-
1
-
-
0036208599
-
Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
-
Kiuchi-Saishin, Y. et al. Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. J. Am. Soc. Nephrol. 13, 875-886 (2002).
-
(2002)
J. Am. Soc. Nephrol
, vol.13
, pp. 875-886
-
-
Kiuchi-Saishin, Y.1
Al, E.2
-
2
-
-
0033774567
-
Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport
-
Fihn, B. M., Sjoqvist, A. & Jodal, M. Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transport. Gastroenterology 11 9 , 1029-1036 (2000).
-
(2000)
Gastroenterology
, vol.11
, Issue.9
, pp. 1029-1036
-
-
Fihn, B.M.1
Sjoqvist, A.2
Jodal, M.3
-
3
-
-
33845910419
-
Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
-
Chieppa, M., Rescigno, M., Huang, A. Y. & Germain, R. N. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J. Exp. Med. 203, 2841-2852 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2841-2852
-
-
Chieppa, M.1
Rescigno, M.2
Huang, A.Y.3
Germain, R.N.4
-
4
-
-
12244297799
-
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
-
Niess, J. H. et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307, 254-258 (2005).
-
(2005)
Science
, vol.307
, pp. 254-258
-
-
Niess, J.H.1
-
5
-
-
33644836224
-
Mucosal vaccines: The promise and the challenge
-
Neutra, M. R. & Kozlowski, P. A. Mucosal vaccines: the promise and the challenge. Nature Rev. Immunol. 6, 148-158 (2006).
-
(2006)
Nature Rev. Immunol
, vol.6
, pp. 148-158
-
-
Neutra, M.R.1
Kozlowski, P.A.2
-
6
-
-
44349132270
-
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
-
Artis, D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nature Rev. Immunol. 8, 411-420 (2008).
-
(2008)
Nature Rev. Immunol
, vol.8
, pp. 411-420
-
-
Artis, D.1
-
7
-
-
44349167059
-
Dendritic cells in intestinal immune regulation
-
Coombes, J. L. & Powrie, F. Dendritic cells in intestinal immune regulation. Nature Rev. Immunol. 8, 435-446 (2008).
-
(2008)
Nature Rev. Immunol
, vol.8
, pp. 435-446
-
-
Coombes, J.L.1
Powrie, F.2
-
8
-
-
54449083567
-
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
-
Johansson, M. E. et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl Acad. Sci. USA 105, 15064-15069 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 15064-15069
-
-
Johansson, M.E.1
Al, E.2
-
10
-
-
41549092745
-
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
-
Heazlewood, C. K. et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 5, e54 (2008).
-
(2008)
PLoS Med
, vol.5
-
-
Heazlewood, C.K.1
-
11
-
-
1542287391
-
Regulated alkali secretion acts in tandem with unstirred layers to regulate mouse gastric surface pH
-
Baumgartner, H. K. & Montrose, M. H. Regulated alkali secretion acts in tandem with unstirred layers to regulate mouse gastric surface pH. Gastroenterology 126, 774-783 (2004).
-
(2004)
Gastroenterology
, vol.126
, pp. 774-783
-
-
Baumgartner, H.K.1
Montrose, M.H.2
-
12
-
-
0029991021
-
Measurements of the jejunal unstirred layer in normal subjects and patients with celiac disease
-
Strocchi, A. et al. Measurements of the jejunal unstirred layer in normal subjects and patients with celiac disease. Am. J. Physiol. 270, G487-G491 (1996).
-
(1996)
Am. J. Physiol
, vol.270
-
-
Strocchi, A.1
Al, E.2
-
13
-
-
0028918891
-
In vivo analysis of cadherin function in the mouse intestinal epithelium: Essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death
-
Hermiston, M. L. & Gordon, J. I. In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J. Cell Biol. 129, 489-506 (1995).
-
(1995)
J. Cell Biol
, vol.129
, pp. 489-506
-
-
Hermiston, M.L.1
Gordon, J.I.2
-
14
-
-
40549109907
-
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2
-
Van Itallie, C. M. et al. The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J. Cell Sci. 121, 298-305 (2008).
-
(2008)
J. Cell Sci
, vol.121
, pp. 298-305
-
-
Van Itallie, C.M.1
-
15
-
-
29244455602
-
Selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores
-
Watson, C. J., Hoare, C. J., Garrod, D. R., Carlson, G. L. & Warhurst, G. Interferon-γ selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores. J. Cell Sci. 11 8 , 5221-5230 (2005).
-
(2005)
J. Cell Sci
, vol.11
, Issue.8
, pp. 5221-5230
-
-
Watson, C.J.1
Hoare, C.J.2
Garrod, D.R.3
Carlson, G.L.4
-
16
-
-
13244298599
-
Interferon-γ and tumour necrosis factor-α synergize to induce intestinal epithelial barrier dysfunction by upregulating myosin light chain kinase expression
-
Wang, F. et al. Interferon-γ and tumour necrosis factor-α synergize to induce intestinal epithelial barrier dysfunction by upregulating myosin light chain kinase expression. Am. J. Pathol. 166, 409-419 (2005).
