메뉴 건너뛰기




Volumn 31, Issue 2, 2016, Pages 169-177

Synaptic failure and α-synuclein

Author keywords

synapse; synuclein; synucleopathies

Indexed keywords

ALPHA SYNUCLEIN;

EID: 84955441116     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26479     Document Type: Review
Times cited : (136)

References (131)
  • 1
    • 84871414210 scopus 로고    scopus 로고
    • The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
    • Lashuel HA, Overk CR, Oueslati A, et al. The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 2013;14:38-48.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 38-48
    • Lashuel, H.A.1    Overk, C.R.2    Oueslati, A.3
  • 2
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • Weinreb PH, Zhen W, Poon AW, et al. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 1996;35:13709-13715.
    • (1996) Biochemistry , vol.35 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3
  • 3
    • 80052398365 scopus 로고    scopus 로고
    • alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    • Bartels T, Choi JG, Selkoe DJ. alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 2011;477:107-110.
    • (2011) Nature , vol.477 , pp. 107-110
    • Bartels, T.1    Choi, J.G.2    Selkoe, D.J.3
  • 4
    • 84919449363 scopus 로고    scopus 로고
    • alpha-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
    • Burre J, Sharma M, Sudhof TC. alpha-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc Natl Acad Sci U S A 2014;111:E4274-4283.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E4274-4283
    • Burre, J.1    Sharma, M.2    Sudhof, T.C.3
  • 6
    • 0032568534 scopus 로고    scopus 로고
    • alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, et al. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci U S A 1998;95:6469-6473.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3
  • 7
    • 0032584686 scopus 로고    scopus 로고
    • Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, et al. Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 1998;251:205-208.
    • (1998) Neurosci Lett , vol.251 , pp. 205-208
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3
  • 8
    • 84879605541 scopus 로고    scopus 로고
    • Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
    • Appel-Cresswell S, Vilarino-Guell C, Encarnacion M, et al. Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. Mov Disord 2013;28:811-813.
    • (2013) Mov Disord , vol.28 , pp. 811-813
    • Appel-Cresswell, S.1    Vilarino-Guell, C.2    Encarnacion, M.3
  • 9
    • 4644290985 scopus 로고    scopus 로고
    • Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
    • Chartier-Harlin MC, Kachergus J, Roumier C, et al. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004;364:1167-1169.
    • (2004) Lancet , vol.364 , pp. 1167-1169
    • Chartier-Harlin, M.C.1    Kachergus, J.2    Roumier, C.3
  • 10
    • 84885461450 scopus 로고    scopus 로고
    • alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
    • Kiely AP, Asi YT, Kara E, et al. alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathol 2013;125:753-769.
    • (2013) Acta Neuropathol , vol.125 , pp. 753-769
    • Kiely, A.P.1    Asi, Y.T.2    Kara, E.3
  • 11
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • Kruger R, Kuhn W, Muller T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 1998;18:106-108.
    • (1998) Nat Genet , vol.18 , pp. 106-108
    • Kruger, R.1    Kuhn, W.2    Muller, T.3
  • 12
    • 84902118984 scopus 로고    scopus 로고
    • Novel alpha-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
    • Pasanen P, Myllykangas L, Siitonen M, et al. Novel alpha-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology. Neurobiol Aging 2014;35:2180 e2181-2185.
    • (2014) Neurobiol Aging , vol.35 , pp. 2180 e2181-2185
    • Pasanen, P.1    Myllykangas, L.2    Siitonen, M.3
  • 13
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 14
    • 0242300619 scopus 로고    scopus 로고
    • alpha-Synuclein locus triplication causes Parkinson's disease
    • Singleton AB, Farrer M, Johnson J, et al. alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003;302:841.
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1    Farrer, M.2    Johnson, J.3
  • 15
    • 10744230149 scopus 로고    scopus 로고
    • The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
    • Zarranz JJ, Alegre J, Gomez-Esteban JC, et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 2004;55:164-173.
    • (2004) Ann Neurol , vol.55 , pp. 164-173
    • Zarranz, J.J.1    Alegre, J.2    Gomez-Esteban, J.C.3
  • 16
    • 33645111633 scopus 로고    scopus 로고
    • Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease
    • Mizuta I, Satake W, Nakabayashi Y, et al. Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Hum Mol Genet 2006;15:1151-1158.
    • (2006) Hum Mol Genet , vol.15 , pp. 1151-1158
    • Mizuta, I.1    Satake, W.2    Nakabayashi, Y.3
  • 17
    • 79951811351 scopus 로고    scopus 로고
    • Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
    • International Parkinson Disease Genomics C, Nalls MA, Plagnol V, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 2011;377:641-649.
    • (2011) Lancet , vol.377 , pp. 641-649
    • Nalls, M.A.1    Plagnol, V.2
  • 18
    • 67249139655 scopus 로고    scopus 로고
    • SNCA variants are associated with increased risk for multiple system atrophy
    • Scholz SW, Houlden H, Schulte C, et al. SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol 2009;65:610-614.
    • (2009) Ann Neurol , vol.65 , pp. 610-614
    • Scholz, S.W.1    Houlden, H.2    Schulte, C.3
  • 19
    • 77951842993 scopus 로고    scopus 로고
    • Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains
    • Jowaed A, Schmitt I, Kaut O, et al. Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. J Neurosci 2010;30:6355-6359.
