Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 270, Issue 4 33-4, 1996, Pages

  Salzman, Andrew L ^a   Denenberg, Alvin G ^a   Ueta, Ikuya ^a   O'Connor, Michael ^a   Linn, Stephen C ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

calcium; isothiourea; nuclear factor B; steroids; tyrosine kinase

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; DAIDZEIN; DEXAMETHASONE; DITHIOCARBAMIC ACID; EGTAZIC ACID; EPIDERMAL GROWTH FACTOR; GAMMA INTERFERON; GENISTEIN; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; PYRROLIDINE DERIVATIVE;

ARTICLE; CELL TRANSFORMATION; CRITICAL ILLNESS; ENZYME INDUCTION; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTESTINE EPITHELIUM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0029881475     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.4.g565     Document Type: Article

References (55)

1. K B DNA binding and inducible NOS mRNA in human epithelial cells. Biochem. Biophys. Res. Commun. 199: 1518-1524, 1994.
2. Asano, K., C. Chee, B. Gaston, C. Lilly, C. Gerard, J. Drazen, and J. Stamler. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91: 10089-10093, 1994.
3. Berrazueta, J., E. Salas, J. Amado, M. Sanchez de Vega, and J. Proveda, Induction of nitric oxide synthase in human mammary arteries in vitro. Eur. J. Pharmacol. 251: 303-305, 1994.
4. Boughton-Smith, N. K., S. M. Evans, C. J. Hawkey, A. T. Cole, M. Balsitis, B. J. Whittle, and S. Moncada. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet 342: 338-340, 1993.
5. Bradford, M. M. A rapid and sensitive method for the quantification of protein dye binding. Anal. Biochem. 72: 248-254, 1995.
6. Charles, I., R, Palmer, M. Hickery, M. Bayliss, A. Chubb, V. Hall, D. Moss, and S. Moncada. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl Acad. Sci. USA 90: 11419-11423, 1993.
7. Cho, H. J., Q. Xie, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, and C. Nathan. Calmodulin is a subunit of nitric oxide synthase from macrophages. J. Exp. Med. 176: 599-604, 1992.
8. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
9. DeBelder, A., M. Radomski, H. Why, P. Richardson, C. Bucknall, E. Salas, J. Martin, and S. Moncada. Nitric oxide synthase activities in human myocardium. Lancet 341: 84-85, 1993.
10. Deitch, E. A. The role of intestinal barrier failure and bacterial transloeation in the development of systemic infection and multiple organ failure. Arch. Surg 125: 403-404, 1990.
11. Dighiero, P., I. Reux, J. Hauw, A. Fillet, Y. Courtois, and O. Goureau. Expression of inducible nitric oxide synthase in cytomegalovirus-infected glial cells of retinas from AIDS patients. Neurosci. Lett. 166: 31-34, 1994.
12. Dong, Z., X. Qi, K. Xie, and I. J. Fidler. Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J. Immunol. 151: 2717-2724, 1993.
13. Drapier, J. C., and J. B. Hibbs. Differentiation of murine macrophages to express nonspecific cytotoxicity in L-argininedependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. J. Immunol. 14: 2829-2838, 1994.
14. Gazzinelli, R. T., I. P. Oswald, S. Hieny, S. L. James, and A. Sher. The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. Eur. J. Immunol. 22: 2501-2506, 1992.
15. Geller, D. A., C. J. Lowenstein, R. A. Shapiro, A. K. Nussler, M. Di Silvio, S. C. Wang, D. K. Nakayama, R. L. Simmons, S. H. Snyder, and T. R. Billiar. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA 90: 3491-3495, 1993.
16. Goureau, O., D. Hicks, and Y. Courtois. Human retinal pigmented epithelial cells produce nitric oxide in response to cytokines. Biochem. Biophys. Res. Commun. 198: 120-126, 1994.
17. Hamid, Q., D. Springall, V. Riveros-Moreno, P. Chanez, P. Howarth, A. Redington, J. Bousquet, P. Godard, S. Holgate, and J. Polak. Induction of nitric oxide synthase in asthma. Lancet 342: 1510-1513, 1993.
18. KB. Nature Lond. 365: 182-185, 1993.
19. Higashi, K., and H. Ogawara. Daidzein inhibits insulin-or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells. Biochim. Biophys. Acta 1221: 29-35, 1994.
20. Kobzik, L., D. S. Bredt, C. J. Lowenstein, J. Drazen, B. Gaston, D. Sugarbaker, and J. S. Stander. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am. J. Resp. Cell Mol. Biol. 9: 371-377, 1993.
21. Kolb-Bachofen, S. Expression of inducible nitric oxide synthase in dermal microvasculature in psoriasis (Abstract). Lancet 344: 1371, 1994.
22. Laszlo, F., B. J. Whittle, and S. Moncada. Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br. J. Pharmacol. 111: 1309-1315, 1994.
23. Lee, S., D. Dickson, W. Liu, and C. Brosnan. Induction of nitric oxide synthase activity in human astrocytes by interleukin-lβ andinterferon-γ. J. Neuroimmunol. 46: 19-24, 1993.
24. Lelchuk, R., M. Radomski, J. Martin, and S. Moncada. Constitutive and inducible nitric oxide synthases in human megakaryoblastic cells. J. Pharmacol. Exp. Ther. 262: 1220-1224, 1992.
