메뉴 건너뛰기




Volumn 12, Issue 1, 2015, Pages 36-49

Crosstalk at the mucosal border: Importance of the gut microenvironment in IBS

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; ENDOCRINE SYSTEM; ENTEROENDOCRINE CELL; ENTEROENDOCRINE SYSTEM; GASTROINTESTINAL TRACT; GENETIC ASSOCIATION; HUMAN; IMMUNE SYSTEM; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; IRRITABLE COLON; MICROBIAL DIVERSITY; MUCOSAL IMMUNITY; NEUROIMMUNOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PERMEABILITY BARRIER; PRIORITY JOURNAL; REVIEW; SPECIES COMPOSITION; CELL COMMUNICATION; GASTROENTERITIS; IMMUNOLOGY; INTESTINE; IRRITABLE BOWEL SYNDROME; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY; RISK FACTOR; TUMOR MICROENVIRONMENT;

EID: 84926189914     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2014.200     Document Type: Review
Times cited : (157)

References (214)
  • 1
    • 33646201684 scopus 로고    scopus 로고
    • Functional bowel disorders
    • Longstreth, G. F. et al. Functional bowel disorders. Gastroenterology 130, 1480-1491 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 1480-1491
    • Longstreth, G.F.1
  • 2
    • 84862651150 scopus 로고    scopus 로고
    • Global prevalence of and risk factors for irritable bowel syndrome: A meta-Analysis
    • e4
    • Lovell, R. M, & Ford, A. C. Global prevalence of and risk factors for irritable bowel syndrome: a meta-Analysis. Clin. Gastroenterol. Hepatol. 10, 712-721.e4 (2012).
    • (2012) Clin. Gastroenterol. Hepatol. , vol.10 , pp. 712-721
    • Lovell, R.M.1    Ford, A.C.2
  • 3
    • 34547440499 scopus 로고
    • Mucous colitis: A delineation of the syndrome with certain observations on its mechanisms and on the role of emotional tension as a precipitating factor
    • White, B. C. J. Mucous colitis: a delineation of the syndrome with certain observations on its mechanisms and on the role of emotional tension as a precipitating factor. Ann. Int. Med. 14, 854-872 (1940).
    • (1940) Ann. Int. Med. , vol.14 , pp. 854-872
    • White, B.C.J.1
  • 4
    • 0036202892 scopus 로고    scopus 로고
    • Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?
    • Whitehead, W. E., Palsson, O., & Jones, K. R. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?. Gastroenterology 122, 1140-1156 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 1140-1156
    • Whitehead, W.E.1    Palsson, O.2    Jones, K.R.3
  • 5
    • 84925557459 scopus 로고
    • The irritable colon syndrome A study of the clinical features, predisposing causes, and prognosis in 130 cases
    • Chaudhary, N. A., & Truelove, S. C. The irritable colon syndrome. A study of the clinical features, predisposing causes, and prognosis in 130 cases. Q. J. Med. 31, 307-322 (1962).
    • (1962) Q. J. Med. , vol.31 , pp. 307-322
    • Chaudhary, N.A.1    Truelove, S.C.2
  • 6
    • 34547586603 scopus 로고    scopus 로고
    • Guidelines on the irritable bowel syndrome: Mechanisms and practical management
    • Spiller, R. et al. Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 56, 1770-1798 (2007).
    • (2007) Gut , vol.56 , pp. 1770-1798
    • Spiller, R.1
  • 7
    • 84862333026 scopus 로고    scopus 로고
    • Colonic transit time and IBS symptoms: What's the link?
    • Tornblom, H. et al. Colonic transit time and IBS symptoms: what's the link?. Am. J. Gastroenterol. 107, 754-760 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 754-760
    • Tornblom, H.1
  • 8
    • 0015581604 scopus 로고
    • Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome
    • Ritchie, J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 14, 125-132 (1973).
    • (1973) Gut , vol.14 , pp. 125-132
    • Ritchie, J.1
  • 9
    • 0025271914 scopus 로고
    • Tolerance for rectosigmoid distention in irritable bowel syndrome
    • Whitehead, W. E. et al. Tolerance for rectosigmoid distention in irritable bowel syndrome. Gastroenterology 98, 1187-1192 (1990).
    • (1990) Gastroenterology , vol.98 , pp. 1187-1192
    • Whitehead, W.E.1
  • 10
    • 34848856669 scopus 로고    scopus 로고
    • Altered rectal perception in irritable bowel syndrome is associated with symptom severity
    • Posserud, I. et al. Altered rectal perception in irritable bowel syndrome is associated with symptom severity. Gastroenterology 133, 1113-1123 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 1113-1123
    • Posserud, I.1
  • 11
    • 78650505214 scopus 로고    scopus 로고
    • Quantitative meta-Analysis identifies brain regions activated during rectal distension in irritable bowel syndrome
    • Tillisch, K., Mayer, E. A., & Labus, J. S. Quantitative meta-Analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology 140, 91-100 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 91-100
    • Tillisch, K.1    Mayer, E.A.2    Labus, J.S.3
  • 13
    • 84881479285 scopus 로고    scopus 로고
    • Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets
    • Mawe, G. M., & Hoffman, J. M. Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets. Nat. Rev. Gastroenterol. Hepatol. 10, 473-486 (2013).
    • (2013) Nat. Rev. Gastroenterol. Hepatol. , vol.10 , pp. 473-486
    • Mawe, G.M.1    Hoffman, J.M.2
  • 14
    • 84871120114 scopus 로고    scopus 로고
    • Intestinal microbiota in functional bowel disorders: A Rome foundation report
    • Simren, M. et al. Intestinal microbiota in functional bowel disorders: a Rome foundation report. Gut 62, 159-176 (2013).
    • (2013) Gut , vol.62 , pp. 159-176
    • Simren, M.1
  • 15
    • 84909595988 scopus 로고    scopus 로고
    • The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis
    • Bercik, P., & Collins, S. M. The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis. Adv. Exp. Med. Biol. 817, 279-289 (2014).
    • (2014) Adv. Exp. Med. Biol. , vol.817 , pp. 279-289
    • Bercik, P.1    Collins, S.M.2
  • 16
    • 84905182016 scopus 로고    scopus 로고
    • The microbiota-gut-brain axis in functional gastrointestinal disorders
    • De Palma, G., Collins, S. M., & Bercik, P. The microbiota-gut-brain axis in functional gastrointestinal disorders. Gut Microbes 5, 419-429 (2014).
    • (2014) Gut Microbes , vol.5 , pp. 419-429
    • De Palma, G.1    Collins, S.M.2    Bercik, P.3
  • 17
    • 79551574749 scopus 로고    scopus 로고
    • The brain-gut axis in abdominal pain syndromes
    • Mayer, E. A., & Tillisch, K. The brain-gut axis in abdominal pain syndromes. Annu. Rev. Med. 62, 381-396 (2011).
    • (2011) Annu. Rev. Med. , vol.62 , pp. 381-396
    • Mayer, E.A.1    Tillisch, K.2
  • 18
    • 84898777631 scopus 로고    scopus 로고
    • Brain-gut microbiome interactions and functional bowel disorders
    • Mayer, E. A., Savidge, T., & Shulman, R. J. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology 146, 1500-1512 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1500-1512
    • Mayer, E.A.1    Savidge, T.2    Shulman, R.J.3
  • 19
    • 80054961002 scopus 로고    scopus 로고
    • Biopsychosocial model of irritable bowel syndrome
    • Tanaka, Y. et al. Biopsychosocial model of irritable bowel syndrome. J. Neurogastroenterol. Motil. 17, 131-139 (2011).
    • (2011) J. Neurogastroenterol. Motil. , vol.17 , pp. 131-139
    • Tanaka, Y.1
  • 20
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota-masters of host development and physiology
    • Sommer, F., & Backhed, F. The gut microbiota-masters of host development and physiology. Nat. Rev. Microbiol. 11, 227-238 (2013).
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 227-238
    • Sommer, F.1    Backhed, F.2
  • 21
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: Regulators of barrier function and immune homeostasis
    • Peterson, L. W., & Artis, D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 14, 141-153 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 22
    • 84910116769 scopus 로고    scopus 로고
    • The yin and yang of bacterial resilience in the human gut microbiota
    • Gibson, M. K., Pesesky, M. W., & Dantas, G. The yin and yang of bacterial resilience in the human gut microbiota. J. Mol. Biol. http://dx.doi.org/10.1016/j.jmb.2014.05.029.
    • J. Mol. Biol.
    • Gibson, M.K.1    Pesesky, M.W.2    Dantas, G.3
  • 23
    • 22344453437 scopus 로고    scopus 로고
    • Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction
    • Akiho, H. et al. Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology 129, 131-141 (2005).
    • (2005) Gastroenterology , vol.129 , pp. 131-141
    • Akiho, H.1
  • 24
    • 3242686372 scopus 로고    scopus 로고
    • Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
    • Bercik, P. et al. Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction. Gastroenterology 127, 179-187 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 179-187
    • Bercik, P.1
  • 25
    • 0033056598 scopus 로고    scopus 로고
    • The role of psychological and biological factors in postinfective gut dysfunction
    • Gwee, K. A. et al. The role of psychological and biological factors in postinfective gut dysfunction. Gut 44, 400-406 (1999).