    • (2010) J Neurosci , vol.30 , pp. 6355-6359
    • Jowaed, A.1    Schmitt, I.2    Kaut, O.3
  • 20
    • 0023722437 scopus 로고
    • Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L, Campanelli JT, Scheller RH. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 1988;8:2804-2815.
    • (1988) J Neurosci , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 21
    • 0029127954 scopus 로고
    • Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
    • George JM, Jin H, Woods WS, et al. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 1995;15:361-372.
    • (1995) Neuron , vol.15 , pp. 361-372
    • George, J.M.1    Jin, H.2    Woods, W.S.3
  • 22
    • 0025943571 scopus 로고
    • The rat brain synucleins; family of proteins transiently associated with neuronal membrane
    • Maroteaux L, Scheller RH. The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res Mol Brain Res 1991;11:335-343.
    • (1991) Brain Res Mol Brain Res , vol.11 , pp. 335-343
    • Maroteaux, L.1    Scheller, R.H.2
  • 23
    • 0028985267 scopus 로고
    • The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A, Masliah E, Yoshimoto M, et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995;14:467-475.
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3
  • 24
    • 0028277520 scopus 로고
    • Identification of two distinct synucleins from human brain
    • Jakes R, Spillantini MG, Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett 1994;345:27-32.
    • (1994) FEBS Lett , vol.345 , pp. 27-32
    • Jakes, R.1    Spillantini, M.G.2    Goedert, M.3
  • 25
    • 0031051539 scopus 로고    scopus 로고
    • Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons
    • Withers GS, George JM, Banker GA, et al. Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. Brain Res Dev Brain Res 1997;99:87-94.
    • (1997) Brain Res Dev Brain Res , vol.99 , pp. 87-94
    • Withers, G.S.1    George, J.M.2    Banker, G.A.3
  • 26
    • 84935491802 scopus 로고    scopus 로고
    • alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons
    • Zaltieri M, Grigoletto J, Longhena F, et al. alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons. J Cell Sci 2015;128:2231-2243.
    • (2015) J Cell Sci , vol.128 , pp. 2231-2243
    • Zaltieri, M.1    Grigoletto, J.2    Longhena, F.3
  • 27
    • 0034193399 scopus 로고    scopus 로고
    • Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
    • Murphy DD, Rueter SM, Trojanowski JQ, et al. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J Neurosci 2000;20:3214-3220.
    • (2000) J Neurosci , vol.20 , pp. 3214-3220
    • Murphy, D.D.1    Rueter, S.M.2    Trojanowski, J.Q.3
  • 28
    • 77957347060 scopus 로고    scopus 로고
    • Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
    • Burre J, Sharma M, Tsetsenis T, et al. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 2010;329:1663-1667.
    • (2010) Science , vol.329 , pp. 1663-1667
    • Burre, J.1    Sharma, M.2    Tsetsenis, T.3
  • 29
    • 0034280435 scopus 로고    scopus 로고
    • Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
    • Kahle PJ, Neumann M, Ozmen L, et al. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci 2000;20:6365-6373.
    • (2000) J Neurosci , vol.20 , pp. 6365-6373
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 30
    • 3342951965 scopus 로고    scopus 로고
    • Lipid rafts mediate the synaptic localization of alpha-synuclein
    • Fortin DL, Troyer MD, Nakamura K, et al. Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 2004;24:6715-6723.
    • (2004) J Neurosci , vol.24 , pp. 6715-6723
    • Fortin, D.L.1    Troyer, M.D.2    Nakamura, K.3
  • 31
    • 24744432079 scopus 로고    scopus 로고
    • A combinatorial code for the interaction of alpha-synuclein with membranes
    • Kubo S, Nemani VM, Chalkley RJ, et al. A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem 2005;280:31664-31672.
    • (2005) J Biol Chem , vol.280 , pp. 31664-31672
    • Kubo, S.1    Nemani, V.M.2    Chalkley, R.J.3
  • 32
    • 84883147939 scopus 로고    scopus 로고
    • Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
    • Garcia-Reitboeck P, Anichtchik O, Dalley JW, et al. Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. Exp Neurol 2013;248:541-545.
    • (2013) Exp Neurol , vol.248 , pp. 541-545
    • Garcia-Reitboeck, P.1    Anichtchik, O.2    Dalley, J.W.3
  • 33
    • 0035341443 scopus 로고    scopus 로고
    • Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    • Simon HH, Saueressig H, Wurst W, et al. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J Neurosci 2001;21:3126-3134.
    • (2001) J Neurosci , vol.21 , pp. 3126-3134
    • Simon, H.H.1    Saueressig, H.2    Wurst, W.3
  • 34
    • 2942552153 scopus 로고    scopus 로고
    • Alpha-synuclein is expressed in different tissues during human fetal development
    • Ltic S, Perovic M, Mladenovic A, et al. Alpha-synuclein is expressed in different tissues during human fetal development. J Mol Neurosci 2004;22:199-204.
    • (2004) J Mol Neurosci , vol.22 , pp. 199-204
    • Ltic, S.1    Perovic, M.2    Mladenovic, A.3
  • 35
    • 37849028683 scopus 로고    scopus 로고
    • Red blood cells are the major source of alpha-synuclein in blood
    • Barbour R, Kling K, Anderson JP, et al. Red blood cells are the major source of alpha-synuclein in blood. Neurodegener Dis 2008;5:55-59.
