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Volumn 1258, Issue 1, 2012, Pages 125-134

Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease

Author keywords

Adherent invasive E. coli; Etiology; Inflammatory bowel disease; Pathogens; Peyer's patches

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN;

EID: 84862896140     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06502.x     Document Type: Article
Times cited : (28)

References (82)
  • 1
    • 77953243617 scopus 로고    scopus 로고
    • The intestinal barrier and its regulation by neuroimmune factors
    • Keita, A.V. & J.D. Soderholm 2010. The intestinal barrier and its regulation by neuroimmune factors. Neurogastroenterol Motil. 22: 718-733.
    • (2010) Neurogastroenterol Motil. , vol.22 , pp. 718-733
    • Keita, A.V.1    Soderholm, J.D.2
  • 3
    • 78650096816 scopus 로고    scopus 로고
    • Importance of disrupted intestinal barrier in inflammatory bowel diseases
    • Salim, S.Y. & J.D. Soderholm 2011. Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm. Bowel Dis. 17: 362-381.
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 362-381
    • Salim, S.Y.1    Soderholm, J.D.2
  • 4
    • 33845384834 scopus 로고    scopus 로고
    • Review article: altering the natural history of Crohn's disease-evidence for and against current therapies
    • Vermeire, S., G. van Assche & P. Rutgeerts 2007. Review article: altering the natural history of Crohn's disease-evidence for and against current therapies. Aliment. Pharmacol. Ther. 25: 3-12.
    • (2007) Aliment. Pharmacol. Ther. , vol.25 , pp. 3-12
    • Vermeire, S.1    van Assche, G.2    Rutgeerts, P.3
  • 5
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky, D.K. 2002. Inflammatory bowel disease. N. Engl. J. Med. 347: 417-429.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 6
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
    • Duchmann, R. et al 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102: 448-455.
    • (1995) Clin. Exp. Immunol. , vol.102 , pp. 448-455
    • Duchmann, R.1
  • 7
    • 0029866466 scopus 로고    scopus 로고
    • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
    • Macpherson, A. et al 1996. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 38: 365-375.
    • (1996) Gut , vol.38 , pp. 365-375
    • Macpherson, A.1
  • 8
    • 33749011189 scopus 로고    scopus 로고
    • Animal models of inflammatory bowel disease: lessons from enteric infections
    • Eckmann, L. 2006. Animal models of inflammatory bowel disease: lessons from enteric infections. Ann. N.Y. Acad. Sci. 1072: 28-38.
    • (2006) Ann. N.Y. Acad. Sci. , vol.1072 , pp. 28-38
    • Eckmann, L.1
  • 9
    • 0032805892 scopus 로고    scopus 로고
    • Colitis in transgenic and knockout animals as models of human inflammatory bowel disease
    • Bhan, A.K. et al 1999. Colitis in transgenic and knockout animals as models of human inflammatory bowel disease. Immunol. Rev. 169: 195-207.
    • (1999) Immunol. Rev. , vol.169 , pp. 195-207
    • Bhan, A.K.1
  • 10
    • 79955566359 scopus 로고    scopus 로고
    • Recent insights into the genetics of inflammatory bowel disease
    • Cho, J.H. & S.R. Brant 2011. Recent insights into the genetics of inflammatory bowel disease. Gastroenterology 140: 1704-1712.
    • (2011) Gastroenterology , vol.140 , pp. 1704-1712
    • Cho, J.H.1    Brant, S.R.2
  • 11
    • 0031437998 scopus 로고    scopus 로고
    • Review article: intestinal permeability in Crohn's disease
    • Meddings, J.B. 1997. Review article: intestinal permeability in Crohn's disease. Aliment. Pharmacol. Ther. 11(Suppl. 3): 47-53.
    • (1997) Aliment. Pharmacol. Ther. , vol.11 , Issue.SUPPL. 3 , pp. 47-53
    • Meddings, J.B.1
  • 12
    • 0026630075 scopus 로고
    • The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease
    • Hollander, D. 1992. The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease. Scand. J. Gastroenterol. 27: 721-726.
