메뉴 건너뛰기




Volumn 22, Issue 2, 2016, Pages 487-504

Gut Microbiota Dysbiosis as Risk and Premorbid Factors of IBD and IBS Along the Childhood-Adulthood Transition

Author keywords

omics, meta omics, and microbial biomarkers; dysbiosis tracking; gastrointestinal disease predictors; gut microbiota dysbiosis scale; microbial community ecology

Indexed keywords

BIOLOGICAL MARKER;

EID: 84955599651     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000602     Document Type: Review
Times cited : (113)

References (196)
  • 1
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DPB, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42:1118-1125.
    • (2010) Nat Genet. , vol.42 , pp. 1118-1125
    • Franke, A.1    Dpb, M.2    Barrett, J.C.3
  • 2
    • 84889585999 scopus 로고    scopus 로고
    • Influence of host immu-noregulatory genes ER stress and gut microbiota on the shared patho-genesis of inflammatory bowel disease and Type 1 diabetes
    • Gjymishka A, Coman RM, Brusko TM, et al. Influence of host immu-noregulatory genes, ER stress and gut microbiota on the shared patho-genesis of inflammatory bowel disease and Type 1 diabetes. Immunotherapy. 2013;5:1357-1366.
    • (2013) Immunotherapy. , vol.5 , pp. 1357-1366
    • Gjymishka, A.1    Coman, R.M.2    Brusko, T.M.3
  • 3
    • 2442453484 scopus 로고    scopus 로고
    • Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: Antibiotics, probiotics, and prebiotics
    • Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroen-terology. 2004;126:1620-1633.
    • (2004) Gastroen-terology. , vol.126 , pp. 1620-1633
    • Sartor, R.B.1
  • 4
    • 84886795788 scopus 로고    scopus 로고
    • Microbiota-mediated colonization resistance against intestinal pathogens
    • Buffie CG, Pamer EG. Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol. 2013;13:790-801.
    • (2013) Nat Rev Immunol. , vol.13 , pp. 790-801
    • Buffie, C.G.1    Pamer, E.G.2
  • 5
    • 84880931423 scopus 로고    scopus 로고
    • Functional profiling of the gut microbiome in disease-associated inflammation
    • Börnigen D, Morgan XC, Franzosa EA, et al. Functional profiling of the gut microbiome in disease-associated inflammation. Genome Med. 2013;5:65.
    • (2013) Genome Med. , vol.5 , pp. 65
    • Börnigen, D.1    Morgan, X.C.2    Franzosa, E.A.3
  • 6
    • 84883509271 scopus 로고    scopus 로고
    • Metagenome and metabolism: The tissue microbiota hypothesis
    • Burcelin R, Serino M, Chabo C, et al. Metagenome and metabolism: the tissue microbiota hypothesis. Diabetes Obes Metab. 2013;15(suppl 3): 61-70.
    • (2013) Diabetes Obes Metab. , vol.15 , pp. 61-70
    • Burcelin, R.1    Serino, M.2    Chabo, C.3
  • 7
    • 44449123588 scopus 로고    scopus 로고
    • Microbiology: The inside story
    • Mullard A. Microbiology: the inside story. Nature. 2008;453:578-580.
    • (2008) Nature. , vol.453 , pp. 578-580
    • Mullard, A.1
  • 8
    • 84864099736 scopus 로고    scopus 로고
    • Early-life gut microbiota under physiological and pathological conditions: The central role of combined meta-omics-based approaches
    • Del Chierico F, Vernocchi P, Bonizzi L, et al. Early-life gut microbiota under physiological and pathological conditions: the central role of combined meta-omics-based approaches. J Proteomics. 2012;75:4580-4587.
    • (2012) J Proteomics. , vol.75 , pp. 4580-4587
    • Del Chierico, F.1    Vernocchi, P.2    Bonizzi, L.3
  • 9
    • 84880595486 scopus 로고    scopus 로고
    • Beyond gene discovery in inflammatory bowel disease: The emerging role of epigenetics
    • Ventham NT, Kennedy NA, Nimmo ER, et al. Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics. Gastro-enterology. 2013;145:293-308.
    • (2013) Gastro-enterology. , vol.145 , pp. 293-308
    • Ventham, N.T.1    Kennedy, N.A.2    Nimmo, E.R.3
  • 10
    • 84875262894 scopus 로고    scopus 로고
    • Microbial ecosystems therapeutics: A new paradigm in medicine?
    • Petrof EO, Claud EC, Gloor GB, et al. Microbial ecosystems therapeutics: a new paradigm in medicine? Benef Microbes. 2013;4:53-65.
    • (2013) Benef Microbes. , vol.4 , pp. 53-65
    • Petrof, E.O.1    Claud, E.C.2    Gloor, G.B.3
  • 11
    • 34248136340 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Clinical aspects and established and evolving therapies
    • Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007;369:1641-1657.
    • (2007) Lancet. , vol.369 , pp. 1641-1657
    • Baumgart, D.C.1    Sandborn, W.J.2
  • 12
    • 24144497765 scopus 로고    scopus 로고
    • The clustering of other chronic inflammatory diseases in inflammatory bowel disease: A population-based study
    • Bernstein CN, Wajda A, Blanchard JF. The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterology. 2005;129:827-836.
    • (2005) Gastroenterology. , vol.129 , pp. 827-836
    • Bernstein, C.N.1    Wajda, A.2    Blanchard, J.F.3
  • 13
    • 78049527939 scopus 로고    scopus 로고
    • Diagnosis and management of iron deficiency anemia in patients with IBD
    • Stein J, Hartmann F, Dignass AU. Diagnosis and management of iron deficiency anemia in patients with IBD. Nat Rev Gastroenterol Hepatol. 2010;7:599-610.
    • (2010) Nat Rev Gastroenterol Hepatol. , vol.7 , pp. 599-610
    • Stein, J.1    Hartmann, F.2    Dignass, A.U.3
  • 14
    • 84872916709 scopus 로고    scopus 로고
    • Nonthyroidal illness syndrome: Is it far away from Crohn's disease?
    • Liu S, Ren J, Zhao Y, et al. Nonthyroidal illness syndrome: is it far away from Crohn's disease? J Clin Gastroenterol. 2013;47:153-159.
    • (2013) J Clin Gastroenterol. , vol.47 , pp. 153-159
    • Liu, S.1    Ren, J.2    Zhao, Y.3
  • 15
    • 78650973052 scopus 로고    scopus 로고
    • High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
    • Walker AW, Sanderson JD, Churcher C, et al. High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol. 2011;11:7.
    • (2011) BMC Microbiol. , vol.11 , pp. 7
    • Walker, A.W.1    Sanderson, J.D.2    Churcher, C.3
  • 16
    • 78649622569 scopus 로고    scopus 로고
    • Dysbiosis of fecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic micro-array
    • Kang S, Denman SE, Morrison M, et al. Dysbiosis of fecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic micro-array. Inflamm Bowel Dis. 2010;16:2034-2042.
    • (2010) Inflamm Bowel Dis. , vol.16 , pp. 2034-2042
    • Kang, S.1    Denman, S.E.2    Morrison, M.3
  • 17
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491:119-124.
    • (2012) Nature. , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 18
    • 79953162067 scopus 로고    scopus 로고
    • Environmental influences on T regulatory cells in inflammatory bowel disease
    • Hardenberg G, Steiner TS, Levings MK. Environmental influences on T regulatory cells in inflammatory bowel disease. Semin Immunol. 2011; 23:130-138.
    • (2011) Semin Immunol. , vol.23 , pp. 130-138
    • Hardenberg, G.1    Steiner, T.S.2    Levings, M.K.3
  • 19
    • 84926298450 scopus 로고    scopus 로고
    • Rectal bacteriotherapy for recurrent Clostridium difficile-associated diarrhoea: Results from a case series of 55 patients in Denmark 2000-2012
    • Tvede M, Tinggaard M, Helms M. Rectal bacteriotherapy for recurrent Clostridium difficile-associated diarrhoea: results from a case series of 55 patients in Denmark 2000-2012. Clin Microbiol Infect. 2015;21:48-53.
    • (2015) Clin Microbiol Infect. , vol.21 , pp. 48-53
    • Tvede, M.1    Tinggaard, M.2    Helms, M.3
  • 20
    • 84931423571 scopus 로고    scopus 로고
    • Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis
    • Rossen NG, Fuentes S, van der Spek MJ, et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology. 2015;149:110-118.
    • (2015) Gastroenterology. , vol.149 , pp. 110-118
    • Rossen, N.G.1    Fuentes, S.2    Van Der Spek, M.J.3
  • 21
    • 84879873877 scopus 로고    scopus 로고
    • Fecal microbiota transplantation: Indications, methods, evidence, and future directions
    • Borody TJ, Paramsothy S, Agrawal G. Fecal microbiota transplantation: indications, methods, evidence, and future directions. Curr Gastroenter-ol Rep. 2013;15:337.
