Recent developments in nanoformulations of lipophilic functional foods

Trends in Food Science and Technology

Volumn 46, Issue 1, 2015, Pages 144-157

  Shin, Gye Hwa ^a   Kim, Jun Tae ^b   Park, Hyun Jin ^a  

^a Korea University   (South Korea)

^b Keimyung University   (South Korea)

Author keywords

Functional foods; Inclusion complex; Nano carrier system; Nanoemulsions; Nanoliposomes; Nanostructured lipid carriers; Nanosuspensions; Nutraceuticals; Polymeric nanoparticles; Protein based carriers; Self emulsifying drug delivery systems; Solid lipid nanoparticles

Indexed keywords

BIOCHEMISTRY; DRUG PRODUCTS; EMULSIFICATION; FUNCTIONAL FOOD; NANOPARTICLES; SOLUBILITY; WATER ABSORPTION;

INCLUSION COMPLEX; NANO-CARRIERS; NANO-EMULSIONS; NANO-SUSPENSIONS; NANOLIPOSOMES; NANOSTRUCTURED LIPID CARRIERS; NUTRACEUTICALS; POLYMERIC NANOPARTICLES; SELF-EMULSIFYING DRUG DELIVERY SYSTEM; SOLID LIPID NANOPARTICLE (SLN);

DRUG DELIVERY;

EID: 84955669486     PISSN: 09242244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tifs.2015.07.005     Document Type: Article

References (94)