    • (1992) Scand. J. Gastroenterol. , vol.27 , pp. 721-726
    • Hollander, D.1
  • 13
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot, J.P. et al 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1
  • 14
    • 20344389060 scopus 로고    scopus 로고
    • Toll-like receptors: linking innate and adaptive immunity
    • Pasare, C. & R. Medzhitov 2005. Toll-like receptors: linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560: 11-18.
    • (2005) Adv. Exp. Med. Biol. , vol.560 , pp. 11-18
    • Pasare, C.1    Medzhitov, R.2
  • 15
    • 78650430453 scopus 로고    scopus 로고
    • Crohn disease: a current perspective on genetics, autophagy and immunity
    • Stappenbeck, T.S. et al 2011. Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy 7: 355-374.
    • (2011) Autophagy , vol.7 , pp. 355-374
    • Stappenbeck, T.S.1
  • 16
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett, J.C. et al 2008. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40: 955-962.
    • (2008) Nat. Genet. , vol.40 , pp. 955-962
    • Barrett, J.C.1
  • 17
    • 50449091647 scopus 로고    scopus 로고
    • Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    • McCarroll, S.A. et al 2008. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat. Genet. 40: 1107-1112.
    • (2008) Nat. Genet. , vol.40 , pp. 1107-1112
    • McCarroll, S.A.1
  • 18
    • 54849421128 scopus 로고    scopus 로고
    • Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
    • Kuballa, P. et al 2008. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One 3: e3391.
    • (2008) PLoS One , vol.3
    • Kuballa, P.1
  • 19
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp, J. et al 2004. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53: 1658-1664.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1
  • 20
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell, K. et al 2008. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456: 259-263.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1
  • 21
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser, A. et al 2008. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134: 743-756.
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1
  • 23
    • 0033070061 scopus 로고    scopus 로고
    • Abnormalities in mucin gene expression in Crohn's disease
    • Buisine, M.P. et al 1999. Abnormalities in mucin gene expression in Crohn's disease. Inflamm. Bowel Dis. 5: 24-32.
    • (1999) Inflamm. Bowel Dis. , vol.5 , pp. 24-32
    • Buisine, M.P.1
  • 24
    • 0035114484 scopus 로고    scopus 로고
    • Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease
    • Kyo, K. et al 2001. Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. J. Hum. Genet. 46: 5-20.
    • (2001) J. Hum. Genet. , vol.46 , pp. 5-20
    • Kyo, K.1
  • 25
    • 0032991667 scopus 로고    scopus 로고
    • Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?
    • Soderholm, J.D. et al 1999. Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease? Gastroenterology 117: 65-72.
    • (1999) Gastroenterology , vol.117 , pp. 65-72
    • Soderholm, J.D.1
  • 26
    • 9344264671 scopus 로고    scopus 로고
    • Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha
    • Soderholm, J.D. et al 2004. Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha. Gut 53: 1817-1824.
    • (2004) Gut , vol.53 , pp. 1817-1824
    • Soderholm, J.D.1
  • 27
    • 4344700784 scopus 로고    scopus 로고
    • Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment
    • Zeissig, S. et al 2004. Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 53: 1295-1302.
    • (2004) Gut , vol.53 , pp. 1295-1302
    • Zeissig, S.1
  • 28
    • 0027441233 scopus 로고
    • Uptake and transport of macromolecules by the intestine: possible role in clinical disorders (an update)
    • Sanderson, I.R. & W.A. Walker 1993. Uptake and transport of macromolecules by the intestine: possible role in clinical disorders (an update). Gastroenterology 104: 622-639.
    • (1993) Gastroenterology , vol.104 , pp. 622-639
    • Sanderson, I.R.1    Walker, W.A.2
  • 29
    • 0030830553 scopus 로고    scopus 로고
    • Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases
    • Sartor, R.B. 1997. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am. J. Gastroenterol. 92: 5S-11S.
    • (1997) Am. J. Gastroenterol. , vol.92
    • Sartor, R.B.1
  • 30
    • 0346734343 scopus 로고    scopus 로고
    • Crohn's disease: the cold chain hypothesis
    • Hugot, J.P. et al 2003. Crohn's disease: the cold chain hypothesis. Lancet 362: 2012-2015.
    • (2003) Lancet , vol.362 , pp. 2012-2015
    • Hugot, J.P.1
  • 31
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: etiology and pathogenesis
    • Fiocchi, C. 1998. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115: 182-205.
