α-synuclein is expressed in different tissues during human fetal development

Journal of Molecular Neuroscience

Volumn 22, Issue 3, 2004, Pages 199-203

  Baltic, Svetlana ^a   Perovic, Milka ^a   Mladenovic, Aleksandra ^a   Raicevic, Nevena ^a   Ruzdijic, Sabera ^a   Rakic, Ljubisav ^b   Kanazir, Selma ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b SERBIAN ACADEMY OF SCIENCES AND ARTS   (Serbia)

Author keywords

Fetal tissues; Human development; synuclein

Indexed keywords

ALPHA SYNUCLEIN; BRAIN PROTEIN; NERVE PROTEIN; SNCA PROTEIN, HUMAN; SNCA PROTEIN, RAT; SYNUCLEIN;

ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONAL TISSUE; FETUS; FETUS (ANATOMY); FETUS DEVELOPMENT; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROCHEMISTRY; NONHUMAN; PRENATAL DEVELOPMENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION; WESTERN BLOTTING; ADRENAL GLAND; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; CELL DIFFERENTIATION; COMPARATIVE STUDY; CYTOLOGY; GENETICS; HEART MUSCLE; KIDNEY; LIVER; LUNG; MALE; METABOLISM; PHYSIOLOGY; SPECIES DIFFERENCE; TESTIS; UPREGULATION; VISCERA;

ADRENAL GLANDS; ALPHA-SYNUCLEIN; ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CELL DIFFERENTIATION; FETUS; HUMANS; KIDNEY; LIVER; LUNG; MALE; MYOCARDIUM; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; ORGAN SPECIFICITY; RATS; SPECIES SPECIFICITY; SYNUCLEINS; TESTIS; UP-REGULATION; VISCERA;

EID: 2942552153     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:22:3:199     Document Type: Article

References (22)

1. Alves da Costa C. (2003) Recent advances on alpha-synuclein cell biology: functions and dysfunctions. Curr. Mol. Med. 3, 17-24.
2. Baba M., Nakajo S., Tu P. H., Tomita T., Nakaya K., Lee V. M., et al. (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152, 879-884.
3. Campbell B. C., McLean C. A., Culvenor J. G., Gai W. P., Blumbergs P. C., Jakala P., et al. (2001) The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease. J. Neurochem. 76, 87-96.
4. Clayton D. F. and George J. M. (1998) The synucleins: the family of proteins involved in synaptic function, plasticity neurodegeneration and disease. Trends Neurosci. 21, 249-254.
5. Feany M. B. and Bender W. W. (2000) A Drosophila model of Parkinson's disease. Nature 404, 394-398.
6. Hashimoto M., Yoshimoto M., Sisk A., Hsu L.J., Sundsmo M., Kittel A., et al. (1997) NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation. Biochem. Biophys. Res. Commun. 237, 611-616.
7. Hsu L. J., Mallory M., Xia Y., Veinbergs I., Hashimoto M., Yoshimoto M., et al. (1998) Expression pattern of synucleins (non-Aβ component of Alzheimer's disease amyloid precursor protein/α-synuclein) during murine brain development. J. Neurochem. 71, 338-344.
8. Hsu L. J., Sagara Y., Arroyo A., Rockenstein E., Sisk A., Mallory M., et al. (2000) α-Synuclein promotes mitochondrial deficit and oxidative stress. Am. J. Pathol. 157, 401-410.
9. Kahle P. J., Neumann M., Ozmen L., Muller V., Jacobsen H., Schindzielorz A., et al. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain. J. Neurosci. 20, 6365-6373.
10. Krüger R., Kuhn W., Müller T., Woitalla D., Graeber M., Kösel S., et al. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108.
11. Langston J. W., Sastry S., Chan P., Forno L. S., Bolin L. M., and Di Monte D. A. (1998) Novel synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease. Exp. Neurol. 154, 684-690.
12. Lavedan C. (1998) The synuclein family. Genome Res. 9, 871-880.
13. Maroteaux L. and Scheller R. H. (1991) The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Mol. Brain Res. 11, 335-343.
14. Masliah E., Rockenstein E., Veinbergs I., Mallory M., Hashimoto M., Takeda A., et al. (2000) Dopaminergic loss and inclusion body formation in α-synuclein mice: implications for neurodegenerative disorders. Science 287, 1265-1269.
15. Matsuoka Y., Vila M., Lincoln S., McCormack A., Picciano M., LaFrancois J., et al. (2001) Lack of nigral pathology in transgenic mice expressing human alpha-synuclein drivenby the tyrosine hydroxylase promoter. Neurobiol. Dis. 8, 535-539.
16. Petersen K., Olesen O. F., and Mikkelsen J. D. (1999) Developmental expression of α-synuclein in rat hippocampus and cerebral cortex. Neuroscience 91, 651-659.
17. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
18. Shin E. C., Cho S. E., Lee D. K., Hur M. W., Paik S. R., Park J. H., and Kim J. (2000) Expression patterns of alpha-synuclein in human hematopoietic cells and in Drosophila at different developmental stages. Mol. Cells 10, 65-70.
19. Tanji K., Mori F., Imaizumi T., Yoshida H., Matsumiya T., Tamo W., et al. (2002) Up regulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages. Pathol. Int. 9, 572-577.
20. Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., et al. (1993) Molecular cloning of cDNA encoding an unrecognised component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 90, 11282-11286.
21. Ueda K., Saitoh T., and Mori H. (1994) Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-Aβ component of Alzheimer's disease amyloid. Biochem. Biophys. Res. Commun. 205, 1366-1372.
22. Uversky V. N., Lee H., Li J., Fink A. L., and Lee S. (2001) Stabilization of partially folded conformation during α-synuclein oligomerization in both purified and cytosolic prepatations. J. Biol. Chem. 47, 43495-43498.