α-Synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

Journal of Neuroscience

Volumn 26, Issue 46, 2006, Pages 11915-11922

  Larsen, Kristin E ^a   Schmitz, Yvonne ^a   Troyer, Matthew D ^c   Mosharov, Eugene ^a   Dietrich, Paula ^a   Quazi, Abrar Z ^d   Savalle, Magali ^a   Nemani, Venu ^c   Chaudhry, Farrukh A ^d   Edwards, Robert H ^c   Stefanis, Leonidas ^a,f   Sulzer, David ^a,b,e  

^a School of Medicine ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF OSLO   (Norway)

^e Black Building ^*  (United States)

^f BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

Amperometry; Catecholamine; Chromaffin; Exocytosis; Parkinson's disease; Secretory

Indexed keywords

ALPHA SYNUCLEIN; CALCIUM; CATECHOLAMINE;

AMPEROMETRY; ANIMAL CELL; ARTICLE; CHROMAFFIN CELL; CONTROLLED STUDY; ELECTRON MICROSCOPY; EVOKED CORTICAL RESPONSE; EXOCYTOSIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KINETICS; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALPHA-SYNUCLEIN; ANIMALS; CALCIUM; CALCIUM SIGNALING; CATECHOLAMINES; CHROMAFFIN CELLS; DISEASE MODELS, ANIMAL; DOPAMINE; EXOCYTOSIS; FEMALE; MALE; MEMBRANE FUSION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; PARKINSONIAN DISORDERS; PC12 CELLS; RATS; SECRETORY VESICLES; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES; TIME FACTORS;

EID: 33751113009     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3821-06.2006     Document Type: Article

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