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Volumn 28, Issue SUPPL 1, 2013, Pages 38-42

Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis

Author keywords

Intestinal microflora; Liver fibrosis; LPS; MyD88; TLR4

Indexed keywords

BACTERIAL DNA; BACTERIUM LIPOPOLYSACCHARIDE; FATTY ACID; HIGH MOBILITY GROUP B1 PROTEIN; LIPOPOLYSACCHARIDE BINDING PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 84880425458     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12019     Document Type: Review
Times cited : (236)

References (59)
  • 1
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140: 805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 2
    • 79251563125 scopus 로고    scopus 로고
    • Current views of toll-like receptor signaling pathways
    • Yamamoto M, Takeda K. Current views of toll-like receptor signaling pathways. Gastroenterol. Res. Pract. 2010; 2010: 240365.
    • (2010) Gastroenterol. Res. Pract. , vol.2010 , pp. 240365
    • Yamamoto, M.1    Takeda, K.2
  • 3
    • 34447116244 scopus 로고    scopus 로고
    • Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    • Chen CJ, Kono H, Golenbock D, Reed G, Akira S, Rock KL. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat. Med. 2007; 13: 851-856.
    • (2007) Nat. Med. , vol.13 , pp. 851-856
    • Chen, C.J.1    Kono, H.2    Golenbock, D.3    Reed, G.4    Akira, S.5    Rock, K.L.6
  • 4
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y etal. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464: 104-107.
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3
  • 5
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: update
    • Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008; 48: 322-335.
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 6
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • Isogawa M, Robek MD, Furuichi Y, Chisari FV. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J. Virol. 2005; 79: 7269-7272.
    • (2005) J. Virol. , vol.79 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 7
    • 0035865249 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta
    • Seki E, Tsutsui H, Nakano H etal. Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J. Immunol. 2001; 166: 2651-2657.
    • (2001) J. Immunol. , vol.166 , pp. 2651-2657
    • Seki, E.1    Tsutsui, H.2    Nakano, H.3
  • 8
    • 75949130109 scopus 로고    scopus 로고
    • Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific
    • Wu J, Meng Z, Jiang M etal. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology 2010; 129: 363-374.
    • (2010) Immunology , vol.129 , pp. 363-374
    • Wu, J.1    Meng, Z.2    Jiang, M.3
  • 9
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003; 37: 1043-1055.
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.H.1    Schwabe, R.F.2    Bataller, R.3    Russo, M.P.4    Jobin, C.5    Brenner, D.A.6
  • 10
    • 36348997503 scopus 로고    scopus 로고
    • Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
    • Watanabe A, Hashmi A, Gomes DA etal. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology 2007; 46: 1509-1518.
    • (2007) Hepatology , vol.46 , pp. 1509-1518
    • Watanabe, A.1    Hashmi, A.2    Gomes, D.A.3
  • 11
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-beta signaling and hepatic fibrosis
    • Seki E, De Minicis S, Osterreicher CH etal. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat. Med. 2007; 13: 1324-1332.
    • (2007) Nat. Med. , vol.13 , pp. 1324-1332
    • Seki, E.1    De Minicis, S.2    Osterreicher, C.H.3
  • 12
    • 77956805892 scopus 로고    scopus 로고
    • Toll-like receptors in the pathogenesis of alcoholic liver disease
    • Petrasek J, Mandrekar P, Szabo G. Toll-like receptors in the pathogenesis of alcoholic liver disease. Gastroenterol. Res. Pract. 2010; 2010: 710381.
    • (2010) Gastroenterol. Res. Pract. , vol.2010 , pp. 710381
    • Petrasek, J.1    Mandrekar, P.2    Szabo, G.3
  • 13
    • 77950825001 scopus 로고    scopus 로고
    • Alcoholic liver disease and the gut-liver axis
    • Szabo G, Bala S. Alcoholic liver disease and the gut-liver axis. World J. Gastroenterol. 2010; 16: 1321-1329.
    • (2010) World J. Gastroenterol. , vol.16 , pp. 1321-1329
    • Szabo, G.1    Bala, S.2
  • 14
    • 68949178506 scopus 로고    scopus 로고
    • Endotoxemia and gut barrier dysfunction in alcoholic liver disease
