Van Der Veen, R.C.1    Hinton, D.R.2    Incardonna, F.3    Hofman, F.M.4
  • 18
    • 0031457801 scopus 로고    scopus 로고
    • Evidence for the production of peroxynitrite in inflammatory CNS demyelination
    • Cross, A. H., Maning, P. T., Stern, M. K., and Misko, T. P. (1997) Evidence for the production of peroxynitrite in inflammatory CNS demyelination. J. Neuroimmunol. 80, 121-130
    • (1997) J. Neuroimmunol. , vol.80 , pp. 121-130
    • Cross, A.H.1    Maning, P.T.2    Stern, M.K.3    Misko, T.P.4
  • 19
  • 20
    • 0031127418 scopus 로고    scopus 로고
    • Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques
    • Wallace, M. N., Geddes, J. G., Farquhar, D. A., and Masson, M. R. (1997) Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques. Exp. Neurol. 144, 266-272
    • (1997) Exp. Neurol. , vol.144 , pp. 266-272
    • Wallace, M.N.1    Geddes, J.G.2    Farquhar, D.A.3    Masson, M.R.4
  • 21
    • 0029840369 scopus 로고    scopus 로고
    • Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND
    • Chou, S. M., Wang, H. S., and Tanaguchi, A. (1996) Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND. J. Neurol. Sci. 139 (Suppl.), 16-26
    • (1996) J. Neurol. Sci. , vol.139 , Issue.SUPPL. , pp. 16-26
    • Chou, S.M.1    Wang, H.S.2    Tanaguchi, A.3
  • 22
    • 0029908148 scopus 로고    scopus 로고
    • 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants
    • 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants. Free Rad. Res. 25, 275-283
    • (1996) Free Rad. Res. , vol.25 , pp. 275-283
    • Whiteman, M.1    Halliwell, B.2
  • 24
    • 0023931481 scopus 로고
    • Tissue specificity and species differences in the distribution of urate oxidase in peroxisomes
    • Usuda, N., Reddy, M. K., Hashimoto, T., Rao, M. S., and Reddy, J. K. (1988) Tissue specificity and species differences in the distribution of urate oxidase in peroxisomes. Lab. Invest. 58, 100-111
    • (1988) Lab. Invest. , vol.58 , pp. 100-111
    • Usuda, N.1    Reddy, M.K.2    Hashimoto, T.3    Rao, M.S.4    Reddy, J.K.5
  • 25
    • 0004053615 scopus 로고
    • 833 pp., Worth Publishers Inc., New York
    • Lehniger, A. L. (1970) Biochemistry, 833 pp., Worth Publishers Inc., New York
    • (1970) Biochemistry
    • Lehniger, A.L.1
  • 26
    • 0024233411 scopus 로고
    • Uricase protein sequences: Conserved during hominid evolution but absent in humans
    • Varela-Eschavarria, A., Montes de Oca-Luna, R., and Barrera-Saldana H. A. (1988) Uricase protein sequences: conserved during hominid evolution but absent in humans. FASEB J. 2, 3092-3096
    • (1988) FASEB J. , vol.2 , pp. 3092-3096
    • Varela-Eschavarria, A.1    Montes De Oca-Luna, R.2    Barrera-Saldana, H.A.3
  • 27
    • 0026592267 scopus 로고
    • Two independent mutational events in the loss of urate oxidase during hominid evolution
    • Wu, X. W., Muzny, D. M., Lee, C. C., and Catskey, C. T. (1992) Two independent mutational events in the loss of urate oxidase during hominid evolution. J. Mol. Evol. 34, 78-84
    • (1992) J. Mol. Evol. , vol.34 , pp. 78-84
    • Wu, X.W.1    Muzny, D.M.2    Lee, C.C.3    Catskey, C.T.4
  • 28
    • 0026335902 scopus 로고
    • Molecular evolution of the urate oxidase-encoding gene in hominid primates: Nonsense mutations
    • Yeldandi, A. V., Yeldandi, V., Kumar, S., Murthy, C. V., Wang, X. D., Alvares, K., Rao, M. S., and Reddy, J. K. (1991) Molecular evolution of the urate oxidase-encoding gene in hominid primates: nonsense mutations. Gene 109, 281-284
    • (1991) Gene , vol.109 , pp. 281-284
    • Yeldandi, A.V.1    Yeldandi, V.2    Kumar, S.3    Murthy, C.V.4    Wang, X.D.5    Alvares, K.6    Rao, M.S.7    Reddy, J.K.8
  • 30
    • 0024357137 scopus 로고
    • Sensitivity and detection efficiency of the peroxidase antiperoxidase PAP. avidin-biotin peroxidase complex ABC., and peroxidase-labeled avidin-biotin LAB. methods