    • (2008) Neurodegener Dis , vol.5 , pp. 55-59
    • Barbour, R.1    Kling, K.2    Anderson, J.P.3
  • 36
    • 84935826761 scopus 로고    scopus 로고
    • Parkinson-causing alpha-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
    • Dettmer U, Newman AJ, Soldner F, et al. Parkinson-causing alpha-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun 2015;6:7314.
    • (2015) Nat Commun , vol.6 , pp. 7314
    • Dettmer, U.1    Newman, A.J.2    Soldner, F.3
  • 37
    • 84867787595 scopus 로고    scopus 로고
    • Systematic mutagenesis of alpha-synuclein reveals distinct sequence requirements for physiological and pathological activities
    • Burre J, Sharma M, Sudhof TC. Systematic mutagenesis of alpha-synuclein reveals distinct sequence requirements for physiological and pathological activities. J Neurosci 2012;32:15227-15242.
    • (2012) J Neurosci , vol.32 , pp. 15227-15242
    • Burre, J.1    Sharma, M.2    Sudhof, T.C.3
  • 38
    • 84879033702 scopus 로고    scopus 로고
    • Native alpha-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
    • Diao J, Burre J, Vivona S, et al. Native alpha-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. Elife 2013;2:e00592.
    • (2013) Elife , vol.2
    • Diao, J.1    Burre, J.2    Vivona, S.3
  • 39
    • 27544507306 scopus 로고    scopus 로고
    • Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    • Chandra S, Gallardo G, Fernandez-Chacon R, et al. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 2005;123:383-396.
    • (2005) Cell , vol.123 , pp. 383-396
    • Chandra, S.1    Gallardo, G.2    Fernandez-Chacon, R.3
  • 40
    • 14644415031 scopus 로고    scopus 로고
    • The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
    • Fernandez-Chacon R, Wolfel M, Nishimune H, et al. The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron 2004;42:237-251.
    • (2004) Neuron , vol.42 , pp. 237-251
    • Fernandez-Chacon, R.1    Wolfel, M.2    Nishimune, H.3
  • 41
    • 84904006504 scopus 로고    scopus 로고
    • Synucleins regulate the kinetics of synaptic vesicle endocytosis
    • Vargas KJ, Makani S, Davis T, et al. Synucleins regulate the kinetics of synaptic vesicle endocytosis. J Neurosci 2014;34:9364-9376.
    • (2014) J Neurosci , vol.34 , pp. 9364-9376
    • Vargas, K.J.1    Makani, S.2    Davis, T.3
  • 42
    • 78650505099 scopus 로고    scopus 로고
    • CSPalpha promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity
    • Sharma M, Burre J, Sudhof TC. CSPalpha promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol 2011;13:30-39.
    • (2011) Nat Cell Biol , vol.13 , pp. 30-39
    • Sharma, M.1    Burre, J.2    Sudhof, T.C.3
  • 43
    • 84859630931 scopus 로고    scopus 로고
    • Identification of CSPalpha clients reveals a role in dynamin 1 regulation
    • Zhang YQ, Henderson MX, Colangelo CM, et al. Identification of CSPalpha clients reveals a role in dynamin 1 regulation. Neuron 2012;74:136-150.
    • (2012) Neuron , vol.74 , pp. 136-150
    • Zhang, Y.Q.1    Henderson, M.X.2    Colangelo, C.M.3
  • 44
    • 77954215793 scopus 로고    scopus 로고
    • Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis
    • Darios F, Ruiperez V, Lopez I, et al. Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO Rep 2010;11:528-533.
    • (2010) EMBO Rep , vol.11 , pp. 528-533
    • Darios, F.1    Ruiperez, V.2    Lopez, I.3
  • 45
    • 84875990438 scopus 로고    scopus 로고
    • alpha-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers
    • DeWitt DC, Rhoades E. alpha-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers. Biochemistry 2013;52:2385-2387.
    • (2013) Biochemistry , vol.52 , pp. 2385-2387
    • DeWitt, D.C.1    Rhoades, E.2
  • 46
    • 84908221942 scopus 로고    scopus 로고
    • alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling
    • Wang L, Das U, Scott DA, et al. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol 2014;24:2319-2326.
    • (2014) Curr Biol , vol.24 , pp. 2319-2326
    • Wang, L.1    Das, U.2    Scott, D.A.3
  • 47
    • 84864258151 scopus 로고    scopus 로고
    • alpha-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis
    • Scott D, Roy S. alpha-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis. J Neurosci 2012;32:10129-10135.
    • (2012) J Neurosci , vol.32 , pp. 10129-10135
    • Scott, D.1    Roy, S.2
  • 48
    • 73549085595 scopus 로고    scopus 로고
    • Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    • Nemani VM, Lu W, Berge V, et al. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 2010;65:66-79.
    • (2010) Neuron , vol.65 , pp. 66-79
    • Nemani, V.M.1    Lu, W.2    Berge, V.3
  • 49
    • 84857716290 scopus 로고    scopus 로고
    • Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons
    • Lundblad M, Decressac M, Mattsson B, et al. Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons. Proc Natl Acad Sci U S A 2012;109:3213-3219.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3213-3219
    • Lundblad, M.1    Decressac, M.2    Mattsson, B.3
  • 50
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich A, Schmitz Y, Farinas I, et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000;25:239-252.
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1    Schmitz, Y.2    Farinas, I.3
  • 51
    • 79956296370 scopus 로고    scopus 로고
    • Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family
    • Anwar S, Peters O, Millership S, et al. Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci 2011;31:7264-7274.