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 32
    • 0345104218 scopus 로고    scopus 로고
    • Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease
    • Schurmann, G. et al 1999. Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease. Int. J. Colorectal Dis. 14: 41-46.
    • (1999) Int. J. Colorectal Dis. , vol.14 , pp. 41-46
    • Schurmann, G.1
  • 33
    • 0035099137 scopus 로고    scopus 로고
    • Monocyte/macrophage activation by normal bacteria and bacterial products: implications for altered epithelial function in Crohn's disease
    • Zareie, M. et al 2001. Monocyte/macrophage activation by normal bacteria and bacterial products: implications for altered epithelial function in Crohn's disease. Am. J. Pathol. 158: 1101-1109.
    • (2001) Am. J. Pathol. , vol.158 , pp. 1101-1109
    • Zareie, M.1
  • 34
    • 0000752197 scopus 로고
    • Junctional complexes in various epithelia
    • Farquhar, M.G. & G.E. Palade 1963. Junctional complexes in various epithelia. J. Cell Biol. 17: 375-412.
    • (1963) J. Cell Biol. , vol.17 , pp. 375-412
    • Farquhar, M.G.1    Palade, G.E.2
  • 35
    • 0022970442 scopus 로고
    • Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor
    • Hollander, D. et al 1986. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann. Intern. Med. 105: 883-885.
    • (1986) Ann. Intern. Med. , vol.105 , pp. 883-885
    • Hollander, D.1
  • 36
    • 0033003669 scopus 로고    scopus 로고
    • Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defense?
    • Soderholm, J.D. et al 1999. Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defense? Gut 44: 96-100.
    • (1999) Gut , vol.44 , pp. 96-100
    • Soderholm, J.D.1
  • 37
    • 0020618323 scopus 로고
    • A freeze fracture study of Crohn's disease of the terminal ileum: changes in epithelial tight junction organization
    • Marin, M.L. et al 1983. A freeze fracture study of Crohn's disease of the terminal ileum: changes in epithelial tight junction organization. Am. J. Gastroenterol. 78: 537-547.
    • (1983) Am. J. Gastroenterol. , vol.78 , pp. 537-547
    • Marin, M.L.1
  • 38
    • 0036177947 scopus 로고    scopus 로고
    • Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    • Soderholm, J.D. et al 2002. Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease. Gut 50: 307-313.
    • (2002) Gut , vol.50 , pp. 307-313
    • Soderholm, J.D.1
  • 39
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig, S. et al 2007. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56: 61-72.
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1
  • 40
    • 0036678630 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
    • Suenaert, P. et al 2002. Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am. J. Gastroenterol. 97: 2000-2004.
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 2000-2004
    • Suenaert, P.1
  • 41
    • 0015257462 scopus 로고
    • The early histological lesion of Crohn's disease
    • Morson, B.C. 1972. The early histological lesion of Crohn's disease. Proc. R. Soc. Med. 65: 71-72.
    • (1972) Proc. R. Soc. Med. , vol.65 , pp. 71-72
    • Morson, B.C.1
  • 42
    • 0036098915 scopus 로고    scopus 로고
    • Distribution of Peyer's patches in the distal ileum
    • Van Kruiningen, H.J. et al 2002. Distribution of Peyer's patches in the distal ileum. Inflamm. Bowel. Dis. 8: 180-185.
    • (2002) Inflamm. Bowel. Dis. , vol.8 , pp. 180-185
    • Van Kruiningen, H.J.1
  • 43
    • 0021266269 scopus 로고
    • Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery
    • Rutgeerts, P. et al 1984. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut 25: 665-672.
    • (1984) Gut , vol.25 , pp. 665-672
    • Rutgeerts, P.1
  • 44
    • 0018896371 scopus 로고
    • The "early" ulcerative lesion of Crohn's disease: correlative light- and scanning electron-microscopic studies
    • Rickert, R.R. & H.W. Carter 1980. The "early" ulcerative lesion of Crohn's disease: correlative light- and scanning electron-microscopic studies. J. Clin. Gastroenterol. 2: 11-19.
