Structural Basis for the Non-catalytic Functions of Protein Kinases

Structure

Volumn 24, Issue 1, 2016, Pages 7-24

  Kung, Jennifer E ^a   Jura, Natalia ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A RAF KINASE; AURORA A KINASE; AURORA C KINASE; B RAF KINASE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE 9; EPHRIN RECEPTOR A4; EPHRIN RECEPTOR A8; EPHRIN RECEPTOR B3; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FOCAL ADHESION KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN KINASE FYN; RAF PROTEIN; SCAFFOLD PROTEIN; SOMATOMEDIN C RECEPTOR; STEM CELL FACTOR;

ALLOSTERISM; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME MODIFICATION; ENZYME REGULATION; ENZYME STRUCTURE; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 84953236882     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.10.020     Document Type: Review

References (127)

1. K. Aertgeerts, R. Skene, J. Yano, B.C. Sang, H. Zou, G. Snell, A. Jennings, K. Iwamoto, N. Habuka, A. Hirokawa, and et al. Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein J. Biol. Chem. 286 2011 18756 18765
2. M.M.U. Ali, T. Bagratuni, E.L. Davenport, P.R. Nowak, M.C. Silva-Santisteban, A. Hardcastle, C. McAndrews, M.G. Rowlands, G.J. Morgan, W. Aherne, and et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response EMBO J. 30 2011 894 905
3. N. Ashida, S. Senbanerjee, S. Kodama, S.Y. Foo, M. Coggins, J.A. Spencer, P. Zamiri, D. Shen, L. Li, T. Sciuto, and et al. IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways Nat. Commun. 2 2011 318
4. B.B. Au-Yeung, S.E. Levin, C. Zhang, L.Y. Hsu, D.A. Cheng, N. Killeen, K.M. Shokat, and A. Weiss A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity Nat. Immunol. 11 2010 1085 1092
5. A.F. Baas, J. Boudeau, G.P. Sapkota, L. Smit, R. Medema, N.A. Morrice, D.R. Alessi, and H.C. Clevers Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD EMBO J. 22 2003 3062 3072
6. J. Bagarova, A.J. Vonner, K.A. Armstrong, J. Börgermann, C.S. Lai, D.Y. Deng, H. Beppu, I. Alfano, P. Filippakopoulos, N.W. Morrell, and et al. Constitutively active ALK2 receptor mutants require type II receptor cooperation Mol. Cell. Biol. 33 2013 2413 2424
7. S.B. Berger, V. Kasparcova, S. Hoffman, B. Swift, L. Dare, M. Schaeffer, C. Capriotti, M. Cook, J. Finger, A. Hughes-Earle, and et al. Cutting edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice J. Immunol. 192 2014 5476 5480
8. J. Boucher, Y. Macotela, O. Bezy, M.A. Mori, K. Kriauciunas, and C.R. Kahn A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis Sci. Signal. 3 2010 ra87
9. J. Boudeau, A.F. Baas, M. Deak, N.A. Morrice, A. Kieloch, M. Schutkowski, A.R. Prescott, H.C. Clevers, and D.R. Alessi MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm EMBO J. 22 2003 5102 5114
10. D.F. Brennan, A.C. Dar, N.T. Hertz, W.C.H. Chao, A.L. Burlingame, K.M. Shokat, and D. Barford A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK Nature 472 2011 366 369
11. M.R. Brewer, S.H. Choi, D. Alvarado, K. Moravcevic, A. Pozzi, M.A. Lemmon, and G. Carpenter The juxtamembrane region of the EGF receptor functions as an activation domain Mol. Cell 34 2009 641 651
12. M. Brockmann, E. Poon, T. Berry, A. Carstensen, H.E. Deubzer, L. Rycak, Y. Jamin, K. Thway, S.P. Robinson, F. Roels, and et al. Small molecule inhibitors of Aurora-A induce proteasomal degradation of N-Myc in childhood neuroblastoma Cancer Cell 24 2013 75 89