    • (1999) Gut , vol.44 , pp. 400-406
    • Gwee, K.A.1
  • 26
    • 84898778474 scopus 로고    scopus 로고
    • Motility response to colonic distention is increased in postinfectious irritable bowel syndrome (PI-IBS)
    • Kanazawa, M. et al. Motility response to colonic distention is increased in postinfectious irritable bowel syndrome (PI-IBS). Neurogastroenterol. Motil. 26, 696-704 (2014).
    • (2014) Neurogastroenterol. Motil. , vol.26 , pp. 696-704
    • Kanazawa, M.1
  • 27
    • 19644363035 scopus 로고    scopus 로고
    • Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice
    • Kimball, E. S. et al. Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G1266-G1273 (2005).
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288 , pp. G1266-G1273
    • Kimball, E.S.1
  • 28
    • 0023514333 scopus 로고
    • Studies on the mechanism of bowel disturbance in ulcerative colitis
    • Rao, S. S. et al. Studies on the mechanism of bowel disturbance in ulcerative colitis. Gastroenterology 93, 934-940 (1987).
    • (1987) Gastroenterology , vol.93 , pp. 934-940
    • Rao, S.S.1
  • 29
    • 0023635765 scopus 로고
    • Anorectal sensitivity and responses to rectal distention in patients with ulcerative colitis
    • Rao, S. S. et al. Anorectal sensitivity and responses to rectal distention in patients with ulcerative colitis. Gastroenterology 93, 1270-1275 (1987).
    • (1987) Gastroenterology , vol.93 , pp. 1270-1275
    • Rao, S.S.1
  • 30
    • 4444360389 scopus 로고    scopus 로고
    • Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction
    • Verdu, E. F. et al. Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction. Gastroenterology 127, 826-837 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 826-837
    • Verdu, E.F.1
  • 31
    • 30944444119 scopus 로고    scopus 로고
    • Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
    • Verdu, E. F. et al. Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut 55, 182-90 (2006).
    • (2006) Gut , vol.55 , pp. 182-190
    • Verdu, E.F.1
  • 32
    • 34047159849 scopus 로고    scopus 로고
    • Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse
    • Verma-Gandhu, M. et al. Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse. Gut 56, 358-364 (2007).
    • (2007) Gut , vol.56 , pp. 358-364
    • Verma-Gandhu, M.1
  • 33
    • 84888202010 scopus 로고    scopus 로고
    • Gut motility and enteroendocrine secretion
    • Wu, T. et al. Gut motility and enteroendocrine secretion. Curr. Opin. Pharmacol. 13, 928-934 (2013).
    • (2013) Curr. Opin. Pharmacol. , vol.13 , pp. 928-934
    • Wu, T.1
  • 34
    • 77953241787 scopus 로고    scopus 로고
    • Gut hormones: Emerging role in immune activation and inflammation
    • Khan, W. I., & Ghia, J. E. Gut hormones: emerging role in immune activation and inflammation. Clin. Exp. Immunol. 161, 19-27 (2010).
    • (2010) Clin. Exp. Immunol. , vol.161 , pp. 19-27
    • Khan, W.I.1    Ghia, J.E.2
  • 35
    • 77955647582 scopus 로고    scopus 로고
    • Gut microbiota in health and disease
    • Sekirov, I. et al. Gut microbiota in health and disease. Physiol. Rev. 90, 859-904 (2010).
    • (2010) Physiol. Rev. , vol.90 , pp. 859-904
    • Sekirov, I.1
  • 36
    • 58149149548 scopus 로고    scopus 로고
    • Overview of the gastrointestinal microbiota
    • Young, V. B., & Schmidt, T. M. Overview of the gastrointestinal microbiota. Adv. Exp. Med. Biol. 635, 29-40 (2008).
    • (2008) Adv. Exp. Med. Biol. , vol.635 , pp. 29-40
    • Young, V.B.1    Schmidt, T.M.2
  • 37
    • 33745594044 scopus 로고    scopus 로고
    • The gut flora as a forgotten organ
    • O'Hara, A. M., & Shanahan, F. The gut flora as a forgotten organ. EMBO Rep. 7, 688-693 (2006).
    • (2006) EMBO Rep. , vol.7 , pp. 688-693
    • O'hara, A.M.1    Shanahan, F.2
  • 38
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • Frank, D. N. et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl Acad. Sci. USA 104, 13780-13785 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13780-13785
    • Frank, D.N.1
  • 39
    • 35348961403 scopus 로고    scopus 로고
    • An ecological and evolutionary perspective on human-microbe mutualism and disease
    • Dethlefsen, L., McFall-Ngai M, & Relman, D. A. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 449, 811-818 (2007).
    • (2007) Nature , vol.449 , pp. 811-818
    • Dethlefsen, L.1    McFall-Ngai, M.2    Relman, D.A.3
  • 40
    • 54349126970 scopus 로고    scopus 로고
    • High-Throughput diversity and functionality analysis of the gastrointestinal tract microbiota
    • Zoetendal, E. G., Rajilic-Stojanovic, M., & de Vos, W. M. High-Throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut 57, 1605-1615 (2008).
    • (2008) Gut , vol.57 , pp. 1605-1615
    • Zoetendal, E.G.1    Rajilic-Stojanovic, M.2    De Vos, W.M.3
  • 41
    • 14844351844 scopus 로고    scopus 로고
    • Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice
    • Swidsinski, A., Loening-Baucke, V., Lochs, H., & Hale, L. P. Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice. World J. Gastroenterol. 11, 113-1140 (2005).
    • (2005) World J. Gastroenterol. , vol.11 , pp. 113-1140
    • Swidsinski, A.1    Loening-Baucke, V.2    Lochs, H.3    Hale, L.P.4
  • 42
    • 84879234708 scopus 로고    scopus 로고
    • Analysis of the human gut microbiome and association with disease
    • Wu, G. D., & Lewis, J. D. Analysis of the human gut microbiome and association with disease. Clin. Gastroenterol. Hepatol. 11, 774-777 (2013).
    • (2013) Clin. Gastroenterol. Hepatol. , vol.11 , pp. 774-777
    • Wu, G.D.1    Lewis, J.D.2
  • 43
    • 84905376185 scopus 로고    scopus 로고
    • Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions
    • Hyland, N. P., Quigley, E. M., & Brint, E. Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions. World J. Gastroenterol. 20, 8859-8866 (2014).
    • (2014) World J. Gastroenterol. , vol.20 , pp. 8859-8866
    • Hyland, N.P.1    Quigley, E.M.2    Brint, E.3
  • 44
    • 84905389962 scopus 로고    scopus 로고
    • Intestinal microbiota in pathophysiology and management of irritable bowel syndrome
    • Lee, K. N., & Lee, O. Y. Intestinal microbiota in pathophysiology and management of irritable bowel syndrome. World J. Gastroenterol. 20, 8886-8897 (2014).
    • (2014) World J. Gastroenterol. , vol.20 , pp. 8886-8897
    • Lee, K.N.1    Lee, O.Y.2
  • 45
    • 65449165950 scopus 로고    scopus 로고
    • Postinfectious irritable bowel syndrome
    • Spiller, R., & Garsed, K. Postinfectious irritable bowel syndrome. Gastroenterology 136, 1979-1988 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1979-1988
    • Spiller, R.1    Garsed, K.2
  • 46
    • 34547477105 scopus 로고    scopus 로고
    • Systematic review and meta-Analysis: The incidence and prognosis of post-infectious irritable bowel syndrome
    • Thabane, M., Kottachchi, D. T., & Marshall, J. K. Systematic review and meta-Analysis: the incidence and prognosis of post-infectious irritable bowel syndrome. Aliment. Pharmacol. Ther. 26, 535-544 (2007).
    • (2007) Aliment. Pharmacol. Ther. , vol.26 , pp. 535-544
    • Thabane, M.1    Kottachchi, D.T.2    Marshall, J.K.3
  • 47
    • 33746712257 scopus 로고    scopus 로고
    • Postinfectious irritable bowel syndrome-A meta-Analysis
    • Halvorson, H. A., Schlett, C. D., & Riddle, M. S. Postinfectious irritable bowel syndrome-A meta-Analysis. Am. J. Gastroenterol. 101, 1894-1899 (2006).
    • (2006) Am. J. Gastroenterol. , vol.101 , pp. 1894-1899
    • Halvorson, H.A.1    Schlett, C.D.2    Riddle, M.S.3
  • 48
    • 84903189712 scopus 로고    scopus 로고
    • Salmonella gastroenteritis during childhood is a risk factor for irritable bowel syndrome in adulthood
    • Cremon, C. et al. Salmonella gastroenteritis during childhood is a risk factor for irritable bowel syndrome in adulthood. Gastroenterology 147, 69-77 (2014).
    • (2014) Gastroenterology , vol.147 , pp. 69-77
    • Cremon, C.1
  • 49
    • 0033636668 scopus 로고    scopus 로고
    • Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
    • Pimentel, M., Chow, E. J., & Lin, H. C. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am. J. Gastroenterol. 95, 3503-3506 (2000).
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 3503-3506
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 50
    • 34249790127 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in patients with irritable bowel syndrome
    • Posserud, I. et al. Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut 56, 802-808 (2007).