    • Rao R. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology 2009; 50: 638-644.
    • (2009) Hepatology , vol.50 , pp. 638-644
    • Rao, R.1
  • 15
    • 0026078067 scopus 로고
    • Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay
    • Fukui H, Brauner B, Bode JC, Bode C. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. J. Hepatol. 1991; 12: 162-169.
    • (1991) J. Hepatol. , vol.12 , pp. 162-169
    • Fukui, H.1    Brauner, B.2    Bode, J.C.3    Bode, C.4
  • 16
    • 0034950477 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
    • Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001; 34: 101-108.
    • (2001) Hepatology , vol.34 , pp. 101-108
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Thurman, R.G.5
  • 17
    • 78751537350 scopus 로고    scopus 로고
    • Enteric dysbiosis associated with a mouse model of alcoholic liver disease
    • Yan AW, Fouts DE, Brandl J etal. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology 2011; 53: 96-105.
    • (2011) Hepatology , vol.53 , pp. 96-105
    • Yan, A.W.1    Fouts, D.E.2    Brandl, J.3
  • 18
    • 0037087374 scopus 로고    scopus 로고
    • Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice
    • Uesugi T, Froh M, Arteel GE etal. Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J. Immunol. 2002; 168: 2963-2969.
    • (2002) J. Immunol. , vol.168 , pp. 2963-2969
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3
  • 19
    • 0035313376 scopus 로고    scopus 로고
    • Reduced early alcohol-induced liver injury in CD14-deficient mice
    • Yin M, Bradford BU, Wheeler MD etal. Reduced early alcohol-induced liver injury in CD14-deficient mice. J. Immunol. 2001; 166: 4737-4742.
    • (2001) J. Immunol. , vol.166 , pp. 4737-4742
    • Yin, M.1    Bradford, B.U.2    Wheeler, M.D.3
  • 20
    • 0028796860 scopus 로고
    • Antibiotics prevent liver injury in rats following long-term exposure to ethanol
    • Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995; 108: 218-224.
    • (1995) Gastroenterology , vol.108 , pp. 218-224
    • Adachi, Y.1    Moore, L.E.2    Bradford, B.U.3    Gao, W.4    Thurman, R.G.5
  • 21
    • 0030983660 scopus 로고    scopus 로고
    • Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis
    • Pennington HL, Hall PM, Wilce PA, Worrall S. Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. J. Gastroenterol. Hepatol. 1997; 12: 305-313.
    • (1997) J. Gastroenterol. Hepatol. , vol.12 , pp. 305-313
    • Pennington, H.L.1    Hall, P.M.2    Wilce, P.A.3    Worrall, S.4
  • 22
  • 23
    • 79959811718 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice
    • Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol. Clin. Exp. Res. 2011; 35: 1509-1518.
    • (2011) Alcohol. Clin. Exp. Res. , vol.35 , pp. 1509-1518
    • Inokuchi, S.1    Tsukamoto, H.2    Park, E.3    Liu, Z.X.4    Brenner, D.A.5    Seki, E.6
  • 24
    • 54449092214 scopus 로고    scopus 로고
    • The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    • Hritz I, Mandrekar P, Velayudham A etal. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 2008; 48: 1224-1231.
    • (2008) Hepatology , vol.48 , pp. 1224-1231
    • Hritz, I.1    Mandrekar, P.2    Velayudham, A.3
  • 25
    • 10744233624 scopus 로고    scopus 로고
    • A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites
    • Frances R, Benlloch S, Zapater P etal. A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites. Hepatology 2004; 39: 484-491.
    • (2004) Hepatology , vol.39 , pp. 484-491
    • Frances, R.1    Benlloch, S.2    Zapater, P.3
  • 26
    • 2442666353 scopus 로고    scopus 로고
    • Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites
    • Frances R, Munoz C, Zapater P etal. Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites. Gut 2004; 53: 860-864.
    • (2004) Gut , vol.53 , pp. 860-864
    • Frances, R.1    Munoz, C.2    Zapater, P.3
  • 27
    • 4544261330 scopus 로고    scopus 로고
    • Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice
    • Romics L Jr, Dolganiuc A, Kodys K etal. Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice. Hepatology 2004; 40: 555-564.
    • (2004) Hepatology , vol.40 , pp. 555-564
    • Romics Jr, L.1    Dolganiuc, A.2    Kodys, K.3
  • 28
    • 33646539166 scopus 로고    scopus 로고
    • Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver
    • Gustot T, Lemmers A, Moreno C etal. Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Hepatology 2006; 43: 989-1000.
    • (2006) Hepatology , vol.43 , pp. 989-1000
    • Gustot, T.1    Lemmers, A.2    Moreno, C.3
  • 29
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 30
    • 79952230506 scopus 로고    scopus 로고
    • Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease
    • Miura K, Seki E, Ohnishi H, Brenner DA. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease. Gastroenterol. Res. Pract. 2010; 2010: 362847.
    • (2010) Gastroenterol. Res. Pract. , vol.2010 , pp. 362847
    • Miura, K.1    Seki, E.2    Ohnishi, H.3    Brenner, D.A.4
  • 31
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L, Valenza V, La Torre G etal. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009; 49: 1877-1887.
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3
  • 32
    • 33847040759 scopus 로고    scopus 로고
    • Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis
    • Brun P, Castagliuolo I, Di Leo V etal. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2007; 292: G518-525.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.292
    • Brun, P.1    Castagliuolo, I.2    Di Leo, V.3
  • 33
    • 39849088160 scopus 로고    scopus 로고
    • Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats
    • Wu WC, Zhao W, Li S. Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats. World J. Gastroenterol. 2008; 14: 313-317.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 313-317
    • Wu, W.C.1    Zhao, W.2    Li, S.3
  • 34
    • 47949095562 scopus 로고    scopus 로고
    • Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis
    • Farhadi A, Gundlapalli S, Shaikh M etal. Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis. Liver Int. 2008; 28: 1026-1033.
    • (2008) Liver Int. , vol.28 , pp. 1026-1033
    • Farhadi, A.1    Gundlapalli, S.2    Shaikh, M.3
  • 35
    • 79954523464 scopus 로고    scopus 로고
    • Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
    • Csak T, Velayudham A, Hritz I etal. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2011; 300: G433-441.
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.300
    • Csak, T.1    Velayudham, A.2    Hritz, I.3
  • 36
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 2007; 47: 571-579.
    • (2007) J. Hepatol. , vol.47 , pp. 571-579
    • Rivera, C.A.1    van Adegboyega, P.2    Rooijen, N.3    Tagalicud, A.4    Allman, M.5    Wallace, M.6
  • 37
    • 84861547908 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice
    • Ye D, Li FY, Lam KS etal. Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Gut 2012; 61: 1058-1067.
    • (2012) Gut , vol.61 , pp. 1058-1067
    • Ye, D.1    Li, F.Y.2    Lam, K.S.3
  • 38
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
    • Miura K, Kodama Y, Inokuchi S etal. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010; 139: 323-34 e7.
    • (2010) Gastroenterology , vol.139
    • Miura, K.1    Kodama, Y.2    Inokuchi, S.3
  • 39
    • 84873289589 scopus 로고    scopus 로고
    • TLR2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation
    • Miura K, Yang L, van Rooijen N, Brenner DA, Ohnishi H, Seki E. TLR2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation. Hepatology 2013; 57: 577-589.
    • (2013) Hepatology , vol.57 , pp. 577-589
    • Miura, K.1    van Yang, L.2    Rooijen, N.3    Brenner, D.A.4    Ohnishi, H.5    Seki, E.6
  • 40
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • Senn JJ. Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J. Biol. Chem. 2006; 281: 26865-26875.
    • (2006) J. Biol. Chem. , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 42
    • 65549131061 scopus 로고    scopus 로고
    • Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway
    • Zu L, He J, Jiang H, Xu C, Pu S, Xu G. Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway. J. Biol. Chem. 2009; 284: 5915-5926.
    • (2009) J. Biol. Chem. , vol.284 , pp. 5915-5926
    • Zu, L.1    He, J.2    Jiang, H.3    Xu, C.4    Pu, S.5    Xu, G.6
  • 44
    • 0141844653 scopus 로고    scopus 로고
    • Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
    • Lee JY, Ye J, Gao Z etal. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J. Biol. Chem. 2003; 278: 37041-37051.
    • (2003) J. Biol. Chem. , vol.278 , pp. 37041-37051
    • Lee, J.Y.1    Ye, J.2    Gao, Z.3
  • 45