-
(2005)
Am. J. Pathol
, vol.166
, pp. 409-419
-
-
Wang, F.1
Al, E.2
-
17
-
-
33749428028
-
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
-
Clayburgh, D. R., Musch, M. W., Leitges, M., Fu, Y. X. & Turner, J. R. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J. Clin. Invest. 11 6 , 2682-2694 (2006).
-
(2006)
J. Clin. Invest
, vol.11
, Issue.6
, pp. 2682-2694
-
-
Clayburgh, D.R.1
Musch, M.W.2
Leitges, M.3
Fu, Y.X.4
Turner, J.R.5
-
18
-
-
0037115724
-
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
-
Amasheh, S. et al. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J. Cell Sci. 11 5 , 4969-4976 (2002).
-
(2002)
J. Cell Sci
, vol.11
, Issue.5
, pp. 4969-4976
-
-
Amasheh, S.1
-
19
-
-
0038701734
-
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture
-
Colegio, O. R., Van Itallie, C., Rahner, C. & Anderson, J. M. Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am. J. Physiol. Cell Physiol. 284, C1346-C1354 (2003).
-
(2003)
Am. J. Physiol. Cell Physiol
, vol.284
-
-
Colegio, O.R.1
Van Itallie, C.2
Rahner, C.3
Anderson, J.M.4
-
20
-
-
0033516683
-
Paracellin-1 a renal tight junction protein required for paracellular Mg2+ resorption
-
Simon, D. B. et al. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science 285, 103-106 (1999).
-
(1999)
Science
, vol.285
, pp. 103-106
-
-
Simon, D.B.1
-
21
-
-
0023510866
-
Structural basis for physiological regulation of paracellular pathways in intestinal epithelia
-
Madara, J. L. & Pappenheimer, J. R. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol. 100, 149-164 (1987).
-
(1987)
J. Membr. Biol
, vol.100
, pp. 149-164
-
-
Madara, J.L.1
Pappenheimer, J.R.2
-
22
-
-
0024525147
-
Intestinal glucose transport using perfused rat jejunum in vivo: Model analysis and derivation of corrected kinetic constants
-
Meddings, J. B. & Westergaard, H. Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants. Clin. Sci. (Lond.) 76, 403-413 (1989).
-
(1989)
Clin. Sci. (Lond.)
, vol.76
, pp. 403-413
-
-
Meddings, J.B.1
Westergaard, H.2
-
23
-
-
0030669302
-
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
-
Turner, J. R. et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am. J. Physiol. 273, C1378-C1385 (1997).
-
(1997)
Am. J. Physiol
, vol.273
-
-
Turner, J.R.1
Al, E.2
-
24
-
-
0035665398
-
Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na+-glucose cotransport
-
Berglund, J. J., Riegler, M., Zolotarevsky, Y., Wenzl, E. & Turner, J. R. Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na+-glucose cotransport. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G1487-G1493 (2001).
-
(2001)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.281
-
-
Berglund, J.J.1
Riegler, M.2
Zolotarevsky, Y.3
Wenzl, E.4
Turner, J.R.5
-
25
-
-
33745193296
-
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
-
Shen, L. et al. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J. Cell Sci. 11 9 , 2095-2106 (2006).
-
(2006)
J. Cell Sci
, vol.11
, Issue.9
, pp. 2095-2106
-
-
Shen, L.1
-
26
-
-
58649090901
-
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis
-
Su, L. et al. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 136, 551-563 (2009).
-
(2009)
Gastroenterology
, vol.136
, pp. 551-563
-
-
Su, L.1
-
27
-
-
0024553788
-
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers
-
Madara, J. L. & Stafford, J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J. Clin. Invest. 83, 724-727 (1989).
-
(1989)
J. Clin. Invest
, vol.83
, pp. 724-727
-
-
Madara, J.L.1
Stafford, J.2
-
28
-
-
0031898947
-
Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumour necrosis factorα
-
Taylor, C. T., Dzus, A. L. & Colgan, S. P. Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumour necrosis factorα. Gastroenterology 11 4 , 657-668 (1998).
-
(1998)
Gastroenterology
, vol.11
, Issue.4
, pp. 657-668
-
-
Taylor, C.T.1
Dzus, A.L.2
Colgan, S.P.3
-
29
-
-
0026482732
-
Modulation of tumour necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability
-
Mullin, J. M., Laughlin, K. V., Marano, C. W., Russo, L. M. & Soler, A. P. Modulation of tumour necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability. Am. J. Physiol. 263, F915-F924 (1992).
-
(1992)
Am. J. Physiol
, vol.263
-
-
Mullin, J.M.1
Laughlin, K.V.2
Marano, C.W.3
Russo, L.M.4
Soler, A.P.5
-
30
-
-
38149087653
-
Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation
-
Mazzon, E. & Cuzzocrea, S. Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation. Respir. Res. 8, 75 (2007).