    • (2007) Gut , vol.56 , pp. 802-808
    • Posserud, I.1
  • 51
    • 22744432798 scopus 로고    scopus 로고
    • Detection of bacterial overgrowth in IBS using the lactulose H2 breath test: Comparison with 14C D xylose and healthy controls
    • Walters, B., & Vanner, S. J. Detection of bacterial overgrowth in IBS using the lactulose H2 breath test: comparison with 14C D xylose and healthy controls. Am. J. Gastroenterol. 100, 1566-1570 (2005).
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 1566-1570
    • Walters, B.1    Vanner, S.J.2
  • 52
    • 50249169511 scopus 로고    scopus 로고
    • The small intestinal bacterial overgrowth. Irritable bowel syndrome hypo thesis: Implications for treatment
    • Vanner, S. The small intestinal bacterial overgrowth. Irritable bowel syndrome hypothesis: implications for treatment. Gut 57, 1315-1321 (2008).
    • (2008) Gut , vol.57 , pp. 1315-1321
    • Vanner, S.1
  • 53
    • 84890685902 scopus 로고    scopus 로고
    • A diet low in FODMAPs reduces symptoms of irritable bowel syndrome
    • e5
    • Halmos, E. P. et al. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology 146, 67-75.e5 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 67-75
    • Halmos, E.P.1
  • 54
    • 77749318556 scopus 로고    scopus 로고
    • The efficacy of probiotics in the treatment of irritable bowel syndrome: A systematic review
    • Moayyedi, P. et al. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut 59, 325-32 (2010).
    • (2010) Gut , vol.59 , pp. 325-332
    • Moayyedi, P.1
  • 55
    • 84899114664 scopus 로고    scopus 로고
    • Safety and tolerability of rifaximin for the treatment of irritable bowel syndrome without constipation: A pooled analysis of randomised, double-blind, placebo-controlled trials
    • Schoenfeld, P. et al. Safety and tolerability of rifaximin for the treatment of irritable bowel syndrome without constipation: a pooled analysis of randomised, double-blind, placebo-controlled trials. Aliment. Pharmacol. Ther. 39, 1161-1168 (2014).
    • (2014) Aliment. Pharmacol. Ther. , vol.39 , pp. 1161-1168
    • Schoenfeld, P.1
  • 56
    • 80054119513 scopus 로고    scopus 로고
    • Molecular analysis of the luminal-And mucosal-Associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome
    • Carroll, I. M. et al. Molecular analysis of the luminal-And mucosal-Associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G799-G807 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.301 , pp. G799-G807
    • Carroll, I.M.1
  • 57
    • 12844273701 scopus 로고    scopus 로고
    • Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome-A longitudinal study in IBS and control subjects
    • Matto, J. et al. Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome-A longitudinal study in IBS and control subjects. FEMS Immunol. Med. Microbiol. 43, 213-222 (2005).
    • (2005) FEMS Immunol. Med. Microbiol. , vol.43 , pp. 213-222
    • Matto, J.1
  • 58
    • 33646259477 scopus 로고    scopus 로고
    • Prevalence and temporal stability of selected clostridial groups in irritable bowel syndrome in relation to predominant faecal bacteria
    • Maukonen, J. et al. Prevalence and temporal stability of selected clostridial groups in irritable bowel syndrome in relation to predominant faecal bacteria. J. Med. Microbiol. 55, 625-633 (2006).
    • (2006) J. Med. Microbiol. , vol.55 , pp. 625-633
    • Maukonen, J.1
  • 59
    • 77957591287 scopus 로고    scopus 로고
    • Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome
    • Malinen, E. et al. Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome. World J. Gastroenterol. 16, 4532-4540 (2010).
    • (2010) World J. Gastroenterol. , vol.16 , pp. 4532-4540
    • Malinen, E.1
  • 60
    • 13944255868 scopus 로고    scopus 로고
    • Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-Time PCR
    • Malinen, E. et al. Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-Time PCR. Am. J. Gastroenterol. 100, 373-382 (2005).
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 373-382
    • Malinen, E.1
  • 61
    • 80054857288 scopus 로고    scopus 로고
    • Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome
    • Rajilic-Stojanovic, M. et al. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology 141, 1792-1801 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1792-1801
    • Rajilic-Stojanovic, M.1
  • 62
    • 84861578319 scopus 로고    scopus 로고
    • An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
    • Jeffery, I. B. et al. An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut 61, 997-1006 (2012).
    • (2012) Gut , vol.61 , pp. 997-1006
    • Jeffery, I.B.1
  • 63
    • 80051785670 scopus 로고    scopus 로고
    • Luminal and mucosal-Associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
    • Carroll, I. M. et al. Luminal and mucosal-Associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Gut Pathog. 2, 19 (2010).
    • (2010) Gut Pathog. , vol.2 , Issue.19
    • Carroll, I.M.1
  • 64
    • 84861185968 scopus 로고    scopus 로고
    • Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
    • e248
    • Carroll, I. M. et al. Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol. Motil. 24, 521-530.e248 (2012).
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 521-530
    • Carroll, I.M.1
  • 65
    • 76849116160 scopus 로고    scopus 로고
    • A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome
    • Codling, C. et al. A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome. Dig. Dis. Sci. 55, 392-397 (2010).
    • (2010) Dig. Dis. Sci. , vol.55 , pp. 392-397
    • Codling, C.1
  • 66
    • 34447104397 scopus 로고    scopus 로고
    • The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects
    • Kassinen, A. et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 133, 24-33 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 24-33
    • Kassinen, A.1
  • 67
    • 67651252736 scopus 로고    scopus 로고
    • Lower Bifidobacteria counts in both duodenal mucosa-Associated and fecal microbiota in irritable bowel syndrome patients
    • Kerckhoffs, A. P. et al. Lower Bifidobacteria counts in both duodenal mucosa-Associated and fecal microbiota in irritable bowel syndrome patients. World J. Gastroenterol. 15, 2887-2892 (2009).
    • (2009) World J. Gastroenterol. , vol.15 , pp. 2887-2892
    • Kerckhoffs, A.P.1
  • 68
    • 74549185684 scopus 로고    scopus 로고
    • Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers
    • Krogius-Kurikka, L. et al. Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers. BMC Gastroenterol. 9, 95 (2009).
    • (2009) BMC Gastroenterol. , vol.9 , pp. 95
    • Krogius-Kurikka, L.1
  • 69
    • 74549200558 scopus 로고    scopus 로고
    • Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification
    • Lyra, A. et al. Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification. World J. Gastroenterol. 15, 5936-5945 (2009).
    • (2009) World J. Gastroenterol. , vol.15 , pp. 5936-5945
    • Lyra, A.1
  • 70
    • 78149341679 scopus 로고    scopus 로고
    • Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota
    • Noor, S. O. et al. Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota. BMC Gastroenterol. 10, 134 (2010).
    • (2010) BMC Gastroenterol. , vol.10 , Issue.134
    • Noor, S.O.1
  • 71
    • 80054851581 scopus 로고    scopus 로고
    • Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome
    • Saulnier, D. M. et al. Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome. Gastroenterology 141, 1782-1791 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1782-1791
    • Saulnier, D.M.1
  • 72
    • 77950670562 scopus 로고    scopus 로고
    • Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome
    • e114-115
    • Tana, C. et al. Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterol. Motil. 22, 512-519.e114-115 (2010).
    • (2010) Neurogastroenterol. Motil. , vol.22 , pp. 512-519
    • Tana, C.1
  • 73
    • 84890985732 scopus 로고    scopus 로고
    • Faecal microbiota composition and host-microbe cross-Talk following gastroenteritis and in postinfectious irritable bowel syndrome
    • Jalanka-Tuovinen, J. et al. Faecal microbiota composition and host-microbe cross-Talk following gastroenteritis and in postinfectious irritable bowel syndrome. Gut 63, 1737-1745 (2014).
    • (2014) Gut , vol.63 , pp. 1737-1745
    • Jalanka-Tuovinen, J.1
  • 74
    • 84869493735 scopus 로고    scopus 로고
    • Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome
    • Rigsbee, L. et al. Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome. Am. J. Gastroenterol. 107, 1740-1751 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 1740-1751
    • Rigsbee, L.1
  • 75
    • 79957601426 scopus 로고    scopus 로고
    • Microbial community and metabolomic comparison of irritable bowel syndrome faeces
    • Ponnusamy, K. et al. Microbial community and metabolomic comparison of irritable bowel syndrome faeces. J. Med. Microbiol. 60, 817-827 (2011).
    • (2011) J. Med. Microbiol. , vol.60 , pp. 817-827
    • Ponnusamy, K.1
  • 76
    • 84885774174 scopus 로고    scopus 로고
    • Fecal protease activity is associated with compositional alterations in the intestinal microbiota
    • Carroll, I. M. et al. Fecal protease activity is associated with compositional alterations in the intestinal microbiota. PLoS ONE 8, e78017 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e78017
    • Carroll, I.M.1
  • 77
    • 84887615888 scopus 로고    scopus 로고
    • Instability of the faecal microbiota in diarrhoea-predominant irritable bowel syndrome
    • Durban, A. et al. Instability of the faecal microbiota in diarrhoea-predominant irritable bowel syndrome. FEMS Microbiol. Ecol. 86, 581-589 (2013).
    • (2013) FEMS Microbiol. Ecol. , vol.86 , pp. 581-589
    • Durban, A.1
  • 78
    • 0020398686 scopus 로고
    • The fecal microbial population in the irritable bowel syndrome
    • Balsari, A. et al. The fecal microbial population in the irritable bowel syndrome. Microbiologica 5, 185-194 (1982).