    • Elias, J. M., Margiotta, M., and Gaboric, D. (1989) Sensitivity and detection efficiency of the peroxidase antiperoxidase PAP. avidin-biotin peroxidase complex ABC., and peroxidase-labeled avidin-biotin LAB. methods. Am. J. Clin. Pathol. 92, 62-67
    • (1989) Am. J. Clin. Pathol. , vol.92 , pp. 62-67
    • Elias, J.M.1    Margiotta, M.2    Gaboric, D.3
  • 31
    • 0017804040 scopus 로고
    • Oxonate-induced hyperuricemia and orotic aciduris in mice
    • Mangoff, S. C., and Milner, J. A. (1978) Oxonate-induced hyperuricemia and orotic aciduris in mice. Proc. Soc. Exp. Biol. Med. 157, 110-115
    • (1978) Proc. Soc. Exp. Biol. Med. , vol.157 , pp. 110-115
    • Mangoff, S.C.1    Milner, J.A.2
  • 32
    • 84944502549 scopus 로고
    • A high-performance liquid chromatographic method for the determination of hypoxanthine, xanthine, uric acid, and allantoin in serum
    • Kock, R., Delvoux, B., and Greiling H. (1992) A high-performance liquid chromatographic method for the determination of hypoxanthine, xanthine, uric acid, and allantoin in serum. Eur. J. Clin. Chem. Clin. Biochem. 31, 303-310
    • (1992) Eur. J. Clin. Chem. Clin. Biochem. , vol.31 , pp. 303-310
    • Kock, R.1    Delvoux, B.2    Greiling, H.3
  • 34
    • 0024508297 scopus 로고
    • Blood-brain barrier breakdown in cold-injured brain is linked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis: Both are coordinately inhibited by verapamil, dexamethasone, and aspirin
    • Koenig, H., Goldstone, A. D., and Lu, C. Y. (1989) Blood-brain barrier breakdown in cold-injured brain is linked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis: both are coordinately inhibited by verapamil, dexamethasone, and aspirin. J. Neurochem. 52, 101-109
    • (1989) J. Neurochem. , vol.52 , pp. 101-109
    • Koenig, H.1    Goldstone, A.D.2    Lu, C.Y.3
  • 35
    • 0022828519 scopus 로고
    • Blood-brain barrier breakdown by cold injury. Polyamine signals mediate acute stimulation of endocytosis, vesicular transport, and microvillus formation in rat cerebral capillaries
    • Trout, J. J., Koenig, H., Goldstone, A. D., and Lu, C. Y. (1986) Blood-brain barrier breakdown by cold injury. Polyamine signals mediate acute stimulation of endocytosis, vesicular transport, and microvillus formation in rat cerebral capillaries. Lab. Invest. 55, 622-631
    • (1986) Lab. Invest. , vol.55 , pp. 622-631
    • Trout, J.J.1    Koenig, H.2    Goldstone, A.D.3    Lu, C.Y.4
  • 36
    • 0031253737 scopus 로고    scopus 로고
    • Fas- and fasI.-deficient mice are resistant to induction of autoimmune encephalomyelitis
    • Waldner, H., Sobel, R. A., Howard, E., and Kuchroo, V. K. (1997) Fas- and fasI.-deficient mice are resistant to induction of autoimmune encephalomyelitis. J. Immunol. 159, 3100-3103
    • (1997) J. Immunol. , vol.159 , pp. 3100-3103
    • Waldner, H.1    Sobel, R.A.2    Howard, E.3    Kuchroo, V.K.4
  • 37
    • 0025817888 scopus 로고
    • Apoptosis in the nervous system in experimental allergic encephalomyelitis
    • Pender, M. P., Nguyen, K. B., McCombe, P. A., and Kerr, J. F. R. (1991) Apoptosis in the nervous system in experimental allergic encephalomyelitis. J. Neurol. Sci. 104, 81-87
    • (1991) J. Neurol. Sci. , vol.104 , pp. 81-87
    • Pender, M.P.1    Nguyen, K.B.2    McCombe, P.A.3    Kerr, J.F.R.4
  • 38
    • 0029116712 scopus 로고
    • Evidence of persistent blood-brain barrier abnormalities in chronic-progressive multiple sclerosis
    • Claudio, L., Raine, C. S., and Brosnan, C. F. (1995) Evidence of persistent blood-brain barrier abnormalities in chronic-progressive multiple sclerosis. Acta Neuropathol. 90, 228-238
    • (1995) Acta Neuropathol. , vol.90 , pp. 228-238
    • Claudio, L.1    Raine, C.S.2    Brosnan, C.F.3
  • 39
    • 0014037816 scopus 로고
    • Changes in cerebrospinal fluid composition following hemodialysis