    • (2013) Curr Gastroenter-ol Rep. , vol.15 , pp. 337
    • Borody, T.J.1    Paramsothy, S.2    Agrawal, G.3
  • 22
    • 16344370762 scopus 로고    scopus 로고
    • Antibacterial and antimycobacterial treatment for inflammatory bowel disease
    • Ohkusa T, Sato N. Antibacterial and antimycobacterial treatment for inflammatory bowel disease. J Gastroenterol Hepatol. 2005;20: 340-351.
    • (2005) J Gastroenterol Hepatol. , vol.20 , pp. 340-351
    • Ohkusa, T.1    Sato, N.2
  • 23
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med. 2009; 361:2066-2078.
    • (2009) N Engl J Med. , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 24
    • 0032216783 scopus 로고    scopus 로고
    • Scope of the problem of functional digestive disorders
    • Talley NJ. Scope of the problem of functional digestive disorders. Eur J Surg Suppl. 1998:35-41.
    • (1998) Eur J Surg Suppl. , pp. 35-41
    • Talley, N.J.1
  • 25
    • 33845656545 scopus 로고    scopus 로고
    • Irritable bowel syndrome: A review on the role of intestinal protozoa and the importance of their detection and diagnosis
    • Stark D, van Hal S, Marriott D, et al. Irritable bowel syndrome: a review on the role of intestinal protozoa and the importance of their detection and diagnosis. Int J Parasitol. 2007;37:11-20.
    • (2007) Int J Parasitol. , vol.37 , pp. 11-20
    • Stark, D.1    Van Hal, S.2    Marriott, D.3
  • 26
    • 33751574668 scopus 로고    scopus 로고
    • Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: Baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study
    • discussion 1710-1711
    • Paré P, Gray J, Lam S, et al. Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study. Clin Ther. 2006;28:1726-1735; discussion 1710-1711.
    • (2006) Clin Ther. , vol.28 , pp. 1726-1735
    • Paré, P.1    Gray, J.2    Lam, S.3
  • 27
    • 84892630733 scopus 로고    scopus 로고
    • On the fiftieth anniversary. Postinfectious irritable bowel syndrome: Mechanisms related to pathogens
    • Grover M, Camilleri M, Smith K, et al. On the fiftieth anniversary. Postinfectious irritable bowel syndrome: mechanisms related to pathogens. Neurogastroenterol Motil. 2014;26:156-167.
    • (2014) Neurogastroenterol Motil. , vol.26 , pp. 156-167
    • Grover, M.1    Camilleri, M.2    Smith, K.3
  • 28
    • 84924804354 scopus 로고    scopus 로고
    • The relationship between irritable bowel syndrome and psychiatric disorders: From molecular changes to clinical manifestations
    • Fadgyas-Stanculete M, Buga AM, Popa-Wagner A, et al. The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations. J Mol Psychiatry. 2014;2:4.
    • (2014) J Mol Psychiatry. , vol.2 , pp. 4
    • Fadgyas-Stanculete, M.1    Buga, A.M.2    Popa-Wagner, A.3
  • 29
    • 34548142214 scopus 로고    scopus 로고
    • New insights in the etiology and pathophysiology of irritable bowel syndrome: Contribution of neonatal stress models
    • Barreau F, Ferrier L, Fioramonti J, et al. New insights in the etiology and pathophysiology of irritable bowel syndrome: contribution of neonatal stress models. Pediatr Res. 2007;62:240-245.
    • (2007) Pediatr Res. , vol.62 , pp. 240-245
    • Barreau, F.1    Ferrier, L.2    Fioramonti, J.3
  • 30
    • 43649100298 scopus 로고    scopus 로고
    • Bacterial flora in irritable bowel syndrome: Role in patho-physiology, implications for management
    • Quigley EM. Bacterial flora in irritable bowel syndrome: role in patho-physiology, implications for management. J Dig Dis. 2007;8:2-7.
    • (2007) J Dig Dis. , vol.8 , pp. 2-7
    • Quigley, E.M.1
  • 31
    • 3142767014 scopus 로고    scopus 로고
    • Intestinal microecology and quality of life in irritable bowel syndrome patients
    • Si JM, Yu YC, Fan YJ, et al. Intestinal microecology and quality of life in irritable bowel syndrome patients. World J Gastroenterol. 2004;10: 1802-1805.
    • (2004) World J Gastroenterol. , vol.10 , pp. 1802-1805
    • Si, J.M.1    Yu, Y.C.2    Fan, Y.J.3
  • 32
    • 34447104397 scopus 로고    scopus 로고
    • The fecal micro-biota of irritable bowel syndrome patients differs significantly from that of healthy subjects
    • Kassinen A, Krogius-Kurikka L, Mäkivuokko H, et al. The fecal micro-biota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology. 2007;133:24-33.
    • (2007) Gastroenterology. , vol.133 , pp. 24-33
    • Kassinen, A.1    Krogius-Kurikka, L.2    Mäkivuokko, H.3
  • 33
    • 77950670562 scopus 로고    scopus 로고
    • Altered profiles of intestinal micro-biota and organic acids may be the origin of symptoms in irritable bowel syndrome
    • e114-e115
    • Tana C, Umesaki Y, Imaoka A, et al. Altered profiles of intestinal micro-biota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterol Motil. 2010;22:512-519, e114-e115.
    • (2010) Neurogastroenterol Motil. , vol.22 , pp. 512-519
    • Tana, C.1    Umesaki, Y.2    Imaoka, A.3
  • 34
    • 34249790127 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in patients with irritable bowel syndrome
    • Posserud I, Stotzer PO, Björnsson ES, et al. Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut. 2007;56: 802-808.
    • (2007) Gut. , vol.56 , pp. 802-808
    • Posserud, I.1    Stotzer, P.O.2    Björnsson, E.S.3
  • 35
    • 1942533051 scopus 로고    scopus 로고
    • Irritable bowel syndrome: In search of an etiology: Role of Blastocystis hominis
    • Yakoob J, Jafri W, Jafri N, et al. Irritable bowel syndrome: in search of an etiology: role of Blastocystis hominis. Am J Trop Med Hyg. 2004;70: 383-385.
    • (2004) Am J Trop Med Hyg. , vol.70 , pp. 383-385
    • Yakoob, J.1    Jafri, W.2    Jafri, N.3
  • 36
  • 37
    • 20544453300 scopus 로고    scopus 로고
    • Irritable bowel syndrome: The need to exclude Dientamoeba fragilis
    • author reply 501-502
    • Windsor JJ, Macfarlane L. Irritable bowel syndrome: the need to exclude Dientamoeba fragilis. Am J Trop Med Hyg. 2005;72:501; author reply 501-502.
    • (2005) Am J Trop Med Hyg. , vol.72 , pp. 501
    • Windsor, J.J.1    Macfarlane, L.2
  • 38
    • 84925358105 scopus 로고    scopus 로고
    • The prevalence of intestinal parasites is not greater among individuals with irritable bowel syndrome: A population-based case-control study
    • Krogsgaard LR, Engsbro AL, Stensvold CR, et al. The prevalence of intestinal parasites is not greater among individuals with irritable bowel syndrome: a population-based case-control study. Clin Gastroenterol Hepatol. 2015;13:507-513.e2.
    • (2015) Clin Gastroenterol Hepatol. , vol.13 , pp. 507-507e2
    • Krogsgaard, L.R.1    Engsbro, A.L.2    Stensvold, C.R.3
  • 39
    • 70349090574 scopus 로고    scopus 로고
    • Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial
    • Bijkerk CJ, de Wit NJ, Muris JW, et al. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. BMJ. 2009;339:b3154.
    • (2009) BMJ. , vol.339 , pp. b3154
    • Bijkerk, C.J.1    De Wit, N.J.2    Muris, J.W.3
  • 40
    • 35348821109 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Current treatment options [in French]
    • Ducrotté P. Irritable bowel syndrome: current treatment options [in French]. Presse Med. 2007;36:1619-1626.
    • (2007) Presse Med. , vol.36 , pp. 1619-1626
    • Ducrotté, P.1
  • 41
    • 84890685902 scopus 로고    scopus 로고
    • A diet low in FODMAPs reduces symptoms of irritable bowel syndrome
    • Halmos EP, Power VA, Shepherd SJ, et al. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology. 2014; 146:67-75.e5.
