A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

Biomaterials

Volumn 34, Issue 27, 2013, Pages 6377-6387

  Gong, ChangYang ^a   Wu, QinJie ^a   Wang, YuJun ^a   Zhang, DouDou ^a   Luo, Feng ^a   Zhao, Xia ^b   Wei, YuQuan ^a   Qian, ZhiYong ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Curcumin; Dermal wound healing; Micelles; Poly( caprolactone); Poly(ethylene glycol); Thermosenstitive hydrogel

Indexed keywords

ANTI-INFLAMMATORY AGENTS; BIODEGRADABLE HYDROGELS; CAPROLACTONE; CONTROLLED DRUG DELIVERY SYSTEMS; CURCUMIN; DERMAL WOUND HEALING; ENCAPSULATION EFFICIENCY; THERMO-SENSITIVE HYDROGEL;

CONTROLLED DRUG DELIVERY; ENCAPSULATION; MICELLES; OXYGEN; POLYETHYLENE GLYCOLS; REPAIR; SOLS; TENSILE STRENGTH; TISSUE;

HYDROGELS;

ANTIOXIDANT; CATALASE; COLLAGEN; CURCUMIN; MACROGOL; POLYCAPROLACTONE; POLYMER; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BIODEGRADABILITY; BODY TEMPERATURE; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENVIRONMENTAL TEMPERATURE; EPIDERMIS; HEAT SENSITIVITY; HISTOPATHOLOGY; HYDROGEL; HYDROPHOBICITY; IN VITRO STUDY; MALE; MICELLE; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN INJURY; TENSILE STRENGTH; THICKNESS; WOUND HEALING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CURCUMIN; DRUG CARRIERS; HYDROGEL; MALE; MICELLES; POLYESTERS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; WOUND HEALING;

EID: 84879105780     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.05.005     Document Type: Article

References (40)