13. M. Bronner, R. Hertz, and J. Bar-Tana Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase Biochem. J. 384 2004 295 305
14. A.J. Brooks, W. Dai, M.L. O'Mara, D. Abankwa, Y. Chhabra, R.A. Pelekanos, O. Gardon, K.A. Tunny, K.M. Blucher, C.J. Morton, and et al. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor Science 344 2014 1249783
15. M. Camps, A. Nichols, C. Gillieron, B. Antonsson, M. Muda, C. Chabert, U. Boschert, and S. Arkinstall Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase Science 280 1998 1262 1265
16. N.M. Chapman, A.N. Yoder, and J.C. Houtman Non-catalytic functions of Pyk2 and Fyn regulate late stage adhesion in human T cells PLoS One 7 2012 e53011
17. Y.P. Chong, T.D. Mulhern, H.J. Zhu, D.J. Fujita, J.D. Bjorge, J.P. Tantiongco, N. Sotirellis, D.S. Lio, G. Scholz, and H.C. Cheng A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity J. Biol. Chem. 279 2004 20752 20766
18. B. Cinar, F.K. Collak, D. Lopez, S. Akgul, N.K. Mukhopadhyay, M. Kilicarslan, D.G. Gioeli, and M.R. Freeman MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling Cancer Res. 71 2011 4303 4313
19. M. Cohen-Armon, L. Visochek, D. Rozensal, A. Kalal, I. Geistrikh, R. Klein, S. Bendetz-Nezer, Z. Yao, and R. Seger DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation Mol. Cell 25 2007 297 308
20. G. De Falco, L. Bagella, P.P. Claudio, A. De Luca, Y. Fu, B. Calabretta, A. Sala, and A. Giordano Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation Oncogene 19 2000 373 379
21. M. Dey, B.R. Mann, A. Anshu, and M.A. Mannan Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop J. Biol. Chem. 289 2014 5747 5757
22. B. Dong, and R.H. Silverman Alternative function of a protein kinase homology domain in 2′, 5′-oligoadenylate dependent RNase L Nucl. Acids Res. 27 1999 439 445
23. E. Erbay, and J. Chen The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism J. Biol. Chem. 276 2001 36079 36082
24. L. Fan, X. Yang, J. Du, M. Marshall, K. Blanchard, and X. Ye A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity Cell Cycle 4 2005 1616 1624
25. M.C. Fleckenstein, M.L. Reese, S. Könen-Waisman, J.C. Boothroyd, J.C. Howard, and T. Steinfeldt A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins PLoS Biol. 10 2012 e1001358
26. N.J. Freedman, A.S. Ament, M. Oppermann, R.H. Stoffel, S.T. Exum, and R.J. Lefkowitz Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity J. Biol. Chem. 272 1997 17734 17743
27. M.J. Garnett, S. Rana, H. Paterson, D. Barford, and R. Marais Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization Mol. Cell 20 2005 963 969
28. R. Ghosh, L. Wang, E.S. Wang, B.G.K. Perera, A. Igbaria, S. Morita, K. Prado, M. Thamsen, D. Caswell, H. Macias, and et al. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress Cell 158 2014 534 548
29. N. Gnesutta, and A. Minden Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4 Mol. Cell. Biol. 23 2003 7838 7848
30. C. Gu, and S. Park The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner Mol. Cell. Biol. 21 2001 4579 4597
31. W.C. Gustafson, J.G. Meyerowitz, E.A. Nekritz, J. Chen, C. Benes, E. Charron, E.F. Simonds, R. Seeger, K.K. Matthay, N.T. Hertz, and et al. Drugging MYCN through an allosteric transition in Aurora kinase A Cancer Cell 26 2014 414 427
32. J.R. Haling, J. Sudhamsu, I. Yen, S. Sideris, W. Sandoval, W. Phung, B.J. Bravo, A.M. Giannetti, A. Peck, A. Masselot, and et al. Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling Cancer Cell 26 2014 402 413