    • (1980) J. Clin. Gastroenterol. , vol.2 , pp. 11-19
    • Rickert, R.R.1    Carter, H.W.2
  • 45
    • 0029948461 scopus 로고    scopus 로고
    • Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry
    • Fujimura, Y., R. Kamoi & M. Iida 1996. Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry. Gut 38: 724-732.
    • (1996) Gut , vol.38 , pp. 724-732
    • Fujimura, Y.1    Kamoi, R.2    Iida, M.3
  • 46
    • 0029841664 scopus 로고    scopus 로고
    • M cells in Peyer's patches of the intestine
    • Gebert, A., H.J. Rothkotter & R. Pabst 1996. M cells in Peyer's patches of the intestine. Int. Rev. Cytol. 167: 91-159.
    • (1996) Int. Rev. Cytol. , vol.167 , pp. 91-159
    • Gebert, A.1    Rothkotter, H.J.2    Pabst, R.3
  • 47
    • 0037438711 scopus 로고    scopus 로고
    • Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches
    • Yamanaka, T. et al 2003. Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J. Immunol. 170: 816-822.
    • (2003) J. Immunol. , vol.170 , pp. 816-822
    • Yamanaka, T.1
  • 48
    • 0030951905 scopus 로고    scopus 로고
    • M cells in the rabbit palatine tonsil: the distribution, spatial arrangement and membrane subdomains as defined by confocal lectin histochemistry
    • Gebert, A. 1997. M cells in the rabbit palatine tonsil: the distribution, spatial arrangement and membrane subdomains as defined by confocal lectin histochemistry. Anat. Embryol. (Berl) 195: 353-358.
    • (1997) Anat. Embryol. (Berl) , vol.195 , pp. 353-358
    • Gebert, A.1
  • 49
    • 34247877512 scopus 로고    scopus 로고
    • Mucosal dendritic cells
    • Iwasaki, A. 2007. Mucosal dendritic cells. Annu. Rev. Immunol. 25: 381-418.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 381-418
    • Iwasaki, A.1
  • 50
    • 0032771395 scopus 로고    scopus 로고
    • The composition and function of M cell apical membranes: implications for microbial pathogenesis
    • Neutra, M.R. et al 1999. The composition and function of M cell apical membranes: implications for microbial pathogenesis. Semin. Immunol. 11: 171-181.
    • (1999) Semin. Immunol. , vol.11 , pp. 171-181
    • Neutra, M.R.1
  • 51
    • 0035174046 scopus 로고    scopus 로고
    • Collaboration of epithelial cells with organized mucosal lymphoid tissues
    • Neutra, M.R., N.J. Mantis & J.P. Kraehenbuhl 2001. Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat. Immunol. 2: 1004-1009.
    • (2001) Nat. Immunol. , vol.2 , pp. 1004-1009
    • Neutra, M.R.1    Mantis, N.J.2    Kraehenbuhl, J.P.3
  • 52
    • 0033953077 scopus 로고    scopus 로고
    • Characterization of M cell development during indomethacin-induced ileitis in rats
    • Kucharzik, T. et al 2000. Characterization of M cell development during indomethacin-induced ileitis in rats. Aliment. Pharmacol. Ther. 14: 247-256.
    • (2000) Aliment. Pharmacol. Ther. , vol.14 , pp. 247-256
    • Kucharzik, T.1
  • 53
    • 20444464523 scopus 로고    scopus 로고
    • Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease
    • Sanders, D.S. 2005. Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease. J. Clin. Pathol. 58: 568-572.
    • (2005) J. Clin. Pathol. , vol.58 , pp. 568-572
    • Sanders, D.S.1
  • 54
    • 0031467095 scopus 로고    scopus 로고
    • The role of M cells in the protection of mucosal membranes
    • Gebert, A. 1997. The role of M cells in the protection of mucosal membranes. Histochem. Cell Biol. 108: 455-470.
    • (1997) Histochem. Cell Biol. , vol.108 , pp. 455-470
    • Gebert, A.1
  • 55
    • 0023677452 scopus 로고
    • Alterations of the immune system in ulcerative colitis and Crohn's disease
    • MacDermott, R.P. & W.F. Stenson 1988. Alterations of the immune system in ulcerative colitis and Crohn's disease. Adv. Immunol. 42: 285-328.