    • Funder, J., and Wieth, J. O. (1967) Changes in cerebrospinal fluid composition following hemodialysis. Lab. Invest. 19, 310-312
    • (1967) Lab. Invest. , vol.19 , pp. 310-312
    • Funder, J.1    Wieth, J.O.2
  • 40
    • 0022480695 scopus 로고
    • Increased concentrations of uric acid in the spinal cord of rats with chronic relapsing experimental allergic encephalomyelitis
    • Honegger, C. G., Krenger, W., and Langemann, H. (1986) Increased concentrations of uric acid in the spinal cord of rats with chronic relapsing experimental allergic encephalomyelitis. Neurosci. Lett. 69, 109-114
    • (1986) Neurosci. Lett. , vol.69 , pp. 109-114
    • Honegger, C.G.1    Krenger, W.2    Langemann, H.3
  • 41
    • 0028587581 scopus 로고
    • Conjugated deferoxamine reduces blood-brain barrier disruption in experimental optic neuritis
    • Guy, J., McGorray, S., Qi, X., Fitzsimmons, J., Mancuso, A., and Rao, N. (1994) Conjugated deferoxamine reduces blood-brain barrier disruption in experimental optic neuritis. Opthalmic Res. 26, 310-323
    • (1994) Opthalmic Res. , vol.26 , pp. 310-323
    • Guy, J.1    McGorray, S.2    Qi, X.3    Fitzsimmons, J.4    Mancuso, A.5    Rao, N.6
  • 43
    • 0031424783 scopus 로고    scopus 로고
    • Inflammatory events at the blood-brain barrier: Regulation of adhesion molecules, cytokine and chemokines by reactive nitrogen and oxygen species
    • Merrill, J. E., and Murphy, S. (1997) Inflammatory events at the blood-brain barrier: regulation of adhesion molecules, cytokine and chemokines by reactive nitrogen and oxygen species. Brain Behav. Immunity 11, 245-263
    • (1997) Brain Behav. Immunity , vol.11 , pp. 245-263
    • Merrill, J.E.1    Murphy, S.2
  • 44
    • 84979139586 scopus 로고
    • The biological significance of uric acid and guanine excretion
    • Keilin, J. (1959) The biological significance of uric acid and guanine excretion. Biol. Rev. 34, 265-296
    • (1959) Biol. Rev. , vol.34 , pp. 265-296
    • Keilin, J.1
  • 45
    • 34249111787 scopus 로고
    • Biochemistry of uric acid and its relation to gout
    • Seegmiller, J. E., Laster, L., and Howell, R. R. (1963) Biochemistry of uric acid and its relation to gout. N. Engl. J. Med. 268, 712-716
    • (1963) N. Engl. J. Med. , vol.268 , pp. 712-716
    • Seegmiller, J.E.1    Laster, L.2    Howell, R.R.3
  • 46
    • 0023634573 scopus 로고
    • Asymptomatic hyperuricemia. Risks and consequences in the normative aging study
    • Campion, E. W., Glynn, R. J., and DeLabry, L. O. (1987) Asymptomatic hyperuricemia. Risks and consequences in the normative aging study. Am. J. Med. 82, 421-426
    • (1987) Am. J. Med. , vol.82 , pp. 421-426
    • Campion, E.W.1    Glynn, R.J.2    DeLabry, L.O.3
  • 47
    • 36949057849 scopus 로고
    • Similar functions of uric acid and ascorbate in man?
    • Proctor, P. (1970) Similar functions of uric acid and ascorbate in man? Nature (London) 228, 868
    • (1970) Nature (London) , vol.228 , pp. 868
    • Proctor, P.1
  • 48
    • 0019787519 scopus 로고
    • Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis
    • Ames, B. N., Cathcart, R. Schwiers, E., and Hochstein, P. (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc. Natl. Acad. Sci. USA 78, 6858-6862
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 6858-6862
    • Ames, B.N.1    Cathcart, R.2    Schwiers, E.3    Hochstein, P.4
  • 49
    • 0028036368 scopus 로고
    • Uric acid is reduced in the substantia nigra in Parkinson's disease: Effect of dopamine oxidation
    • Church, W. H., and Ward, V. L. (1994) Uric acid is reduced in the substantia nigra in Parkinson's disease: effect of dopamine oxidation. Brain Res. Bull. 33, 419-425
    • (1994) Brain Res. Bull. , vol.33 , pp. 419-425
    • Church, W.H.1    Ward, V.L.2


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