    • (1982) Microbiologica , vol.5 , pp. 185-194
    • Balsari, A.1
  • 79
    • 84858604441 scopus 로고    scopus 로고
    • Structural alterations of faecal and mucosa-Associated bacterial communities in irritable bowel syndrome
    • Durban, A. et al. Structural alterations of faecal and mucosa-Associated bacterial communities in irritable bowel syndrome. Environ. Microbiol. Rep. 4, 242-247 (2012).
    • (2012) Environ. Microbiol. Rep. , vol.4 , pp. 242-247
    • Durban, A.1
  • 80
    • 80053602622 scopus 로고    scopus 로고
    • Real-Time PCR analysis of enteric pathogens from fecal samples of irritable bowel syndrome subjects
    • Rinttila, T. et al. Real-Time PCR analysis of enteric pathogens from fecal samples of irritable bowel syndrome subjects. Gut Pathog. 3, 6 (2011).
    • (2011) Gut Pathog. , vol.3 , Issue.6
    • Rinttila, T.1
  • 81
    • 3142767014 scopus 로고    scopus 로고
    • Intestinal microecology and quality of life in irritable bowel syndrome patients
    • Si, J. M. et al. Intestinal microecology and quality of life in irritable bowel syndrome patients. World J. Gastroenterol. 10, 1802-1805 (2004).
    • (2004) World J. Gastroenterol. , vol.10 , pp. 1802-1805
    • Si, J.M.1
  • 82
    • 84155180844 scopus 로고    scopus 로고
    • Distinct microbial populations exist in the mucosa-Associated microbiota of sub-groups of irritable bowel syndrome
    • Parkes, G. C. et al. Distinct microbial populations exist in the mucosa-Associated microbiota of sub-groups of irritable bowel syndrome. Neurogastroenterol. Motil. 24, 31-39 (2012).
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 31-39
    • Parkes, G.C.1
  • 83
    • 77957075815 scopus 로고    scopus 로고
    • Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    • De Filippo, C. et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc. Natl Acad. Sci. USA 107, 14691-14696 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 14691-14696
    • De Filippo, C.1
  • 84
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-Term dietary patterns with gut microbial enterotypes
    • Wu, G. D. et al. Linking long-Term dietary patterns with gut microbial enterotypes. Science 334, 105-108 (2011).
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1
  • 85
    • 84876468494 scopus 로고    scopus 로고
    • Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
    • Kashyap, P. C. et al. Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice. Gastroenterology 144, 967-977 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 967-977
    • Kashyap, P.C.1
  • 86
    • 84919768380 scopus 로고    scopus 로고
    • Diets that differ in their FODMAP content alter the colonic luminal microenvironment
    • Halmos, E. P. et al. Diets that differ in their FODMAP content alter the colonic luminal microenvironment. Gut http://dx.doi.org/10.1136/gutjnl-2014-307264.
    • Gut
    • Halmos, E.P.1
  • 87
    • 33847294713 scopus 로고    scopus 로고
    • Alteration of sulfate and hydrogen metabolism in the human colon by changing intestinal transit rate
    • Lewis, S., & Cochrane, S. Alteration of sulfate and hydrogen metabolism in the human colon by changing intestinal transit rate. Am. J. Gastroenterol. 102, 624-633 (2007).
    • (2007) Am. J. Gastroenterol. , vol.102 , pp. 624-633
    • Lewis, S.1    Cochrane, S.2
  • 88
    • 0033862083 scopus 로고    scopus 로고
    • Relationships between transit time in man and in vitro fermentation of dietary fiber by fecal bacteria
    • Oufir, L. E. et al. Relationships between transit time in man and in vitro fermentation of dietary fiber by fecal bacteria. Eur. J. Clin. Nutr. 54, 603-609 (2000).
    • (2000) Eur. J. Clin. Nutr. , vol.54 , pp. 603-609
    • Oufir, L.E.1
  • 89
    • 84868555218 scopus 로고    scopus 로고
    • The microbiota link to irritable bowel syndrome: An emerging story
    • Jeffery, I. B. et al. The microbiota link to irritable bowel syndrome: an emerging story. Gut Microbes 3, 572-576 (2012).
    • (2012) Gut Microbes , vol.3 , pp. 572-576
    • Jeffery, I.B.1
  • 90
    • 80051535923 scopus 로고    scopus 로고
    • The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    • e1-3
    • Bercik, P. et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141, 599-609.e1-3 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 599-609
    • Bercik, P.1
  • 91
    • 84881316043 scopus 로고    scopus 로고
    • Altered colonic function and microbiota profile in a mouse model of chronic depression
    • Park, A. J. et al. Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol. Motil. 25, 733-e575 (2013).
    • (2013) Neurogastroenterol. Motil. , vol.25 , pp. 733-e575
    • Park, A.J.1
  • 92
    • 84904411548 scopus 로고    scopus 로고
    • Correlation between the human fecal microbiota and depression
    • Naseribafrouei, A. et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol. Motil. 26, 1155-1162 (2014).
    • (2014) Neurogastroenterol. Motil. , vol.26 , pp. 1155-1162
    • Naseribafrouei, A.1
  • 93
    • 84894502674 scopus 로고    scopus 로고
    • IBS with intestinal microbial dysbiosis: A new and clinically relevant subgroup?
    • Simrén, M. IBS with intestinal microbial dysbiosis: a new and clinically relevant subgroup?. Gut 63, 1685-1686 (2014).
    • (2014) Gut , vol.63 , pp. 1685-1686
    • Simrén, M.1
  • 94
    • 44949161833 scopus 로고    scopus 로고
    • Gastrointestinal microbiota in irritable bowel syndrome: Their role in its pathogenesis and treatment
    • Parkes, G. C. et al. Gastrointestinal microbiota in irritable bowel syndrome: their role in its pathogenesis and treatment. Am. J. Gastroenterol. 103, 1557-1567 (2008).
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 1557-1567
    • Parkes, G.C.1
  • 96
    • 79959911030 scopus 로고    scopus 로고
    • Classification and functions of enteroendocrine cells of the lower gastrointestinal tract
    • Gunawardene, A. R., Corfe, B. M., & Staton, C. A. Classification and functions of enteroendocrine cells of the lower gastrointestinal tract. Int. J. Exp. Pathol. 92, 219-231 (2011).
    • (2011) Int. J. Exp. Pathol. , vol.92 , pp. 219-231
    • Gunawardene, A.R.1    Corfe, B.M.2    Staton, C.A.3
  • 97
    • 0032834725 scopus 로고    scopus 로고
    • Stroking human jejunal mucosa induces 5 HT release and Cl-secretion via afferent neurons and 5 HT4 receptors
    • Kellum, J. M. et al. Stroking human jejunal mucosa induces 5 HT release and Cl-secretion via afferent neurons and 5 HT4 receptors. Am. J. Physiol. 277, G515-G520 (1999).
    • (1999) Am. J. Physiol. , vol.277 , pp. G515-G520
    • Kellum, J.M.1
  • 98
    • 34347204910 scopus 로고    scopus 로고
    • CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5 hydroxytryptamine production in enteric infection
    • Wang, H. et al. CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5 hydroxytryptamine production in enteric infection. Gut 56, 949-957 (2007).
    • (2007) Gut , vol.56 , pp. 949-957
    • Wang, H.1
  • 99
    • 0037405738 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate colonic transit via intraluminal 5 HT release in rats
    • Fukumoto, S. et al. Short-chain fatty acids stimulate colonic transit via intraluminal 5 HT release in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284, R1269-R1276 (2003).
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.284 , pp. R1269-R1276
    • Fukumoto, S.1
  • 100
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon, M. D., & Tack, J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132, 397-414 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 101
    • 33644976832 scopus 로고    scopus 로고
    • Effect of MKC 733, a 5 HT receptor partial agonist, on bowel motility and symptoms in subjects with constipation: An exploratory study
    • Fujita, T. et al. Effect of MKC 733, a 5 HT receptor partial agonist, on bowel motility and symptoms in subjects with constipation: an exploratory study. J. Clin. Pharm. Ther. 30, 611-622 (2005).
    • (2005) J. Clin. Pharm. Ther. , vol.30 , pp. 611-622
    • Fujita, T.1
  • 102
    • 44349130441 scopus 로고    scopus 로고
    • A placebo-controlled trial of prucalopride for severe chronic constipation
    • Camilleri, M. et al. A placebo-controlled trial of prucalopride for severe chronic constipation. N. Engl. J. Med. 358, 2344-2354 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2344-2354
    • Camilleri, M.1
  • 103
    • 0025219706 scopus 로고
    • GR 38032F (ondansetron), a selective 5HT3 receptor antagonist, slows colonic transit in healthy man
    • Talley, N. J. et al. GR 38032F (ondansetron), a selective 5HT3 receptor antagonist, slows colonic transit in healthy man. Dig. Dis. Sci. 35, 477-480 (1990).
    • (1990) Dig. Dis. Sci. , vol.35 , pp. 477-480
    • Talley, N.J.1
  • 104
    • 0033625752 scopus 로고    scopus 로고
    • Alosetron a 5 HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers
    • Houghton, L. A., Foster, J. M., & Whorwell, P. J. Alosetron, a 5 HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers. Aliment. Pharmacol. Ther. 14, 775-782 (2000).