1. Ahmed, K., Li, Y., McClements, D. J., & Xiao, H. (2012). Nanoemulsion-and emulsionbased delivery systems for curcumin: encapsulation and release properties. Food Chemistry, 132, 799-807.
2. Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Science, 90, 7915-7922.
3. Anandharamakrishnan, C. (2000). Techniques for formation of nanoemulsions. In J. P. Clark, J. W. Finley, D. Rodriguez-Lazaro, D. Topping, & R. W. Hartel (Eds.), Techniques for nanoencapsulation of food ingredients (pp. 7-16). New York Heidelberg Dordrecht London: Springer.
4. Arunkumar, R., Harish Prashanth, K. V., & Baskaran, V. (2013). Promising interaction between nanoencapsulated lutein with low molecular weight chitosan: characterization and bioavailability of lutein in vitro and in vivo. Food Chemistry, 141, 327-337.
5. Augustin, M. A., & Hemar, Y. (2009). Nano-and micro-structured assemblies for encapsulation of food ingredients. Chemical Society Reviews, 38, 902-912.
6. Augustin, M. A., Sanguansri, L., & Lockett, T. (2013). Nano-and micro-encapsulated systems for enhancing the delivery of resveratrol. Annals of the New York Academy of Science, 1290, 107-112.
7. Belhaj, N., Dupuis, F., Arab-Tehrany, E., Denis, F. M., Paris, C., Lartaud, I., et al. (2012). Formulation, characterization and pharmacokinetic studies of coenzyme Q10 PUFA's nanoemulsions. European Journal of Pharmaceutical Sciences, 47, 305-312.
8. Benson, S. P., & Pleiss, J. (2014). Molecular dynamics simulations of self-emulsifying drug-delivery systems (SEDDS): influence of excipients on droplet nanostructure and drug localization. Langmuir, 30, 8471-8480.
9. Brandl, M. (2001). Liposomes as drug carriers: a technological approach. Biotechnology Annual Review, 7, 59-85.
10. Choi, A. Y., Kim, C. T., Park, H. Y., Kim, H. O., Lee, N. R., Lee, K. E., et al. (2013). Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan. Journal of Agricultural and Food Chemistry, 61, 2096-2102.
11. Davis, M. E., & Brewster, M. E. (2004). Cyclodextrin-based pharmaceutics: past, present and future. Nature Reviews Drug Discovery, 3, 1023-1035.
12. Deshpande, P. P., Biswas, S., & Torchilin, V. P. (2013). Current trends in the use of liposomes for tumor targeting. Nanomedicine, 8, 1509-1528.
13. Dey, T. K., Ghosh, S., Ghosh, M., Koley, H., & Dhar, P. (2012). Comparative study of gastrointestinal absorption of EPA & DHA rich fish oil from nano and conventional emulsion formulation in rats. Food Research International, 49, 72-79.
14. Ezhilarasi, P. N., Karthik, P., Chhanwal, N., & Anandharamakrishnan, C. (2013). Nanoencapsulation techniques for food bioactive components: a review. Food and Bioprocess Technology, 6, 628-647.
15. Fang, M., Jin, Y., Bao, W., Gao, H., Xu, M., Wang, D., et al. (2012). In vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration. International Journal of Nanomedicine, 7, 5395-5404.
16. Fathi, M., Mozafari, M. R., & Mohebbi, M. (2012). Nanoencapsulation of food ingredients using lipid based delivery systems. Trends in Food Science and Technology, 23, 13-27.
17. Frenzel, M., Krolak, E., Wagner, A. E., & Steffen-Heins, A. (2015). Physicochemical properties of WPI coated liposomes serving as stale transporters in a real food matrix. LWT-Food Science and Technology, 63, 527-534.
18. Gokce, E. H., Korkmaz, E., Tuncay-Tanriverdi, S., Dellera, E., Sandri, G., Bonferoni, M. C., et al. (2012). A comparative evaluation of coenzyme Q 10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers. International Journal of Nanomedicine, 7, 5109-5117.
19. Gong, C., Wu, Q., Wang, Y., Zhang, D., Luo, F., Zhao, X., et al. (2013). A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials, 34, 6377-6387.
20. Gonnet, M., Lethuaut, L., & Boury, F. (2010). New trends in encapsulation of liposoluble vitamins. Journal of Controlled Release, 146, 276-290.
21. Gunasekaran, S., Ko, S., & Xiao, L. (2007). Use of whey proteins for encapsulation and controlled delivery applications. Journal of Food Engineering, 83, 31-40.
22. Haham, M., Ish-Shalom, S., Nodelman, M., Duek, I., Segal, E., Kustanovich, M., et al. (2012). Stability and bioavailability of vitamin D nanoencapsulated in casein micelles. Food & Function, 3, 737-744.
23. Ha, H. K., Kim, J.W., Lee, M. R., & Lee, W. J. (2013). Formation and characterization of quercetin-loaded chitosan oligosaccharide/β-lactoglobulin nanoparticle. Food Research International, 52, 82-90.
24. Harde, H., Das, M., & Jain, S. (2011). Solid lipid nanoparticles: an oral bioavailability enhancer vehicle. Expert Opinion on Drug Delivery, 8, 1407-1424.
25. Hatcher, H., Planalp, R., Cho, J., Torti, F. M., & Torti, S. V. (2008). Curcumin: from ancient medicine to current clinical trials. Cellular and Molecular Life Sciences, 65, 1631-1652.