-
(2007)
Respir. Res
, vol.8
, pp. 75
-
-
Mazzon, E.1
Cuzzocrea, S.2
-
31
-
-
57349100454
-
Proinflammatory cytokines tumour necrosis factor-α and interferon-γ alter tight junction structure and function in the rat parotid gland Par-C10 cell line
-
Baker, O. J. et al. Proinflammatory cytokines tumour necrosis factor-α and interferon-γ alter tight junction structure and function in the rat parotid gland Par-C10 cell line. Am. J. Physiol. Cell Physiol. 295, C1191-C1201 (2008).
-
(2008)
Am. J. Physiol. Cell Physiol
, vol.295
-
-
Baker, O.J.1
Al, E.2
-
32
-
-
0034786091
-
Synergistic effects of tumour necrosis factor-α and thrombin in increasing endothelial permeability
-
Tiruppathi, C., Naqvi, T., Sandoval, R., Mehta, D. & Malik, A. B. Synergistic effects of tumour necrosis factor-α and thrombin in increasing endothelial permeability. Am. J. Physiol. Lung Cell. Mol. Physiol. 281, L958-L968 (2001).
-
(2001)
Am. J. Physiol. Lung Cell. Mol. Physiol
, vol.281
-
-
Tiruppathi, C.1
Naqvi, T.2
Sandoval, R.3
Mehta, D.4
Malik, A.B.5
-
33
-
-
0032923705
-
Tumour necrosis factor α antibody (infliximab) therapy profoundly downregulates the inflammation in Crohn's ileocolitis
-
Baert, F. J. et al. Tumour necrosis factor α antibody (infliximab) therapy profoundly downregulates the inflammation in Crohn's ileocolitis. Gastroenterology 11 6 , 22-28 (1999).
-
(1999)
Gastroenterology
, vol.11
, Issue.6
, pp. 22-28
-
-
Baert, F.J.1
-
34
-
-
0030767126
-
Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock
-
Tamion, F. et al. Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock. Am. J. Physiol. 273, G314-G321 (1997).
-
(1997)
Am. J. Physiol
, vol.273
-
-
Tamion, F.1
Al, E.2
-
35
-
-
0033011210
-
Tumour necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease
-
Brown, G. R. et al. Tumour necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. Gastroenterology 11 6 , 593-601 (1999).
-
(1999)
Gastroenterology
, vol.11
, Issue.6
, pp. 593-601
-
-
Brown, G.R.1
-
36
-
-
0036678630
-
Anti-tumour necrosis factor treatment restores the gut barrier in Crohn's disease
-
Suenaert, P. et al. Anti-tumour necrosis factor treatment restores the gut barrier in Crohn's disease. Am. J. Gastroenterol. 97, 2000-2004 (2002).
-
(2000)
Am. J. Gastroenterol
, vol.97
, pp. 2002
-
-
Suenaert, P.1
Al, E.2
-
37
-
-
33745746660
-
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
-
Van der Sluis, M. et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131 , 117-129 (2006).
-
(2006)
Gastroenterology
, vol.131
, pp. 117-129
-
-
Van Der Sluis, M.1
-
38
-
-
26444577545
-
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo
-
Clayburgh, D. R. et al. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J. Clin. Invest. 11 5 , 2702-2715 (2005).
-
(2005)
J. Clin. Invest
, vol.11
, Issue.5
, pp. 2702-2715
-
-
Clayburgh, D.R.1
Al, E.2
-
39
-
-
0036305854
-
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
-
Zolotarevsky, Y. et al. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123, 163-172 (2002).
-
(2002)
Gastroenterology
, vol.123
, pp. 163-172
-
-
Zolotarevsky, Y.1
-
40
-
-
13844308129
-
Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
-
Ma, T. Y., Boivin, M. A., Ye, D., Pedram, A. & Said, H. M. Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G422-G430 (2005).
-
(2005)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.288
-
-
Ma, T.Y.1
Boivin, M.A.2
Ye, D.3
Pedram, A.4
Said, H.M.5
-
41
-
-
34548478100
-
Roles of Rho/ROCK and MLCK in TNF-α-induced changes in endothelial morphology and permeability
-
McKenzie, J. A. & Ridley, A. J. Roles of Rho/ROCK and MLCK in TNF-α-induced changes in endothelial morphology and permeability. J. Cell. Physiol. 213, 221-228 (2007).
-
(2007)
J. Cell. Physiol
, vol.213
, pp. 221-228
-
-
McKenzie, J.A.1
Ridley, A.J.2
-
42
-
-
33748747620
-
Tumour necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signalling events. Characterization of the human long myosin light chain kinase promoter
-
Graham, W. V. et al. Tumour necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signalling events. Characterization of the human long myosin light chain kinase promoter. J. Biol. Chem. 281, 26205-26215 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 26205-26215
-
-
Graham, W.V.1
Al, E.2
-
43
-
-
30944443377
-
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
-
Blair, S. A., Kane, S. V., Clayburgh, D. R. & Turner, J. R. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab. Invest. 86, 191-201 (2006).