    • (2000) Aliment. Pharmacol. Ther. , vol.14 , pp. 775-782
    • Houghton, L.A.1    Foster, J.M.2    Whorwell, P.J.3
  • 105
    • 0031594743 scopus 로고    scopus 로고
    • 5 HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy
    • Gregory, R. E., & Ettinger, D. S. 5 HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs 55, 173-189 (1998).
    • (1998) Drugs , vol.55 , pp. 173-189
    • Gregory, R.E.1    Ettinger, D.S.2
  • 106
    • 0025652485 scopus 로고
    • Serotonin uptake and serotonin uptake inhibition
    • Fuller, R. W., & Wong, D. T. Serotonin uptake and serotonin uptake inhibition. Ann. N. Y. Acad. Sci. 600, 68-78 (1990).
    • (1990) Ann. N. Y. Acad. Sci. , vol.600 , pp. 68-78
    • Fuller, R.W.1    Wong, D.T.2
  • 107
    • 0001260758 scopus 로고
    • Observations on the release and turnover rate of 5 hydroxytryptamine in the gastrointestinal tract
    • Erspamer, V., & Testini, A. Observations on the release and turnover rate of 5 hydroxytryptamine in the gastrointestinal tract. J. Pharm. Pharmacol. 11, 618-623 (1959).
    • (1959) J. Pharm. Pharmacol. , vol.11 , pp. 618-623
    • Erspamer, V.1    Testini, A.2
  • 108
    • 0031980886 scopus 로고    scopus 로고
    • Postprandial plasma 5 hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: A pilot study
    • Bearcroft, C. P., Perrett D, & Farthing, M. J. Postprandial plasma 5 hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 42, 42-46 (1998).
    • (1998) Gut , vol.42 , pp. 42-46
    • Bearcroft, C.P.1    Perrett, D.2    Farthing, M.J.3
  • 109
    • 16844380691 scopus 로고    scopus 로고
    • Abnormalities of 5 hydroxytryptamine metabolism in irritable bowel syndrome
    • Dunlop, S. P. et al. Abnormalities of 5 hydroxytryptamine metabolism in irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 3, 349-357 (2005).
    • (2005) Clin. Gastroenterol. Hepatol. , vol.3 , pp. 349-357
    • Dunlop, S.P.1
  • 110
    • 30044442329 scopus 로고    scopus 로고
    • Altered 5 hydroxytryptamine signaling in patients with constipation-And diarrhea-predominant irritable bowel syndrome
    • Atkinson, W. et al. Altered 5 hydroxytryptamine signaling in patients with constipation-And diarrhea-predominant irritable bowel syndrome. Gastroenterology 130, 34-43 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 34-43
    • Atkinson, W.1
  • 111
    • 84884418594 scopus 로고    scopus 로고
    • Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin
    • Shekhar, C. et al. Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin. Gastroenterology 145, 749-757 (2013).
    • (2013) Gastroenterology , vol.145 , pp. 749-757
    • Shekhar, C.1
  • 112
    • 0035020937 scopus 로고    scopus 로고
    • Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits
    • Miwa, J. et al. Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits. Digestion 63, 188-194 (2001).
    • (2001) Digestion , vol.63 , pp. 188-194
    • Miwa, J.1
  • 113
    • 47649118832 scopus 로고    scopus 로고
    • Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients
    • Kerckhoffs, A. P. et al. Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients. Neurogastroenterol. Motil. 20, 900-907 (2008).
    • (2008) Neurogastroenterol. Motil. , vol.20 , pp. 900-907
    • Kerckhoffs, A.P.1
  • 114
    • 77951974241 scopus 로고    scopus 로고
    • Mucosal serotonin signaling is altered in chronic constipation but not in opiate-induced constipation
    • Costedio, M. M. et al. Mucosal serotonin signaling is altered in chronic constipation but not in opiate-induced constipation. Am. J. Gastroenterol. 105, 1173-1180 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 1173-1180
    • Costedio, M.M.1
  • 115
    • 0345059404 scopus 로고    scopus 로고
    • Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
    • Dunlop, S. P. et al. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology 125, 1651-1659 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 1651-1659
    • Dunlop, S.P.1
  • 116
    • 2942525747 scopus 로고    scopus 로고
    • Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
    • Coates, M. D. et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126, 1657-1664 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1657-1664
    • Coates, M.D.1
  • 117
    • 77953899448 scopus 로고    scopus 로고
    • Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients
    • Faure, C. et al. Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology 139, 249-258 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 249-258
    • Faure, C.1
  • 118
    • 84868552001 scopus 로고    scopus 로고
    • Chromogranin A cell density in the rectum of patients with irritable bowel syndrome
    • El-Salhy, M. et al. Chromogranin A cell density in the rectum of patients with irritable bowel syndrome. Mol. Med. Report 6, 1223-1225 (2012).
    • (2012) Mol. Med. Report , vol.6 , pp. 1223-1225
    • El-Salhy, M.1
  • 119
    • 78649244540 scopus 로고    scopus 로고
    • Chromogranin A as a possible tool in the diagnosis of irritable bowel syndrome
    • El-Salhy, M., Lomholt-Beck, B., & Hausken, T. Chromogranin A as a possible tool in the diagnosis of irritable bowel syndrome. Scand. J. Gastroenterol. 45, 1435-1439 (2010).
    • (2010) Scand. J. Gastroenterol. , vol.45 , pp. 1435-1439
    • El-Salhy, M.1    Lomholt-Beck, B.2    Hausken, T.3
  • 120
    • 84875265864 scopus 로고    scopus 로고
    • Reduced chromogranin A cell density in the ileum of patients with irritable bowel syndrome
    • El-Salhy, M., Wendelbo, I. H., & Gundersen, D. Reduced chromogranin A cell density in the ileum of patients with irritable bowel syndrome. Mol. Med. Report 7, 1241-1244 (2013).
    • (2013) Mol. Med. Report , vol.7 , pp. 1241-1244
    • El-Salhy, M.1    Wendelbo, I.H.2    Gundersen, D.3
  • 121
    • 84857919909 scopus 로고    scopus 로고
    • Altered levels of fecal chromogranins and secretogranins in IBS: Relevance for pathophysiology and symptoms?
    • Ohman, L. et al. Altered levels of fecal chromogranins and secretogranins in IBS: relevance for pathophysiology and symptoms?. Am. J. Gastroenterol. 107, 440-447 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 440-447
    • Hman, L.1
  • 122
    • 84883588093 scopus 로고    scopus 로고
    • Irritable bowel syndrome: The role of gut neuroendocrine peptides
    • El-Salhy, M. et al. Irritable bowel syndrome: the role of gut neuroendocrine peptides. Front. Biosci. (Elite Ed.) 4, 2783-2800 (2012).
    • (2012) Front. Biosci. (Elite Ed.) , vol.4 , pp. 2783-2800
    • El-Salhy, M.1
  • 123
    • 0347360213 scopus 로고    scopus 로고
    • Microbial endocrinology and infectious disease in the 21st century
    • Lyte, M. Microbial endocrinology and infectious disease in the 21st century. Trends Microbiol. 12, 14-20 (2004).
    • (2004) Trends Microbiol. , vol.12 , pp. 14-20
    • Lyte, M.1
  • 124
    • 84914817437 scopus 로고    scopus 로고
    • Communication between bacteria and their hosts
    • Freestone, P. Communication between bacteria and their hosts. Scientifica (Cairo) 2013, 361073 (2013).
    • (2013) Scientifica (Cairo) , vol.2013 , pp. 361073
    • Freestone, P.1
  • 125
    • 33745599094 scopus 로고    scopus 로고
    • Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease
    • Coleman, N. S. et al. Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease. Clin. Gastroenterol. Hepatol. 4, 874-881 (2006).
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 874-881
    • Coleman, N.S.1
  • 126
    • 79955383575 scopus 로고    scopus 로고
    • Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation
    • e1
    • Foley, S. et al. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation. Gastroenterology 140, 1434-1443.e1 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 1434-1443
    • Foley, S.1
  • 127
    • 0038339428 scopus 로고    scopus 로고
    • Serotonin availability is increased in mucosa of guinea pigs with TNBS induced colitis
    • Linden, D. R. et al. Serotonin availability is increased in mucosa of guinea pigs with TNBS induced colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G207-G216 (2003).
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.285 , pp. G207-G216
    • Linden, D.R.1
  • 128
    • 23044439323 scopus 로고    scopus 로고
    • Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis
    • Linden, D. R. et al. Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastroenterol. Motil. 17, 565-574 (2005).
    • (2005) Neurogastroenterol. Motil. , vol.17 , pp. 565-574
    • Linden, D.R.1
  • 129
    • 70350097269 scopus 로고    scopus 로고
    • Serotonin has a key role in pathogenesis of experimental colitis
    • Ghia, J. E. et al. Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 137, 1649-1660 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1649-1660
    • Ghia, J.E.1
  • 130
    • 77953343631 scopus 로고    scopus 로고
    • Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter
    • e229
    • Haub, S. et al. Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter. Neurogastroenterol. Motil. 22, 826-834.e229 (2010).
