Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson's disease

Journal of Molecular Neuroscience

Volumn 43, Issue 3, 2011, Pages 246-250

  Facheris, Maurizio F ^a,b,c   Hicks, Andrew A ^a,b   Minelli, Cosetta ^a,b   Hagenah, Johann M ^b   Kostic, Vladimir ^d   Campbell, Susan ^e   Hayward, Caroline ^e   Volpato, Claudia B ^a,b   Pattaro, Cristian ^a,b   Vitart, Veronique ^e   Wright, Alan ^e   Campbell, Harry ^e,f   Klein, Christine ^b   Pramstaller, Peter P ^a,b,c  

^a INSTITUTE FOR RENEWABLE ENERGY   (Italy)

^b UNIVERSITY OF LÜBECK   (Germany)

^c CENTRAL HOSPITAL OF BOLZANO   (Italy)

^d UNIVERSITY OF BELGRADE   (Serbia)

^e WESTERN GENERAL HOSPITAL   (United Kingdom)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Glucose transporter; Oxidative stress; Parkinson's disease age at onset; Uric acid

Indexed keywords

URIC ACID;

ALLELE; ARTICLE; FEMALE; GENE; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; ONSET AGE; PARKINSON DISEASE; SLC2A9 GENE; URIC ACID BLOOD LEVEL;

AGE OF ONSET; ALLELES; FEMALE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; MALE; PARKINSON DISEASE; POLYMORPHISM, GENETIC; SEX FACTORS; URIC ACID;

EID: 79955864999     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9409-y     Document Type: Article

References (13)

1. Becker BF, Reinholz N, Leipert B, Raschke P, Permanetter B, Gerlach E (1991) Role of uric acid as an endogenous radical scavenger and antioxidant. Chest 100:176S-181S
2. Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M et al (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Med 5:e197
3. Church WH, Ward VL (1994) Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. Brain Res Bull 33:419-425
4. Dehghan A, Kottgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F et al (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372:1953-1961
5. Döring A, Gieger C, Mehta D, Gohlke H, Prokisch H, Coassin S et al (2008) SLC2A9 influences uric acid concentrations with pronounced gender-specific effects. Nat Genet 40:430-436 (Pubitemid 351454014)
6. Fedorova L, Fedorov A (2003) Introns in gene evolution. Genetica 118:123-131 (Pubitemid 36821044)
7. Greene CS, Penrod NM, Williams SM, Moore JH (2009) Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS ONE 4:e56
8. Higgins JP, Thompson SG, Deeks JJ et al (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557-560 (Pubitemid 37088507)
9. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181-184
10. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M et al (2009) Meta-analysis of 28, 141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 5:e1000504
11. Kutzing MK, Firestein BL (2008) Altered uric acid levels and disease states. J Pharmacol Exp Ther 324:1-7 (Pubitemid 350294141)
12. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D et al (2008) Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch Neurol 65:716-723 (Pubitemid 351831449)
13. Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, Palmer CN et al (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40:437-442 (Pubitemid 351450879)