-
(2006)
Lab. Invest
, vol.86
, pp. 191-201
-
-
Blair, S.A.1
Kane, S.V.2
Clayburgh, D.R.3
Turner, J.R.4
-
44
-
-
34250190636
-
LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms
-
Schwarz, B. T. et al. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology 132, 2383-2394 (2007).
-
(2007)
Gastroenterology
, vol.132
, pp. 2383-2394
-
-
Schwarz, B.T.1
-
45
-
-
45949086355
-
Mechanism of IL-1β-induced increase in intestinal epithelial tight junction permeability
-
Al-Sadi, R., Ye, D., Dokladny, K. & Ma, T. Y. Mechanism of IL-1β-induced increase in intestinal epithelial tight junction permeability. J. Immunol. 180, 5653-5661 (2008).
-
(2008)
J. Immunol
, vol.180
, pp. 5653-5661
-
-
Al-Sadi, R.1
Ye, D.2
Dokladny, K.3
Ma, T.Y.4
-
46
-
-
59849102721
-
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation
-
Wroblewski, L. E. et al. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology 136, 236-246 (2009).
-
(2009)
Gastroenterology
, vol.136
, pp. 236-246
-
-
Wroblewski, L.E.1
-
47
-
-
0036789132
-
Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion
-
Scott, K. G., Meddings, J. B., Kirk, D. R., Lees-Miller, S. P. & Buret, A. G. Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Gastroenterology 123, 1179-1190 (2002).
-
(2002)
Gastroenterology
, vol.123
, pp. 1179-1190
-
-
Scott, K.G.1
Meddings, J.B.2
Kirk, D.R.3
Lees-Miller, S.P.4
Buret, A.G.5
-
48
-
-
26244450671
-
Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats
-
Moriez, R. et al. Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats. Am. J. Pathol. 167, 1071-1079 (2005).
-
(2005)
Am. J. Pathol
, vol.167
, pp. 1071-1079
-
-
Moriez, R.1
Al, E.2
-
49
-
-
18744402249
-
LPS-induced lung inflammation is linked to increased epithelial permeability: Role of MLCK
-
Eutamene, H. et al. LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK. Eur. Respir. J. 25, 789-796 (2005).
-
(2005)
Eur. Respir. J
, vol.25
, pp. 789-796
-
-
Eutamene, H.1
Al, E.2
-
50
-
-
33645449666
-
Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents
-
Ferrier, L. et al. Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents. Am. J. Pathol. 168, 1148-1154 (2006).
-
(2006)
Am. J. Pathol
, vol.168
, pp. 1148-1154
-
-
Ferrier, L.1
Al, E.2
-
51
-
-
70349317350
-
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
-
Van Itallie, C. M., Fanning, A. S., Bridges, A. & Anderson, J. M. ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol. Biol. Cell 20, 3930-3940 (2009).
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 3930-3940
-
-
Van Itallie, C.M.1
Fanning, A.S.2
Bridges, A.3
Anderson, J.M.4
-
52
-
-
70350437248
-
Adenosine monophosphate activated protein kinase mediates the interferon-γ-induced decrease in intestinal epithelial barrier function
-
Scharl, M., Paul, G., Barrett, K. E. & McCole, D. F. Adenosine monophosphate activated protein kinase mediates the interferon-γ-induced decrease in intestinal epithelial barrier function. J. Biol. Chem. 284, 27952-127563 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 27952-127563
-
-
Scharl, M.1
Paul, G.2
Barrett, K.E.3
McCole, D.F.4
-
53
-
-
26244442836
-
Mechanism of IFN-γ-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
-
Utech, M. et al. Mechanism of IFN-γ-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane. Mol. Biol. Cell 16, 5040-5052 (2005).
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 5040-5052
-
-
Utech, M.1
Al, E.2
-
54
-
-
24344457031
-
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis
-
Shen, L. & Turner, J. R. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol. Biol. Cell 16, 3919-3936 (2005).
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 3919-3936
-
-
Shen, L.1
Turner, J.R.2
-
55
-
-
67650511699
-
Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells
-
Stamatovic, S. M., Keep, R. F. , Wang, M. M., Jankovic, I. & Andjelkovic, A. V. Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J. Biol. Chem. 284, 19053-19066 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 19053-19066
-
-
Stamatovic, S.M.1
Keep, R.F.2
Wang, M.M.3
Jankovic, I.4
Andjelkovic, A.V.5
-
56
-
-
20444481707
-
Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
-
Bruewer, M. et al. Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J. 19, 923-933 (2005).
-
(2005)
FASEB J
, vol.19
, pp. 923-933
-
-
Bruewer, M.1
-
57
-
-
58249092789
-
TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration
-
Chun, J. & Prince, A. TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration. Cell Host Microbe 5, 47-58 (2009).
