-
1
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A., Schmitz Y., Farinas I., Choi-Lundberg D., Ho W.H., Castillo P.E., Shinsky N., Verdugo J.M., Armanini M., Ryan A., Hynes M., Phillips H., Sulzer D., Rosenthal A. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000, 25:239-252.
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
Hynes, M.11
Phillips, H.12
Sulzer, D.13
Rosenthal, A.14
-
2
-
-
77950521882
-
Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice
-
Al-Wandi A., Ninkina N., Millership S., Williamson S.J.M., Jones P.A., Buchman V.L. Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiol. Aging 2010, 31:796-804.
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 796-804
-
-
Al-Wandi, A.1
Ninkina, N.2
Millership, S.3
Williamson, S.J.M.4
Jones, P.A.5
Buchman, V.L.6
-
3
-
-
79956296370
-
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family
-
Anwar S., Peters O., Millership S., Ninkina N., Doig N., Connor-Robson N., Threlfell S., Kooner G., Deacon R.M., Bannerman D.M., Bolam J.P., Chandra S.S., Cragg S.J., Wade-Martins R., Buchman V.L. Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J. Neurosci. 2011, 31:7264-7274.
-
(2011)
J. Neurosci.
, vol.31
, pp. 7264-7274
-
-
Anwar, S.1
Peters, O.2
Millership, S.3
Ninkina, N.4
Doig, N.5
Connor-Robson, N.6
Threlfell, S.7
Kooner, G.8
Deacon, R.M.9
Bannerman, D.M.10
Bolam, J.P.11
Chandra, S.S.12
Cragg, S.J.13
Wade-Martins, R.14
Buchman, V.L.15
-
4
-
-
57649140366
-
Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies
-
Bryant C.D., Zhang N.N., Sokoloff G., Fanselow M.S., Ennes H.S., Palmer A.A., McRoberts J.A. Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies. J. Neurogenet. 2008, 22:315-331.
-
(2008)
J. Neurogenet.
, vol.22
, pp. 315-331
-
-
Bryant, C.D.1
Zhang, N.N.2
Sokoloff, G.3
Fanselow, M.S.4
Ennes, H.S.5
Palmer, A.A.6
McRoberts, J.A.7
-
5
-
-
77957347060
-
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burre J., Sharma M., Tsetsenis T., Buchman V., Etherton M.R., Sudhof T.C. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 2010, 329:1663-1667.
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burre, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Sudhof, T.C.6
-
6
-
-
27544507306
-
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
-
Chandra S., Gallardo G., Fernandez-Chacon R., Schluter O.M., Sudhof T.C. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 2005, 123:383-396.
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernandez-Chacon, R.3
Schluter, O.M.4
Sudhof, T.C.5
-
7
-
-
77954215793
-
Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis
-
Darios F., Ruiperez V., Lopez I., Villanueva J., Gutierrez L.M., Davletov B. Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO Rep. 2010, 11:528-533.
-
(2010)
EMBO Rep.
, vol.11
, pp. 528-533
-
-
Darios, F.1
Ruiperez, V.2
Lopez, I.3
Villanueva, J.4
Gutierrez, L.M.5
Davletov, B.6
-
8
-
-
77954379317
-
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease
-
Garcia-Reitboeck P., Anichtchik O., Bellucci A., Iovino M., Ballini C., Fineberg E., Ghetti B., Della C.L., Spano P., Tofaris G.K., Goedert M., Spillantini M.G. SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. Brain 2010, 133:2032-2044.
-
(2010)
Brain
, vol.133
, pp. 2032-2044
-
-
Garcia-Reitboeck, P.1
Anichtchik, O.2
Bellucci, A.3
Iovino, M.4
Ballini, C.5
Fineberg, E.6
Ghetti, B.7
Della, C.L.8
Spano, P.9
Tofaris, G.K.10
Goedert, M.11
Spillantini, M.G.12
-
9
-
-
77955346228
-
Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects
-
Gasser T. Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects. Prog. Brain Res. 2010, 183:3-20.
-
(2010)
Prog. Brain Res.
, vol.183
, pp. 3-20
-
-
Gasser, T.1
-
10
-
-
0029127954
-
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
-
George J.M., Jin H., Woods W.S., Clayton D.F. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 1995, 15:361-372.