33. Y. Han, J. Donovan, S. Rath, G. Whitney, A. Chitrakar, and A. Korennykh Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response Science 343 2014 1244 1248
34. S.B. Hari, E.A. Merritt, and D.J. Maly Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases Chem. Biol. 21 2014 628 635
35. A.J. Harvey, and M.R. Crompton Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation Oncogene 22 2003 5006 5010
36. G. Hatzivassiliou, K. Song, I. Yen, B.J. Brandhuber, D.J. Anderson, R. Alvarado, M.J.C. Ludlam, D. Stokoe, S.L. Gloor, G. Vigers, and et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth Nature 464 2010 431 435
37. S.J. Heidorn, C. Milagre, S. Whittaker, A. Nourry, I. Niculescu-Duvas, N. Dhomen, J. Hussain, J.S. Reis-Filho, C.J. Springer, C. Pritchard, and et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF Cell 140 2010 209 221
38. N.T. Hertz, A. Berthet, M.L. Sos, K.S. Thorn, A.L. Burlingame, K. Nakamura, and K.M. Shokat A neo-substrate that amplifies catalytic activity of Parkinson's-disease-related kinase PINK1 Cell 154 2013 737 747
39. M.C. Herzig, C. Kolly, E. Persohn, D. Theil, T. Schweizer, T. Hafner, C. Stemmelen, T.J. Troxler, P. Schmid, S. Danner, and et al. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice Hum. Mol. Genet. 20 2011 4209 4223
40. M. Higuchi, K. Onishi, C. Kikuchi, and Y. Gotoh Scaffolding function of PAK in the PDK1-Akt pathway Nat. Cell Biol. 10 2008 1356 1364
41. J.M. Hildebrand, M.C. Tanzer, I.S. Lucet, S.N. Young, S.K. Spall, P. Sharma, C. Pierotti, J.-M. Garnier, R.C.J. Dobson, A.I. Webb, and et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death Proc. Natl. Acad. Sci. USA 111 2014 15072 15077
42. C. Hong, K.S. Moorefield, P. Jun, K.D. Aldape, S. Kharbanda, H.S. Phillips, and J.F. Costello Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth Proc. Natl. Acad. Sci. USA 104 2007 10974 10979
43. Y. Hu, V. Baud, T. Oga, K.I. Kim, K. Yoshida, and M. Karin IKKalpha controls formation of the epidermis independently of NF-kappaB Nature 410 2001 710 714
44. S. Hu, Z. Xie, A. Onishi, X. Yu, L. Jiang, J. Lin, H.-S. Rho, C. Woodard, H. Wang, J.-S. Jeong, and et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling Cell 139 2009 610 622
45. J. Hu, H. Yu, A.P. Kornev, J. Zhao, E.L. Filbert, S.S. Taylor, and A.S. Shaw Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF Proc. Natl. Acad. Sci. USA 108 2011 6067 6072
46. J. Hu, E.C. Stites, H. Yu, E.A. Germino, H.S. Meharena, P.J.S. Stork, A.P. Kornev, S.S. Taylor, and A.S. Shaw Allosteric activation of functionally asymmetric RAF kinase dimers Cell 154 2013 1036 1046
47. H. Huang, E. Zeqiraj, B. Dong, B.K. Jha, N.M. Duffy, S. Orlicky, N. Thevakumaran, M. Talukdar, M.C. Pillon, D.F. Ceccarelli, and et al. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity Mol. Cell 53 2014 221 234
48. M. Huse, and J. Kuriyan The conformational plasticity of protein kinases Cell 109 2002 275 282
49. T. Igishi, S. Fukuhara, V. Patel, B.Z. Katz, K.M. Yamada, and J.S. Gutkind Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation J. Biol. Chem. 274 1999 30738 30746
50. N. Jura, N.F. Endres, K. Engel, S. Deindl, R. Das, M.H. Lamers, D.E. Wemmer, X. Zhang, and J. Kuriyan Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment Cell 137 2009 1293 1307
51. N. Jura, Y. Shan, X. Cao, D.E. Shaw, and J. Kuriyan Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3 Proc. Natl. Acad. Sci. USA 106 2009 21608 21613
