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Volumn 7, Issue 12, 2012, Pages

Non-Catalytic Functions of Pyk2 and Fyn Regulate Late Stage Adhesion in Human T Cells

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE FYN; T LYMPHOCYTE RECEPTOR;

EID: 84871645790     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053011     Document Type: Article
Times cited : (20)

References (48)
  • 1
    • 44049096985 scopus 로고    scopus 로고
    • T cell activation and the cytoskeleton: you can't have one without the other
    • Gomez TS, Billadeau DD, (2008) T cell activation and the cytoskeleton: you can't have one without the other. Adv Immunol 97: 1-64.
    • (2008) Adv Immunol , vol.97 , pp. 1-64
    • Gomez, T.S.1    Billadeau, D.D.2
  • 3
    • 78649895015 scopus 로고    scopus 로고
    • Cytoskeletal cross-talk in the control of T cell antigen receptor signaling
    • Lasserre R, Alcover A, (2010) Cytoskeletal cross-talk in the control of T cell antigen receptor signaling. FEBS Lett 584: 4845-4850.
    • (2010) FEBS Lett , vol.584 , pp. 4845-4850
    • Lasserre, R.1    Alcover, A.2
  • 4
    • 81755165750 scopus 로고    scopus 로고
    • Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases
    • Cleland SY, Siegel RM, (2011) Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases. FEBS Lett 585: 3710-3714.
    • (2011) FEBS Lett , vol.585 , pp. 3710-3714
    • Cleland, S.Y.1    Siegel, R.M.2
  • 5
    • 78649854248 scopus 로고    scopus 로고
    • Multiple pathways leading from the T-cell antigen receptor to the actin cytoskeleton network
    • Reicher B, Barda-Saad M, (2010) Multiple pathways leading from the T-cell antigen receptor to the actin cytoskeleton network. FEBS Lett 584: 4858-4864.
    • (2010) FEBS Lett , vol.584 , pp. 4858-4864
    • Reicher, B.1    Barda-Saad, M.2
  • 6
    • 79951669207 scopus 로고    scopus 로고
    • The immune system in atherosclerosis
    • Hansson GK, Hermansson A, (2011) The immune system in atherosclerosis. Nat Immunol 12: 204-212.
    • (2011) Nat Immunol , vol.12 , pp. 204-212
    • Hansson, G.K.1    Hermansson, A.2
  • 7
    • 82955195629 scopus 로고    scopus 로고
    • T cell-driven initiation and propagation of autoimmune diabetes
    • Bettini M, Vignali DA, (2011) T cell-driven initiation and propagation of autoimmune diabetes. Curr Opin Immunol 23: 754-760.
    • (2011) Curr Opin Immunol , vol.23 , pp. 754-760
    • Bettini, M.1    Vignali, D.A.2
  • 9
    • 0035075507 scopus 로고    scopus 로고
    • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT
    • Bunnell SC, Kapoor V, Trible RP, Zhang W, Samelson LE, (2001) Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14: 315-329.
    • (2001) Immunity , vol.14 , pp. 315-329
    • Bunnell, S.C.1    Kapoor, V.2    Trible, R.P.3    Zhang, W.4    Samelson, L.E.5
  • 10
    • 12344272845 scopus 로고    scopus 로고
    • Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton
    • Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, et al. (2005) Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat Immunol 6: 80-89.
    • (2005) Nat Immunol , vol.6 , pp. 80-89
    • Barda-Saad, M.1    Braiman, A.2    Titerence, R.3    Bunnell, S.C.4    Barr, V.A.5
  • 11
    • 0034536632 scopus 로고    scopus 로고
    • Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner
    • Borroto A, Gil D, Delgado P, Vicente-Manzanares M, Alcover A, et al. (2000) Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner. Eur J Immunol 30: 3403-3410.
    • (2000) Eur J Immunol , vol.30 , pp. 3403-3410
    • Borroto, A.1    Gil, D.2    Delgado, P.3    Vicente-Manzanares, M.4    Alcover, A.5
  • 12
    • 18244368702 scopus 로고    scopus 로고
    • Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function
    • Ostergaard HL, Lysechko TL, (2005) Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function. Immunol Res 31: 267-282.
    • (2005) Immunol Res , vol.31 , pp. 267-282
    • Ostergaard, H.L.1    Lysechko, T.L.2
  • 13
    • 77951184829 scopus 로고    scopus 로고
    • Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
    • Schaller MD, (2010) Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci 123: 1007-1013.
    • (2010) J Cell Sci , vol.123 , pp. 1007-1013
    • Schaller, M.D.1
  • 14
    • 0031571195 scopus 로고    scopus 로고
    • T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck
    • Berg NN, Ostergaard HL, (1997) T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck. J Immunol 159: 1753-1757.