    • (2014) Gastroenterology. , vol.146 , pp. 67-67e5
    • Halmos, E.P.1    Power, V.A.2    Shepherd, S.J.3
  • 42
    • 84928639685 scopus 로고    scopus 로고
    • Role of FODMAPs in patients with irritable bowel syndrome: A review
    • Mansueto P, Seidita A, D'Alcamo A, et al. Role of FODMAPs in patients with irritable bowel syndrome: a review. Nutr Clin Pract. 2015;30:665-682.
    • (2015) Nutr Clin Pract. , vol.30 , pp. 665-682
    • Mansueto, P.1    Seidita, A.2    D'Alcamo, A.3
  • 44
    • 77957557412 scopus 로고    scopus 로고
    • A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease
    • Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010;16:4504-4514.
    • (2010) World J Gastroenterol. , vol.16 , pp. 4504-4514
    • Rahimi, R.1    Shams-Ardekani, M.R.2    Abdollahi, M.3
  • 45
    • 84871120114 scopus 로고    scopus 로고
    • Intestinal microbiota in functional bowel disorders: A Rome foundation report
    • Simrén M, Barbara G, Flint HJ, et al. Intestinal microbiota in functional bowel disorders: a Rome foundation report. Gut. 2013;62:159-176.
    • (2013) Gut. , vol.62 , pp. 159-176
    • Simrén, M.1    Barbara, G.2    Flint, H.J.3
  • 46
    • 24344474273 scopus 로고    scopus 로고
    • The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: A double-blind randomized-controlled study
    • Vahedi H, Merat S, Rashidioon A, et al. The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. Aliment Pharmacol Ther. 2005;22:381-385.
    • (2005) Aliment Pharmacol Ther. , vol.22 , pp. 381-385
    • Vahedi, H.1    Merat, S.2    Rashidioon, A.3
  • 47
    • 84860644097 scopus 로고    scopus 로고
    • Brain-gut-microbe communication in health and disease
    • Grenham S, Clarke G, Cryan JF, et al. Brain-gut-microbe communication in health and disease. Front Physiol. 2011;2:94.
    • (2011) Front Physiol. , vol.2 , pp. 94
    • Grenham, S.1    Clarke, G.2    Cryan, J.F.3
  • 48
    • 84926315282 scopus 로고    scopus 로고
    • The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems
    • Carabotti M, Scirocco A, Maselli MA, et al. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28:203-209.
    • (2015) Ann Gastroenterol. , vol.28 , pp. 203-209
    • Carabotti, M.1    Scirocco, A.2    Ma, M.3
  • 49
    • 84938379194 scopus 로고    scopus 로고
    • Neuropeptides and the microbiota-gut-brain axis
    • Holzer P, Farzi A. Neuropeptides and the microbiota-gut-brain axis. Adv Exp Med Biol. 2014;817:195-219.
    • (2014) Adv Exp Med Biol. , vol.817 , pp. 195-219
    • Holzer, P.1    Farzi, A.2
  • 50
    • 36649018334 scopus 로고    scopus 로고
    • Synthesis of gamma-aminobutyric acid by lactic acid bacteria isolated from a variety of Italian cheeses
    • Siragusa S, De Angelis M, Di Cagno R, et al. Synthesis of gamma-aminobutyric acid by lactic acid bacteria isolated from a variety of Italian cheeses. Appl Environ Microbiol. 2007;73:7283-7290.
    • (2007) Appl Environ Microbiol. , vol.73 , pp. 7283-7290
    • Siragusa, S.1    De Angelis, M.2    Di Cagno, R.3
  • 51
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour
    • Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012;13: 701-712.
    • (2012) Nat Rev Neurosci. , vol.13 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 52
    • 77954833498 scopus 로고    scopus 로고
    • The infant intestinal microbiome: Friend or foe?
    • Mshvildadze M, Neu J. The infant intestinal microbiome: friend or foe? Early Hum Dev. 2010;86(suppl 1):67-71.
    • (2010) Early Hum Dev. , vol.86 , pp. 67-71
    • Mshvildadze, M.1    Neu, J.2
  • 53
    • 58449119188 scopus 로고    scopus 로고
    • Establishment of the gut microbiota in Western infants
    • Adlerberth I, Wold AE. Establishment of the gut microbiota in Western infants. Acta Paediatr. 2009;98:229-238.
    • (2009) Acta Paediatr. , vol.98 , pp. 229-238
    • Adlerberth, I.1    Wold, A.E.2
  • 54
    • 15544369658 scopus 로고    scopus 로고
    • Host-bacterial mutualism in the human intestine
    • Bäckhed F, Ley RE, Sonnenburg JL, et al. Host-bacterial mutualism in the human intestine. Science. 2005;307:1915-1920.
    • (2005) Science. , vol.307 , pp. 1915-1920
    • Bäckhed, F.1    Ley, R.E.2    Sonnenburg, J.L.3
  • 55
    • 84874479799 scopus 로고    scopus 로고
    • Animals in a bacterial world, a new imperative for the life sciences
    • McFall-Ngai M, Hadfield MG, Bosch TCG, et al. Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci USA. 2013;110:3229-3236.
    • (2013) Proc Natl Acad Sci USA. , vol.110 , pp. 3229-3236
    • McFall-Ngai, M.1    Hadfield, M.G.2    Tcg, B.3
  • 56
    • 84857052430 scopus 로고    scopus 로고
    • Hygiene hypothesis and autoimmune diseases
    • Rook GA. Hygiene hypothesis and autoimmune diseases. Clin Rev Allergy Immunol. 2012;42:5-15.
    • (2012) Clin Rev Allergy Immunol. , vol.42 , pp. 5-15
    • Rook, G.A.1
  • 57
    • 80051856839 scopus 로고    scopus 로고
    • The human gut microbiome: Ecology and recent evolutionary changes
    • Walter J, Ley R. The human gut microbiome: ecology and recent evolutionary changes. Annu Rev Microbiol. 2011;65:411-429.
    • (2011) Annu Rev Microbiol. , vol.65 , pp. 411-429
    • Walter, J.1    Ley, R.2
  • 58
    • 85027927719 scopus 로고    scopus 로고
    • Enterotypes of the human gut microbiome
    • Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011;473:174-180.
    • (2011) Nature. , vol.473 , pp. 174-180
    • Arumugam, M.1    Raes, J.2    Pelletier, E.3
  • 59
    • 84862276328 scopus 로고    scopus 로고
    • Function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207-214.
    • (2012) Nature. , vol.486 , pp. 207-214
  • 60
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg PB, Bik EM, Bernstein CN, et al. Diversity of the human intestinal microbial flora. Science. 2005;308:1635-1638.
    • (2005) Science. , vol.308 , pp. 1635-1638
    • Eckburg, P.B.1    Bik, E.M.2    Bernstein, C.N.3
  • 61
    • 83755222630 scopus 로고    scopus 로고
    • Microbial eukaryotes in the human microbiome: Ecology, evolution, and future directions
    • Parfrey LW, Walters WA, Knight R. Microbial eukaryotes in the human microbiome: ecology, evolution, and future directions. Front Microbiol. 2011;2:153.
    • (2011) Front Microbiol. , vol.2 , pp. 153
    • Parfrey, L.W.1    Walters, W.A.2    Knight, R.3
  • 62
    • 77957075815 scopus 로고    scopus 로고
    • Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    • De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA. 2010;107:14691-14696.
    • (2010) Proc Natl Acad Sci USA. , vol.107 , pp. 14691-14696
    • De Filippo, C.1    Cavalieri, D.2    Di Paola, M.3
  • 63
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486:222-227.
    • (2012) Nature. , vol.486 , pp. 222-227
    • Yatsunenko, T.1    Rey, F.E.2    Manary, M.J.3
  • 64
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380:2095-2128.
    • (2012) Lancet. , vol.380 , pp. 2095-2128
    • Lozano, R.1    Naghavi, M.2    Foreman, K.3
  • 66
    • 3042590934 scopus 로고    scopus 로고
    • The causes of intestinal dysbiosis: A review
    • Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev. 2004;9:180-197.
    • (2004) Altern Med Rev. , vol.9 , pp. 180-197
    • Hawrelak, J.A.1    Myers, S.P.2
  • 68
    • 84876493328 scopus 로고    scopus 로고
    • Active ulcerative colitis associated with low prevalence of Blastocystis and Dientamoeba fragilis infection
    • Petersen AM, Stensvold CR, Mirsepasi H, et al. Active ulcerative colitis associated with low prevalence of Blastocystis and Dientamoeba fragilis infection. Scand J Gastroenterol. 2013;48:638-639.
    • (2013) Scand J Gastroenterol. , vol.48 , pp. 638-639
    • Petersen, A.M.1    Stensvold, C.R.2    Mirsepasi, H.3
  • 69
    • 84887023907 scopus 로고    scopus 로고
    • Blastocystis: Getting to grips with our guileful guest
    • Scanlan PD, Stensvold CR. Blastocystis: getting to grips with our guileful guest. Trends Parasitol. 2013;29:523-529.