-
(2009)
Cell Host Microbe
, vol.5
, pp. 47-58
-
-
Chun, J.1
Prince, A.2
-
58
-
-
0033635344
-
Complex phenotype of mice lacking occludin, a component of tight junction strands
-
Saitou, M. et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol. Biol. Cell 11 , 4131-4142 (2000).
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 4131-4142
-
-
Saitou, M.1
Al, E.2
-
59
-
-
0029786313
-
Phosphorylation and activation of myosin by Rho-associated kinase (Rho- kinase)
-
DOI 10.1074/jbc.271.34.20246
-
Amano, M. et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271, 20246-20249 (1996). (Pubitemid 26281788)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.34
, pp. 20246-20249
-
-
Amano, M.1
Ito, M.2
Kimura, K.3
Fukata, Y.4
Chihara, K.5
Nakano, T.6
Matsuura, Y.7
Kaibuchi, K.8
-
60
-
-
0026355532
-
Effect of phosphorylation of myosin light chain by myosin light chain kinase and protein kinase C on conformational change and ATPase activities of human platelet myosin
-
Higashihara, M., Takahata, K. & Kurokawa, K. Effect of phosphorylation of myosin light chain by myosin light chain kinase and protein kinase C on conformational change and ATPase activities of human platelet myosin. Blood 78, 3224-3231 (1991).
-
(1991)
Blood
, vol.78
, pp. 3224-3231
-
-
Higashihara, M.1
Takahata, K.2
Kurokawa, K.3
-
61
-
-
0032514134
-
And functional regulation of tight junctions by rhoA and rac1 small GTPases
-
Jou, T. S., Schneeberger, E. E. & James Nelson, W. Structural and functional regulation of tight junctions by rhoA and rac1 small GTPases. J. Cell Biol. 142, 101-115 (1998).
-
(1998)
J. Cell Biol
, vol.142
, pp. 101-115
-
-
Jou, T.S.1
Schneeberger, E.E.2
Nelson, J.3
Structural, W.4
-
62
-
-
9444242736
-
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho- kinase)
-
Kimura, K. et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248 (1996). (Pubitemid 26285892)
-
(1996)
Science
, vol.273
, Issue.5272
, pp. 245-248
-
-
Kimura, K.1
Ito, M.2
Amano, M.3
Chihara, K.4
Fukata, Y.5
Nakafuku, M.6
Yamamori, B.7
Feng, J.8
Nakano, T.9
Okawa, K.10
Iwamatsu, A.11
Kaibuchi, K.12
-
63
-
-
34250827107
-
Energy-dependent regulation of cell structure by AMP-activated protein kinase
-
Lee, J. H. et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 447, 1017-1020 (2007).
-
(2007)
Nature
, vol.447
, pp. 1017-1020
-
-
Lee, J.H.1
-
64
-
-
23244455992
-
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
-
Heller, F. et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129, 550-564 (2005).
-
(2005)
Gastroenterology
, vol.129
, pp. 550-564
-
-
Heller, F.1
-
66
-
-
67651215624
-
Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am. J. Physiol
-
Wray, C. et al. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 297, L219-L227 (2009).
-
(2009)
Lung Cell. Mol. Physiol
, vol.297
-
-
Wray, C.1
Al, E.2
-
67
-
-
52649123158
-
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
-
Weber, C. R., Nalle, S. C., Tretiakova, M., Rubin, D. T. & Turner, J. R. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab. Invest. 88, 1110-1120 (2008).
-
(2008)
Lab. Invest
, vol.88
, pp. 1110-1120
-
-
Weber, C.R.1
Nalle, S.C.2
Tretiakova, M.3
Rubin, D.T.4
Turner, J.R.5
-
68
-
-
22144499164
-
Claudin-1 regulates cellular transformation and metastatic behaviour in colon cancer
-
Dhawan, P. et al. Claudin-1 regulates cellular transformation and metastatic behaviour in colon cancer. J. Clin. Invest. 11 5 , 1765-1776 (2005).
-
(2005)
J. Clin. Invest
, vol.11
, Issue.5
, pp. 1765-1776
-
-
Dhawan, P.1
Al, E.2
-
69
-
-
0037216498
-
Increased expression of interleukin 17 in inflammatory bowel disease
-
Fujino, S. et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52, 65-70 (2003).
-
(2003)
Gut
, vol.52
, pp. 65-70
-
-
Fujino, S.1
-
70
-
-
0034128634
-
Claudins regulate the intestinal barrier in response to immune mediators
-
Kinugasa, T. , Sakaguchi, T., Gu, X. & Reinecker, H. C. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 11 8 , 1001-1011 (2000).
-
(2000)
Gastroenterology
, vol.11
, Issue.8
, pp. 1001-1011
-
-
Kinugasa, T.1
Sakaguchi, T.2
Gu, X.3
Reinecker, H.C.4
-
71
-
-
60549090106
-
Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site
-
Yu, A. S. et al. Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J. Gen. Physiol. 133, 111-127 (2009).