    • (1997) J Immunol , vol.159 , pp. 1753-1757
    • Berg, N.N.1    Ostergaard, H.L.2
  • 15
    • 66849101632 scopus 로고    scopus 로고
    • Adhesion signaling - crosstalk between integrins, Src and Rho
    • Huveneers S, Danen EH, (2009) Adhesion signaling- crosstalk between integrins, Src and Rho. J Cell Sci 122: 1059-1069.
    • (2009) J Cell Sci , vol.122 , pp. 1059-1069
    • Huveneers, S.1    Danen, E.H.2
  • 17
    • 77950579398 scopus 로고    scopus 로고
    • The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems
    • Collins M, Tremblay M, Chapman N, Curtiss M, Rothman PB, et al. (2010) The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. J Leukoc Biol 87: 691-701.
    • (2010) J Leukoc Biol , vol.87 , pp. 691-701
    • Collins, M.1    Tremblay, M.2    Chapman, N.3    Curtiss, M.4    Rothman, P.B.5
  • 18
    • 77952321910 scopus 로고    scopus 로고
    • T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells
    • Collins M, Bartelt RR, Houtman JC, (2010) T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells. Mol Immunol 47: 1665-1674.
    • (2010) Mol Immunol , vol.47 , pp. 1665-1674
    • Collins, M.1    Bartelt, R.R.2    Houtman, J.C.3
  • 19
    • 0030902281 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling
    • Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, et al. (1997) Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J Exp Med 185: 1253-1259.
    • (1997) J Exp Med , vol.185 , pp. 1253-1259
    • Qian, D.1    Lev, S.2    van Oers, N.S.3    Dikic, I.4    Schlessinger, J.5
  • 20
    • 79151485101 scopus 로고    scopus 로고
    • Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells
    • St-Pierre J, Lysechko TL, Ostergaard HL, (2011) Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells. Cell Signal 23: 718-730.
    • (2011) Cell Signal , vol.23 , pp. 718-730
    • St-Pierre, J.1    Lysechko, T.L.2    Ostergaard, H.L.3
  • 21
    • 0036644069 scopus 로고    scopus 로고
    • TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion
    • Sancho D, Montoya MC, Monjas A, Gordon-Alonso M, Katagiri T, et al. (2002) TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion. J Immunol 169: 292-300.
    • (2002) J Immunol , vol.169 , pp. 292-300
    • Sancho, D.1    Montoya, M.C.2    Monjas, A.3    Gordon-Alonso, M.4    Katagiri, T.5
  • 22
    • 79957621253 scopus 로고    scopus 로고
    • The insider's guide to leukocyte integrin signalling and function
    • Hogg N, Patzak I, Willenbrock F, (2011) The insider's guide to leukocyte integrin signalling and function. Nat Rev Immunol 11: 416-426.
    • (2011) Nat Rev Immunol , vol.11 , pp. 416-426
    • Hogg, N.1    Patzak, I.2    Willenbrock, F.3
  • 23
    • 84863258188 scopus 로고    scopus 로고
    • Integrin signalling and function in immune cells
    • Zhang Y, Wang H, (2012) Integrin signalling and function in immune cells. Immunology 135: 268-275.
    • (2012) Immunology , vol.135 , pp. 268-275
    • Zhang, Y.1    Wang, H.2
  • 24
    • 44649191160 scopus 로고    scopus 로고
    • T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76
    • Nguyen K, Sylvain NR, Bunnell SC, (2008) T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. Immunity 28: 810-821.
    • (2008) Immunity , vol.28 , pp. 810-821
    • Nguyen, K.1    Sylvain, N.R.2    Bunnell, S.C.3
  • 25
    • 0037444474 scopus 로고    scopus 로고
    • The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis-dependent target cell killing
    • Lyubchenko TA, Wurth GA, Zweifach A, (2003) The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis-dependent target cell killing. J Physiol 547: 835-847.
    • (2003) J Physiol , vol.547 , pp. 835-847
    • Lyubchenko, T.A.1    Wurth, G.A.2    Zweifach, A.3
  • 26
    • 25444486136 scopus 로고    scopus 로고
    • Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes
    • Shen A, Puente LG, Ostergaard HL, (2005) Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes. Immunology 116: 276-286.
    • (2005) Immunology , vol.116 , pp. 276-286
    • Shen, A.1    Puente, L.G.2    Ostergaard, H.L.3
  • 27
    • 61849128182 scopus 로고    scopus 로고
    • T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
    • Salmond RJ, Filby A, Qureshi I, Caserta S, Zamoyska R, (2009) T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol Rev 228: 9-22.