    • (2011) J Neurosci , vol.31 , pp. 7264-7274
    • Anwar, S.1    Peters, O.2    Millership, S.3
  • 52
    • 0035066885 scopus 로고    scopus 로고
    • Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
    • Lee FJ, Liu F, Pristupa ZB, et al. Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J 2001;15:916-926.
    • (2001) FASEB J , vol.15 , pp. 916-926
    • Lee, F.J.1    Liu, F.2    Pristupa, Z.B.3
  • 53
    • 0037451858 scopus 로고    scopus 로고
    • Attenuation of dopamine transporter activity by alpha-synuclein
    • Wersinger C, Sidhu A. Attenuation of dopamine transporter activity by alpha-synuclein. Neurosci Lett 2003;340:189-192.
    • (2003) Neurosci Lett , vol.340 , pp. 189-192
    • Wersinger, C.1    Sidhu, A.2
  • 54
    • 39149111608 scopus 로고    scopus 로고
    • Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells
    • Guo JT, Chen AQ, Kong Q, et al. Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells. Cell Mol Neurobiol 2008;28:35-47.
    • (2008) Cell Mol Neurobiol , vol.28 , pp. 35-47
    • Guo, J.T.1    Chen, A.Q.2    Kong, Q.3
  • 55
    • 83755181403 scopus 로고    scopus 로고
    • alpha-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter
    • Swant J, Goodwin JS, North A, et al. alpha-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. J Biol Chem 2011;286:43933-43943.
    • (2011) J Biol Chem , vol.286 , pp. 43933-43943
    • Swant, J.1    Goodwin, J.S.2    North, A.3
  • 56
    • 84940535866 scopus 로고    scopus 로고
    • Dopamine transporter activity is modulated by alpha-synuclein
    • Butler B, Goodwin S, Saha K, et al. Dopamine transporter activity is modulated by alpha-synuclein. J Biol Chem 2015;290:19009.
    • (2015) J Biol Chem , vol.290 , pp. 19009
    • Butler, B.1    Goodwin, S.2    Saha, K.3
  • 57
    • 0033215063 scopus 로고    scopus 로고
    • Synucleins in synaptic plasticity and neurodegenerative disorders
    • Clayton DF, George JM. Synucleins in synaptic plasticity and neurodegenerative disorders. J Neurosci Res 1999;58:120-129.
    • (1999) J Neurosci Res , vol.58 , pp. 120-129
    • Clayton, D.F.1    George, J.M.2
  • 58
    • 0035901724 scopus 로고    scopus 로고
    • Testosterone regulates alpha-synuclein mRNA in the avian song system
    • Hartman VN, Miller MA, Clayton DF, et al. Testosterone regulates alpha-synuclein mRNA in the avian song system. Neuroreport 2001;12:943-946.
    • (2001) Neuroreport , vol.12 , pp. 943-946
    • Hartman, V.N.1    Miller, M.A.2    Clayton, D.F.3
  • 59
    • 0037109727 scopus 로고    scopus 로고
    • Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    • Cabin DE, Shimazu K, Murphy D, et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 2002;22:8797-8807.
    • (2002) J Neurosci , vol.22 , pp. 8797-8807
    • Cabin, D.E.1    Shimazu, K.2    Murphy, D.3
  • 60
    • 79952532984 scopus 로고    scopus 로고
    • Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein
    • Chadchankar H, Ihalainen J, Tanila H, et al. Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein. Brain Res 2011;1382:37-44.
    • (2011) Brain Res , vol.1382 , pp. 37-44
    • Chadchankar, H.1    Ihalainen, J.2    Tanila, H.3
  • 61
    • 33746533924 scopus 로고    scopus 로고
    • Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    • Cooper AA, Gitler AD, Cashikar A, et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006;313:324-328.
    • (2006) Science , vol.313 , pp. 324-328
    • Cooper, A.A.1    Gitler, A.D.2    Cashikar, A.3
  • 62
    • 38349160161 scopus 로고    scopus 로고
    • The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
    • Gitler AD, Bevis BJ, Shorter J, et al. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A 2008;105:145-150.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 145-150
    • Gitler, A.D.1    Bevis, B.J.2    Shorter, J.3
  • 63
    • 77952900626 scopus 로고    scopus 로고
    • Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs
    • Thayanidhi N, Helm JR, Nycz DC, et al. Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs. Mol Biol Cell 2010;21:1850-1863.
    • (2010) Mol Biol Cell , vol.21 , pp. 1850-1863
    • Thayanidhi, N.1    Helm, J.R.2    Nycz, D.C.3
  • 64
    • 84924625546 scopus 로고    scopus 로고
    • Impaired intracellular trafficking defines early Parkinson's disease
    • Hunn BH, Cragg SJ, Bolam JP, et al. Impaired intracellular trafficking defines early Parkinson's disease. Trends Neurosci 2015;38:178-188.
    • (2015) Trends Neurosci , vol.38 , pp. 178-188
    • Hunn, B.H.1    Cragg, S.J.2    Bolam, J.P.3
  • 65
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba M, Nakajo S, Tu PH, et al. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998;152:879-884.
    • (1998) Am J Pathol , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3
  • 66
    • 67349279396 scopus 로고    scopus 로고
    • Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    • Beach TG, Adler CH, Lue L, et al. Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 2009;117:613-634.