-
(1995)
Neuron
, vol.15
, pp. 361-372
-
-
George, J.M.1
Jin, H.2
Woods, W.S.3
Clayton, D.F.4
-
11
-
-
78650431984
-
Alpha/beta/gamma-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
-
Greten-Harrison B., Polydoro M., Morimoto-Tomita M., Diao L., Williams A.M., Nie E.H., Makani S., Tian N., Castillo P.E., Buchman V.L., Chandra S.S. alpha/beta/gamma-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:19573-19578.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 19573-19578
-
-
Greten-Harrison, B.1
Polydoro, M.2
Morimoto-Tomita, M.3
Diao, L.4
Williams, A.M.5
Nie, E.H.6
Makani, S.7
Tian, N.8
Castillo, P.E.9
Buchman, V.L.10
Chandra, S.S.11
-
12
-
-
0031866281
-
Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development
-
Hsu L.J., Mallory M., Xia Y., Veinbergs I., Hashimoto M., Yoshimoto M., Thal L.J., Saitoh T., Masliah E. Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J. Neurochem. 1998, 71:338-344.
-
(1998)
J. Neurochem.
, vol.71
, pp. 338-344
-
-
Hsu, L.J.1
Mallory, M.2
Xia, Y.3
Veinbergs, I.4
Hashimoto, M.5
Yoshimoto, M.6
Thal, L.J.7
Saitoh, T.8
Masliah, E.9
-
13
-
-
72449191782
-
Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
-
Kadkhodaei B., Ito T., Joodmardi E., Mattsson B., Rouillard C., Carta M., Muramatsu S., Sumi-Ichinose C., Nomura T., Metzger D., Chambon P., Lindqvist E., Larsson N.G., Olson L., Bjorklund A., Ichinose H., Perlmann T. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J. Neurosci. 2009, 29:15923-15932.
-
(2009)
J. Neurosci.
, vol.29
, pp. 15923-15932
-
-
Kadkhodaei, B.1
Ito, T.2
Joodmardi, E.3
Mattsson, B.4
Rouillard, C.5
Carta, M.6
Muramatsu, S.7
Sumi-Ichinose, C.8
Nomura, T.9
Metzger, D.10
Chambon, P.11
Lindqvist, E.12
Larsson, N.G.13
Olson, L.14
Bjorklund, A.15
Ichinose, H.16
Perlmann, T.17
-
15
-
-
34548341065
-
The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease
-
Michell A.W., Tofaris G.K., Gossage H., Tyers P., Spillantini M.G., Barker R.A. The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell Transplant. 2007, 16:461-474.
-
(2007)
Cell Transplant.
, vol.16
, pp. 461-474
-
-
Michell, A.W.1
Tofaris, G.K.2
Gossage, H.3
Tyers, P.4
Spillantini, M.G.5
Barker, R.A.6
-
16
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di I.G., Golbe L.I., Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di, I.G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
17
-
-
2642553802
-
Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
-
Robertson D.C., Schmidt O., Ninkina N., Jones P.A., Sharkey J., Buchman V.L. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. J. Neurochem. 2004, 89:1126-1136.
-
(2004)
J. Neurochem.
, vol.89
, pp. 1126-1136
-
-
Robertson, D.C.1
Schmidt, O.2
Ninkina, N.3
Jones, P.A.4
Sharkey, J.5
Buchman, V.L.6
-
18
-
-
84864258151
-
Alpha-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis
-
Scott D., Roy S. alpha-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis. J. Neurosci. 2012, 32:10129-10135.
-
(2012)
J. Neurosci.
, vol.32
, pp. 10129-10135
-
-
Scott, D.1
Roy, S.2
-
19
-
-
0035341443
-
Fate of midbrain dopaminergic neurons controlled by the engrailed genes
-
Simon H.H., Saueressig H., Wurst W., Goulding M.D., O'Leary D.D. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J. Neurosci. 2001, 21:3126-3134.
-
(2001)
J. Neurosci.
, vol.21
, pp. 3126-3134
-
-
Simon, H.H.1
Saueressig, H.2
Wurst, W.3
Goulding, M.D.4
O'Leary, D.D.5
-
20
-
-
0038051417
-
Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors
-
Simon H.H., Bhatt L., Gherbassi D., Sgado P., Alberi L. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Ann. N. Y. Acad. Sci. 2003, 991:36-47.
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.991
, pp. 36-47
-
-
Simon, H.H.1
Bhatt, L.2
Gherbassi, D.3
Sgado, P.4
Alberi, L.5
-
21
-
-
0242300619
-
Alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton A.B.., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., Gwinn-Hardy K. alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003, 302:841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B..1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
22
-
-
0035789203
-
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
-
Specht C.G., Schoepfer R. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neurosci. 2001, 2:11.
-
(2001)
BMC Neurosci.
, vol.2
, pp. 11
-
-
Specht, C.G.1
Schoepfer, R.2
-
23
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997, 388:839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
24
-
-
0032568534
-
Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:6469-6473.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
25
-
-
0025988759
-
Different rates of age-related loss for four murine monoaminergic neuronal populations
-
Tatton W.G., Greenwood C.E., Verrier M.C., Holland D.P., Kwan M.M., Biddle F.E. Different rates of age-related loss for four murine monoaminergic neuronal populations. Neurobiol. Aging 1991, 12:543-556.