    • (2013) Trends Parasitol. , vol.29 , pp. 523-529
    • Scanlan, P.D.1    Stensvold, C.R.2
  • 70
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • Frank DN, St Amand AL, Feldman RA, et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA. 2007;104:13780-13785.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 13780-13785
    • Frank, D.N.1    St Amand, A.L.2    Feldman, R.A.3
  • 71
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev. 2009;89:147-191.
    • (2009) Physiol Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3
  • 72
    • 33748209543 scopus 로고    scopus 로고
    • Colonic health: Fermentation and short chain fatty acids
    • Wong JM, de Souza R, Kendall CWC, et al. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006;40:235-243.
    • (2006) J Clin Gastroenterol. , vol.40 , pp. 235-243
    • Wong, J.M.1    De Souza, R.2    Cwc, K.3
  • 73
    • 2542456800 scopus 로고    scopus 로고
    • Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases
    • Tlaskalová-Hogenová H, Stepánková R, Hudcovic T, et al. Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol Lett. 2004;93:97-108.
    • (2004) Immunol Lett. , vol.93 , pp. 97-108
    • Tlaskalová-Hogenová, H.1    Stepánková, R.2    Hudcovic, T.3
  • 74
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011;331:337-341.
    • (2011) Science. , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3
  • 75
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009;139:485-498.
    • (2009) Cell. , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3
  • 76
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9:313-323.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 77
    • 0036212170 scopus 로고    scopus 로고
    • Butyrate inhibits NF-kappaB activation in lamina propria macrophages of patients with ulcerative colitis
    • Lührs H, Gerke T, Müller JG, et al. Butyrate inhibits NF-kappaB activation in lamina propria macrophages of patients with ulcerative colitis. Scand J Gastroenterol. 2002;37:458-466.
    • (2002) Scand J Gastroenterol. , vol.37 , pp. 458-466
    • Lührs, H.1    Gerke, T.2    Müller, J.G.3
  • 78
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009;461:1282-1286.
    • (2009) Nature. , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1    Vieira, A.T.2    Ng, A.3
  • 79
    • 0031709152 scopus 로고    scopus 로고
    • Development and maintenance of the gut-associated lymphoid tissue (GALT): The roles of enteric bacteria and viruses
    • Cebra JJ, Periwal SB, Lee G, et al. Development and maintenance of the gut-associated lymphoid tissue (GALT): the roles of enteric bacteria and viruses. Dev Immunol. 1998;6:13-18.
    • (1998) Dev Immunol. , vol.6 , pp. 13-18
    • Cebra, J.J.1    Periwal, S.B.2    Lee, G.3
  • 80
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra D, Brézillon C, Bérard M, et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature. 2008;456:507-510.
    • (2008) Nature. , vol.456 , pp. 507-510
    • Bouskra, D.1    Brézillon, C.2    Bérard, M.3
  • 81
    • 34548428699 scopus 로고    scopus 로고
    • Immune development in jejunal mucosa after colonization with selected commensal gut bacteria: A study in germ-free pigs
    • Haverson K, Rehakova Z, Sinkora J, et al. Immune development in jejunal mucosa after colonization with selected commensal gut bacteria: a study in germ-free pigs. Vet Immunol Immunopathol. 2007;119:243-253.
    • (2007) Vet Immunol Immunopathol. , vol.119 , pp. 243-253
    • Haverson, K.1    Rehakova, Z.2    Sinkora, J.3
  • 82
    • 77954051526 scopus 로고    scopus 로고
    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    • Hapfelmeier S, Lawson MAE, Slack E, et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science. 2010;328:1705-1709.
    • (2010) Science. , vol.328 , pp. 1705-1709
    • Hapfelmeier, S.1    Mae, L.2    Slack, E.3
  • 83
    • 78650465542 scopus 로고    scopus 로고
    • Gut microbiota, lipopolysacchar-ides, and innate immunity in the pathogenesis of obesity and cardiovascular risk
    • Manco M, Putignani L, Bottazzo GF. Gut microbiota, lipopolysacchar-ides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. Endocr Rev. 2010;31:817-844.
    • (2010) Endocr Rev. , vol.31 , pp. 817-844
    • Manco, M.1    Putignani, L.2    Bottazzo, G.F.3
  • 84
    • 84879343905 scopus 로고    scopus 로고
    • Control of pathogens and path-obionts by the gut microbiota
    • Kamada N, Chen GY, Inohara N, et al. Control of pathogens and path-obionts by the gut microbiota. Nat Immunol. 2013;14:685-690.
    • (2013) Nat Immunol. , vol.14 , pp. 685-690
    • Kamada, N.1    Chen, G.Y.2    Inohara, N.3
  • 85
    • 23044509165 scopus 로고    scopus 로고
    • Modulation of gut mucosal biofilms
    • Kleessen B, Blaut M. Modulation of gut mucosal biofilms. Br J Nutr. 2005;93(suppl 1):S35-S40.
    • (2005) Br J Nutr. , vol.93 , pp. S35-S40
    • Kleessen, B.1    Blaut, M.2
  • 86
    • 37149022209 scopus 로고    scopus 로고
    • Review article: The role of butyrate on colonic function
    • Hamer HM, Jonkers D, Venema K, et al. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008;27:104-119.
    • (2008) Aliment Pharmacol Ther. , vol.27 , pp. 104-119
    • Hamer, H.M.1    Jonkers, D.2    Venema, K.3
  • 87
    • 2342660790 scopus 로고    scopus 로고
    • Functional food science and gastrointestinal physiology and function
    • Salminen S, Bouley C, Boutron-Ruault MC, et al. Functional food science and gastrointestinal physiology and function. Br J Nutr. 1998;80 (suppl 1):S147-S171.
    • (1998) Br J Nutr. , vol.80 , pp. S147-S171
    • Salminen, S.1    Bouley, C.2    Boutron-Ruault, M.C.3
  • 88
    • 0037180433 scopus 로고    scopus 로고
    • Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
    • Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci USA. 2002;99:15451-15455.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , pp. 15451-15455
    • Stappenbeck, T.S.1    Hooper, L.V.2    Gordon, J.I.3
  • 89
    • 84880425458 scopus 로고    scopus 로고
    • Toll-like receptors in alcoholic liver disease, nonalcoholic steatohepatitis and carcinogenesis
    • Roh YS, Seki E. Toll-like receptors in alcoholic liver disease, nonalcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol 2013;28(suppl 1):38-42.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 38-42
    • Roh, Y.S.1    Seki, E.2
  • 90
    • 84890554765 scopus 로고    scopus 로고
    • Pathological bacterial translocation in liver cirrhosis
    • Wiest R, Lawson M, Geuking M. Pathological bacterial translocation in liver cirrhosis. J Hepatol. 2014;60:197-209.
    • (2014) J Hepatol. , vol.60 , pp. 197-209
    • Wiest, R.1    Lawson, M.2    Geuking, M.3
  • 91
    • 84871860548 scopus 로고    scopus 로고
    • Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxae-mia
    • Moreira APB, Texeira TFS, Ferreira AB, et al. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxae-mia. Br J Nutr. 2012;108:801-809.
    • (2012) Br J Nutr. , vol.108 , pp. 801-809
    • Apb, M.1    Tfs, T.2    Ferreira, A.B.3
  • 92
    • 34548399000 scopus 로고    scopus 로고
    • Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    • Lupp C, Robertson ML, Wickham ME, et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe. 2007;2:204.
    • (2007) Cell Host Microbe. , vol.2 , pp. 204
    • Lupp, C.1    Robertson, M.L.2    Wickham, M.E.3
  • 93
    • 84878432985 scopus 로고    scopus 로고
    • Probiotics, prebiotics and immunomo-dulation of gut mucosal defences: Homeostasis and immunopathology
    • Hardy H, Harris J, Lyon E, et al. Probiotics, prebiotics and immunomo-dulation of gut mucosal defences: homeostasis and immunopathology. Nutrients. 2013;5:1869-1912.
    • (2013) Nutrients. , vol.5 , pp. 1869-1912
    • Hardy, H.1    Harris, J.2    Lyon, E.3
  • 94
    • 84898835480 scopus 로고    scopus 로고
    • Manipulation of the microbiota for treatment of IBS and IBD-challenges and controversies
    • Shanahan F, Quigley EM. Manipulation of the microbiota for treatment of IBS and IBD-challenges and controversies. Gastroenterology. 2014; 146:1554-1563.
    • (2014) Gastroenterology. , vol.146 , pp. 1554-1563
    • Shanahan, F.1    Quigley, E.M.2
  • 95
    • 84893707135 scopus 로고    scopus 로고
    • Intestinal microbiota, diet and health
    • Power SE, O'Toole PW, Stanton C, et al. Intestinal microbiota, diet and health. Br J Nutr. 2014;111:387-402.
