α-Synuclein regulation of the dopaminergic transporter: A possible role in the pathogenesis of Parkinson's disease

FEBS Letters

Volumn 565, Issue 1-3, 2004, Pages 1-5

  Sidhu, Anita ^a   Wersinger, Christophe ^a   Vernier, Philippe ^b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CNRS   (France)

Author keywords

Synuclein; 1 Methyl 4 phenyl 1,2,3,6 tetrahydropyrimidine; Dopamine transporter; LB, Lewy body; Lewy bodies; Neurodegeneration; Parkinson's disease; PD, Parkinson's disease; SN, substantia nigra; Synucleinopathies; wt, wild type

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; DOPAMINE TRANSPORTER; VESICULAR TRANSPORT PROTEIN;

DOPAMINE UPTAKE; DOPAMINERGIC SYSTEM; HUMAN; LEWY BODY; NERVE DEGENERATION; NERVE ENDING; NEUROCHEMISTRY; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SHORT SURVEY; TRANSPORT KINETICS;

ALPHA-SYNUCLEIN; ANIMALS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PARKINSON DISEASE; SYNUCLEINS;

EID: 2342496196     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.03.063     Document Type: Short Survey

References (50)

1. Hornykiewicz O. Neurology. 51:1998;S2-S9
2. Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M.J., Jonnalagada S., Chernova T., Dehajia A., Lavedan C., Gasser T., Steinbach P.J., Wilkinson K.D., Polymeropoulos M.H. Nature. 395:1998;451-452
3. Gasser T. Genetics of Parkinson's disease. J. Neurol. 248(10):2001;833-840
4. Bonifati V., Rizzu P., van Baren M.J., Schaap O., Breedveld G.J., Krieger E., Dekker M.C., Squitieri F., Ibanez P., Joosse M., van Dongen J.W., Vanacore N., van Swieten J.C., Brice A., Meco G., van Duijn C.M., Oostra B.A., Heutink P. Science. 299:2003;256-259
5. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., DiIorio G., Golbe L.I., Nussbaum R.T. Science. 276:1997;2045-2047
6. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J.T., Schols L., Riess O. Nat. Genet. 18:1998;106-108
7. Scott W.K., Yamaoka L.H., Stajich J.M., Scott B.L., Vance J.M., Roses A.D., Pericak-Vance M.A., Watts R.L., Nance M., Hubble J., Koller W., Stern M.B., Colcher A., Allen F.H Jr., Hiner B.C., Jankovic J., Ondo W., Laing N.G., Mastaglia F., Goetz C., Pappert E., Small G.W., Masterman D., Haines J.L., Davies T.L. Neurogenetics. 2:1999;191-192
8. Chan P., Jiang X., Forno L.S., Di Monte D.A., Tanner C.M., Langston J.W. Neurology. 50:1998;1136-1137
9. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., Goedert M. Nature. 388:1997;839-840
10. Takeda A., Mallory M., Sundsmo M., Honer W., Hansen L., Masliah E. Am. J. Pathol. 152:1998;367-372
11. Clayton D.F., George J.M. Trends Neurosci. 21:1998;249-254
12. Lavedan C. Genome Res. 8:1998;871-880
13. Kahle P.J., Neumann M., Ozman L., Haass C. Ann. N.Y. Acad. Sci. 920:2000;33-41
14. Maries E., Dass B., Collier T.J., Kordower J.H., Steece-Collier K. Nat. Rev. Neurosci. 4:2003;727-738
15. Clayton D.F., George J.M. J. Neurosci. Res. 58(1):1999;120-129
16. George J.M. Genome Biol. 3:2002;1-6
17. Maroteaux L., Campanelli J.T., Scheller R.H. J. Neurosci. 8:1988;2804-2815
18. Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A., Kondo J., Ihara Y., Saitoh T. Proc. Natl. Acad. Sci. USA. 90:1994;11282-11286
19. Jakes R., Spillantini M.G., Goedert M. FEBS Lett. 345:1994;27-32
20. Lotharius J., Brundin P. Nat. Rev. Neurosci. 3:2002;932-942
21. Petersen K., Olesen O.F., Mikkelsen J.D. Neuroscience. 91:1999;651-659
22. George J.M., Jin H., Woods W.S., Clayton D.F. Neuron. 15(2):1995;361-372
23. Conway K.A., Rochet J.C., Bieganski R.M., Lansbury P.T. Jr. Science. 294:2001;1346-1349
24. Lee H.J., Lee S.J. J. Biol. Chem. 277:2002;48976-48983
25. El-Agnaf O.M., Jakes R., Curran M.D., Wallace A. FEBS Lett. 440:1998;67-70
26. Hashimoto M., Hsu L.J., Xia Y., Takeda A., Sisk A., Sundsmo M., Masliah E. Neuroreport. 10:1999;717-721
27. Conway K.A., Lee S.J., Rochet J.C., Ding T.T., Williamson R.E., Lansbury P.T. Jr. Proc. Natl. Acad. Sci. USA. 97:2000;571-576
28. Sherer T.B., Betarbet R., Stout A.K., Lund S., Baptista M., Panov A.V., Cookson M.R., Greenamyre J.T. J. Neurosci. 22(16):2002;7006-7015
29. Youdim M.B. J. Neural Transm. Suppl. 65:2003;73-88
30. Graham D.G. Mol. Pharmacol. 14:1978;633-643
31. Chen N., Reith M.E. Eur. J. Pharmacol. 405:2000;329-339
32. Zahniser N.R., Doolen S. Pharmacol. Ther. 92:2001;21-55
33. Gainetdinov R.R., Caron M.G. Annu. Rev. Pharmacol. Toxicol. 43:2003;261-284
34. Pristupa Z.B., McConkey F., Liu F., Man H.Y., Lee F.J., Wang Y.T., Niznik H.B. Synapse. 30:1998;79-87
35. Melikian H.E., Buckley K.M. J. Neurosci. 19:1999;7699-7710
36. Daniels G.M., Amara S.G. J. Biol. Chem. 274:1999;35794-35801
37. Wersinger C., Sidhu A. Neurosci. Lett. 340:2003;189-192
38. Wersinger C., Prou D., Vernier P., Sidhu A. FASEB J. 17(14):2003;2151- 2153
39. Wersinger, C., Banta, M. and Sidhu, A. (2004). Comparative analyses of alpha-synuclein expression levels in rat brain tissues and transfected cells. Neurosci. Lett. (in press manuscript NSL510)
40. Wersinger, C., Vernier, P. and Sidhu, A. (2004). Biochemistry (in press manuscript bi035308s)
41. Lee F.J., Liu F., Pristupa Z.B., Niznik H.B. FASEB J. 15:2001;916-926
42. Wersinger C., Prou D., Vernier P., Niznik H.B., Sidhu A. Mol. Cell. Neurosci. 24(1):2003;91-105
43. Lotharius J., Barg S., Wiekop P., Lundberg C., Raymon H.K., Brundin P. J. Biol. Chem. 277:2002;38884-38894
44. Weihe E., Eiden L.E. FASEB J. 14:2000;2435-2449
45. Feany M.B., Bender W.W. Nature. 404(6776):2000;394-398
46. Giasson B.I., Duda J.E., Quinn S.M., Zhang B., Trojanowski J.Q., Lee V.M. Neuron. 34:2002;521-533
47. Ciliax B.J., Drash G.W., Staley J.K., Haber S., Mobley C.J., Miller G.W., Mufson E.J., Mash D.C., Levey A.I. J. Comp. Neurol. 409:1999;38-56
48. Kakimura J., Kitamura Y., Takata K., Kohno Y., Nomura Y., Taniguchi T. Eur. J. Pharmacol. 417(1-2):2001;59-67
49. Kanda S., Bishop J.F., Eglitis M.A., Yang Y., Mouradian M.M. Neuroscience. 97(2):2000;279-284
50. Dauer W., Kholodilov N., Vila M., Trillat A.C., Goodchild R., Larsen K.E., Staal R., Tieu K., Schmitz Y., Yuan C.A., Rocha M., Jackson-Lewis V., Hersch S., Sulzer D., Przedborski S., Burke R., Hen R. Proc. Natl. Acad. Sci. USA. 99(22):2002;14524-14529