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 2001; 276: 16683-16689.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 46
    • 58149310977 scopus 로고    scopus 로고
    • Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity
    • Schaeffler A, Gross P, Buettner R etal. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. Immunology 2009; 126: 233-245.
    • (2009) Immunology , vol.126 , pp. 233-245
    • Schaeffler, A.1    Gross, P.2    Buettner, R.3
  • 47
    • 73949110679 scopus 로고    scopus 로고
    • Saturated fatty acids do not directly stimulate Toll-like receptor signaling
    • Erridge C, Samani NJ. Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler. Thromb. Vasc. Biol. 2009; 29: 1944-1949.
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 1944-1949
    • Erridge, C.1    Samani, N.J.2
  • 48
    • 0037378005 scopus 로고    scopus 로고
    • The molecular basis for the lack of immunostimulatory activity of vertebrate DNA
    • Stacey KJ, Young GR, Clark F etal. The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. J. Immunol. 2003; 170: 3614-3620.
    • (2003) J. Immunol. , vol.170 , pp. 3614-3620
    • Stacey, K.J.1    Young, G.R.2    Clark, F.3
  • 49
    • 84861529405 scopus 로고    scopus 로고
    • Inflammation: the gut takes a toll on liver cancer
    • Alderton GK. Inflammation: the gut takes a toll on liver cancer. Nat. Rev. Cancer 2012; 12: 379.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 379
    • Alderton, G.K.1
  • 50
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005; 121: 977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 51
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse models to study human cancer
    • Lee JS, Chu IS, Mikaelyan A etal. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat. Genet. 2004; 36: 1306-1311.
    • (2004) Nat. Genet. , vol.36 , pp. 1306-1311
    • Lee, J.S.1    Chu, I.S.2    Mikaelyan, A.3
  • 52
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S etal. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3
  • 53
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • Dapito DH, Mencin A, Gwak GY etal. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 2012; 21: 504-516.
    • (2012) Cancer Cell , vol.21 , pp. 504-516
    • Dapito, D.H.1    Mencin, A.2    Gwak, G.Y.3
  • 54
    • 77957948007 scopus 로고    scopus 로고
    • Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents
    • Yu LX, Yan HX, Liu Q etal. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology 2010; 52: 1322-1333.
    • (2010) Hepatology , vol.52 , pp. 1322-1333
    • Yu, L.X.1    Yan, H.X.2    Liu, Q.3
  • 55
    • 60849102149 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog
    • Machida K, Tsukamoto H, Mkrtchyan H etal. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc. Natl. Acad. Sci. U.S.A. 2009; 106: 1548-1553.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 1548-1553
    • Machida, K.1    Tsukamoto, H.2    Mkrtchyan, H.3
  • 56
    • 76249087046 scopus 로고    scopus 로고
    • Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
    • Inokuchi S, Aoyama T, Miura K etal. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 2010; 107: 844-849.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 844-849
    • Inokuchi, S.1    Aoyama, T.2    Miura, K.3
  • 57
    • 0036084728 scopus 로고    scopus 로고
    • Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide
    • Liu S, Gallo DJ, Green AM etal. Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect. Immun. 2002; 70: 3433-3442.
    • (2002) Infect. Immun. , vol.70 , pp. 3433-3442
    • Liu, S.1    Gallo, D.J.2    Green, A.M.3
  • 58
    • 0033779915 scopus 로고    scopus 로고
    • Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes
    • Matsumura T, Ito A, Takii T, Hayashi H, Onozaki K. Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J. Interferon Cytokine Res. 2000; 20: 915-921.
    • (2000) J. Interferon Cytokine Res. , vol.20 , pp. 915-921
    • Matsumura, T.1    Ito, A.2    Takii, T.3    Hayashi, H.4    Onozaki, K.5
  • 59
    • 43649109029 scopus 로고    scopus 로고
    • Inflammation and cancer: role of nuclear factor-kappaB activation
    • Maeda S, Omata M. Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci. 2008; 99: 836-842.
    • (2008) Cancer Sci. , vol.99 , pp. 836-842
    • Maeda, S.1    Omata, M.2


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