    • (2014) Br J Nutr. , vol.111 , pp. 387-402
    • Power, S.E.1    O'Toole, P.W.2    Stanton, C.3
  • 96
    • 84889634755 scopus 로고    scopus 로고
    • Systematic review with metaanalysis: Non-alcoholic steatohepatitis-a case for personalised treatment based on pathogenic targets
    • Younossi ZM, Reyes MJ, Mishra A, et al. Systematic review with metaanalysis: non-alcoholic steatohepatitis-a case for personalised treatment based on pathogenic targets. Aliment Pharmacol Ther. 2014;39:3-14.
    • (2014) Aliment Pharmacol Ther. , vol.39 , pp. 3-14
    • Younossi, Z.M.1    Reyes, M.J.2    Mishra, A.3
  • 97
    • 34848912627 scopus 로고    scopus 로고
    • Selective increases of bifidobac-teria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    • Cani PD, Neyrinck AM, Fava F, et al. Selective increases of bifidobac-teria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia. 2007;50:2374-2383.
    • (2007) Diabetologia. , vol.50 , pp. 2374-2383
    • Cani, P.D.1    Neyrinck, A.M.2    Fava, F.3
  • 98
    • 80054925355 scopus 로고    scopus 로고
    • Eating for two: How metabolism establishes interspecies interactions in the gut
    • Fischbach MA, Sonnenburg JL. Eating for two: how metabolism establishes interspecies interactions in the gut. Cell Host Microbe. 2011;10: 336-347.
    • (2011) Cell Host Microbe. , vol.10 , pp. 336-347
    • Ma, F.1    Sonnenburg, J.L.2
  • 99
    • 78751580602 scopus 로고    scopus 로고
    • Dominant and diet-responsive groups of bacteria within the human colonic microbiota
    • Walker AW, Ince J, Duncan SH, et al. Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J. 2011;5:220-230.
    • (2011) ISME J. , vol.5 , pp. 220-230
    • Walker, A.W.1    Ince, J.2    Duncan, S.H.3
  • 100
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • Wu GD, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:105-108.
    • (2011) Science. , vol.334 , pp. 105-108
    • Wu, G.D.1    Chen, J.2    Hoffmann, C.3
  • 101
    • 65549099573 scopus 로고    scopus 로고
    • Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
    • Raffatellu M, George MD, Akiyama Y, et al. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe. 2009;5:476-486.
    • (2009) Cell Host Microbe. , vol.5 , pp. 476-486
    • Raffatellu, M.1    George, M.D.2    Akiyama, Y.3
  • 102
    • 24044451233 scopus 로고    scopus 로고
    • Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cyto-kines in respiratory tract epithelium
    • Harper RW, Xu C, Eiserich JP, et al. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cyto-kines in respiratory tract epithelium. FEBS Lett. 2005;579:4911-4917.
    • (2005) FEBS Lett. , vol.579 , pp. 4911-4917
    • Harper, R.W.1    Xu, C.2    Eiserich, J.P.3
  • 103
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginine
    • Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664-666.
    • (1988) Nature. , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 104
    • 0029881475 scopus 로고    scopus 로고
    • Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers
    • Salzman A, Denenberg AG, Ueta I, et al. Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers. Am J Physiol. 1996;270:G565-G573.
    • (1996) Am J Physiol. , vol.270 , pp. G565-G573
    • Salzman, A.1    Denenberg, A.G.2    Ueta, I.3
  • 105
    • 0028081788 scopus 로고
    • Greatly increased luminal nitric oxide in ulcerative colitis
    • Lundberg JO, Hellström PM, Lundberg JM, et al. Greatly increased luminal nitric oxide in ulcerative colitis. Lancet. 1994;344:1673-1674.
    • (1994) Lancet. , vol.344 , pp. 1673-1674
    • Lundberg, J.O.1    Hellström, P.M.2    Lundberg, J.M.3
  • 107
    • 84871956840 scopus 로고    scopus 로고
    • Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonization
    • Sharon I, Morowitz MJ, Thomas BC, et al. Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonization. Genome Res. 2013;23:111-120.
    • (2013) Genome Res. , vol.23 , pp. 111-120
    • Sharon, I.1    Morowitz, M.J.2    Thomas, B.C.3
  • 108
    • 77957157893 scopus 로고    scopus 로고
    • Gut inflammation provides a respiratory electron acceptor for Salmonella
    • Winter SE, Thiennimitr P, Winter MG, et al. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature. 2010;467:426-429.
    • (2010) Nature. , vol.467 , pp. 426-429
    • Winter, S.E.1    Thiennimitr, P.2    Winter, M.G.3
  • 109
    • 84867192879 scopus 로고    scopus 로고
    • Intestinal inflammation targets cancer-inducing activity of the microbiota
    • Arthur JC, Perez-Chanona E, Mühlbauer M, et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. 2012; 338:120-123.
    • (2012) Science. , vol.338 , pp. 120-123
    • Arthur, J.C.1    Perez-Chanona, E.2    Mühlbauer, M.3
  • 110
    • 84860668802 scopus 로고    scopus 로고
    • Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the micro-biota
    • Ayres JS, Trinidad NJ, Vance RE. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the micro-biota. Nat Med. 2012;18:799-806.
    • (2012) Nat Med. , vol.18 , pp. 799-806
    • Ayres, J.S.1    Trinidad, N.J.2    Vance, R.E.3
  • 111
    • 84865175815 scopus 로고    scopus 로고
    • Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation
    • Taur Y, Xavier JB, Lipuma L, et al. Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2012;55:905-914.
    • (2012) Clin Infect Dis. , vol.55 , pp. 905-914
    • Taur, Y.1    Xavier, J.B.2    Lipuma, L.3
  • 113
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel disease: Current status and the future ahead
    • Kostic AD, Xavier RJ, Gevers D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology. 2014;146:1489-1499.
    • (2014) Gastroenterology. , vol.146 , pp. 1489-1499
    • Kostic, A.D.1    Xavier, R.J.2    Gevers, D.3
  • 115
    • 83655191565 scopus 로고    scopus 로고
    • Epithelial barrier: An interface for the cross-communication between gut flora and immune system
    • Goto Y, Kiyono H. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev. 2012;245:147-163.
    • (2012) Immunol Rev. , vol.245 , pp. 147-163
    • Goto, Y.1    Kiyono, H.2
  • 116
    • 84862896140 scopus 로고    scopus 로고
    • Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease
    • Keita AV, Söderholm JD. Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease. Ann N Y Acad Sci. 2012;1258:125-134.
    • (2012) Ann N y Acad Sci. , vol.1258 , pp. 125-134
    • Keita, A.V.1    Söderholm, J.D.2
  • 117
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9:799-809.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 118
    • 77957278004 scopus 로고    scopus 로고
    • Cytoskeletal regulation of epithelial barrier function during inflammation
    • Ivanov AI, Parkos CA, Nusrat A. Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol. 2010;177:512-524.
    • (2010) Am J Pathol. , vol.177 , pp. 512-524
    • Ivanov, A.I.1    Parkos, C.A.2    Nusrat, A.3
  • 119
    • 84882797836 scopus 로고    scopus 로고
    • Intestinal permeability defects: Is it time to treat?
    • Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat? Clin Gastroenterol Hepatol. 2013;11:1075-1083.
    • (2013) Clin Gastroenterol Hepatol. , vol.11 , pp. 1075-1083
    • Ma, O.1    Turner, J.R.2
  • 120
    • 33749007683 scopus 로고    scopus 로고
    • Inflammatory bowel disease and the apical junctional complex
    • Bruewer M, Samarin S, Nusrat A. Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci. 2006;1072:242-252.
    • (2006) Ann N y Acad Sci. , vol.1072 , pp. 242-252
    • Bruewer, M.1    Samarin, S.2    Nusrat, A.3
  • 121
    • 84877575913 scopus 로고    scopus 로고
    • Diarrhoea-predominant irritable bowel syndrome: An organic disorder with structural abnormalities in the jejunal epithelial barrier
    • Martínez C, Lobo B, Pigrau M, et al. Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut. 2013;62:1160-1168.
    • (2013) Gut. , vol.62 , pp. 1160-1168
    • Martínez, C.1    Lobo, B.2    Pigrau, M.3
  • 122
    • 84873716991 scopus 로고    scopus 로고
    • Regulation of intestinal epithelial permeability by tight junctions
    • Suzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci. 2013;70:631-659.