-
(1991)
Neurobiol. Aging
, vol.12
, pp. 543-556
-
-
Tatton, W.G.1
Greenwood, C.E.2
Verrier, M.C.3
Holland, D.P.4
Kwan, M.M.5
Biddle, F.E.6
-
26
-
-
79551619339
-
Resistance to MPTP-neurotoxicity in a-synuclein knowckout mice is complemented by human a-synuclein and associated with increased b-synuclein and Akt activation
-
Thomas B., Mandir A.S., West N., Liu Y., Andrabi S.A., Stirling W., Dawson V.L., Dawson T.M., Lee M.K. Resistance to MPTP-neurotoxicity in a-synuclein knowckout mice is complemented by human a-synuclein and associated with increased b-synuclein and Akt activation. PLoS One 2011, 6(1):e16706.
-
(2011)
PLoS One
, vol.6
, Issue.1
-
-
Thomas, B.1
Mandir, A.S.2
West, N.3
Liu, Y.4
Andrabi, S.A.5
Stirling, W.6
Dawson, V.L.7
Dawson, T.M.8
Lee, M.K.9
-
27
-
-
33646097224
-
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders
-
Tofaris G.K., Garcia-Reitboek R.P., Humby T., Lambourne S.L., O'Connell M., Ghetti B., Gossage H., Emson P.C., Wilkinson L.S., Goedert M., Spillantini M.G. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. J. Neurosci. 2006, 26:3942-3950.
-
(2006)
J. Neurosci.
, vol.26
, pp. 3942-3950
-
-
Tofaris, G.K.1
Garcia-Reitboek, R.P.2
Humby, T.3
Lambourne, S.L.4
O'Connell, M.5
Ghetti, B.6
Gossage, H.7
Emson, P.C.8
Wilkinson, L.S.9
Goedert, M.10
Spillantini, M.G.11
-
28
-
-
0033572907
-
Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice
-
Wallen A., Zetterstrom R.H., Solomin L., Arvidsson M., Olson L., Perlmann T. Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice. Exp. Cell Res. 1999, 253:737-746.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 737-746
-
-
Wallen, A.1
Zetterstrom, R.H.2
Solomin, L.3
Arvidsson, M.4
Olson, L.5
Perlmann, T.6
-
29
-
-
0033083082
-
Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias
-
West M.J. Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci. 1999, 22:51-61.
-
(1999)
Trends Neurosci.
, vol.22
, pp. 51-61
-
-
West, M.J.1
-
30
-
-
8544232135
-
Human wild-type alpha-synuclein impairs neurogenesis
-
Winner B., Lie D.C., Rockenstein E., Aigner R., Aigner L., Masliah E., Kuhn H.G., Winkler J. Human wild-type alpha-synuclein impairs neurogenesis. J. Neuropathol. Exp. Neurol. 2004, 63:1155-1166.
-
(2004)
J. Neuropathol. Exp. Neurol.
, vol.63
, pp. 1155-1166
-
-
Winner, B.1
Lie, D.C.2
Rockenstein, E.3
Aigner, R.4
Aigner, L.5
Masliah, E.6
Kuhn, H.G.7
Winkler, J.8
-
31
-
-
84870015777
-
Role of alpha-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus
-
Winner B., Regensburger M., Schreglmann S., Boyer L., Prots I., Rockenstein E., Mante M., Zhao C., Winkler J., Masliah E., Gage F.H. Role of alpha-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J. Neurosci. 2012, 32:16906-16916.
-
(2012)
J. Neurosci.
, vol.32
, pp. 16906-16916
-
-
Winner, B.1
Regensburger, M.2
Schreglmann, S.3
Boyer, L.4
Prots, I.5
Rockenstein, E.6
Mante, M.7
Zhao, C.8
Winkler, J.9
Masliah, E.10
Gage, F.H.11
-
32
-
-
77952090587
-
Expression and subcellular location of alpha-synuclein during mouse-embryonic development
-
Zhong S.C., Luo X., Chen X.S., Cai Q.Y., Liu J., Chen X.H., Yao Z.X. Expression and subcellular location of alpha-synuclein during mouse-embryonic development. Cell. Mol. Neurobiol. 2010, 30:469-482.
-
(2010)
Cell. Mol. Neurobiol.
, vol.30
, pp. 469-482
-
-
Zhong, S.C.1
Luo, X.2
Chen, X.S.3
Cai, Q.Y.4
Liu, J.5
Chen, X.H.6
Yao, Z.X.7
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