Formulation, characterization and pharmacokinetic studies of coenzyme Q10 PUFA's nanoemulsions

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 2, 2012, Pages 305-312

  Belhaj, Nabila ^a   Dupuis, Franois ^b   Arab Tehrany, Elmira ^a   Denis, Frédéric M ^c   Paris, Cédric ^a   Lartaud, Isabelle ^b   Linder, Michel ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c Laboratoires le Stum   (France)

Author keywords

Bioavailability; Coenzyme Q10; LC PUFA; Nanoemulsion; Salmon lecithin

Indexed keywords

FAT DROPLET; KANEKAQ10; PHOSPHATIDYLCHOLINE; POLYUNSATURATED FATTY ACID; SOYBEAN OIL; UBIDECARENONE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; LIPID COMPOSITION; MALE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EMULSIONS; FATTY ACIDS; FISH OILS; LECITHINS; MALE; NANOSTRUCTURES; RATS; RATS, WISTAR; SOLUBILITY; UBIQUINONE;

EID: 84864404840     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.06.008     Document Type: Article

References (41)

1. P. Balakrishnan, B.-J. Lee, D.H. Oh, J.O. Kim, Y.-I. Lee, D.-D. Kim, J.-P. Jee, Y.-B. Lee, J.S. Woo, C.S. Yong, and H.-G. Choi Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems Int. J. Pharm. 374 2009 66 72
2. G. Bank, D. Kagan, and D. Madhavi Coenzyme Q10: clinical update and bioavailability J. Evidence Complement. Altern. Med. 16 2011 129 137
3. N. Belhaj, E. Arab-Tehrany, and M. Linder Oxidative kinetics of salmon oil in bulk and in nanoemulsion stabilized by marine lecithin Process Biochem. 45 2010 187 195
4. . Cambiella, J.M. Benito, C. Pazos, and J. Coca Interfacial properties of oil-in-water emulsions designed to be used as metalworking fluids Colloids Surf., A 305 2007 112 119
5. G. Chansiri, R.T. Lyons, M.V. Patel, and S.L. Hem Effect of surface charge on the stability of oil/water emulsions during steam sterilization J. Pharm. Sci. 88 1999 454 458
6. C.H. Choi, S.H. Kim, S. Shanmugam, R. Baskaran, J.S. Park, C.S. Yong, H.G. Choi, B.K. Yoo, and K. Han Relative bioavailability of coenzyme Q10 in emulsion and liposome formulations Biomolecules Therap. 18 2010 99 105
7. J.-C. Colas, W. Shi, V.S.N.M. Rao, A. Omri, M.R. Mozafari, and H. Singh Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting Micron 38 2007 841 847
8. G.C. Dos Santos, L.M.G. Antunes, A.C. Dos Santos, and M.D.L.P. Bianchi Coenzyme Q10 and its effects in the treatment of neurodegenerative diseases Braz. J. Pharm. Sci. 45 2009 607 618
9. G. Fricker, T. Kromp, A. Wendel, A. Blume, J. Zirkel, H. Rebmann, C. Setzer, R.-O. Quinkert, F. Martin, and C. Müller-Goymann Phospholipids and lipid-based formulations in oral drug delivery Pharm. Res. 27 2010 1469 1486
10. G.A. Gbogouri, M. Linder, J. Fanni, and M. Parmentier Influence of hydrolysis degree on the functional properties of salmon byproducts hydrolysates J. Food Sci. 69 2004 C615 C622
11. G. Hansen, P. Christensen, E. Tüchsen, and T. Lund Sensitive and selective analysis of coenzyme Q10 in human serum by negative APCI LC-MS Analyst 129 2004 45 50
12. J. Hatanaka, Y. Kimura, Z. Lai-Fu, S. Onoue, and S. Yamada Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q10 formulations Int. J. Pharm. 363 2008 112 117
13. F.S. Henna Lu, N.S. Nielsen, M. Timm-Heinrich, and C. Jacobsen Oxidative stability of marine phospholipids in the liposomal form and their applications Lipids 46 2011 3 23
14. C.-F. Hung, C.-L. Fang, M.-H. Liao, and J.-Y. Fang The effect of oil components on the physicochemical properties and drug delivery of emulsions: tocol emulsion versus lipid emulsion Int. J. Pharm. 335 2007 193 202
15. J.S. Joo Coenzyme Q-10 and cardiovascular health: to take or not to take - that is the question Nutrition Bytes 10 2005
16. V. Klang, N.B. Matsko, C. Valenta, and F. Hofer Electron microscopy of nanoemulsions: an essential tool for characterisation and stability assessment Micron 43 2012 85 103
17. T.R. Kommuru, B. Gurley, M.A. Khan, and I.K. Reddy Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment Int. J. Pharm. 212 2001 233 246