    • (2013) Cell Mol Life Sci. , vol.70 , pp. 631-659
    • Suzuki, T.1
  • 123
    • 0037369552 scopus 로고    scopus 로고
    • Intestinal epithelial responses to enteric pathogens: Effects on the tight junction barrier, ion transport, and inflammation
    • Berkes J, Viswanathan VK, Savkovic SD, et al. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut. 2003;52:439-451.
    • (2003) Gut. , vol.52 , pp. 439-451
    • Berkes, J.1    Viswanathan, V.K.2    Savkovic, S.D.3
  • 124
    • 84857082954 scopus 로고    scopus 로고
    • Differential targeting of the E-Cadherin/P-Catenin complex by gram-positive probiotic lactobacilli improves epithelial barrier function
    • Hummel S, Veltman K, Cichon C, et al. Differential targeting of the E-Cadherin/P-Catenin complex by gram-positive probiotic lactobacilli improves epithelial barrier function. Appl Environ Microbiol. 2012;78:1140-1147.
    • (2012) Appl Environ Microbiol. , vol.78 , pp. 1140-1147
    • Hummel, S.1    Veltman, K.2    Cichon, C.3
  • 125
    • 0028959170 scopus 로고
    • E-cadherin expression in intestinal epithelium
    • Dogan A, Wang ZD, Spencer J. E-cadherin expression in intestinal epithelium. J Clin Pathol. 1995;48:143-146.
    • (1995) J Clin Pathol. , vol.48 , pp. 143-146
    • Dogan, A.1    Wang, Z.D.2    Spencer, J.3
  • 126
    • 84889681706 scopus 로고    scopus 로고
    • Western diet induces dysbiosis with increased e coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
    • Martinez-Medina M, Denizot J, Dreux N, et al. Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut. 2014;63:116-124.
    • (2014) Gut. , vol.63 , pp. 116-124
    • Martinez-Medina, M.1    Denizot, J.2    Dreux, N.3
  • 127
    • 84894231578 scopus 로고    scopus 로고
    • Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS
    • Wilcz-Villega E, McClean S, O'Sullivan M. Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterol Motil 2014;26:316-325.
    • (2014) Neurogastroenterol Motil , vol.26 , pp. 316-325
    • Wilcz-Villega, E.1    McClean, S.2    O'Sullivan, M.3
  • 128
    • 84870016400 scopus 로고    scopus 로고
    • Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology
    • Yu LC, Wang JT, Wei SC, et al. Host-microbial interactions and regulation of intestinal epithelial barrier function: from physiology to pathology. World J Gastrointest Pathophysiol. 2012;3:27-43.
    • (2012) World J Gastrointest Pathophysiol. , vol.3 , pp. 27-43
    • Yu, L.C.1    Wang, J.T.2    Wei, S.C.3
  • 129
    • 69949088176 scopus 로고    scopus 로고
    • Better living through microbial action: The benefits of the mammalian gastrointestinal microbiota on the host
    • Leser TD, Mølbak L. Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host. Environ Microbiol. 2009;11:2194-2206.
    • (2009) Environ Microbiol. , vol.11 , pp. 2194-2206
    • Leser, T.D.1    Mølbak, L.2
  • 130
    • 0038392691 scopus 로고    scopus 로고
    • Intestinal barrier: An interface between health and disease
    • Farhadi A, Banan A, Fields J, et al. Intestinal barrier: an interface between health and disease. J Gastroenterol Hepatol. 2003;18:479-497.
    • (2003) J Gastroenterol Hepatol. , vol.18 , pp. 479-497
    • Farhadi, A.1    Banan, A.2    Fields, J.3
  • 131
    • 0030851464 scopus 로고    scopus 로고
    • Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase
    • Fiorentini C, Fabbri A, Flatau G, et al. Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase. J Biol Chem. 1997;272:19532-19537.
    • (1997) J Biol Chem. , vol.272 , pp. 19532-19537
    • Fiorentini, C.1    Fabbri, A.2    Flatau, G.3
  • 132
    • 77954272420 scopus 로고    scopus 로고
    • EspM inhibits pedestal formation by enterohaemorrhagic Escherichia coli and enteropathogenic E. Coli and disrupts the architecture of a polarized epithelial monolayer
    • Simovitch M, Sason H, Cohen S, et al. EspM inhibits pedestal formation by enterohaemorrhagic Escherichia coli and enteropathogenic E. coli and disrupts the architecture of a polarized epithelial monolayer. Cell Microbiol. 2010;12:489-505.
    • (2010) Cell Microbiol. , vol.12 , pp. 489-505
    • Simovitch, M.1    Sason, H.2    Cohen, S.3
  • 133
    • 84918810194 scopus 로고    scopus 로고
    • Implication of miRNAs for inflammatory bowel disease treatment: Systematic review
    • Chen WX, Ren LH, Shi RH. Implication of miRNAs for inflammatory bowel disease treatment: systematic review. World J Gastrointest Pathophysiol. 2014;5:63-70.
    • (2014) World J Gastrointest Pathophysiol. , vol.5 , pp. 63-70
    • Chen, W.X.1    Ren, L.H.2    Shi, R.H.3
  • 134
    • 83555161689 scopus 로고    scopus 로고
    • MicroRNAs in inflammatory bowel disease
    • Pekow JR, Kwon JH. MicroRNAs in inflammatory bowel disease. In-flamm Bowel Dis. 2012;18:187-193.
    • (2012) In-flamm Bowel Dis. , vol.18 , pp. 187-193
    • Pekow, J.R.1    Kwon, J.H.2
  • 135
    • 84896051012 scopus 로고    scopus 로고
    • Downregulation of microRNA-107 in intestinal CD11c(+) myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression
    • Xue X, Cao AT, Cao X, et al. Downregulation of microRNA-107 in intestinal CD11c(+) myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression. Eur J Immunol. 2014;44:673-682.
    • (2014) Eur J Immunol. , vol.44 , pp. 673-682
    • Xue, X.1    Cao, A.T.2    Cao, X.3
  • 136
    • 79955753386 scopus 로고    scopus 로고
    • Microbiota modulate host gene expression via microRNAs
    • Dalmasso G, Nguyen HTT, Yan Y, et al. Microbiota modulate host gene expression via microRNAs. PLoS One. 2011;6:e19293.
    • (2011) PLoS One. , vol.6 , pp. e19293
    • Dalmasso, G.1    Htt, N.2    Yan, Y.3
  • 137
    • 79959961092 scopus 로고    scopus 로고
    • Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis
    • Lepage P, Häsler R, Spehlmann ME, et al. Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology. 2011;141:227-236.
    • (2011) Gastroenterology. , vol.141 , pp. 227-236
    • Lepage, P.1    Häsler, R.2    Spehlmann, M.E.3
  • 138
    • 66149090810 scopus 로고    scopus 로고
    • Pouchitis, similar to active ulcerative colitis, is associated with impaired butyrate oxidation by intestinal mucosa
    • De Preter V, Bulteel V, Suenaert P, et al. Pouchitis, similar to active ulcerative colitis, is associated with impaired butyrate oxidation by intestinal mucosa. Inflamm Bowel Dis. 2009;15:335-340.
    • (2009) Inflamm Bowel Dis. , vol.15 , pp. 335-340
    • De Preter, V.1    Bulteel, V.2    Suenaert, P.3
  • 139
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell. 2004;118:229-241.
    • (2004) Cell. , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3
  • 140
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Bäckhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA. 2004; 101:15718-15723.
    • (2004) Proc Natl Acad Sci USA. , vol.101 , pp. 15718-15723
    • Bäckhed, F.1    Ding, H.2    Wang, T.3
  • 141
    • 0030799478 scopus 로고    scopus 로고
    • Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production
    • Eckmann L, Stenson WF, Savidge TC, et al. Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. J Clin Invest. 1997;100: 296-309.
    • (1997) J Clin Invest. , vol.100 , pp. 296-309
    • Eckmann, L.1    Stenson, W.F.2    Savidge, T.C.3
  • 142
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008;132:344-362.
    • (2008) Cell. , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 143
    • 0031925362 scopus 로고    scopus 로고
    • Activation of nuclear factor kappa B inflammatory bowel disease
    • Schreiber S, Nikolaus S, Hampe J. Activation of nuclear factor kappa B inflammatory bowel disease. Gut. 1998;42:477-484.
    • (1998) Gut. , vol.42 , pp. 477-484
    • Schreiber, S.1    Nikolaus, S.2    Hampe, J.3
  • 144
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci A, Becker C, Wullaert A, et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007;446:557-561.
    • (2007) Nature. , vol.446 , pp. 557-561
    • Nenci, A.1    Becker, C.2    Wullaert, A.3
  • 145
    • 33947573767 scopus 로고    scopus 로고
    • Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    • Zaph C, Troy AE, Taylor BC, et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007;446: 552-556.