25. Marczin, N., A. Papapetropoulos, and J. D. Catravas. Tyrosine kinase inhibitors suppress endotoxin-and IL-lβinduced NO synthesis in aortic smooth muscle cells. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1014-H1018, 1993.
26. Misko, T. P., R. J. Schiling, D. Salvemini, W. M. Moore, and M. G. Currie. A fluorometric assay for the measurement of nitrite in biological samples. Anal. Biochem. 214: 11-16, 1993.
27. 2--calmodulin independent NO-synthase. Biochem. Biophys. Res. Commun. 191: 327-334, 1993.
28. Nathan, Q., and Q. Xie. Nitric oxide synthases: roles, tolls, and controls. Cell 78: 915-918, 1994.
29. Nicolson, A. G., N. E. Haites, N. G. McKay, M. W. Wilson, A. M. MacLeod, and N. Benjamin. Induction of nitric oxide synthase in human mesangial cells. Biochem. Biophys. Res. Commun. 193: 1269-1274, 1993.
30. Nunokawa, Y., N. Ishida, and S. Tanaka. Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular homeostasis-Biochem. Biophys. Res. Commun. 200: 802-807, 1994.
31. Nussler, A. K., M. Di Silvio, T. R, Billiar, R. A. Hoffman, D. A. Geller, R. Selby, J. Madariaga, and R. L. Simmons. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176: 261-264, 1992.
32. Palmer, R. M. J., M. S. Hickery, I. G. Charles, S. Moncada, and M. T. Bayliss. Induction of nitric oxide synthase in human chondrocytes. Biochem. Biophys. Res. Commun. 193: 398-405, 1993.
33. Rachmilewitz, D., F. Karmeli, R. Eliakim, R. Stalnikowicz, Z. Ackerman, G. Amir, and J. S. Stander. Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients. Gut 35: 1394-1397, 1994.
34. + depletion. Biochem. Biophys. Res. Commun. 199: 1270-1277, 1994
35. Ralston, S., D. Todd, M. Helfrich, N. Benjamin, and P. Grabowski. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135: 330-336, 1994.
36. Rees, D. D., S. Cellek, and R. M. J. Palmer. Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: insight into endotoxin shock. Biochem. Biophys. Res. Commun. 173: 541-546, 1990.
37. Roediger, W. E. W., M. J. Lawson, S. H. Nance, and B. C. Radcliffe. Detectable colonie nitrite levels in inflammatory bowel disease. Digestion 35: 199-204, 1986.
38. Rosenkranz-Weiss, P., W. C. Sessa, S. Milstien, S. Kaufman, C. A. Watson, and J. S. Pober. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilican vein endothelial cells. J. Clin. Invest. 93: 2236-2243, 1994.
39. Salzman, A. L. Nitric oxide in the gut. New Horizons 3: 352-364, 1995.
40. Salzman, A. L., M. J. Menconi, N. Unno, R. M. Ezzell, D. M. Casey, P. K. Gonzales, and M. P. Fink. Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G361-G373, 1994.
41. BB in vascular smooth muscle cells. Eur. J. Pharmacol. 216: 379-383, 1992.
42. Sherman, P. A., V. E. Laubaeh, B. R. Reep, and E. R. Wood. Purification and cDNA sequency of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry 32: 11600-11605, 1993.
43. Southan, G. J., C. Szabo, and C. Thiemermann. Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br. J. Pharmacol. 114: 510-516, 1995.
44. Stadler, J., R. D. Curran, J. B. Ochoa, B. G. Harbrecht, R. A, Huffman, R. L. Simmons, and T. R. Billiar. Effect of endogenous nitric oxide on mitochondrial respiration of rat hepatocytes in vitro and in vivo. Arch. Surg. 126: 186-191, 1994.
45. Stadler, J., R. D. Curran, J. B. Ochoa, B. G. Harbrecht, R. L. Simmons, and T. R. Biliar. Effect of endogenous nitric oxide on mitochondrial respiration of rat hepatocytes in vitro and in vivo. Arch. Surg. 126: 186-191, 1991.
46. Szabó, C. Alterations in the production of nitric oxide in various forms of circulatory shock. New Horizons 3: 3-32, 1994.
47. Szabó, C., and C. Thiemermann. Invited opinion: role of nitric oxide in haemorrhagic, traumatic and anaphylactic shock and in thermal injury. Shock 2: 145-155, 1994.
48. Szabó, C., C. Thiemermann, and J. R. Vane. Dihydropyridme modulators of calcium channels inhibit the induction of nitric oxide synthase by endotoxin in cultured J774.2 cells. Biochem. Biophys. Res. Commun. 196: 825-830, 1993.
49. 48a. Szabó, C., B. Zingarelli, M. O'Connor, and A. Salzman. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA 93: 1753-1758, 1996.
50. Tepperman, B. L., J. F. Brown, and B. J. R. Whittle. Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G214-G218, 1993.
51. Unno, N., M. J. Menconi, M. Smith, and M. P. Fink. Nitric oxide mediates interferon-γ-mduced hyperpermeability in cultured human intestinal epithelial monolayers. Crit. Care Med. 23: 1170-1176, 1995.
52. Welsh, N., D. L. Eizirik, K. Bendtzen, and S. Sandier. Interleukin-lβ-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129: 3167-3173, 1991.
53. Whittle, B. J. R. Nitric oxide in gastrointestinal physiology and pathology. In: Physiology of the Gastrointestinal Tract, edited by L. R. Johnson. New York: Raven, 1994, p. 267-294.
54. KB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269: 4705-4708, 1994.
55. Xie, Q., and C. Nathan. The high-output nitric oxide pathway: role and regulation. J. Leukocyte Biol. 56: 576-582, 1994.