-
(2009)
J. Gen. Physiol
, vol.133
, pp. 111-127
-
-
Yu, A.S.1
Al, E.2
-
72
-
-
70350399482
-
Structure-function studies of claudin extracellular domains by cysteine-scanning mutagenesis
-
Angelow, S. & Yu, A. S. Structure-function studies of claudin extracellular domains by cysteine-scanning mutagenesis. J. Biol. Chem. 284, 29205-29217 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 29205-29217
-
-
Angelow, S.1
Yu, A.S.2
-
73
-
-
0022970442
-
Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor
-
Hollander, D. et al. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann. Intern. Med. 105, 883-885 (1986).
-
(1986)
Ann. Intern. Med
, vol.105
, pp. 883-885
-
-
Hollander, D.1
Al, E.2
-
75
-
-
65249115914
-
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
-
Noguchi, E., Homma, Y., Kang, X., Netea, M. G. & Ma, X. A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nature Immunol. 10, 471-479 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 471-479
-
-
Noguchi, E.1
Homma, Y.2
Kang, X.3
Netea, M.G.4
Ma, X.5
-
76
-
-
0033228442
-
Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora
-
Madsen, K. L. et al. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm. Bowel Dis. 5, 262-270 (1999).
-
(1999)
Inflamm. Bowel Dis
, vol.5
, pp. 262-270
-
-
Madsen, K.L.1
Al, E.2
-
77
-
-
33645049332
-
The primary defect in experimental ileitis originates from a nonhematopoietic source
-
Olson, T. S. et al. The primary defect in experimental ileitis originates from a nonhematopoietic source. J. Exp. Med. 203, 541-552 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 541-552
-
-
Olson, T.S.1
Al, E.2
-
78
-
-
0027217379
-
Intestinal permeability and the prediction of relapse in Crohn's disease
-
Wyatt, J., Vogelsang, H., Hubl, W., Waldhoer, T. & Lochs, H. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 341, 1437-1439 (1993).
-
(1993)
Lancet
, vol.341
, pp. 1437-1439
-
-
Wyatt, J.1
Vogelsang, H.2
Hubl, W.3
Waldhoer, T.4
Lochs, H.5
-
79
-
-
0028972499
-
Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
-
Hermiston, M. L. & Gordon, J. I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270, 1203-1207 (1995).
-
(1995)
Science
, vol.270
, pp. 1203-1207
-
-
Hermiston, M.L.1
Gordon, J.I.2
-
80
-
-
67650667753
-
Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
-
Yan, Y. et al. Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis. PLoS One 4, e6073 (2009).
-
(2009)
PLoS One
, vol.4
-
-
Yan, Y.1
-
81
-
-
0035123651
-
Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone
-
Williams, K. L. et al. Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology 120, 925-937 (2001).
-
(2001)
Gastroenterology
, vol.120
, pp. 925-937
-
-
Williams, K.L.1
-
82
-
-
33846017279
-
Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury
-
Brown, S. L. et al. Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J. Clin. Invest. 11 7 , 258-269 (2007).
-
(2007)
J. Clin. Invest
, vol.11
, Issue.7
, pp. 258-269
-
-
Brown, S.L.1
Al, E.2
-
83
-
-
33748271299
-
Cox-2 is regulated by Toll-like receptor-4 (TLR4) signalling: Role in proliferation and apoptosis in the intestine
-
Fukata, M. et al. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signalling: Role in proliferation and apoptosis in the intestine. Gastroenterology 131, 862-877 (2006).
-
(2006)
Gastroenterology
, vol.131
, pp. 862-877
-
-
Fukata, M.1
-
84
-
-
0024267211
-
Crohn's disease - A permeability disorder of the tight junction?
-
Hollander, D. Crohn's disease - a permeability disorder of the tight junction? Gut 29, 1621-1624 (1988).
-
(1988)
Gut
, vol.29
, pp. 1621-1624
-
-
Hollander, D.1
-
85
-
-
0034465898
-
Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
-
Irvine, E. J. & Marshall, J. K. Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology 11 9 , 1740-1744 (2000).
-
(2000)
Gastroenterology
, vol.11
, Issue.9
, pp. 1740-1744
-
-
Irvine, E.J.1
Marshall, J.K.2
-
86
-
-
84873516176
-
Genetic ablation of myosin light chain kinase limits epithelial barrier dysfunction and attenuates experimental inflammatory bowel disease
-
Su, L., Nalle, S. C., Sullivan, E. A., Fu, Y.-X. & Turner, J. R. Genetic ablation of myosin light chain kinase limits epithelial barrier dysfunction and attenuates experimental inflammatory bowel disease. Gastroenterology Abstr.136, A81 (2009).