    • (2007) Nature. , vol.446 , pp. 552-556
    • Zaph, C.1    Troy, A.E.2    Taylor, B.C.3
  • 146
    • 77958558890 scopus 로고    scopus 로고
    • Functional metagenomics: A high throughput screening method to decipher microbiota-driven NF-KB modulation in the human gut
    • e13092
    • Lakhdari O, Cultrone A, Tap J, et al. Functional metagenomics: a high throughput screening method to decipher microbiota-driven NF-KB modulation in the human gut. PLoS One. 2010;5:pii:e13092.
    • (2010) PLoS One. , vol.5
    • Lakhdari, O.1    Cultrone, A.2    Tap, J.3
  • 147
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut micro-biome correlates with metabolic markers
    • Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut micro-biome correlates with metabolic markers. Nature. 2013;500:541-546.
    • (2013) Nature. , vol.500 , pp. 541-546
    • Le Chatelier, E.1    Nielsen, T.2    Qin, J.3
  • 148
    • 84883057637 scopus 로고    scopus 로고
    • Dietary intervention impact on gut microbial gene richness
    • Cotillard A, Kennedy SP, Kong LC, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013;500:585-588.
    • (2013) Nature. , vol.500 , pp. 585-588
    • Cotillard, A.1    Kennedy, S.P.2    Kong, L.C.3
  • 149
    • 72949091232 scopus 로고    scopus 로고
    • Bacterial community variation in human body habitats across space and time
    • Costello EK, Lauber CL, Hamady M, et al. Bacterial community variation in human body habitats across space and time. Science. 2009;326: 1694-1697.
    • (2009) Science. , vol.326 , pp. 1694-1697
    • Costello, E.K.1    Lauber, C.L.2    Hamady, M.3
  • 150
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59-65.
    • (2010) Nature. , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3
  • 151
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    • Manichanh C, Rigottier-Gois L, Bonnaud E, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut. 2006;55:205-211.
    • (2006) Gut. , vol.55 , pp. 205-211
    • Manichanh, C.1    Rigottier-Gois, L.2    Bonnaud, E.3
  • 152
    • 84861987332 scopus 로고    scopus 로고
    • Taking stock of the human microbiome and disease
    • Balter M. Taking stock of the human microbiome and disease. Science. 2012;336:1246-1247.
    • (2012) Science. , vol.336 , pp. 1246-1247
    • Balter, M.1
  • 153
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol. 2004;4:371-379.
    • (2004) Nat Rev Immunol. , vol.4 , pp. 371-379
    • La Cava, A.1    Matarese, G.2
  • 154
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394:897-901.
    • (1998) Nature. , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3
  • 155
    • 0032143821 scopus 로고    scopus 로고
    • Helper T cell differentiation is controlled by the cell cycle
    • Bird JJ, Brown DR, Mullen AC, et al. Helper T cell differentiation is controlled by the cell cycle. Immunity. 1998;9:229-237.
    • (1998) Immunity. , vol.9 , pp. 229-237
    • Bird, J.J.1    Brown, D.R.2    Mullen, A.C.3
  • 156
    • 33846974390 scopus 로고    scopus 로고
    • Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier
    • Peng L, He Z, Chen W, et al. Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier. Pediatr Res. 2007;61:37-41.
    • (2007) Pediatr Res. , vol.61 , pp. 37-41
    • Peng, L.1    He, Z.2    Chen, W.3
  • 157
    • 79959201412 scopus 로고    scopus 로고
    • Human nutrition, the gut micro-biome and the immune system
    • Kau AL, Ahern PP, Griffin NW, et al. Human nutrition, the gut micro-biome and the immune system. Nature. 2011;474:327-336.
    • (2011) Nature. , vol.474 , pp. 327-336
    • Kau, A.L.1    Ahern, P.P.2    Griffin, N.W.3
  • 159
    • 84879426139 scopus 로고    scopus 로고
    • Proteomics and metabolomics in inflammatory bowel disease
    • Yau Y, Leong RW, Zeng M, et al. Proteomics and metabolomics in inflammatory bowel disease. J Gastroenterol Hepatol. 2013;28:1076-1086.
    • (2013) J Gastroenterol Hepatol. , vol.28 , pp. 1076-1086
    • Yau, Y.1    Leong, R.W.2    Zeng, M.3
  • 160
    • 84892885269 scopus 로고    scopus 로고
    • A metaproteomic pipeline to identify newborn mouse gut phylotypes
    • Del Chierico F, Petrucca A, Mortera SL, et al. A metaproteomic pipeline to identify newborn mouse gut phylotypes. J Proteomics. 2014;97:17-26.
    • (2014) J Proteomics. , vol.97 , pp. 17-26
    • Del Chierico, F.1    Petrucca, A.2    Mortera, S.L.3
  • 161
    • 84908554334 scopus 로고    scopus 로고
    • Bacterial protein signals are associated with Crohn's disease
    • Juste C, Kreil DP, Beauvallet C, et al. Bacterial protein signals are associated with Crohn's disease. Gut. 2014;63:1566-1577.
    • (2014) Gut. , vol.63 , pp. 1566-1577
    • Juste, C.1    Kreil, D.P.2    Beauvallet, C.3
  • 162
    • 84863923380 scopus 로고    scopus 로고
    • Reproducible quantification of cancer-associated proteins in body fluids using targeted proteomics
    • Hüttenhain R, Soste M, Selevsek N, et al. Reproducible quantification of cancer-associated proteins in body fluids using targeted proteomics. Sci Transl Med. 2012;4:142ra94.
    • (2012) Sci Transl Med. , vol.4 , pp. 142ra94
    • Hüttenhain, R.1    Soste, M.2    Selevsek, N.3
  • 163
    • 84857847927 scopus 로고    scopus 로고
    • Multiplex targeted proteomic assay for biomarker detection in plasma: A pancreatic cancer biomarker case study
    • Pan S, Chen R, Brand RE, et al. Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J Proteome Res. 2012;11:1937-1948.
    • (2012) J Proteome Res. , vol.11 , pp. 1937-1948
    • Pan, S.1    Chen, R.2    Brand, R.E.3
  • 164
    • 84871519258 scopus 로고    scopus 로고
    • Sample size planning for classification models
    • Beleites C, Neugebauer U, Bocklitz T, et al. Sample size planning for classification models. Anal Chim Acta. 2013;760:25-33.
    • (2013) Anal Chim Acta. , vol.760 , pp. 25-33
    • Beleites, C.1    Neugebauer, U.2    Bocklitz, T.3
  • 166
    • 84876144335 scopus 로고    scopus 로고
    • Ten challenges for systems medicine
    • Capobianco E. Ten challenges for systems medicine. Front Genet. 2012; 3:193.
    • (2012) Front Genet. , vol.3 , pp. 193
    • Capobianco, E.1
  • 167
    • 77956468993 scopus 로고    scopus 로고
    • Sample size and statistical power considerations in high-dimensionality data settings: A comparative study of classification algorithms
    • Guo Y, Graber A, McBurney RN, et al. Sample size and statistical power considerations in high-dimensionality data settings: a comparative study of classification algorithms. BMC Bioinformatics. 2010;11:447.
    • (2010) BMC Bioinformatics. , vol.11 , pp. 447
    • Guo, Y.1    Graber, A.2    McBurney, R.N.3
  • 168
    • 0028671846 scopus 로고
    • Seven ways to increase power without increasing N
    • Hansen WB, Collins LM. Seven ways to increase power without increasing N. NIDA Res Monogr. 1994;142:184-195.
    • (1994) NIDA Res Monogr. , vol.142 , pp. 184-195
    • Hansen, W.B.1    Collins, L.M.2
  • 169
    • 80455122669 scopus 로고    scopus 로고
    • Sample size and power calculations made simple
    • McCrum-Gardner E. Sample size and power calculations made simple. Int J Ther Rehabil. 2010;17:10-14.
    • (2010) Int J Ther Rehabil. , vol.17 , pp. 10-14
    • McCrum-Gardner, E.1
  • 170
    • 0038237368 scopus 로고    scopus 로고
    • Estimating dataset size requirements for classifying DNA microarray data
    • Mukherjee S, Tamayo P, Rogers S, et al. Estimating dataset size requirements for classifying DNA microarray data. J Comput Biol. 2003;10: 119-142.
    • (2003) J Comput Biol. , vol.10 , pp. 119-142
    • Mukherjee, S.1    Tamayo, P.2    Rogers, S.3
  • 171
    • 84863638955 scopus 로고    scopus 로고
    • Sample size estimation and power analysis for clinical research studies
    • Suresh K, Chandrashekara S. Sample size estimation and power analysis for clinical research studies. J Hum Reprod Sci. 2012;5:7-13.