52. N. Jura, X. Zhang, N.F. Endres, M.A. Seeliger, T. Schindler, and J. Kuriyan Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms Mol. Cell 42 2011 9 22
53. W.J. Kaiser, H. Sridharan, C. Huang, P. Mandal, J.W. Upton, P.J. Gough, C.A. Sehon, R.W. Marquis, J. Bertin, and E.S. Mocarski Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL J. Biol. Chem. 288 2013 31268 31279
54. T.-H. Kang, and K.-T. Kim Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase Nat. Cell Biol. 8 2006 863 869
55. J.-I. Kang, and B.-Y. Ahn HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2 Biochem. Biophys. Res. Comm. 407 2011 248 253
56. H. Katsuta, S. Tsuji, Y. Niho, T. Kurosaki, and D. Kitamura Lyn-mediated down-regulation of B cell antigen receptor signaling: inhibition of protein kinase C activation by Lyn in a kinase-independent fashion J. Immunol. 160 1998 1547 1551
57. K. Keeshan, Y. He, B.J. Wouters, O. Shestova, L. Xu, H. Sai, C.G. Rodriguez, I. Maillard, J.W. Tobias, P. Valk, and et al. Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia Cancer Cell 10 2006 401 411
58. M.A. Kelliher, S. Grimm, Y. Ishida, F. Kuo, B.Z. Stanger, and P. Leder The death domain kinase RIP mediates the TNF-induced NF-kappaB signal Immunity 8 1998 297 303
59. E. Kiss-Toth, S.M. Bagstaff, H.Y. Sung, V. Jozsa, C. Dempsey, J.C. Caunt, K.M. Oxley, D.H. Wyllie, T. Polgar, M. Harte, and et al. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades J. Biol. Chem. 279 2004 42703 42708
60. W. Kolch Coordinating ERK/MAPK signalling through scaffolds and inhibitors Nat. Rev. Mol. Cell Biol. 6 2005 827 837
61. K. Kollmann, G. Heller, C. Schneckenleithner, W. Warsch, R. Scheicher, R.G. Ott, M. Schäfer, S. Fajmann, M. Schlederer, A.-I. Schiefer, and et al. A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis Cancer Cell 24 2013 167 181
62. A.V. Korennykh, P.F. Egea, A.A. Korostelev, J. Finer-Moore, R.M. Stroud, C. Zhang, K.M. Shokat, and P. Walter Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 BMC Biol. 9 2011 48
63. A.V. Korennykh, P.F. Egea, A.A. Korostelev, J. Finer-Moore, C. Zhang, K.M. Shokat, R.M. Stroud, and P. Walter The unfolded protein response signals through high-order assembly of Ire1 Nature 457 2009 687 693
64. K. Kullander, N.K. Mather, F. Diella, M. Dottori, A.W. Boyd, and R. Klein Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo Neuron 29 2001 73 84
65. L.K. Langeberg, and J.D. Scott Signalling scaffolds and local organization of cellular behaviour Nat. Rev. Mol. Cell Biol. 16 2015 232 244
66. K.P.K. Lee, M. Dey, D. Neculai, C. Cao, T.E. Dever, and F. Sicheri Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing Cell 132 2008 89 100
67. J. Lennartsson, R. Shivakrupa, and D. Linnekin Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit J. Biol. Chem. 279 2004 44544 44553
68. B.W. Lin, Y.C. Wang, P.Y. Chang-Liao, Y.J. Lin, S.T. Yang, J.H. Tsou, K.C. Chang, Y.W. Liu, J.T. Tseng, C.T. Lee, and et al. Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B Cell Death Dis. 5 2014 e1106
69. P. Littlefield, L. Liu, V. Mysore, Y. Shan, D.E. Shaw, and N. Jura Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations Sci. Signal. 7 2014 ra114
70. N.C. Luetteke, H.K. Phillips, T.H. Qiu, N.G. Copeland, H.S. Earp, N.A. Jenkins, and D.C. Lee The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase Genes Dev. 8 1994 399 413