18. L. Lauritzen, H.S. Hansen, M.H. Jorgensen, and K.F. Michaelsen The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina Prog. Lipid Res. 40 2001 1 94
19. M. Linder, N. Belhaj, P. Sautot, and E.A. Tehrany From krill to whale: an overview of marine fatty acids and lipid compositions OCL - Ol Corps Gras Li 17 2010 194 204
20. M. Linder, J. Fanni, and M. Parmentier Proteolytic extraction of salmon oil and PUFA concentration by lipases Mar. Biotechnol. 7 2005 70 76
21. M. Linder, E. Matouba, J. Fanni, and M. Parmentier Enrichment of salmon oil with n-3 PUFA by lipolysis, filtration and enzymatic re-esterification Eur. J. Lipid Sci. Technol. 104 2002 455 462
22. M. Mancuso, D. Orsucci, L. Volpi, V. Calsolaro, and G. Siciliano Coenzyme Q10 in neuromuscular and neurodegenerative disorders Curr. Drug Targets 11 2010 111 121
23. M.V. Miles The uptake and distribution of coenzyme Q(10) Mitochondrion 7 2007 S72 S77
24. M.V. Miles, P. Horn, L. Miles, P. Tang, P. Steele, and T. DeGrauw Bioequivalence of coenzyme Q10 from over-the-counter supplements Nutr. Res. 22 2002 919 929
25. S. Molyneux, C. Florkowski, Y. McGrane, M. Lever, and P. George Concentration response to the coenzyme Q10 supplement Q-Gel in human volunteers Nutr. Res. 27 2007 307 312
26. W.R. Morrison, and L.M. Smith Preparation of fatty acid methyl esters and dimethylacetals from lipids J. Lipid Res. 5 1964 600 608
27. P.R. Nepal, H.K. Han, and H.K. Choi Preparation and in vitro-in vivo evaluation of Witepsol® H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q10 Eur. J. Pharm. Sci. 39 2010 224 232
28. R. Neslihan Gursoy, and S. Benita Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomedicine & Pharmacotherapy 58 2004 173 182
29. S.A. Nespolo, M.A. Bevan, D.Y.C. Chan, F. Grieser, and G.W. Stevens Hydrodynamic and electrokinetic properties of decane droplets in aqueous sodium dodecyl sulfate solutions Langmuir 17 2001 7210 7218
30. Y. Onuki, C. Hagiwara, K. Sugibayashi, and K. Takayama Specific effect of polyunsaturated fatty acids on the cholesterol-poor membrane domain in a model membrane Chem. Pharm. Bull. 56 2008 1103 1109
31. Y. Onuki, M. Morishita, K. Takayama, S. Tokiwa, Y. Chiba, K. Isowa, and T. Nagai In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption Int. J. Pharm. 198 2000 147 156
32. P. Sautot, M. Tarek, M.J. Stébé, C. Paris, E. Arab-Tehrany, and M. Linder Structural, hydration, and phase transition properties of phosphatidylcholine from salmon heads Eur. J. Lipid Sci. Technol. 113 2011 744 755
33. S. Shafiq, F. Shakeel, S. Talegaonkar, F.J. Ahmad, R.K. Khar, and M. Ali Development and bioavailability assessment of ramipril nanoemulsion formulation Eur. J. Pharm. Biopharm. 66 2007 227 243
34. W. Stillwell, and S.R. Wassall Docosahexaenoic acid: membrane properties of a unique fatty acid Chem. Phys. Lipids 126 2003 1 27
35. 13C-NMR regioisomeric analysis of EPA and DHA in fish oil derived triacylglycerol concentrates JAOCS, J. Am. Oil Chem. Soc. 87 2010 1425 1433
36. S. Suzuki, Y. Hinokio, M. Ohtomo, M. Hirai, A. Hirai, M. Chiba, S. Kasuga, Y. Satoh, H. Akai, and T. Toyota The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation Diabetologia 41 1998 584 588
37. P. Thanatuksorn, K. Kawai, M. Hayakawa, M. Hayashi, and K. Kajiwara Improvement of the oral bioavailability of coenzyme Q10 by emulsification with fats and emulsifiers used in the food industry LWT - Food Sci. Technol. 42 2009 385 390
38. R. Wajda, J. Zirkel, and T. Schaffer Increase of bioavailability of coenzyme Q(10) and vitamin E J. Med. Food 10 2007 731 734
39. L. Wang, J. Dong, J. Chen, J. Eastoe, and X. Li Design and optimization of a new self-nanoemulsifying drug delivery system J. Colloid Interface Sci. 330 2009 443 448
40. M. Weis, S.A. Mortensen, M.R. Rassing, J. Moller-Sonnergaard, G. Poulsen, and S.N. Rasmussen Bioavailability of four oral Coenzyme Q10 formulations in healthy volunteers Mol. Aspects Med. 15 Suppl. 1 1994 273 280
41. S. Xia, S. Xu, X. Zhang, F. Zhong, and Z. Wang Nanoliposomes mediate Coenzyme Q10 transport and accumulation across human intestinal caco-2 cell monolayer J. Agri. Food Chem. 57 2009 7989 7996