Novel solid self-emulsifying drug delivery system of coenzyme Q 10 with improved photochemical and pharmacokinetic behaviors

European Journal of Pharmaceutical Sciences

Volumn 46, Issue 5, 2012, Pages 492-499

  Onoue, Satomi ^a   Uchida, Atushi ^a   Kuriyama, Kazuki ^a   Nakamura, Tatsuya ^a   Seto, Yoshiki ^a   Kato, Masashi ^a   Hatanaka, Junya ^a,b   Tanaka, Toshiyuki ^c   Miyoshi, Hiroyuki ^c   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b Novel Formulation Technology Project   (Japan)

^c Ohkawara Kakohki Co Ltd   (Japan)

Author keywords

Bioavailability; Coenzyme Q 10; Dissolution; Photostability; Solid self emulsifying drug delivery system

Indexed keywords

FATTY ACID; HYDROXYPROPYLCELLULOSE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCROSE ESTER DERIVATIVE; SUPEROXIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SCREENING; DRUG STABILITY; EMULSION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHOTOCHEMISTRY; PHOTODEGRADATION; PHOTOREACTIVITY; POWDER; PRIORITY JOURNAL; RAT; SOLID SELF EMULSIFYING DRUG DELIVERY SYSTEM; SPRAY DRYING;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DIETARY SUPPLEMENTS; DRUG CARRIERS; DRUG STABILITY; EMULSIONS; FATTY ACIDS; LIPIDS; MALE; METABOLIC CLEARANCE RATE; PARTICLE SIZE; PHOTOLYSIS; POWDERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SUPEROXIDES; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES; UBIQUINONE;

EID: 84861194922     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.03.015     Document Type: Article

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