71. P.J. Lupardus, M. Ultsch, H. Wallweber, P. Bir Kohli, A.R. Johnson, and C. Eigenbrot Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for janus kinase (JAK) autoinhibition Proc. Natl. Acad. Sci. USA 111 2014 8025 8030
72. S. Maddika, and J. Chen Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase Nature 11 2009 409 419
73. P. Mandal, S.B. Berger, S. Pillay, K. Moriwaki, C. Huang, H. Guo, J.D. Lich, J. Finger, V. Kasparcova, B. Votta, and et al. RIP3 induces apoptosis independent of pronecrotic kinase activity Mol. Cell 56 2014 481 495
74. G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 1912 1934
75. M.M. McKay, D.A. Ritt, and D.K. Morrison RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling Curr. Biol. 21 2011 563 568
76. A.S. Mendez, J. Alfaro, M.A. Morales-Soto, A.C. Dar, E. McCullagh, K. Gotthardt, H. Li, D. Acosta-Alvear, C. Sidrauski, A.V. Korennykh, and et al. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic ELife 4 2015 10.7554/eLife.05434
77. J.M. Mendrola, F. Shi, J.H. Park, and M.A. Lemmon Receptor tyrosine kinases with intracellular pseudokinase domains Biochem. Soc. Trans. 41 2013 1029 1036
78. K.A. Merrick, L. Wohlbold, C. Zhang, J.J. Allen, D. Horiuchi, N.E. Huskey, A. Goga, K.M. Shokat, and R.P. Fisher Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation Mol. Cell 42 2011 624 636
79. H. Miao, K. Strebhardt, E.B. Pasquale, T.L. Shen, J.L. Guan, and B. Wang Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases J. Biol. Chem. 280 2005 923 932
80. P.J. Miettinen, J.E. Berger, J. Meneses, Y. Phung, R.A. Pedersen, Z. Werb, and R. Derynck Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor Nature 376 1995 337 341
81. M. Mitsushima, F. Toyoshima, and E. Nishida Dual role of Cdc42 in spindle orientation control of adherent cells Mol. Cell. Biol. 29 2009 2816 2827
82. J. Monsey, W. Shen, P. Schlesinger, and R. Bose Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system J. Biol. Chem. 285 2010 7035 7044
83. J. Mooz, T.K. Oberoi-Khanuja, G.S. Harms, W. Wang, B.S. Jaiswal, S. Seshagiri, R. Tikkanen, and K. Rajalingam Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration Sci. Signal. 7 2014 ra73
84. M.E. Moreno-García, K. Sommer, H. Rincon-Arano, M. Brault, J. Ninomiya-Tsuji, L.E. Matesic, and D.J. Rawlings Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation Mol. Cell. Biol. 33 2013 1149 1163
85. J.M. Murphy, P.E. Czabotar, J.M. Hildebrand, I.S. Lucet, J.-G. Zhang, S. Alvarez-Diaz, R. Lewis, N. Lalaoui, D. Metcalf, A.I. Webb, and et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism Immunity 39 2013 443 453
86. J.M. Murphy, Q. Zhang, S.N. Young, M.L. Reese, F.P. Bailey, P.A. Eyers, D. Ungureanu, H. Hammarén, O. Silvennoinen, L.N. Varghese, and et al. A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties Biochem. J. 457 2013 323 334
87. J.M. Murphy, Y. Nakatani, S.A. Jamieson, W. Dai, I.S. Lucet, and P.D. Mace Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase Structure 23 2015 2111 2121
88. K. Newton, D.L. Dugger, K.E. Wickliffe, N. Kapoor, M.C. de Almagro, D. Vucic, L. Komuves, R.E. Ferrando, D.M. French, J. Webster, and et al. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis Science 343 2014 1357 1360
89. V. Nikoletopoulou, H. Lickert, J.M. Frade, C. Rencurel, P. Giallonardo, L. Zhang, M. Bibel, and Y.A. Barde Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not Nature 467 2010 59 63
90. T. Okuzumi, D. Fiedler, C. Zhang, D.C. Gray, B. Aizenstein, R. Hoffman, and K.M. Shokat Inhibitor hijacking of Akt activation Nat. Chem. Biol. 5 2009 484 493