26. Hejri, A., Khosravi, A., Gharanjig, K., & Hejazi, M. (2013). Optimisation of the formulation of b-carotene loaded nanostructured lipid carriers prepared by solvent diffusion method. Food Chemistry, 141, 117-123.
27. Jackson, C. J. C., & Paliyath, G. (2011). Functional foods and nutraceuticals. In G. Paliyath, M. Bakovic, & K. Shetty (Eds.), Functional foods, nutraceuticals, and degenerative disease prevention (1st ed., pp. 11-43). John Wiley & Sons, Inc.
28. Joshi, R. P., Negi, G., Kumar, A., Pawar, Y. B., Munjal, B., Bansal, A. K., et al. (2013). SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection. Nanomedicine: Nanotechnology, Biology and Medicine, 9, 776-785.
29. Kabanov, A. V., & Vinogradov, S. V. (2009). Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angewandte Chemie International Edition, 48, 5418-5429.
30. Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., & Farokhzad, O. C. (2012). Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chemical Society Reviews, 41, 2971-3010.
31. Karadag, A., Ozcelik, B., & Huang, Q. (2014). Quercetin nanosuspensions produced by high-pressure homogenization. Journal of Agricultural and Food Chemistry, 62, 1852-1859.
32. Karadag, A., Yang, X., Ozcelik, B., & Huang, Q. (2013). Optimization of preparation conditions for quercetin nanoemulsions using response surface methodology. Journal of Agricultural and Food Chemistry, 61, 2130-2139.
33. Keck, C. M., Baisaeng, N., Durand, P., Prost, M., Meinke, M. C., & Müller, R. H. (2014). Oil-enriched, ultra-small nanostructured lipid carriers (usNLC): a novel delivery system based on flipeflop structure. International Journal of Pharmaceutics, 477, 227-235.
34. Khalil, N. M., Do Nascimento, T. C. F., Casa, D. M., Dalmolin, L. F., De Mattos, A. C., Hoss, I., et al. (2013). Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats. Colloids and Surfaces B: Biointerfaces, 101, 353-360.
35. Kim, S. O., Ha, T. V. A., Choi, Y. J., & Ko, S. H. (2014). Optimization of homogenizationevaporation process for lycopene nanoemulsion production and its beverage applications. Journal of Food Science, 79. N1604eN1601.
36. Kim, J. Y., Seo, T. R., & Lim, S. T. (2013). Preparation of aqueous dispersion of bcarotene nano-composites through complex formation with starch dextrin. Food Hydrocolloids, 33, 256-263.
37. Kohlrneier, L., & Hastings, S. B. (1995). Epidemiologic evidence of a role of carotenoids in cardiovascular disease prevention. American Society for Clinical Nutrition, 62, 1370Se1376S.
38. Lacatusu, I., Mitrea, E., Badea, N., Stan, R., Oprea, O., & Meghea, A. (2013). Lipid nanoparticles based on omega-3 fatty acids as effective carriers for lutein delivery. preparation and in vitro characterization studies. Journal of Functional Foods, 5, 1260-1269.
39. Liang, R., Shoemaker, C. F., Yang, X., Zhong, F., & Huang, Q. (2013). Stability and bioaccessibility of b-carotene in nanoemulsions stabilized by modified starches. Journal of Agricultural and Food Chemistry, 61, 1249-1257.
40. Liu, L., Tang, Y., Gao, C., Li, Y., Chen, S., Xiong, T., et al. (2014). Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers. Colloids and Surfaces B: Biointerfaces, 115, 125-131.
41. Livney, Y. D. (2010). Milk proteins as vehicles for bioactives. Current Opinion in Colloid & Interface Science, 15, 73-83.
42. Mangolim, C. S., Moriwaki, C., Nogueira, A. C., Sato, F., Baesso, M. L., Neto, A. M., et al. (2014). Curcumine β-cyclodextrin inclusion complex: stability, solubility, characterisation by FT-IR, FT-Raman, X-ray diffraction and photoacoustic spectroscopy, and food application. Food Chemistry, 153, 361-370.
43. Maurer, N., Fenske, D. B., & Cullis, P. R. (2001). Developments in liposomal drug delivery systems. Expert Opinion on Biological Therapy, 1, 923-947.
44. Mazzarino, L., Travelet, C., Ortega-Murillo, S., Otsuka, I., Pignot-Paintrand, I., Lemos-Senna, E., et al. (2012). Elaboration of chitosan-coated nanoparticles loaded with curcumin for mucoadhesive applications. Journal of Colloid and Interface Science, 370, 58-66.
45. McClements, D. J. (2012). Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter, 8, 1719-1729.
46. McClements, D. J., Decker, E. A., Park, Y., & Weiss, J. (2009). Structural design principles for delivery of bioactive components in nutraceuticals and functional foods. Critical Reviews in Food Science and Nutrition, 49, 557-606.
47. McClements, D. J., & Li, Y. (2010). Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components. Advances in Colloid and Interface Science, 159, 213-228.