    • (2010) Neurogastroenterol. Motil. , vol.22 , pp. 826-834
    • Haub, S.1
  • 131
    • 12344262202 scopus 로고    scopus 로고
    • Effects of the neuropeptide secretoneurin on natural killer cell migration and cytokine release
    • Feistritzer, C. et al. Effects of the neuropeptide secretoneurin on natural killer cell migration and cytokine release. Regul. Pept. 126, 195-201 (2005).
    • (2005) Regul. Pept. , vol.126 , pp. 195-201
    • Feistritzer, C.1
  • 132
    • 78649899816 scopus 로고    scopus 로고
    • The antimicrobial peptides derived from chromogranin/secretogranin family, new actors of innate immunity
    • Shooshtarizadeh, P. et al. The antimicrobial peptides derived from chromogranin/secretogranin family, new actors of innate immunity. Regul. Pept. 165, 102-110 (2010).
    • (2010) Regul. Pept. , vol.165 , pp. 102-110
    • Shooshtarizadeh, P.1
  • 133
    • 84887212359 scopus 로고    scopus 로고
    • Two chromogranin a derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2
    • Zhang, D. et al. Two chromogranin a derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2. PLoS ONE 4, e4501 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e4501
    • Zhang, D.1
  • 134
    • 67650333217 scopus 로고    scopus 로고
    • Principles and clinical implications of the brain gut enteric microbiota axis
    • Rhee, S. H., Pothoulakis, C., & Mayer, E. A. Principles and clinical implications of the brain gut enteric microbiota axis. Nat. Rev. Gastroenterol. Hepatol. 6, 306-214 (2009).
    • (2009) Nat. Rev. Gastroenterol. Hepatol. , vol.6 , pp. 306-214
    • Rhee, S.H.1    Pothoulakis, C.2    Mayer, E.A.3
  • 136
    • 84866237041 scopus 로고    scopus 로고
    • The gut barrier: New acquisitions and therapeutic approaches
    • Suppl.
    • Scaldaferri, F. et al. The gut barrier: new acquisitions and therapeutic approaches. J. Clin. Gastroenterol. 46 (Suppl.), S12-S17 (2012).
    • (2012) J. Clin. Gastroenterol. , vol.46 , pp. S12-S17
    • Scaldaferri, F.1
  • 137
    • 84861170097 scopus 로고    scopus 로고
    • Intestinal barrier function in health and gastrointestinal disease
    • Camilleri, M. et al. Intestinal barrier function in health and gastrointestinal disease. Neurogastroenterol. Motil. 24, 503-512 (2012).
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 503-512
    • Camilleri, M.1
  • 138
    • 80055048012 scopus 로고    scopus 로고
    • Urine sugars for in vivo gut permeability: Validation and comparisons in irritable bowel syndrome-diarrhea and controls
    • Rao, A. S. et al. Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G919-G928 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.301 , pp. G919-G928
    • Rao, A.S.1
  • 139
    • 72449168957 scopus 로고    scopus 로고
    • Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion
    • Camilleri, M. et al. Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion. Neurogastroenterol. Motil. 22, e15-e26 (2010).
    • (2010) Neurogastroenterol. Motil. , vol.22 , pp. e15-e26
    • Camilleri, M.1
  • 140
    • 0027338122 scopus 로고
    • Intestinal permeability to [51Cr] EDTA in infectious diarrhea
    • Zuckerman, M. J. et al. Intestinal permeability to [51Cr]EDTA in infectious diarrhea. Dig. Dis. Sci. 38, 1651-1657 (1993).
    • (1993) Dig. Dis. Sci. , vol.38 , pp. 1651-1657
    • Zuckerman, M.J.1
  • 141
    • 0033665517 scopus 로고    scopus 로고
    • Increased rectal mucosal enteroendocrine cells T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
    • Spiller, R. C. et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47, 804-811 (2000).
    • (2000) Gut , vol.47 , pp. 804-811
    • Spiller, R.C.1
  • 142
    • 11144330063 scopus 로고    scopus 로고
    • Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton
    • Marshall, J. K. et al. Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario. Aliment. Pharmacol. Ther. 20, 1317-1322 (2004).
    • (2004) Ontario. Aliment. Pharmacol. Ther. , vol.20 , pp. 1317-1322
    • Marshall, J.K.1
  • 143
    • 58849136276 scopus 로고    scopus 로고
    • Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: Involvement of soluble mediators
    • Piche, T. et al. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut 58, 196-201 (2009).
    • (2009) Gut , vol.58 , pp. 196-201
    • Piche, T.1
  • 144
    • 33744830627 scopus 로고    scopus 로고
    • Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes
    • Dunlop, S. P. et al. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am. J. Gastroenterol. 101, 1288-1294 (2006).
    • (2006) Am. J. Gastroenterol. , vol.101 , pp. 1288-1294
    • Dunlop, S.P.1
  • 145
    • 82955233025 scopus 로고    scopus 로고
    • The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype
    • Bertiaux-Vandaele, N. et al. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am. J. Gastroenterol. 106, 2165-2173 (2011).
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 2165-2173
    • Bertiaux-Vandaele, N.1
  • 146
    • 84877575913 scopus 로고    scopus 로고
    • Diarrhoea-predominant irritable bowel syndrome: An organic disorder with structural abnormalities in the jejunal epithelial barrier
    • Martinez, C. et al. Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut 62, 1160-1168 (2013).
    • (2013) Gut , vol.62 , pp. 1160-1168
    • Martinez, C.1
  • 147
    • 84894231578 scopus 로고    scopus 로고
    • Reduced e cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS
    • Wilcz-Villega, E., McClean S., & O'Sullivan, M. Reduced E cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterol. Motil. 26, 316-325 (2014).
    • (2014) Neurogastroenterol. Motil. , vol.26 , pp. 316-325
    • Wilcz-Villega, E.1    McClean, S.2    O'sullivan, M.3
  • 148
    • 84863820738 scopus 로고    scopus 로고
    • Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal mucosa
    • Gustafsson, J. K., Hansson, G. C., & Sjovall, H. Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal mucosa. Neurogastroenterol. Motil. 24, e381-e391 (2012).
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. e381-e391
    • Gustafsson, J.K.1    Hansson, G.C.2    Sjovall, H.3
  • 149
    • 84897985897 scopus 로고    scopus 로고
    • Functional bowel symptoms in quiescent inflammatory bowel diseases: Role of epithelial barrier disruption and low-grade inflammation
    • Vivinus-Nebot, M. et al. Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation. Gut 63, 744-752 (2014).
    • (2014) Gut , vol.63 , pp. 744-752
    • Vivinus-Nebot, M.1
  • 150
    • 70349799526 scopus 로고    scopus 로고
    • Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome
    • Zhou, Q., Zhang, B., & Verne, G. N. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain 146, 41-46 (2009).
    • (2009) Pain , vol.146 , pp. 41-46
    • Zhou, Q.1    Zhang, B.2    Verne, G.N.3
  • 151
    • 84881183059 scopus 로고    scopus 로고
    • Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS
    • Annahazi, A. et al. Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS. Am. J. Gastroenterol. 108, 1322-1331 (2013).
    • (2013) Am. J. Gastroenterol. , vol.108 , pp. 1322-1331
    • Annahazi, A.1
  • 152
    • 42549168553 scopus 로고    scopus 로고
    • Increased faecal serine protease activity in diarrhoeic IBS patients: A colonic lumenal factor impairing colonic permeability and sensitivity
    • Gecse, K. et al. Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity. Gut 57, 591-599 (2008).
    • (2008) Gut , vol.57 , pp. 591-599
    • Gecse, K.1
  • 153
    • 84855463406 scopus 로고    scopus 로고
    • Combination of allergic factors can worsen diarrheic irritable bowel syndrome: Role of barrier defects and mast cells
    • Vivinus-Nebot, M. et al. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am. J. Gastroenterol. 107, 75-81 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 75-81
    • Vivinus-Nebot, M.1
  • 154
    • 84888354417 scopus 로고    scopus 로고
    • Tumor necrosis factor-neuropeptide y cross talk regulates inflammation, epithelial barrier functions, and colonic motility
    • Chandrasekharan, B. et al. Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility. Inflamm. Bowel Dis. 19, 2535-2546 (2013).
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. 2535-2546
    • Chandrasekharan, B.1
  • 155
    • 84892690208 scopus 로고    scopus 로고
    • Regulation of paracellular permeability: Factors and mechanisms
    • Hu, Y. J. et al. Regulation of paracellular permeability: factors and mechanisms. Mol. Biol. Rep. 40, 6123-6142 (2013).
    • (2013) Mol. Biol. Rep. , vol.40 , pp. 6123-6142
    • Hu, Y.J.1
  • 156
    • 84876719598 scopus 로고    scopus 로고
    • Mucosal mast cell count is associated with intestinal permeability in patients with diarrhea predominant irritable bowel syndrome
    • Lee, H. et al. Mucosal mast cell count is associated with intestinal permeability in patients with diarrhea predominant irritable bowel syndrome. J. Neurogastroenterol. Motil. 19, 244-250 (2013).
    • (2013) J. Neurogastroenterol. Motil. , vol.19 , pp. 244-250
    • Lee, H.1
  • 157
    • 84880235634 scopus 로고    scopus 로고
    • Mast cell tryptase reduces junctional adhesion molecule A (JAM A) expression in intestinal epithelial cells: Implications for the mechanisms of barrier dysfunction in irritable bowel syndrome
    • Wilcz-Villega, E. M., McClean, S., & O'Sullivan, M. A. Mast cell tryptase reduces junctional adhesion molecule A (JAM A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome. Am. J. Gastroenterol. 108, 1140-1151 (2013).