91. T. Otto, S. Horn, M. Brockmann, U. Eilers, L. Schüttrumpf, N. Popov, A.M. Kenney, J.H. Schulte, R. Beijersbergen, H. Christiansen, and et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma Cancer Cell 15 2009 67 78
92. F.R. Papa, C. Zhang, K. Shokat, and P. Walter Bypassing a kinase activity with an ATP-competitive drug Science 302 2003 1533 1537
93. R. Perrault, B. Wright, B. Storie, A. Hatherell, and P. Zahradka Tyrosine kinase-independent activation of extracellular-regulated kinase (ERK) 1/2 by the insulin-like growth factor-1 receptor Cell Signal. 23 2011 739 746
94. P.I. Poulikakos, C. Zhang, G. Bollag, K.M. Shokat, and N. Rosen RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Nature 464 2010 427 430
95. L. Qi, J.E. Heredia, J.Y. Altarejos, R. Screaton, N. Goebel, S. Niessen, I.X. Macleod, C.W. Liew, R.N. Kulkarni, J. Bain, and et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism Science 312 2006 1763 1766
96. H. Qi, M. Jin, Y. Duan, X. Du, Y. Zhang, F. Ren, Y. Wang, Q. Tian, X. Wang, Q. Wang, and et al. FGFR3 induces degradation of BMP type I receptor to regulate skeletal development Biochim. Biophys. Acta 1843 2014 1237 1247
97. C. Qiu, M.K. Tarrant, S.H. Choi, A. Sathyamurthy, R. Bose, S. Banjade, A. Pal, W.G. Bornmann, M.A. Lemmon, P.A. Cole, and et al. Mechanism of activation and inhibition of the HER4/ErbB4 kinase Structure 16 2008 460 467
98. T. Rajakulendran, M. Sahmi, M. Lefrançois, F. Sicheri, and M. Therrien A dimerization-dependent mechanism drives RAF catalytic activation Nature 461 2009 542 545
99. M.L. Reese, and J.C. Boothroyd A conserved non-canonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on toxoplasma virulence J. Biol. Chem. 286 2011 29366 29375
100. M.L. Reese, N. Shah, and J.C. Boothroyd The toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases J. Biol. Chem. 289 2014 27849 27858
101. J. Rodriguez, F. Calvo, J.M. González, B. Casar, V. Andrés, and P. Crespo ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes J. Cell Biol. 191 2010 967 979
102. J. Rossy, D.M. Owen, D.J. Williamson, Z. Yang, and K. Gaus Conformational states of the kinase Lck regulate clustering in early T cell signaling Nat. Immunol. 14 2012 82 89
103. T. Sapir, S. Sapoznik, T. Levy, D. Finkelshtein, A. Shmueli, T. Timm, E.M. Mandelkow, and O. Reiner Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration J. Neurosci. 28 2008 5710 5720
104. E.D. Scheeff, J. Eswaran, G. Bunkoczi, S. Knapp, and G. Manning Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site Structure 17 2009 128 138
105. Y. Shan, K. Gnanasambandan, D. Ungureanu, E.T. Kim, H. Hammarén, K. Yamashita, O. Silvennoinen, D.E. Shaw, and S.R. Hubbard Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase Nat. Struct. Mol. Biol. 21 2014 579 584
106. P.S. Shapiro, A.M. Whalen, N.S. Tolwinski, J. Wilsbacher, S.J. Froelich-Ammon, M. Garcia, N. Osheroff, and N.G. Ahn Extracellular signal-regulated kinase activates topoisomerase IIα through a mechanism independent of phosphorylation Mol. Cell. Biol. 19 1999 3551 3560
107. F. Shi, S.E. Telesco, Y. Liu, R. Radhakrishnan, and M.A. Lemmon ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation Proc. Natl. Acad. Sci. USA 107 2010 7692 7697
108. J. Stamos, M.X. Sliwkowski, and C. Eigenbrot Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor J. Biol. Chem. 277 2002 46265 46272