-
(2009)
Gastroenterology Abstr.136
, vol.81
-
-
Su, L.1
Nalle, S.C.2
Sullivan, E.A.3
Fu, Y.-X.4
Turner, J.R.5
-
87
-
-
47849092068
-
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins
-
Xu, J. et al. Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins. Nature Immunol. 9, 880-886 (2008).
-
(2008)
Nature Immunol
, vol.9
, pp. 880-886
-
-
Xu, J.1
-
88
-
-
58249085436
-
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse
-
Arrieta, M. C., Madsen, K., Doyle, J. & Meddings, J. Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 58, 41-48 (2009).
-
(2009)
Gut
, vol.58
, pp. 41-48
-
-
Arrieta, M.C.1
Madsen, K.2
Doyle, J.3
Meddings, J.4
-
89
-
-
46049083963
-
Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease
-
Vetrano, S. et al. Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 135, 173-184 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 173-184
-
-
Vetrano, S.1
-
90
-
-
37549038994
-
JAM-A regulates permeability and inflammation in the intestine in vivo
-
Laukoetter, M. G. et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J. Exp. Med. 204, 3067-3076 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 3067-3076
-
-
Laukoetter, M.G.1
Al, E.2
-
91
-
-
33846195036
-
Deletion of JAM-A causes morphological defects in the corneal epithelium
-
Kang, L. I. et al. Deletion of JAM-A causes morphological defects in the corneal epithelium. Int. J. Biochem. Cell Biol. 39, 576-585 (2007).
-
(2007)
Int. J. Biochem. Cell Biol
, vol.39
, pp. 576-585
-
-
Kang, L.I.1
Al, E.2
-
92
-
-
55449095474
-
A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis
-
Boirivant, M. et al. A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis. Gastroenterology 135, 1612-1623 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 1612-1623
-
-
Boirivant, M.1
-
93
-
-
67649243735
-
Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning
-
Iliev, I. D., Mileti, E., Matteoli, G., Chieppa, M. & Rescigno, M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. (2009).
-
(2009)
Mucosal Immunol.
-
-
Iliev, I.D.1
Mileti, E.2
Matteoli, G.3
Chieppa, M.4
Rescigno, M.5
-
94
-
-
38649115342
-
Microbial influences in inflammatory bowel diseases
-
Sartor, R. B. Microbial influences in inflammatory bowel diseases. Gastroenterology 134, 577-594 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 577-594
-
-
Sartor, R.B.1
-
95
-
-
33845910428
-
The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease
-
Ewaschuk, J. B., Tejpar, Q. Z., Soo, I., Madsen, K. & Fedorak, R. N. The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease. Curr. Gastroenterol. Rep. 8, 486-498 (2006).
-
(2006)
Curr. Gastroenterol. Rep
, vol.8
, pp. 486-498
-
-
Ewaschuk, J.B.1
Tejpar, Q.Z.2
Soo, I.3
Madsen, K.4
Fedorak, R.N.5
-
96
-
-
0031114247
-
Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+ CD45RBhigh T cells to SCID recipients
-
Aranda, R. et al. Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients. J. Immunol. 158, 3464-3473 (1997).
-
(1997)
J. Immunol
, vol.158
, pp. 3464-3473
-
-
Aranda, R.1
-
97
-
-
0032412057
-
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
-
Sellon, R. K. et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66, 5224-5231 (1998).
-
(1998)
Infect. Immun
, vol.66
, pp. 5224-5231
-
-
Sellon, R.K.1
Al, E.2
-
98
-
-
54349106465
-
Barrier-protective function of intestinal epithelial Toll-like receptor 2
-
Cario, E. Barrier-protective function of intestinal epithelial Toll-like receptor 2. Mucosal Immunol. 1, S62-S66 (2008).
-
(2008)
Mucosal Immunol
, vol.1
-
-
Cario, E.1
-
99
-
-
34447503805
-
17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007).
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
-
100
-
-
34547788180
-
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism
-
Coombes, J. L. et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J. Exp. Med. 204, 1757-1764 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 1757-1764
-
-
Coombes, J.L.1
Al, E.2
-
101
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser, A. et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743-756 (2008).
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
-
102
-
-
44349136821
-
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
-
Fisher, S. A. et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genet. 40, 710-712 (2008).
-
(2008)
Nature Genet
, vol.40
, pp. 710-712
-
-
Fisher, S.A.1
-
103
-
-
38849163741
-
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
-
Watanabe, T. et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Invest. 11 8 , 545-559 (2008).
-
(2008)
J. Clin. Invest
, vol.11
, Issue.8
, pp. 545-559
-
-
Watanabe, T.1
Al, E.2
-
104
-
-
35648995482
-
NOD2 transgenic mice exhibit enhanced MDP-mediated downregulation of TLR2 responses and resistance to colitis induction
-
Yang, Z. et al. NOD2 transgenic mice exhibit enhanced MDP-mediated downregulation of TLR2 responses and resistance to colitis induction. Gastroenterology 133, 1510-1521 (2007).
