Development of curcumin nanocrystal: Physical aspects

Journal of Pharmaceutical Sciences

Volumn 102, Issue 1, 2013, Pages 204-214

  Rachmawati, Heni ^a,b   Shaal, Loaye Al ^b   Müller, Rainer H ^b   Keck, Cornelia M ^b  

^a BANDUNG INSTITUTE OF TECHNOLOGY   (Indonesia)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Aggregation; Crsytallinity; Curcumin; Electrostatic stabilization; High pressure homogenization; Nanocrystals; Nanoparticle; Polymers; Steric stabilization; Surface charge

Indexed keywords

CARBOXYMETHYLCELLULOSE; CURCUMIN; DODECYL SULFATE SODIUM; NANOCRYSTAL; POLYVINYL ALCOHOL; POVIDONE; TOCOFERSOLAN;

ARTICLE; CRYSTAL STRUCTURE; DRUG SOLUBILITY; DRUG STABILITY; LOW TEMPERATURE; PARTICLE SIZE; ROOM TEMPERATURE; SURFACE CHARGE; SUSPENSION; TEMPERATURE DEPENDENCE; ZETA POTENTIAL;

EID: 84870661007     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23335     Document Type: Article

References (30)

1. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. 2007. Biovailability of curcumin: Problems and Promises. Mol Pharm 4(6):808-818.
2. Tonnesen HH, Masson M, Loftsson T. 2002. Studies of curcumin and curcuminoids, cyclodextrin complexation, solubility, chemical and photochemical stability. Int J Pharm 244:127-135.
3. Wang YJ, Pan MH, Chery AL, Lin LI, Hoy S, Hsieh CV, Lia JK. 1997. Stability of curcumin in buffer solution and characterization of its degradation product. J Pharm Biomed Anal 15:1867-1876.
4. Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R. 1995. Antitumor and antioxidant activity of natural curcuminoids. Cancer Lett 94:79-83.
5. Gescher AJ, Sharma RA, Steward WP. 1992. Cancer chemoprevention by dietary constituents: A tale of failure and promise. Lancet Oncol 11:226-230.
6. Jayaprakasha GK, Jaganmohan L, Sakariah KK. 2006. Antioxidant activities of curcumin, demethoxy curcumin and bisdemethoxy curcumin. Food Chem 98:720-724.
7. Tonnesen HH, Greenhil JVL. 1992. Studies on curcumin and curcuminoids XXII curcumin as a reducing agent and as a radical scavenger. Int J Pharm 87:79-87.
8. Chan MM, Huang HI, Fenton MR, Fong D. 1998. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem Pharmacol 55(12):1955-1962.
9. Kim YS, Ahn Y, Hong MH, Joo SY, Kim KH, Sohn IS, Park HW, Hong YJ, Kim JH, Kim W, Jeong MH, Cho JG, Park JC, Kang JC. 2007. Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells. J Cardiovasc Pharmacol 50(1):41-49.
10. Vanisree AJ, Sudha N. 2006. Curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver. Mol Cell Biochem 288(1-2):115-123.
11. Rukkumani R, Aruna K, Varma PS, Rajasekaran KN, Menon VP. 2005. Comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles. J Med Food 8(2):256-260.
12. De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A, Nair GB, Mukhopadhyay AK. 2009. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob Agents Chemother 53(4):1592-1597.
13. Panchatcharam M, Miriyala S, Gayathri VS, Suguna L. 2006. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem 290(1-2):87-96.
14. Seehofer D, Schirmeier A, Bengmark S, Carter J, Koch M, Glanemann M, Nüssler AK, Neuhaus P, Menger MD. 2009. Inhibitory effect of curcumin on early liver regeneration following partial hepatectomy in rats. J Surg Res 155(2):195-200.
15. Priya S, Sudhakaran PR. 2008. Curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells. Indian J Biochem Biophys 45(5):317-325.
16. Lao CD, Demierre MF, Sondak VK. 2006. Targeting events in melanoma carcinogenesis for the prevention of melanoma. Expert Rev Anticancer Ther 6(11):1559-1568.
17. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY. 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21 (4B):2895-2900.
18. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64(4):353-356.
19. Muller, RH, Moschwitzer FN, Bushrab FN. 2006. Manufacturing of nanoparticles by milling and homogenization techniques. In Nanoparticle technology for drug delivery; Gupta, RB, Kompella, UB, Eds. New York City, New York: Taylor & Francis Group, pp 21-52.
20. Eerdenbrugh BV, Van den Mooter G, Augustijns P. 2008. Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid product. Int J Pharm 364:67-75.
21. Lee J, Choi JY, Park CH. 2008. Characteristics of polymers enabling nano-comminution of water-insoluble drugs. Int J Pharm 355:328-336.
22. Choi JY, Yoo JY, Kwak HS, Nam BU, Lee J. 2005. Role of polymeric stabilizers for drug nanocrystal dispersions. Curr Appl Phys 5:472-474.
23. Müller, RH, Peters K, Becker R, Kruss B. 1995. Nanosuspensions-A novel formulation for the i.v. administration of poorly soluble drugs. Budapest, Hungary: 1st World Meeting APG/APV, pp 491-492.
24. Peters K. 1999. Nanosuspensionen-ein neues formulierungsprinzip für schwerlösliche Arzneistoffe. Ph.D. Thesis. Berlin, Germany: Freie Universität Berlin.
25. Eerdenbrugh BV, Vermant J, Martens JA, Froyen L, Humbeeck JV, Augustijns P, Den Mooter GV. 2009. A screening study of surface stabilization during the production of drug nanocrystals. J Pharm Sci 98:2091-2103.
26. Mu L, Seow PH, Ang SN, Feng SS. 2004. Study on surfactant coating of polymeric nanoparticles for controlled delivery of anticancer drug. Colloid Polym Sci 283:58-65.
27. Janke S. 2001. The theory of high-pressure homogenization. In Dispersion techniques for laboratory and industrial scale processing; Muller RH, Bohm BHL, Eds. Stuttgart, Germany: Wissenschafttiche Verlagsgesellschaft mbH.
28. Müller, RH. 1996. Zetapotential und Partikeladung in der Laborpraxis. Stuttgart, Germany: Wissenschaftliche Verlagsgeselschaft mbH.
29. Mauludin R, Müller RH, Keck CM. 2009. Kinetic solubility and dissolution velocity of rutin nanocrystals. Eur J Pharm Sci 36:502-510.
30. R. Suryanarayanan 1995. X-ray powder diffractometry. In Physical characterization of pharmaceutical solids; Brittain HG; Ed. New York City, New York: Marcel Dekker, pp 187-221.