    • (2009) Acta Neuropathol , vol.117 , pp. 613-634
    • Beach, T.G.1    Adler, C.H.2    Lue, L.3
  • 67
    • 7944238570 scopus 로고    scopus 로고
    • Lewy body-related alpha-synucleinopathy in the aged human brain
    • Jellinger KA. Lewy body-related alpha-synucleinopathy in the aged human brain. J Neural Transm 2004;111:1219-1235.
    • (2004) J Neural Transm , vol.111 , pp. 1219-1235
    • Jellinger, K.A.1
  • 68
    • 41149177434 scopus 로고    scopus 로고
    • The progression of pathology in longitudinally followed patients with Parkinson's disease
    • Halliday G, Hely M, Reid W, et al. The progression of pathology in longitudinally followed patients with Parkinson's disease. Acta Neuropathol 2008;115:409-415.
    • (2008) Acta Neuropathol , vol.115 , pp. 409-415
    • Halliday, G.1    Hely, M.2    Reid, W.3
  • 69
    • 0034827449 scopus 로고    scopus 로고
    • Cortical Lewy body pathology in the diagnosis of dementia
    • Harding AJ, Halliday GM. Cortical Lewy body pathology in the diagnosis of dementia. Acta Neuropathol 2001;102:355-363.
    • (2001) Acta Neuropathol , vol.102 , pp. 355-363
    • Harding, A.J.1    Halliday, G.M.2
  • 70
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak H, Del Tredici K, Rub U, et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197-211.
    • (2003) Neurobiol Aging , vol.24 , pp. 197-211
    • Braak, H.1    Del Tredici, K.2    Rub, U.3
  • 71
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno LS. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 1996;55:259-272.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 72
    • 0031474418 scopus 로고    scopus 로고
    • Contribution of somal Lewy bodies to neuronal death
    • Tompkins MM, Hill WD. Contribution of somal Lewy bodies to neuronal death. Brain Res 1997;775:24-29.
    • (1997) Brain Res , vol.775 , pp. 24-29
    • Tompkins, M.M.1    Hill, W.D.2
  • 73
    • 0344285993 scopus 로고    scopus 로고
    • Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies
    • Gomez-Isla T, Growdon WB, McNamara M, et al. Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies. Neurology 1999;53:2003-2009.
    • (1999) Neurology , vol.53 , pp. 2003-2009
    • Gomez-Isla, T.1    Growdon, W.B.2    McNamara, M.3
  • 74
    • 0033923545 scopus 로고    scopus 로고
    • Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease
    • Mattila PM, Rinne JO, Helenius H, et al. Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathol 2000;100:285-290.
    • (2000) Acta Neuropathol , vol.100 , pp. 285-290
    • Mattila, P.M.1    Rinne, J.O.2    Helenius, H.3
  • 75
    • 34547626782 scopus 로고    scopus 로고
    • In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
    • Weisman D, Cho M, Taylor C, et al. In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. Neurology 2007;69:356-359.
    • (2007) Neurology , vol.69 , pp. 356-359
    • Weisman, D.1    Cho, M.2    Taylor, C.3
  • 76
    • 84858259953 scopus 로고    scopus 로고
    • Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease
    • Parkkinen L, O'Sullivan SS, Collins C, et al. Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease. J Parkinsons Dis 2011;1:277-286.
    • (2011) J Parkinsons Dis , vol.1 , pp. 277-286
    • Parkkinen, L.1    O'Sullivan, S.S.2    Collins, C.3
  • 77
    • 84871273435 scopus 로고    scopus 로고
    • Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
    • Milber JM, Noorigian JV, Morley JF, et al. Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease. Neurology 2012;79:2307-2314.
    • (2012) Neurology , vol.79 , pp. 2307-2314
    • Milber, J.M.1    Noorigian, J.V.2    Morley, J.F.3
  • 78
    • 79952742454 scopus 로고    scopus 로고
    • In vivo demonstration that alpha-synuclein oligomers are toxic
    • Winner B, Jappelli R, Maji SK, et al. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A 2011;108:4194-4199.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4194-4199
    • Winner, B.1    Jappelli, R.2    Maji, S.K.3
  • 79
    • 70350338222 scopus 로고    scopus 로고
    • Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models
    • Karpinar DP, Balija MB, Kugler S, et al. Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J 2009;28:3256-3268.
    • (2009) EMBO J , vol.28 , pp. 3256-3268
    • Karpinar, D.P.1    Balija, M.B.2    Kugler, S.3
  • 80
    • 84938704559 scopus 로고    scopus 로고
    • Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain
    • Roberts RF, Wade-Martins R, Alegre-Abarrategui J. Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain. Brain 2015;138:1642-1657.
    • (2015) Brain , vol.138 , pp. 1642-1657
    • Roberts, R.F.1    Wade-Martins, R.2    Alegre-Abarrategui, J.3
  • 81
    • 0033874288 scopus 로고    scopus 로고
    • The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases
    • Schulz-Schaeffer WJ, Tschoke S, Kranefuss N, et al. The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases. Am J Pathol 2000;156:51-56.
    • (2000) Am J Pathol , vol.156 , pp. 51-56
    • Schulz-Schaeffer, W.J.1    Tschoke, S.2    Kranefuss, N.3
  • 82
    • 33846997878 scopus 로고    scopus 로고
    • Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    • Kramer ML, Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007;27:1405-1410.