48. Mitri, K., Shegokar, R., Gohla, S., Anselmi, C., & Müller, R. H. (2011). Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance. International Journal of Pharmaceutics, 414, 267-275.
49. Moon, H. S., Lee, H. G., Chung, C., Choi, Y., & Cho, C. (2008). Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability. Nutrition & Metabolism, 5, 16-24.
50. Mori, A., Lehmann, S., O'Kelly, J., Kumagai, T., Desmond, J. C., Pervan, M., et al. (2006). Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Research, 66, 3222-3229.
51. Naksuriya, O., Okonogi, S., Schiffelers, R. M., & Hennink, R. M. (2014). Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials, 35, 3365-3383.
52. Nerome, H., Machmudah, S., Fukuzato, R., Higashiura, T., Youn, Y., Lee, Y., et al. (2013). Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation. The Journal of Supercritical Fluids, 83, 97-103.
53. Oehlke, K., Adamiuk, M., Behsnilian, D., Gräf, V., Mayer-Miebach, E., Walz, E., et al. (2014). Potential bioavailability enhancement of bioactive compounds using food-grade engineered nanomaterials: a review of the existing evidence. Food & Function, 5, 1341-1359.
54. Onoue, S., Uchida, A., Kuriyama, K., Nakamura, T., Seto, Y., Kato, M., et al. (2012). Novel solid self-emulsifying drug delivery system of coenzyme Q10 with improved photochemical and pharmacokinetic behaviors. European Journal of Pharmaceutical Sciences, 46, 492-499.
55. Pandita, D., Kumar, S., Poonia, N., & Lather, V. (2014). Solid lipid nanoparticles enhance oral bioavailability of resveratrol, a natural polyphenol. Food Research International, 62, 1165-1174.
56. Pan, K., Luo, Y., Gan, Y., Baek, S. J., & Zhong, Q. (2014). pH-driven encapsulation of curcumin in self assembled casein nanoparticles for enhanced dispersibility and bioactivity. Soft Matter, 10, 6820-6830.
57. Pan, K., Zhong, Q., & Baek, S. J. (2013). Enhanced dispersibility and bioactivity of curcumin by encapsulation in casein nanocapsules. Journal of Agricultural and Food Chemistry, 61, 6036-6043.
58. Pardeshi, C., Rajput, P., Belgamwar, V., Tekade, A., Patil, G., Chaudhary, K., et al. (2012). Solid lipid based nanocarriers: an overview. Acta Pharmaceutica, 62, 433-472.
59. Patel, A. R., Heussen, P., Hazekamp, J., Drost, E., & Velikov, K. P. (2012). Quercetin loaded biopolymeric colloidal particles prepared by simultaneous precipitation of quercetin with hydrophobic protein in aqueous medium. Food Chemistry, 133, 423-429.
60. Patel, A. R., & Velikov, K. P. (2011). Colloidal delivery systems in foods: a general comparison with oral drug delivery. LWT Food Science and Technology, 44, 1958-1964.
61. Pinheiro, A. C., Lad, M., Silva, H. D., Coimbra, M. A., Boland, M., & Vicente, A. A. (2013). Unravelling the behaviour of curcumin nanoemulsionsduring in vitro digestion: effect of the surface charge. Soft Matter, 9, 3147-3154.
62. Popat, A., Karmakar, S., Jambhrunkar, S., Xu, C., & Yu, C. (2014). Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids and Surfaces B: Biointerfaces, 117, 520-527.
63. Pouton, C. W. (2006). Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. European Journal of Pharmaceutical Sciences, 29, 278-287.
64. Pradhan, M., Singh, D., & Singh, M. R. (2013). Novel colloidal carriers for psoriasis: current issues, mechanistic insight and novel delivery approaches. Journal of Controlled Release, 170, 380-395.
65. Qian, C., Decker, E. A., Xiao, H., & McClements, D. J. (2013). Impact of lipid nanoparticle physical state on particle aggregation and b-carotene degradation: potential limitations of solid lipid nanoparticles. Food Research International, 52, 342-349.
66. Quinones, J. P., Gothelf, K. V., Kjems, J., Yang, C., Caballero, A. M. H., Schmidte, C., et al. (2013). Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of DL-α-tocopherol. Carbohydrate Polymers, 92, 856-864.
67. Rabinow, B. E. (2004). Nanosuspensions in drug delivery. Nature Reviews Drug Discovery, 3, 785-796.
68. Rachmawati, H., Shaal, L. A., Müller, R. H., & Keck, C. M. (2013). Development of curcumin nanocrystal: physical aspects. Journal of Pharmaceutical Sciences, 102, 204-214.
69. Raemdonck, K., Demeester, J., & Smedt, S. D. (2009). Advanced nanogel engineering for drug delivery. Soft Matter, 5, 707-715.
70. Ramos, O. L., Pereira, R. N., Rodrigues, R., Teixeira, J. A., Vicente, A. A., & Malcata, F. X. (2014). Physical effects upon whey protein aggregation for nano-coating production. Food Research International, 66, 344-355.
71. Salminen, H., Aulbach, S., Leuenberger, B. H., Tedeschi, C., & Weiss, J. (2014). Influence of surfactant composition on physical and oxidative stability of quillaja saponin-stabilized lipid particles with encapsulated u-3fish oil. Colloids and Surfaces B: Biointerfaces, 122, 46-55.