    • (2013) Am. J. Gastroenterol. , vol.108 , pp. 1140-1151
    • Wilcz-Villega, E.M.1    McClean, S.2    O'sullivan, M.A.3
  • 158
    • 84862336762 scopus 로고    scopus 로고
    • The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations
    • Martinez, C. et al. The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations. Am. J. Gastroenterol. 107, 736-746 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 736-746
    • Martinez, C.1
  • 159
    • 84863111766 scopus 로고    scopus 로고
    • CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-A
    • Overman, E. L., Rivier, J. E., & Moeser, A. J. CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-A. PLoS ONE 7, e39935 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e39935
    • Overman, E.L.1    Rivier, J.E.2    Moeser, A.J.3
  • 160
    • 38349087186 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
    • Wallon, C. et al. Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut 57, 50-58 (2008).
    • (2008) Gut , vol.57 , pp. 50-58
    • Wallon, C.1
  • 161
    • 84904052767 scopus 로고    scopus 로고
    • Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell dependent mechanism
    • Vanuytsel, T. et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell dependent mechanism. Gut 63, 1293-1299 (2014).
    • (2014) Gut , vol.63 , pp. 1293-1299
    • Vanuytsel, T.1
  • 162
    • 84878019164 scopus 로고    scopus 로고
    • Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-Associated epithelium and during stress in rats
    • Keita, A. V. et al. Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-Associated epithelium and during stress in rats. Neurogastroenterol. Motil. 25, e406-e417 (2013).
    • (2013) Neurogastroenterol. Motil. , vol.25 , pp. e406-e417
    • Keita, A.V.1
  • 163
    • 77949833947 scopus 로고    scopus 로고
    • Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis
    • Villani, A. C. et al. Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis. Gastroenterology 138, 1502-1513 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1502-1513
    • Villani, A.C.1
  • 164
    • 84870530192 scopus 로고    scopus 로고
    • Association of HLA-DQ gene with bowel transit, barrier function, and inflammation in irritable bowel syndrome with diarrhea
    • Vazquez-Roque, M. I. et al. Association of HLA-DQ gene with bowel transit, barrier function, and inflammation in irritable bowel syndrome with diarrhea. Am. J. Physiol. Gastrointest. Liver Physiol. 303, G1262-G1269 (2012).
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.303 , pp. G1262-G1269
    • Vazquez-Roque, M.I.1
  • 165
    • 10744225624 scopus 로고    scopus 로고
    • Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    • Barbara, G. et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126, 693-702 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 693-702
    • Barbara, G.1
  • 166
    • 0347185342 scopus 로고    scopus 로고
    • Activated mast cells infiltrate in close proximity to enteric nerves in diarrhea-predominant irritable bowel syndrome
    • Park, C. H. et al. Activated mast cells infiltrate in close proximity to enteric nerves in diarrhea-predominant irritable bowel syndrome. J. Korean Med. Sci. 18, 204-210 (2003).
    • (2003) J. Korean Med. Sci. , vol.18 , pp. 204-210
    • Park, C.H.1
  • 167
    • 77949263115 scopus 로고    scopus 로고
    • Pathogenesis of IBS: Role of inflammation, immunity and neuroimmune interactions
    • Ohman, L, & Simren, M. Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions. Nat. Rev. Gastroenterol. Hepatol. 7, 163-173 (2010).
    • (2010) Nat. Rev. Gastroenterol. Hepatol. , vol.7 , pp. 163-173
    • Ohman, L.1    Simren, M.2
  • 168
    • 66949139754 scopus 로고    scopus 로고
    • T cell activation in patients with irritable bowel syndrome
    • Ohman, L. et al. T cell activation in patients with irritable bowel syndrome. Am. J. Gastroenterol. 104, 1205-1212 (2009).
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 1205-1212
    • Ohman, L.1
  • 169
    • 26244463712 scopus 로고    scopus 로고
    • A controlled study of colonic immune activity and b7+ blood T lymphocytes in patients with irritable bowel syndrome
    • Ohman, L. et al. A controlled study of colonic immune activity and b7+ blood T lymphocytes in patients with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 3, 980-986 (2005).
    • (2005) Clin. Gastroenterol. Hepatol. , vol.3 , pp. 980-986
    • Ohman, L.1
  • 170
    • 79751499345 scopus 로고    scopus 로고
    • Differential expression of toll-like receptors in patients with irritable bowel syndrome
    • Brint, E. K. et al. Differential expression of toll-like receptors in patients with irritable bowel syndrome. Am. J. Gastroenterol. 106, 329-336 (2011).
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 329-336
    • Brint, E.K.1
  • 171
    • 84865066764 scopus 로고    scopus 로고
    • Role of toll like receptors in irritable bowel syndrome: Differential mucosal immune activation according to the disease subtype
    • Belmonte, L. et al. Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtype. PLoS ONE 7, e42777 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e42777
    • Belmonte, L.1
  • 172
    • 84859306064 scopus 로고    scopus 로고
    • Increased TLR2 expression on blood monocytes in irritable bowel syndrome patients
    • Ohman, L. et al. Increased TLR2 expression on blood monocytes in irritable bowel syndrome patients. Eur. J. Gastroenterol. Hepatol. 24, 398-405 (2012).
    • (2012) Eur. J. Gastroenterol. Hepatol. , vol.24 , pp. 398-405
    • Ohman, L.1
  • 173
    • 77957844957 scopus 로고    scopus 로고
    • Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity
    • Scully, P. et al. Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity. Am. J. Gastroenterol. 105, 2235-2243 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 2235-2243
    • Scully, P.1
  • 174
    • 84856720903 scopus 로고    scopus 로고
    • Serum and colonic mucosal immune markers in irritable bowel syndrome
    • Chang, L. et al. Serum and colonic mucosal immune markers in irritable bowel syndrome. Am. J. Gastroenterol. 107, 262-272 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 262-272
    • Chang, L.1
  • 175
    • 54749094008 scopus 로고    scopus 로고
    • Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL 6 in irritable bowel syndrome: Role of muscarinic receptors
    • Dinan, T. G. et al. Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL 6 in irritable bowel syndrome: role of muscarinic receptors. Am. J. Gastroenterol. 103, 2570-2576 (2008).
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 2570-2576
    • Dinan, T.G.1
  • 176
    • 32044459306 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: Plasma cytokines as a potential biomarker?
    • Dinan, T. G. et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?. Gastroenterology 130, 304-311 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 304-311
    • Dinan, T.G.1
  • 177
    • 62449272602 scopus 로고    scopus 로고
    • Immune dysfunction in patients with functional gastrointestinal disorders
    • Kindt, S. et al. Immune dysfunction in patients with functional gastrointestinal disorders. Neurogastroenterol. Motil. 21, 389-398 (2009).
    • (2009) Neurogastroenterol. Motil. , vol.21 , pp. 389-398
    • Kindt, S.1
  • 178
    • 84903213255 scopus 로고    scopus 로고
    • Cytokine imbalance in irritable bowel syndrome: A systematic review and meta-Analysis
    • Bashashati, M. et al. Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-Analysis. Neurogastroenterol. Motil. 26, 1036-1048 (2014).
    • (2014) Neurogastroenterol. Motil. , vol.26 , pp. 1036-1048
    • Bashashati, M.1
  • 179
    • 33947324517 scopus 로고    scopus 로고
    • Immune activation in patients with irritable bowel syndrome
    • Liebregts, T. et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology 132, 913-920 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 913-920
    • Liebregts, T.1
  • 180
    • 0037378888 scopus 로고    scopus 로고
    • Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome
    • Gwee, K. A. et al. Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gut 52, 523-526 (2003).
    • (2003) Gut , vol.52 , pp. 523-526
    • Gwee, K.A.1
  • 181
    • 84870766908 scopus 로고    scopus 로고
    • Interleukin 6 modulates colonic transepithelial ion transport in the stress-sensitive wistar kyoto rat
    • O'Malley, D., Dinan, T. G., & Cryan, J. F. Interleukin 6 modulates colonic transepithelial ion transport in the stress-sensitive wistar kyoto rat. Front. Pharmacol. 3, 190 (2012).
    • (2012) Front. Pharmacol. , vol.3 , Issue.190
    • O'malley, D.1    Dinan, T.G.2    Cryan, J.F.3
  • 182
    • 84862727180 scopus 로고    scopus 로고
    • Rethinking inflammation: Neural circuits in the regulation of immunity
    • Olofsson, P. S. et al. Rethinking inflammation: neural circuits in the regulation of immunity. Immunol. Rev. 248, 188-204 (2012).
    • (2012) Immunol. Rev. , vol.248 , pp. 188-204
    • Olofsson, P.S.1
  • 183
    • 84866677472 scopus 로고    scopus 로고
    • Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
    • e4
    • Anitha, M. et al. Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology 143, 1006-1016.e4 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 1006-1016
    • Anitha, M.1
  • 184
    • 84904573974 scopus 로고    scopus 로고
    • Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility
    • Muller, P. A. et al. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell 158, 300-313 (2014).
    • (2014) Cell , vol.158 , pp. 300-313
    • Muller, P.A.1
  • 185
    • 84904539601 scopus 로고    scopus 로고
    • GI motility: Microbiota and macrophages join forces
    • Robinette, M. L., & Colonna, M. GI motility: microbiota and macrophages join forces. Cell 158, 239-240 (2014).