    • (2007) J Neurosci , vol.27 , pp. 1405-1410
    • Kramer, M.L.1    Schulz-Schaeffer, W.J.2
  • 83
    • 41849151164 scopus 로고    scopus 로고
    • Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay
    • Kramer ML, Behrens C, Schulz-Schaeffer WJ. Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay. Biotechniques 2008;44:403-411.
    • (2008) Biotechniques , vol.44 , pp. 403-411
    • Kramer, M.L.1    Behrens, C.2    Schulz-Schaeffer, W.J.3
  • 84
    • 77957266699 scopus 로고    scopus 로고
    • Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice
    • Tanji K, Mori F, Mimura J, et al. Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice. Acta Neuropathol 2010;120:145-154.
    • (2010) Acta Neuropathol , vol.120 , pp. 145-154
    • Tanji, K.1    Mori, F.2    Mimura, J.3
  • 85
    • 39749123263 scopus 로고    scopus 로고
    • Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    • Orimo S, Uchihara T, Nakamura A, et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008;131:642-650.
    • (2008) Brain , vol.131 , pp. 642-650
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3
  • 86
    • 77950511411 scopus 로고    scopus 로고
    • Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
    • Klein JC, Eggers C, Kalbe E, et al. Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo. Neurology 2010;74:885-892.
    • (2010) Neurology , vol.74 , pp. 885-892
    • Klein, J.C.1    Eggers, C.2    Kalbe, E.3
  • 87
    • 0036792789 scopus 로고    scopus 로고
    • Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease
    • Tiraboschi P, Hansen LA, Alford M, et al. Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease. Arch Gen Psychiatry 2002;59:946-951.
    • (2002) Arch Gen Psychiatry , vol.59 , pp. 946-951
    • Tiraboschi, P.1    Hansen, L.A.2    Alford, M.3
  • 88
    • 0028279958 scopus 로고
    • Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease
    • Perry EK, Haroutunian V, Davis KL, et al. Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease. Neuroreport 1994;5:747-749.
    • (1994) Neuroreport , vol.5 , pp. 747-749
    • Perry, E.K.1    Haroutunian, V.2    Davis, K.L.3
  • 89
    • 0032874321 scopus 로고    scopus 로고
    • Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution
    • Piggott MA, Marshall EF, Thomas N, et al. Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution. Brain 1999;122(Pt 8):1449-1468.
    • (1999) Brain , vol.122 , pp. 1449-1468
    • Piggott, M.A.1    Marshall, E.F.2    Thomas, N.3
  • 90
    • 0031682676 scopus 로고    scopus 로고
    • Biochemical aspects of Parkinson's disease
    • Hornykiewicz O. Biochemical aspects of Parkinson's disease. Neurology 1998;51:S2-S9.
    • (1998) Neurology , vol.51 , pp. S2-S9
    • Hornykiewicz, O.1
  • 91
    • 77953796839 scopus 로고    scopus 로고
    • A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration
    • Scott DA, Tabarean I, Tang Y, et al. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci 2010;30:8083-8095.
    • (2010) J Neurosci , vol.30 , pp. 8083-8095
    • Scott, D.A.1    Tabarean, I.2    Tang, Y.3
  • 92
    • 33751113009 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
    • Larsen KE, Schmitz Y, Troyer MD, et al. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci 2006;26:11915-11922.
    • (2006) J Neurosci , vol.26 , pp. 11915-11922
    • Larsen, K.E.1    Schmitz, Y.2    Troyer, M.D.3
  • 93
    • 84862646368 scopus 로고    scopus 로고
    • Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
    • Gaugler MN, Genc O, Bobela W, et al. Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. Acta Neuropathol 2012;123:653-669.
    • (2012) Acta Neuropathol , vol.123 , pp. 653-669
    • Gaugler, M.N.1    Genc, O.2    Bobela, W.3
  • 94
    • 77954379317 scopus 로고    scopus 로고
    • SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease
    • Garcia-Reitbock P, Anichtchik O, Bellucci A, et al. SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. Brain 2010;133:2032-2044.
    • (2010) Brain , vol.133 , pp. 2032-2044
    • Garcia-Reitbock, P.1    Anichtchik, O.2    Bellucci, A.3
  • 95
    • 84885743813 scopus 로고    scopus 로고
    • Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
    • Janezic S, Threlfell S, Dodson PD, et al. Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A 2013;110:E4016-4025.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E4016-4025
    • Janezic, S.1    Threlfell, S.2    Dodson, P.D.3
  • 96
    • 0024434128 scopus 로고
    • Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization
    • German DC, Manaye K, Smith WK, et al. Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization. Ann Neurol 1989;26:507-514.
    • (1989) Ann Neurol , vol.26 , pp. 507-514
    • German, D.C.1    Manaye, K.2    Smith, W.K.3
  • 97
    • 0023874410 scopus 로고
    • Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications
    • Kish SJ, Shannak K, Hornykiewicz O. Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. N Engl J Med 1988;318:876-880.
    • (1988) N Engl J Med , vol.318 , pp. 876-880
    • Kish, S.J.1    Shannak, K.2    Hornykiewicz, O.3
  • 98
    • 67849118598 scopus 로고    scopus 로고
    • In vivo imaging of synaptic function in the central nervous system: I. Movement disorders and dementia
    • Nikolaus S, Antke C, Muller HW. In vivo imaging of synaptic function in the central nervous system: I. Movement disorders and dementia. Behav Brain Res 2009;204:1-31.