1. Yates C.C., Whaley D., Babu R., Zhang J., Krishna P., Beckman E., et al. The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models. Biomaterials 2007, 28:3977-3986.
2. Kim H.N., Hong Y., Kim M.S., Kim S.M., Suh K.-Y. Effect of orientation and density of nanotopography in dermal wound healing. Biomaterials 2012, 33:8782-8792.
3. Harmon A.M., Kong W., Buensuceso C.S., Gorman A.J., Muench T.R. Effects of fibrin pad hemostat on the wound healing process invivo and invitro. Biomaterials 2011, 32:9594-9601.
4. Ruszczak Z. Effect of collagen matrices on dermal wound healing. Adv Drug Delivery Rev 2003, 55:1595-1611.
5. Hardwicke J., Ferguson E.L., Moseley R., Stephens P., Thomas D.W., Duncan R. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. JControl Release 2008, 130:275-283.
6. Hardwicke J., Moseley R., Stephens P., Harding K., Duncan R., Thomas D.W. Bioresponsive dextrin-rhEGF conjugates: invitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Mol Pharm 2010, 7:699-707.
7. Hardwicke J., Song B., Moseley R., Thomas D.W. Investigation of the potential of polymer therapeutics in corneal re-epithelialisation. Brit J Ophthalmol 2010, 94:1566-1570.
8. Anumolu S.N.S., Menjoge A.R., Deshmukh M., Gerecke D., Stein S., Laskin J., et al. Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries. Biomaterials 2011, 32:1204-1217.
9. Tran N.Q., Joung Y.K., Lih E., Park K.D. In situ forming and rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing. Biomacromolecules 2011, 12:2872-2880.
10. Judith R., Nithya M., Rose C., Mandal A. Application of a PDGF-containing novel gel for cutaneous wound healing. Life Sci 2010, 87:1-8.
11. Singh S. From exotic spice to modern drug?. Cell 2007, 130:765-768.
12. Jagetia G.C., Aggarwal B.B. "Spicing up" of the immune system by curcumin. JClin Immunol 2007, 27:19-35.
13. Tang H., Murphy C.J., Zhang B., Shen Y., Van Kirk E.A., Murdoch W.J., et al. Curcumin polymers as anticancer conjugates. Biomaterials 2010, 31:7139-7149.
14. Yallapu M.M., Jaggi M., Chauhan S.C. Curcumin nanoformulations: a future nanomedicine for cancer. Drug Discov Today 2012, 17:71-80.
15. Maheshwari R.K., Singh A.K., Gaddipati J., Srimal R.C. Multiple biological activities of curcumin: a short review. Life Sci 2006, 78:2081-2087.
16. Jagetia G.C., Rajanikant G. Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of γ-radiation. JSurg Res 2004, 120:127-138.
17. Gopinath D., Ahmed M.R., Gomathi K., Chitra K., Sehgal P., Jayakumar R. Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 2004, 25:1911-1917.
18. Safavy A., Raisch K.P., Mantena S., Sanford L.L., Sham S.W., Krishna N.R., et al. Design and development of water-soluble curcumin conjugates as potential anticancer agents. JMed Chem 2007, 50:6284-6288.
19. Anand P., Kunnumakkara A.B., Newman R.A., Aggarwal B.B. Bioavailability of curcumin: problems and promises. Mol Pharm 2007, 4:807-818.
20. Li L., Braiteh F.S., Kurzrock R. Liposome-encapsulated curcumin. Cancer 2005, 104:1322-1331.
21. Gong C.Y., Wang Y.J., Wang X.H., Wei X.W., Wu Q.J., Wang B.L., et al. Biodegradable self-assembled PEG-PCL-PEG micelles for hydrophobic drug delivery, part 2: invitro and invivo toxicity evaluation. JNanopart Res 2011, 13:721-731.
22. Gong C.Y., Shi S.A., Dong P.W., Kan B., Gou M.L., Wang X.H., et al. Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. Int J Pharm 2009, 365:89-99.
23. Gong C.Y., Yang B., Qian Z.Y., Zhao X., Wu Q.J., Qi X.R., et al. Improving intraperitoneal chemotherapeutic effect and preventing postsurgical adhesions simultaneously with biodegradable micelles. Nanomed Nanotechnol 2012, 8:963-973.
24. Gong C.Y., Xie Y., Wu Q.J., Wang Y., Deng S., Xiong D., et al. Improving antitumor activity with polymeric micelles entrapping paclitaxel in pulmonary carcinoma. Nanoscale 2012, 4:6004-6017.
25. Gong C., Deng S., Wu Q., Xiang M., Wei X., Li L., et al. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials 2013, 34:1413-1432.
26. Gong C.Y., Wang C., Wang Y.J., Wu Q.J., Zhang D.D., Luo F., et al. Efficient inhibition of colorectal peritoneal carcinomatosis by drug loaded micelles in thermosensitive hydrogel composites. Nanoscale 2012, 4:3095-3104.
27. Hardwicke J.T., Hart J., Bell A., Duncan R., Thomas D.W., Moseley R. The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse. JControl Release 2011, 152:411-417.
28. Gomathi K., Gopinath D., Rafiuddin Ahmed M., Jayakumar R. Quercetin incorporated collagen matrices for dermal wound healing processes in rat. Biomaterials 2003, 24:2767-2772.
29. Egan M.E., Pearson M., Weiner S.A., Rajendran V., Rubin D., Glöckner-Pagel J., et al. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science 2004, 304:600-602.
30. Goel A., Kunnumakkara A.B., Aggarwal B.B. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol 2008, 75:787-809.
31. Jovanovic S.V., Boone C.W., Steenken S., Trinoga M., Kaskey R.B. How curcumin works preferentially with water soluble antioxidants. JAm Chem Soc 2001, 123:3064-3068.
32. Wu W., Shen J., Banerjee P., Zhou S. Water-dispersible multifunctional hybrid nanogels for combined curcumin and photothermal therapy. Biomaterials 2011, 32:598-609.
33. Li L., Ahmed B., Mehta K., Kurzrock R. Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer. Mol Cancer Ther 2007, 6:1276-1282.
34. Lin C.C., Lin H.Y., Chen H.C., Yu M.W., Lee M.H. Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions. Food Chem 2009, 116:923-928.
35. Tomren M., Masson M., Loftsson T., Tønnesen H.H. Studies on curcumin and curcuminoids: XXXI. Symmetric and asymmetric curcuminoids: stability, activity and complexation with cyclodextrin. Int J Pharm 2007, 338:27-34.
36. Wang S., Tan M., Zhong Z., Chen M., Wang Y. Nanotechnologies for curcumin: an ancient puzzler meets modern solutions. JNanomater 2011, 2011:723178.
37. Arul V., Kartha R., Jayakumar R. Atherapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices. Life Sci 2007, 80:275-284.
38. Chen R.N., Wang G.M., Chen C.H., Ho H.O., Sheu M.T. Development of N, O-(carboxymethyl) chitosan/collagen matrixes as a wound dressing. Biomacromolecules 2006, 7:1058-1064.
39. Wang X., Martindale J.L., Liu Y., Holbrook N.J. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 1998, 333:291-300.
40. S6k signaling pathway. JBiol Chem 1999, 274:32596-32602.