    • (2012) J Hum Reprod Sci. , vol.5 , pp. 7-13
    • Suresh, K.1    Chandrashekara, S.2
  • 172
    • 84926189914 scopus 로고    scopus 로고
    • Crosstalk at the mucosal border: Importance of the gut microenvironment in IBS
    • Öhman L, Törnblom H, Simrén M. Crosstalk at the mucosal border: importance of the gut microenvironment in IBS. Nat Rev Gastroenterol Hepatol. 2015;12:36-49.
    • (2015) Nat Rev Gastroenterol Hepatol. , vol.12 , pp. 36-49
    • Öhman, L.1    Törnblom, H.2    Simrén, M.3
  • 174
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489:220-230.
    • (2012) Nature. , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3
  • 176
    • 84920571337 scopus 로고    scopus 로고
    • Pathogens' exploitation of the intestinal food web
    • Pham NTA, Lawley TD. Pathogens' exploitation of the intestinal food web. Cell Host Microbe. 2014;16:703-705.
    • (2014) Cell Host Microbe. , vol.16 , pp. 703-705
    • Nta, P.1    Lawley, T.D.2
  • 177
    • 84883858159 scopus 로고    scopus 로고
    • Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis
    • Molloy MJ, Grainger JR, Bouladoux N, et al. Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis. Cell Host Microbe. 2013;14:318-328.
    • (2013) Cell Host Microbe. , vol.14 , pp. 318-328
    • Molloy, M.J.1    Grainger, J.R.2    Bouladoux, N.3
  • 178
    • 84881559009 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii and human intestinal health
    • Miquel S, Martín R, Rossi O, et al. Faecalibacterium prausnitzii and human intestinal health. Curr Opin Microbiol. 2013;16:255-261.
    • (2013) Curr Opin Microbiol. , vol.16 , pp. 255-261
    • Miquel, S.1    Martín, R.2    Rossi, O.3
  • 179
    • 84943276398 scopus 로고    scopus 로고
    • Understanding probi-otics' role in allergic children: The clue of gut microbiota profiling
    • Vernocchi P, Del Chierico F, Fiocchi AG, et al. Understanding probi-otics' role in allergic children: the clue of gut microbiota profiling. Curr Opin Allergy Clin Immunol. 2015;15:495-503.
    • (2015) Curr Opin Allergy Clin Immunol. , vol.15 , pp. 495-503
    • Vernocchi, P.1    Del Chierico, F.2    Fiocchi, A.G.3
  • 180
    • 84925541323 scopus 로고    scopus 로고
    • Complex host genetics influence the microbiome in inflammatory bowel disease
    • Knights D, Silverberg MS, Weersma RK, et al. Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med. 2014;6:107.
    • (2014) Genome Med. , vol.6 , pp. 107
    • Knights, D.1    Silverberg, M.S.2    Weersma, R.K.3
  • 182
    • 84919865470 scopus 로고    scopus 로고
    • Next generation sequencing and the future of genetic diagnosis
    • Lohmann K, Klein C. Next generation sequencing and the future of genetic diagnosis. Neurotherapeutics. 2014;11:699-707.
    • (2014) Neurotherapeutics. , vol.11 , pp. 699-707
    • Lohmann, K.1    Klein, C.2
  • 183
    • 84928555455 scopus 로고    scopus 로고
    • Managing, analysing, and integrating big data in medical bioinformatics: Open problems and future perspectives
    • Merelli I, Pérez-Sánchez H, Gesing S, et al. Managing, analysing, and integrating big data in medical bioinformatics: open problems and future perspectives. Biomed Res Int. 2014;2014:134023.
    • (2014) Biomed Res Int. , vol.2014 , pp. 134023
    • Merelli, I.1    Pérez-Sánchez, H.2    Gesing, S.3
  • 184
    • 84871454511 scopus 로고    scopus 로고
    • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
    • Holmes E, Li JV, Marchesi JR, et al. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metab. 2012;16:559-564.
    • (2012) Cell Metab. , vol.16 , pp. 559-564
    • Holmes, E.1    Li, J.V.2    Marchesi, J.R.3
  • 185
    • 84902657623 scopus 로고    scopus 로고
    • Finding the missing links among metabolites, microbes, and the host
    • Dorrestein PC, Mazmanian SK, Knight R. Finding the missing links among metabolites, microbes, and the host. Immunity. 2014;40:824-832.
    • (2014) Immunity. , vol.40 , pp. 824-832
    • Dorrestein, P.C.1    Mazmanian, S.K.2    Knight, R.3
  • 186
    • 84901422463 scopus 로고    scopus 로고
    • The role of diet on intestinal microbiota metabolism: Downstream impacts on host immune function and health, and therapeutic implications
    • Goldsmith JR, Sartor RB. The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. J Gastroenterol. 2014;49:785-798.
    • (2014) J Gastroenterol. , vol.49 , pp. 785-798
    • Goldsmith, J.R.1    Sartor, R.B.2
  • 187
    • 84865288536 scopus 로고    scopus 로고
    • Interkingdom metabolic transformations captured by microbial imaging mass spectrometry
    • Moree WJ, Phelan VV, Wu CH, et al. Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proc Natl Acad Sci USA. 2012;109:13811-13816.
    • (2012) Proc Natl Acad Sci USA. , vol.109 , pp. 13811-13816
    • Moree, W.J.1    Phelan, V.V.2    Wu, C.H.3
  • 188
    • 84883430904 scopus 로고    scopus 로고
    • Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metab-olome
    • Traxler MF, Watrous JD, Alexandrov T, et al. Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metab-olome. mBio. 2013;4:pii:e00459-13.
    • (2013) MBio. , vol.4
    • Traxler, M.F.1    Watrous, J.D.2    Alexandrov, T.3
  • 189
    • 73549086351 scopus 로고    scopus 로고
    • Translating metabolic exchange with imaging mass spectrometry
    • Yang YL, Xu Y, Straight P, et al. Translating metabolic exchange with imaging mass spectrometry. Nat Chem Biol. 2009;5:885-887.
    • (2009) Nat Chem Biol. , vol.5 , pp. 885-887
    • Yang, Y.L.1    Xu, Y.2    Straight, P.3
  • 190
    • 84875698694 scopus 로고    scopus 로고
    • Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion
    • Seyer A, Cantiello M, Bertrand-Michel J, et al. Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion. PLoS One. 2013;8:e58224.
    • (2013) PLoS One. , vol.8 , pp. e58224
    • Seyer, A.1    Cantiello, M.2    Bertrand-Michel, J.3
  • 191
    • 84902673930 scopus 로고    scopus 로고
    • The human gut micro-biota: A dynamic interplay with the host from birth to senescence settled during childhood
    • Putignani L, Del Chierico F, Petrucca A, et al. The human gut micro-biota: a dynamic interplay with the host from birth to senescence settled during childhood. Pediatr Res. 2014;76:2-10.
    • (2014) Pediatr Res. , vol.76 , pp. 2-10
    • Putignani, L.1    Del Chierico, F.2    Petrucca, A.3
  • 192
    • 84900387954 scopus 로고    scopus 로고
    • A physicians' wish list for the clinical application of intestinal metagenomics
    • Klymiuk I, Högenauer C, Halwachs B, et al. A physicians' wish list for the clinical application of intestinal metagenomics. PLoS Med. 2014;11: e1001627.
    • (2014) PLoS Med. , vol.11 , pp. e1001627
    • Klymiuk, I.1    Högenauer, C.2    Halwachs, B.3
  • 193
    • 79952712983 scopus 로고    scopus 로고
    • Gut microbiome-host interactions in health and disease
    • Kinross JM, Darzi AW, Nicholson JK. Gut microbiome-host interactions in health and disease. Genome Med. 2011;3:14.
    • (2011) Genome Med. , vol.3 , pp. 14
    • Kinross, J.M.1    Darzi, A.W.2    Nicholson, J.K.3
  • 195
    • 47949106374 scopus 로고    scopus 로고
    • Epidemiology of inflammatory bowel disease in a German twin cohort: Results of a nationwide study
    • Spehlmann ME, Begun AZ, Burghardt J, et al. Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study. Inflamm Bowel Dis. 2008;14:968-976.
    • (2008) Inflamm Bowel Dis. , vol.14 , pp. 968-976
    • Spehlmann, M.E.1    Begun, A.Z.2    Burghardt, J.3
  • 196
    • 33644987372 scopus 로고    scopus 로고
    • A survey on patient educational needs in irritable bowel syndrome and attitudes toward participation in clinical research
    • Halpert AD, Thomas AC, Hu Y, et al. A survey on patient educational needs in irritable bowel syndrome and attitudes toward participation in clinical research. J Clin Gastroenterol. 2006;40:37-43.
    • (2006) J Clin Gastroenterol. , vol.40 , pp. 37-43
    • Halpert, A.D.1    Thomas, A.C.2    Hu, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.