    • (1988) Adv. Immunol. , vol.42 , pp. 285-328
    • MacDermott, R.P.1    Stenson, W.F.2
  • 56
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A.J. & T. Uhr 2004. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303: 1662-1665.
    • (2004) Science , vol.303 , pp. 1662-1665
    • Macpherson, A.J.1    Uhr, T.2
  • 57
    • 19544385282 scopus 로고    scopus 로고
    • Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
    • Macpherson, A.J., M.B. Geuking & K.D. McCoy 2005. Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology 115: 153-162.
    • (2005) Immunology , vol.115 , pp. 153-162
    • Macpherson, A.J.1    Geuking, M.B.2    McCoy, K.D.3
  • 58
    • 0041807542 scopus 로고    scopus 로고
    • Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region
    • Tamagawa, H. et al 2003. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab. Invest. 83: 1045-1053.
    • (2003) Lab. Invest. , vol.83 , pp. 1045-1053
    • Tamagawa, H.1
  • 59
    • 0033626630 scopus 로고    scopus 로고
    • Translocation of Yersinia entrocolitica across reconstituted intestinal epithelial monolayers is triggered by Yersinia invasin binding to beta1 integrins apically expressed on M-like cells
    • Schulte, R. et al 2000. Translocation of Yersinia entrocolitica across reconstituted intestinal epithelial monolayers is triggered by Yersinia invasin binding to beta1 integrins apically expressed on M-like cells. Cell Microbiol. 2: 173-185.
    • (2000) Cell Microbiol. , vol.2 , pp. 173-185
    • Schulte, R.1
  • 60
    • 0037047104 scopus 로고    scopus 로고
    • Transepithelial transport of HIV-1 by M cells is receptor-mediated
    • Fotopoulos, G. et al 2002. Transepithelial transport of HIV-1 by M cells is receptor-mediated. Proc. Natl. Acad. Sci. USA 99: 9410-9414.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9410-9414
    • Fotopoulos, G.1
  • 61
    • 0031253619 scopus 로고    scopus 로고
    • The influence of normal microbial flora on the development of chronic mucosal inflammation
    • Sartor, R.B. 1997. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res. Immunol. 148: 567-576.
    • (1997) Res. Immunol. , vol.148 , pp. 567-576
    • Sartor, R.B.1
  • 62
    • 0036140777 scopus 로고    scopus 로고
    • Mucosal flora in inflammatory bowel disease
    • Swidsinski, A. et al 2002. Mucosal flora in inflammatory bowel disease. Gastroenterology 122: 44-54.
    • (2002) Gastroenterology , vol.122 , pp. 44-54
    • Swidsinski, A.1
  • 63
    • 0036117798 scopus 로고    scopus 로고
    • Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease
    • Neut, C. et al 2002. Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease. Am. J. Gastroenterol. 97: 939-946.
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 939-946
    • Neut, C.1
  • 64
    • 2342442430 scopus 로고    scopus 로고
    • Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    • Ott, S.J. et al 2004. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 53: 685-693.
    • (2004) Gut , vol.53 , pp. 685-693
    • Ott, S.J.1
  • 65
    • 0026649731 scopus 로고
    • Mycobacterium paratuberculosis DNA in Crohn's disease tissue
    • Sanderson, J.D. et al 1992. Mycobacterium paratuberculosis DNA in Crohn's disease tissue. Gut 33: 890-896.
    • (1992) Gut , vol.33 , pp. 890-896
    • Sanderson, J.D.1
  • 66
    • 0142242225 scopus 로고    scopus 로고
    • Ileitis due to Yersinia pseudotuberculosis in Crohn's disease
    • Homewood, R. et al 2003. Ileitis due to Yersinia pseudotuberculosis in Crohn's disease. J. Infect. 47: 328-332.
    • (2003) J. Infect. , vol.47 , pp. 328-332
    • Homewood, R.1
  • 67
    • 61649113941 scopus 로고    scopus 로고
    • Prevalence of infectious pathogens in Crohn's disease
    • Knosel, T. et al 2009. Prevalence of infectious pathogens in Crohn's disease. Pathol. Res. Pract. 205: 223-230.