    • (2009) Behav Brain Res , vol.204 , pp. 1-31
    • Nikolaus, S.1    Antke, C.2    Muller, H.W.3
  • 99
    • 63849332293 scopus 로고    scopus 로고
    • Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy
    • Chung CY, Koprich JB, Siddiqi H, et al. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci 2009;29:3365-3373.
    • (2009) J Neurosci , vol.29 , pp. 3365-3373
    • Chung, C.Y.1    Koprich, J.B.2    Siddiqi, H.3
  • 100
    • 80053613574 scopus 로고    scopus 로고
    • Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
    • Volpicelli-Daley LA, Luk KC, Patel TP, et al. Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 2011;72:57-71.
    • (2011) Neuron , vol.72 , pp. 57-71
    • Volpicelli-Daley, L.A.1    Luk, K.C.2    Patel, T.P.3
  • 101
    • 84872744821 scopus 로고    scopus 로고
    • Monomeric synucleins generate membrane curvature
    • Westphal CH, Chandra SS. Monomeric synucleins generate membrane curvature. J Biol Chem 2013;288:1829-1840.
    • (2013) J Biol Chem , vol.288 , pp. 1829-1840
    • Westphal, C.H.1    Chandra, S.S.2
  • 102
    • 84874611934 scopus 로고    scopus 로고
    • Large alpha-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
    • Choi BK, Choi MG, Kim JY, et al. Large alpha-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking. Proc Natl Acad Sci U S A 2013;110:4087-4092.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 4087-4092
    • Choi, B.K.1    Choi, M.G.2    Kim, J.Y.3
  • 103
    • 84902170828 scopus 로고    scopus 로고
    • Is Parkinson's disease a vesicular dopamine storage disorder?. Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatum
    • Pifl C, Rajput A, Reither H, et al. Is Parkinson's disease a vesicular dopamine storage disorder?. Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatum. J Neurosci 2014;34:8210-8218.
    • (2014) J Neurosci , vol.34 , pp. 8210-8218
    • Pifl, C.1    Rajput, A.2    Reither, H.3
  • 104
    • 2342496196 scopus 로고    scopus 로고
    • alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease
    • Sidhu A, Wersinger C, Vernier P. alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. FEBS Lett 2004;565:1-5.
    • (2004) FEBS Lett , vol.565 , pp. 1-5
    • Sidhu, A.1    Wersinger, C.2    Vernier, P.3
  • 105
    • 2542533137 scopus 로고    scopus 로고
    • The dopamine transporter: importance in Parkinson's disease
    • Nutt JG, Carter JH, Sexton GJ. The dopamine transporter: importance in Parkinson's disease. Ann Neurol 2004;55:766-773.
    • (2004) Ann Neurol , vol.55 , pp. 766-773
    • Nutt, J.G.1    Carter, J.H.2    Sexton, G.J.3
  • 106
    • 0025284551 scopus 로고
    • Dopamine receptors and transporters in Parkinson's disease and schizophrenia
    • Seeman P, Niznik HB. Dopamine receptors and transporters in Parkinson's disease and schizophrenia. FASEB J 1990;4:2737-2744.
    • (1990) FASEB J , vol.4 , pp. 2737-2744
    • Seeman, P.1    Niznik, H.B.2
  • 107
    • 82855172161 scopus 로고    scopus 로고
    • Redistribution of DAT/alpha-synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson's disease
    • Bellucci A, Navarria L, Falarti E, et al. Redistribution of DAT/alpha-synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson's disease. PLoS One 2011;6:e27959.
    • (2011) PLoS One , vol.6
    • Bellucci, A.1    Navarria, L.2    Falarti, E.3
  • 108
    • 51649089030 scopus 로고    scopus 로고
    • Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation
    • Bellucci A, Collo G, Sarnico I, et al. Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation. J Neurochem 2008;106:560-577.
    • (2008) J Neurochem , vol.106 , pp. 560-577
    • Bellucci, A.1    Collo, G.2    Sarnico, I.3
  • 109
    • 69149089854 scopus 로고    scopus 로고
    • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    • Desplats P, Lee HJ, Bae EJ, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 2009;106:13010-13015.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13010-13015
    • Desplats, P.1    Lee, H.J.2    Bae, E.J.3
  • 110
    • 43249110200 scopus 로고    scopus 로고
    • Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    • Li JY, Englund E, Holton JL, et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 2008;14:501-503.
    • (2008) Nat Med , vol.14 , pp. 501-503
    • Li, J.Y.1    Englund, E.2    Holton, J.L.3
  • 111
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, et al. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008;14:504-506.
    • (2008) Nat Med , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3
  • 112
    • 84942860108 scopus 로고    scopus 로고
    • Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism
    • Prusiner SB, Woerman AL, Mordes DA, et al. Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A 2015;
    • (2015) Proc Natl Acad Sci U S A
    • Prusiner, S.B.1    Woerman, A.L.2    Mordes, D.A.3
  • 113
    • 79551519276 scopus 로고    scopus 로고
    • alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
    • Hansen C, Angot E, Bergstrom AL, et al. alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 2011;121:715-725.
    • (2011) J Clin Invest , vol.121 , pp. 715-725
    • Hansen, C.1    Angot, E.2    Bergstrom, A.L.3
  • 114
    • 0038748401 scopus 로고    scopus 로고
    • Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
    • Braak H, Rub U, Gai WP, et al. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 2003;110:517-536.
    • (2003) J Neural Transm , vol.110 , pp. 517-536
    • Braak, H.1    Rub, U.2    Gai, W.P.3
  • 116
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice
    • Luk KC, Kehm VM, Zhang B, et al. Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. J Exp Med 2012;209:975-986.