109. S.S. Taylor, and A.P. Kornev Protein kinases: evolution of dynamic regulatory proteins Trends Biochem. Sci. 36 2011 65 77
110. N. Thevakumaran, H. Lavoie, D.A. Critton, A. Tebben, A. Marinier, F. Sicheri, and M. Therrien Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation Nat. Struct. Mol. Biol. 22 2015 37 43
111. L.N. Varghese, D. Ungureanu, N.P.D. Liau, S.N. Young, A. Laktyushin, H. Hammarén, I.S. Lucet, N.A. Nicola, O. Silvennoinen, J.J. Babon, and et al. Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses Biochem. J. 458 2014 395 405
112. I. Vivanco, Z.C. Chen, B. Tanos, B. Oldrini, W.Y. Hsieh, N. Yannuzzi, C. Campos, and I.K. Mellinghoff A kinase-independent function of AKT promotes cancer cell survival ELife 3 2014 e03571
113. P.T.C. Wan, M.J. Garnett, S.M. Roe, S. Lee, D. Niculescu-Duvaz, V.M. Good, C.G. Project, C.M. Jones, C.J. Marshall, C.J. Springer, and et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Cell 116 2004 855 867
114. L. Wang, B.G.K. Perera, S.B. Hari, B. Bhhatarai, B.J. Backes, M.A. Seeliger, S.C. Schürer, S.A. Oakes, F.R. Papa, and D.J. Maly Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors Nat. Chem. Biol. 8 2012 982 989
115. H. Wang, L. Sun, L. Su, J. Rizo, L. Liu, L.-F. Wang, F.-S. Wang, and X. Wang Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3 Mol. Cell 54 2014 133 146
116. F. Weis-Garcia, and J. Massagué Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling EMBO J. 15 1996 276 289
117. S. Wenglowsky, L. Ren, K.A. Ahrendt, E.R. Laird, I. Aliagas, B. Alicke, A.J. Buckmelter, E.F. Choo, V. Dinkel, B. Feng, and et al. Pyrazolopyridine inhibitors of B-Raf(V600E). Part 1: the development of selective, orally bioavailable, and efficacious inhibitors ACS Med. Chem. Lett. 2 2011 342 347
118. T. Xie, W. Peng, C. Yan, J. Wu, X. Gong, and Y. Shi Structural insights into RIP3-mediated necroptotic signaling Cell Rep. 5 2013 70 78
119. S. Xu, M. Tong, J. Huang, Y. Zhang, Y. Qiao, W. Weng, W. Liu, J. Wang, and F. Sun TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells FEBS Lett. 588 2014 4334 4341
120. T. Yokoyama, Y. Kanno, Y. Yamazaki, T. Takahara, S. Miyata, and T. Nakamura Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis Blood 116 2010 2768 2775
121. E. Zeqiraj, B.M. Filippi, M. Deak, D.R. Alessi, and D.M.F. van Aalten Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation Science 326 2009 1707 1711
122. E. Zeqiraj, B.M. Filippi, S. Goldie, I. Navratilova, J. Boudeau, M. Deak, D.R. Alessi, and D.M.F. van Aalten ATP and MO25α regulate the conformational state of the STRADα pseudokinase and activation of the LKB1 tumour suppressor PLoS Biol. 7 2009 e1000126
123. M. Zhang, and H. Riedel Insulin receptor kinase-independent signaling via tyrosine phosphorylation of phosphatase PHLPP1 J. Cell. Biochem. 107 2009 65 75
124. X. Zhang, J. Gureasko, K. Shen, P.A. Cole, and J. Kuriyan An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor Cell 125 2006 1137 1149
125. X. Zhang, K.A. Pickin, R. Bose, N. Jura, P.A. Cole, and J. Kuriyan Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface Nature 450 2007 741 744
126. X. Zhao, X. Peng, S. Sun, A.Y. Park, and J.L. Guan Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development J. Cell Biol. 189 2010 955 965
127. R. Zhu, X. Lu, M. Pradhan, S.P. Armstrong, G.B. Storchan, C.C. Chow, and S.S. Simons Jr. A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction Biochemistry 53 2014 1753 1767