    • (2014) Cell , vol.158 , pp. 239-240
    • Robinette, M.L.1    Colonna, M.2
  • 186
    • 0036893131 scopus 로고    scopus 로고
    • Full-Thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome
    • Tornblom, H. et al. Full-Thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 123, 1972-1979 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 1972-1979
    • Tornblom, H.1
  • 187
    • 0036083346 scopus 로고    scopus 로고
    • Activation of the mucosal immune system in irritable bowel syndrome
    • Chadwick, V. S. et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 122, 1778-1783 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 1778-1783
    • Chadwick, V.S.1
  • 188
    • 59749085184 scopus 로고    scopus 로고
    • Mucosal immune activation in irritable bowel syndrome: Gender-dependence and association with digestive symptoms
    • Cremon, C. et al. Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am. J. Gastroenterol. 104, 392-400 (2009).
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 392-400
    • Cremon, C.1
  • 189
    • 84906318425 scopus 로고    scopus 로고
    • Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients
    • Sundin, J. et al. Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients. Scand. J. Gastroenterol. 49, 1068-1075 (2014).
    • (2014) Scand. J. Gastroenterol. , vol.49 , pp. 1068-1075
    • Sundin, J.1
  • 190
    • 84866182203 scopus 로고    scopus 로고
    • Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome
    • Chen, J., Zhang, Y., & Deng, Z. Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome. BMC Gastroenterol. 12, 91 (2012).
    • (2012) BMC Gastroenterol. , vol.12 , pp. 91
    • Chen, J.1    Zhang, Y.2    Deng, Z.3
  • 191
    • 33846337118 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in irritable bowel syndrome patients
    • Holmen, N. et al. CD4+CD25+ regulatory T cells in irritable bowel syndrome patients. Neurogastroenterol. Motil. 19, 119-125 (2007).
    • (2007) Neurogastroenterol. Motil. , vol.19 , pp. 119-125
    • Holmen, N.1
  • 192
    • 65949087893 scopus 로고    scopus 로고
    • B cell activation in patients with irritable bowel syndrome (IBS)
    • e27
    • Ohman, L. et al. B cell activation in patients with irritable bowel syndrome (IBS). Neurogastroenterol. Motil. 21, 644-650.e27 (2009).
    • (2009) Neurogastroenterol. Motil. , vol.21 , pp. 644-650
    • Ohman, L.1
  • 193
    • 84941299655 scopus 로고    scopus 로고
    • Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations
    • Vicario, M. et al. Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations. Gut http://dx.doi.org/10.1136/gutjnl-2013-306236.
    • Gut
    • Vicario, M.1
  • 194
    • 52049083187 scopus 로고    scopus 로고
    • Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients
    • Schoepfer, A. M. et al. Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients. Neurogastroenterol. Motil. 20, 1110-1118 (2008).
    • (2008) Neurogastroenterol. Motil. , vol.20 , pp. 1110-1118
    • Schoepfer, A.M.1
  • 195
    • 84900385526 scopus 로고    scopus 로고
    • Involvement of interleukin-17A induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction
    • Akiho, H. et al. Involvement of interleukin-17A induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction. PLoS ONE 9, e92960 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e92960
    • Akiho, H.1
  • 196
    • 84858400807 scopus 로고    scopus 로고
    • Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders
    • Akiho, H., Ihara, E., Motomura, Y., & Nakamura, K. Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders. World J. Gastrointest. Pathophysiol. 2, 72-81 (2011).
    • (2011) World J. Gastrointest. Pathophysiol. , vol.2 , pp. 72-81
    • Akiho, H.1    Ihara, E.2    Motomura, Y.3    Nakamura, K.4
  • 197
    • 84870298788 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms are associated with irritable bowel syndrome: A systematic review and meta analysis
    • Bashashati, M. et al. Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta analysis. Neurogastroenterol. Motil. 24, 1102-e566 (2012).
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 1102-e566
    • Bashashati, M.1
  • 198
    • 33644646892 scopus 로고    scopus 로고
    • Role of tumor necrosis factor-Alpha and interleukin 10 gene polymorphisms in irritable bowel syndrome
    • van der Veek, P. P. et al. Role of tumor necrosis factor-Alpha and interleukin 10 gene polymorphisms in irritable bowel syndrome. Am. J. Gastroenterol. 100, 2510-2516 (2005).
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 2510-2516
    • Van Der Veek, P.P.1
  • 199
    • 84865149218 scopus 로고    scopus 로고
    • Interleukin 8 and 10 gene polymorphisms in irritable bowel syndrome
    • Romero-Valdovinos, M. et al. Interleukin 8 and 10 gene polymorphisms in irritable bowel syndrome. Mol. Biol. Rep. 39, 8837-8843 (2012).
    • (2012) Mol. Biol. Rep. , vol.39 , pp. 8837-8843
    • Romero-Valdovinos, M.1
  • 200
    • 84878767661 scopus 로고    scopus 로고
    • Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): Association with TNFSF15 and TNFa
    • Swan, C. et al. Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFa. Gut 63, 985-994 (2013).
    • (2013) Gut , vol.63 , pp. 985-994
    • Swan, C.1
  • 201
    • 80052862553 scopus 로고    scopus 로고
    • Association of TNFSF15 polymorphism with irritable bowel syndrome
    • Zucchelli, M. et al. Association of TNFSF15 polymorphism with irritable bowel syndrome. Gut 60, 1671-1677 (2011).
    • (2011) Gut , vol.60 , pp. 1671-1677
    • Zucchelli, M.1
  • 202
    • 84902660842 scopus 로고    scopus 로고
    • RNA sequencing shows transcriptomic changes in rectosigmoid mucosa in patients with irritable bowel syndrome-diarrhea: A pilot case-control study
    • Camilleri, M. et al. RNA sequencing shows transcriptomic changes in rectosigmoid mucosa in patients with irritable bowel syndrome-diarrhea: a pilot case-control study. Am. J. Physiol. Gastrointest. Liver Physiol. 306, G1089-G1098 (2014).
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.306 , pp. G1089-G1098
    • Camilleri, M.1
  • 203
    • 46349106355 scopus 로고    scopus 로고
    • Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
    • Akbar, A. et al. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut 57, 923-929 (2008).
    • (2008) Gut , vol.57 , pp. 923-929
    • Akbar, A.1
  • 204
    • 3242680477 scopus 로고    scopus 로고
    • Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis
    • Wang, L. H., Fang, X. C., & Pan, G. Z. Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis. Gut 53, 1096-1101 (2004).
    • (2004) Gut , vol.53 , pp. 1096-1101
    • Wang, L.H.1    Fang, X.C.2    Pan, G.Z.3
  • 205
    • 84892676671 scopus 로고    scopus 로고
    • Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS
    • Di Nardo, G. et al. Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS. Neurogastroenterol. Motil. 26, 196-204 (2014).
    • (2014) Neurogastroenterol. Motil. , vol.26 , pp. 196-204
    • Di Nardo, G.1
  • 206
    • 84896392823 scopus 로고    scopus 로고
    • Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome
    • Nasser, Y. et al. Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome. Neurogastroenterol. Motil. 26, 455-469 (2014).
    • (2014) Neurogastroenterol. Motil. , vol.26 , pp. 455-469
    • Nasser, Y.1
  • 207
    • 33846193703 scopus 로고    scopus 로고
    • Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    • Barbara, G. et al. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 132, 26-37 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 26-37
    • Barbara, G.1
  • 208
    • 70349423402 scopus 로고    scopus 로고
    • Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    • Buhner, S. et al. Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology 137, 1425-1434 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1425-1434
    • Buhner, S.1
  • 209
    • 84870300639 scopus 로고    scopus 로고
    • Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons
    • Balestra, B. et al. Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons. Neurogastroenterol. Motil. 24, 1118-e570 (2012).
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 1118-e570
    • Balestra, B.1
  • 210
    • 33847342529 scopus 로고    scopus 로고
    • Role for protease activity in visceral pain in irritable bowel syndrome
    • Cenac, N. et al. Role for protease activity in visceral pain in irritable bowel syndrome. J. Clin. Invest. 117, 636-647 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 636-647
    • Cenac, N.1
  • 211
    • 79960055079 scopus 로고    scopus 로고
    • Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome
    • Cremon, C. et al. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am. J. Gastroenterol. 106, 1290-1298 (2011).
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 1290-1298
    • Cremon, C.1
  • 212
    • 84870295502 scopus 로고    scopus 로고
    • Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients
    • Buhner, S. et al. Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients. Neurogastroenterol. Motil. 24, 1134-e572 (2012).
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 1134-e572
    • Buhner, S.1
  • 213
    • 84885473060 scopus 로고    scopus 로고
    • Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: A role for PAR2
    • Valdez-Morales, E. E. et al. Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2. Am. J. Gastroenterol. 108, 1634-1643 (2013).
    • (2013) Am. J. Gastroenterol. , vol.108 , pp. 1634-1643
    • Valdez-Morales, E.E.1
  • 214
    • 84884283276 scopus 로고    scopus 로고
    • Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes
    • Hughes, P. A. et al. Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes. Gut 62, 1456-1465 (2013).
    • (2013) Gut , vol.62 , pp. 1456-1465
    • Hughes, P.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.