    • (2012) J Exp Med , vol.209 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3
  • 117
    • 84897977607 scopus 로고    scopus 로고
    • Lewy body extracts from Parkinson disease brains trigger alpha-synuclein pathology and neurodegeneration in mice and monkeys
    • Recasens A, Dehay B, Bove J, et al. Lewy body extracts from Parkinson disease brains trigger alpha-synuclein pathology and neurodegeneration in mice and monkeys. Ann Neurol 2014;75:351-362.
    • (2014) Ann Neurol , vol.75 , pp. 351-362
    • Recasens, A.1    Dehay, B.2    Bove, J.3
  • 118
    • 77649284470 scopus 로고    scopus 로고
    • Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
    • Pan-Montojo F, Anichtchik O, Dening Y, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One 2010;5:e8762.
    • (2010) PLoS One , vol.5
    • Pan-Montojo, F.1    Anichtchik, O.2    Dening, Y.3
  • 119
    • 84870769168 scopus 로고    scopus 로고
    • Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
    • Pan-Montojo F, Schwarz M, Winkler C, et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep 2012;2:898.
    • (2012) Sci Rep , vol.2 , pp. 898
    • Pan-Montojo, F.1    Schwarz, M.2    Winkler, C.3
  • 120
    • 84904428155 scopus 로고    scopus 로고
    • Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease
    • Kelly LP, Carvey PM, Keshavarzian A, et al. Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease. Mov Disord 2014;29:999-1009.
    • (2014) Mov Disord , vol.29 , pp. 999-1009
    • Kelly, L.P.1    Carvey, P.M.2    Keshavarzian, A.3
  • 121
    • 84922092995 scopus 로고    scopus 로고
    • Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
    • Holmqvist S, Chutna O, Bousset L, et al. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol 2014;128:805-820.
    • (2014) Acta Neuropathol , vol.128 , pp. 805-820
    • Holmqvist, S.1    Chutna, O.2    Bousset, L.3
  • 122
    • 84862680670 scopus 로고    scopus 로고
    • Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
    • Angot E, Steiner JA, Lema Tome CM, et al. Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo. PLoS One 2012;7:e39465.
    • (2012) PLoS One , vol.7
    • Angot, E.1    Steiner, J.A.2    Lema Tome, C.M.3
  • 123
    • 84880025984 scopus 로고    scopus 로고
    • Caudo-rostral brain spreading of alpha-synuclein through vagal connections
    • Ulusoy A, Rusconi R, Perez-Revuelta BI, et al. Caudo-rostral brain spreading of alpha-synuclein through vagal connections. EMBO Mol Med 2013;5:1051-1059.
    • (2013) EMBO Mol Med , vol.5 , pp. 1051-1059
    • Ulusoy, A.1    Rusconi, R.2    Perez-Revuelta, B.I.3
  • 125
    • 84868148328 scopus 로고    scopus 로고
    • Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport
    • Freundt EC, Maynard N, Clancy EK, et al. Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport. Ann Neurol 2012;72:517-524.
    • (2012) Ann Neurol , vol.72 , pp. 517-524
    • Freundt, E.C.1    Maynard, N.2    Clancy, E.K.3
  • 126
    • 14244261725 scopus 로고    scopus 로고
    • Axonal transport defects: a common theme in neurodegenerative diseases
    • Roy S, Zhang B, Lee VM, et al. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol 2005;109:5-13.
    • (2005) Acta Neuropathol , vol.109 , pp. 5-13
    • Roy, S.1    Zhang, B.2    Lee, V.M.3
  • 127
    • 0023731157 scopus 로고
    • Axonal transport in neurological disease
    • Griffin JW, Watson DF. Axonal transport in neurological disease. Ann Neurol 1988;23:3-13.
    • (1988) Ann Neurol , vol.23 , pp. 3-13
    • Griffin, J.W.1    Watson, D.F.2
  • 128
    • 34547467082 scopus 로고    scopus 로고
    • Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
    • Caudle WM, Richardson JR, Wang MZ, et al. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J Neurosci 2007;27:8138-8148.
    • (2007) J Neurosci , vol.27 , pp. 8138-8148
    • Caudle, W.M.1    Richardson, J.R.2    Wang, M.Z.3
  • 129
    • 84864144621 scopus 로고    scopus 로고
    • Potential role of alpha-synuclein in neurodegeneration: studies in a rat animal model
    • Stoica G, Lungu G, Bjorklund NL, et al. Potential role of alpha-synuclein in neurodegeneration: studies in a rat animal model. J Neurochem 2012;122:812-822.
    • (2012) J Neurochem , vol.122 , pp. 812-822
    • Stoica, G.1    Lungu, G.2    Bjorklund, N.L.3
  • 130
    • 84863188413 scopus 로고    scopus 로고
    • Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease
    • Chu Y, Morfini GA, Langhamer LB, et al. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain 2012;135:2058-2073.
    • (2012) Brain , vol.135 , pp. 2058-2073
    • Chu, Y.1    Morfini, G.A.2    Langhamer, L.B.3
  • 131
    • 33847770318 scopus 로고    scopus 로고
    • 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C
    • Morfini G, Pigino G, Opalach K, et al. 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proc Natl Acad Sci U S A 2007;104:2442-2447.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2442-2447
    • Morfini, G.1    Pigino, G.2    Opalach, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.