-
(2007)
Gastroenterology
, vol.133
, pp. 1510-1521
-
-
Yang, Z.1
-
105
-
-
37649013801
-
Chronic stimulation of Nod2 mediates tolerance to bacterial products
-
Hedl, M., Li, J., Cho, J. H. & Abraham, C. Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc. Natl Acad. Sci. USA 104, 19440-19445 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19440-19445
-
-
Hedl, M.1
Li, J.2
Cho, J.H.3
Abraham, C.4
-
106
-
-
33645026321
-
Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease
-
Kraus, T. A., Cheifetz, A., Toy, L., Meddings, J. B. & Mayer, L. Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease. Inflamm. Bowel Dis. 12, 82-88 (2006).
-
(2006)
Inflamm. Bowel Dis
, vol.12
, pp. 82-88
-
-
Kraus, T.A.1
Cheifetz, A.2
Toy, L.3
Meddings, J.B.4
Mayer, L.5
-
107
-
-
12544256432
-
Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation
-
Shiue, H., Musch, M. W., Wang, Y., Chang, E. B. & Turner, J. R. Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J. Biol. Chem. 280, 1688-1695 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 1688-1695
-
-
Shiue, H.1
Musch, M.W.2
Wang, Y.3
Chang, E.B.4
Turner, J.R.5
-
108
-
-
0014429850
-
Decrease in net stool output in cholera during intestinal perfusion with glucose-containing solutions
-
Hirschhorn, N. et al. Decrease in net stool output in cholera during intestinal perfusion with glucose-containing solutions. N. Engl. J. Med. 279, 176-181 (1968).
-
(1968)
N. Engl. J. Med
, vol.279
, pp. 176-181
-
-
Hirschhorn, N.1
Al, E.2
-
109
-
-
33845995125
-
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
-
Zeissig, S. et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56, 61-72 (2007).
-
(2007)
Gut
, vol.56
, pp. 61-72
-
-
Zeissig, S.1
-
110
-
-
17644395272
-
Intestinal permeability in long-term follow-up of patients with celiac disease on a gluten-free diet
-
Duerksen, D. R., Wilhelm-Boyles, C. & Parry, D. M. Intestinal permeability in long-term follow-up of patients with celiac disease on a gluten-free diet. Dig. Dis. Sci. 50, 785-790 (2005).
-
(2005)
Dig. Dis. Sci
, vol.50
, pp. 785-790
-
-
Duerksen, D.R.1
Wilhelm-Boyles, C.2
Parry, D.M.3
-
111
-
-
0019996563
-
Intestinal permeability in children with Crohn's disease and coeliac disease
-
Pearson, A. D., Eastham, E. J., Laker, M. F., Craft, A. W. & Nelson, R. Intestinal permeability in children with Crohn's disease and coeliac disease. Br. Med. J. (Clin. Res. Ed) 285, 20-21 (1982).
-
(1982)
Br. Med. J. (Clin. Res. Ed)
, vol.285
, pp. 20-21
-
-
Pearson, A.D.1
Eastham, E.J.2
Laker, M.F.3
Craft, A.W.4
Nelson, R.5
-
112
-
-
33749466490
-
IFN-γ-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction
-
Wang, F. et al. IFN-γ-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 131, 1153-1163 (2006).
-
(2006)
Gastroenterology
, vol.131
, pp. 1153-1163
-
-
Wang, F.1
-
113
-
-
0028519015
-
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
-
Powrie, F. et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1, 553-562 (1994).
-
(1994)
Immunity
, vol.1
, pp. 553-562
-
-
Powrie, F.1
-
114
-
-
35348945960
-
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells
-
Stepankova, R. et al. Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells. Inflamm. Bowel Dis. 13, 1202-1211 (2007).
-
(2007)
Inflamm. Bowel Dis
, vol.13
, pp. 1202-1211
-
-
Stepankova, R.1
Al, E.2
-
115
-
-
44349190298
-
Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a-/-mice
-
Collett, A. et al. Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a-/-mice. Inflamm. Bowel Dis. 14, 620-631 (2008).
-
(2008)
Inflamm. Bowel Dis
, vol.14
, pp. 620-631
-
-
Collett, A.1
Al, E.2
-
116
-
-
21744441440
-
Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/-mice
-
Resta-Lenert, S., Smitham, J. & Barrett, K. E. Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/-mice. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G153-G162 (2005).
-
(2005)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.289
-
-
Resta-Lenert, S.1
Smitham, J.2
Barrett, K.E.3
-
117
-
-
0035112067
-
Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins
-
Nusrat, A. et al. Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins. Infect. Immun. 69, 1329-1336 (2001).
-
(2001)
Infect. Immun
, vol.69
, pp. 1329-1336
-
-
Nusrat, A.1
Al, E.2
-
118
-
-
0035095037
-
Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function
-
McNamara, B. P. et al. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J. Clin. Invest. 107, 621-629 (2001).
-
(2001)
J. Clin. Invest
, vol.107
, pp. 621-629
-
-
McNamara, B.P.1
Al, E.2
|