    • (2009) Pathol. Res. Pract. , vol.205 , pp. 223-230
    • Knosel, T.1
  • 68
    • 4143069158 scopus 로고    scopus 로고
    • High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    • Darfeuille-Michaud, A. et al 2004. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 127: 412-421.
    • (2004) Gastroenterology , vol.127 , pp. 412-421
    • Darfeuille-Michaud, A.1
  • 69
    • 3242737791 scopus 로고    scopus 로고
    • Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    • Martin, H.M. et al 2004. Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology 127: 80-93.
    • (2004) Gastroenterology , vol.127 , pp. 80-93
    • Martin, H.M.1
  • 70
    • 0036741464 scopus 로고    scopus 로고
    • Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls
    • Kleessen, B. et al 2002. Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls. Scand. J. Gastroenterol. 37: 1034-1041.
    • (2002) Scand. J. Gastroenterol. , vol.37 , pp. 1034-1041
    • Kleessen, B.1
  • 71
    • 44649139179 scopus 로고    scopus 로고
    • Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease
    • Keita, A.V. et al 2008. Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease. J. Pathol. 215: 135-144.
    • (2008) J. Pathol. , vol.215 , pp. 135-144
    • Keita, A.V.1
  • 72
    • 58249112153 scopus 로고    scopus 로고
    • CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease
    • Salim, S.Y. et al 2009. CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease. Am. J. Pathol. 174: 82-90.
    • (2009) Am. J. Pathol. , vol.174 , pp. 82-90
    • Salim, S.Y.1
  • 73
    • 0032768352 scopus 로고    scopus 로고
    • Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease
    • Boudeau, J. et al 1999. Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease. Infect. Immun. 67: 4499-509.
    • (1999) Infect. Immun. , vol.67 , pp. 4499-4509
    • Boudeau, J.1
  • 74
    • 0031758230 scopus 로고    scopus 로고
    • Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
    • Darfeuille-Michaud, A. et al 1998. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology 115: 1405-1413.
    • (1998) Gastroenterology , vol.115 , pp. 1405-1413
    • Darfeuille-Michaud, A.1
  • 75
    • 34249886868 scopus 로고    scopus 로고
    • CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
    • Barnich, N. et al 2007. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J. Clin. Invest. 117: 1566-1574.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1566-1574
    • Barnich, N.1
  • 76
    • 79952230127 scopus 로고    scopus 로고
    • Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae
    • Chassaing, B. et al 2011. Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae. J. Clin. Invest. 121: 966-975.
    • (2011) J. Clin. Invest. , vol.121 , pp. 966-975
    • Chassaing, B.1
  • 77
    • 84855644351 scopus 로고    scopus 로고
    • Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and Crohn's disease patients
    • Denizot, J. et al 2012 Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and Crohn's disease patients. Inflamm. Bowel Dis. 18: 294-304.
    • (2012) Inflamm. Bowel Dis. , vol.18 , pp. 294-304
    • Denizot, J.1
  • 78
    • 0035897412 scopus 로고    scopus 로고
    • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells
    • Furuse, M. et al 2001. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J. Cell Biol. 153: 263-272.
    • (2001) J. Cell Biol. , vol.153 , pp. 263-272
    • Furuse, M.1
  • 79
    • 0036079594 scopus 로고    scopus 로고
    • Paneth cell trypsin is the processing enzyme for human defensin-5
    • Ghosh, D. et al 2002. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat. Immunol. 3: 583-590.
    • (2002) Nat. Immunol. , vol.3 , pp. 583-590
    • Ghosh, D.1
  • 80
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp, J. et al 2005. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. USA 102: 18129-18134.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18129-18134
    • Wehkamp, J.1
  • 81
    • 40449103288 scopus 로고    scopus 로고
    • Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin
    • Elphick, D., S. Liddell & Y.R. Mahida 2008. Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin. Am. J. Pathol. 172: 702-713.
    • (2008) Am. J. Pathol. , vol.172 , pp. 702-713
    • Elphick, D.1    Liddell, S.2    Mahida, Y.R.3
  • 82
    • 37349070287 scopus 로고    scopus 로고
    • The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4
    • Wehkamp, J. et al 2007. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J. Immunol. 179: 3109-3118.
    • (2007) J. Immunol. , vol.179 , pp. 3109-3118
    • Wehkamp, J.1


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