72. Salvia-Trujillo, L., Qian, C., Martín-Belloso, O., & McClements, D. J. (2013). Modulating b-carotene bioaccessibility by controlling oil composition and concentration in edible nanoemulsions. Food Chemistry, 139, 878-884.
73. Sessa, M., Balestrieri, M. L., Ferrari, G., Servillo, L., Castaldo, D., D'Onofrio, N., et al. (2014). Bioavailability of encapsulated resveratrol into nanoemulsions-based delivery systems. Food Chemistry, 147, 42-50.
74. Shanmugam, S., Baskaran, R., Balakrishnan, P., Thapa, P., Yong, C. S., & Yoo, B. K. (2011). Solid self-nanoemulsifying drug delivery system (s-SNEDDS) containing phosphatidylcholine for enhanced bioavailability of highly lipophilic bioactive carotenoid lutein. European Journal of Pharmaceutics and Biopharmaceutics, 79, 250-257.
75. Shin, G. H., Chung, S. K., Kim, J. T., Joung, H. J., & Park, H. J. (2013). Preparation of chitosan-coated nanoliposomes for improving the mucoadhesive property of curcumin using the ethanol injection method. Journal of Agricultural and Food Chemistry, 61, 11119-11126.
76. Solans, C., Izquierdo, P., Nolla, J., Azemar, N., & Garcia-Celma, M. (2005). Nanoemulsions. Current Opinion in Colloid & Interface Science, 10, 102-110.
77. Stegemann, S., Leveiller, F., Franchi, D., de Jong, H., & Lindene, H. (2007). When poor solubility becomes an issue: from early stage to proof of concept. European journal of Pharmaceutical Sciences, 31, 249-261.
78. Sun, J., Bi, C., Chan, H. M., Sun, S., Zhang, Q., & Zheng, Y. (2013). Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability. Colloids and Surfaces B: Biointerfaces, 111, 367-375.
79. Sun, M., Su, X., Ding, B., He, X., Liu, X., Yu, A., et al. (2012). Advances in nanotechnology-based delivery systems for curcumin. Nanomedicine, 7, 1085-1100.
80. Swarnakar, N. K., Jain, A. K., Singh, R. P., Godugu, C., Das, M., & Jain, S. (2011). Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. Biomaterials, 32, 6860-6874.
81. Takahashi, M., Uechi, S., Takara, K., Asikin, Y., & Wada, K. (2009). Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. Journal of Agricultural and Food Chemistry, 57, 9141-9146.
82. Tamjidi, F., Shahedi, M., Varshosaz, J., & Nasirpour, A. (2013). Nanostructured lipid carriers (NLC): a potential delivery system for bioactive food molecules. Innovative Food Science & Emerging Technologies, 19, 29-43.
83. Tan, C., Zhang, Y., Abbas, S., Feng, B., Zhang, X., & Xia, S. (2014). Modulation of the carotenoid bioaccessibility through liposomal encapsulation. Colloids and Surfaces B: Biointerfaces, 123, 692-700.
84. Torchilin, V. P. (2007). Targeted pharmaceutical nanocarriers for cancer therapy and imaging. The AAPS Journal, 9, E128eE147.
85. Velikov, K. P., & Pelan, E. (2008). Colloidal delivery systems for micronutrients and nutraceuticals. Soft Matter, 4, 1964-1980.
86. Walker, R., Decker, E. A., & McClements, D. J. (2015). Development of food-grade nanoemulsions and emulsions for delivery of omega-3 fatty acids: opportunities and obstacles in the food industry. Food & Function, 6, 42-55.
87. Xie, X., Tao, Q., Zou, Y., Zhang, F., Guo, M., Wang, Y., et al. (2011). PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. Journal of Agricultural and Food Chemistry, 59, 9280-9289.
88. Yadav, V. R., Prasad, S., Kannappan, R., Ravindran, J., Chaturvedi, M. M., Vaahtera, L., et al. (2010). Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochemical Pharmacology, 80, 1021-1032.
89. Yi, J., Lam, T. I., Yokoyama, W., Cheng, L. W., & Zhong, F. (2015). Beta-carotene encapsulated in food protein nanoparticles reduces peroxyl radical oxidation in Caco-2 cells. Food Hydrocolloids, 43, 31-40.
90. Yoo, J., Baskaran, R., & Yoo, B. K. (2013). Self-nanoemulsifying drug delivery system of lutein: physicochemical properties and effect on bioavailability of Warfarin. Biomolecules & Therapeutics, 21, 173-179.
91. Zaki, N. M. (2014). Strategies for oral delivery and mitochondrial targeting of CoQ10. Drug Delivery, 29, 1-14.
92. Zhang, L., Hayes, D. G., Chen, G., & Zhong, Q. (2013). Transparent dispersions of milkfat-based nanostructured lipid carriers for delivery of b-carotene. Journal of Agricultural and Food Chemistry, 61, 9435-9443.
93. Zhao, L., Du, J., Duan, Y., Zang, Y., Zhang, H., Yang, C., et al. (2012). Curcumin loaded mixed micelles composed of Pluronic P123 and F68: preparation, optimization and in vitro characterization. Colloids and Surfaces B: Biointerfaces, 97, 101-108.
94. Zhou, H., Liu, G., Zhang, J., Sun, N., Duan, M., Yan, Z., et al. (2014). Novel lipid-free nanoformulation for improving oral bioavailability of coenzyme Q10. BioMed Research International. Article ID 793879.