    • (2009) Immunol Rev , vol.228 , pp. 9-22
    • Salmond, R.J.1    Filby, A.2    Qureshi, I.3    Caserta, S.4    Zamoyska, R.5
  • 28
    • 36549009460 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation
    • Alcazar I, Marques M, Kumar A, Hirsch E, Wymann M, et al. (2007) Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation. J Exp Med 204: 2977-2987.
    • (2007) J Exp Med , vol.204 , pp. 2977-2987
    • Alcazar, I.1    Marques, M.2    Kumar, A.3    Hirsch, E.4    Wymann, M.5
  • 29
    • 67349125816 scopus 로고    scopus 로고
    • PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes
    • Cruz-Orcutt N, Houtman JC, (2009) PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes. Mol Immunol 46: 2274-2283.
    • (2009) Mol Immunol , vol.46 , pp. 2274-2283
    • Cruz-Orcutt, N.1    Houtman, J.C.2
  • 30
    • 0026793938 scopus 로고
    • Wortmannin, a microbial product inhibitor of myosin light chain kinase
    • Nakanishi S, Kakita S, Takahashi I, Kawahara K, Tsukuda E, et al. (1992) Wortmannin, a microbial product inhibitor of myosin light chain kinase. J Biol Chem 267: 2157-2163.
    • (1992) J Biol Chem , vol.267 , pp. 2157-2163
    • Nakanishi, S.1    Kakita, S.2    Takahashi, I.3    Kawahara, K.4    Tsukuda, E.5
  • 31
    • 79952772660 scopus 로고    scopus 로고
    • Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells
    • Shim EK, Jung SH, Lee JR, (2011) Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells. J Immunol 186: 2926-2935.
    • (2011) J Immunol , vol.186 , pp. 2926-2935
    • Shim, E.K.1    Jung, S.H.2    Lee, J.R.3
  • 32
    • 69249089318 scopus 로고    scopus 로고
    • B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading
    • Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, et al. (2009) B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem 284: 22865-22877.
    • (2009) J Biol Chem , vol.284 , pp. 22865-22877
    • Tse, K.W.1    Dang-Lawson, M.2    Lee, R.L.3    Vong, D.4    Bulic, A.5
  • 34
    • 0035254857 scopus 로고    scopus 로고
    • A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT
    • Ku GM, Yablonski D, Manser E, Lim L, Weiss A, (2001) A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J 20: 457-465.
    • (2001) EMBO J , vol.20 , pp. 457-465
    • Ku, G.M.1    Yablonski, D.2    Manser, E.3    Lim, L.4    Weiss, A.5
  • 35
    • 45649085424 scopus 로고    scopus 로고
    • Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity
    • Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, et al. (2008) Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J Mol Biol 380: 704-716.
    • (2008) J Mol Biol , vol.380 , pp. 704-716
    • Takeuchi, K.1    Yang, H.2    Ng, E.3    Park, S.Y.4    Sun, Z.Y.5
  • 36
    • 34548732682 scopus 로고    scopus 로고
    • Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon
    • Kesti T, Ruppelt A, Wang JH, Liss M, Wagner R, et al. (2007) Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. J Immunol 179: 878-885.
    • (2007) J Immunol , vol.179 , pp. 878-885
    • Kesti, T.1    Ruppelt, A.2    Wang, J.H.3    Liss, M.4    Wagner, R.5
  • 37
    • 0037188899 scopus 로고    scopus 로고
    • Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
    • Gil D, Schamel WW, Montoya M, Sanchez-Madrid F, Alarcon B, (2002) Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109: 901-912.
    • (2002) Cell , vol.109 , pp. 901-912
    • Gil, D.1    Schamel, W.W.2    Montoya, M.3    Sanchez-Madrid, F.4    Alarcon, B.5
  • 38
    • 77954887980 scopus 로고    scopus 로고
    • Cooperative interactions at the SLP-76 complex are critical for actin polymerization
    • Barda-Saad M, Shirasu N, Pauker MH, Hassan N, Perl O, et al. (2010) Cooperative interactions at the SLP-76 complex are critical for actin polymerization. EMBO J 29: 2315-2328.
    • (2010) EMBO J , vol.29 , pp. 2315-2328
    • Barda-Saad, M.1    Shirasu, N.2    Pauker, M.H.3    Hassan, N.4    Perl, O.5
  • 39
    • 84860246467 scopus 로고    scopus 로고
    • Studying the Dynamics of SLP-76, Nck, and Vav1 Multimolecular Complex Formation in Live Human Cells with Triple-Color FRET
    • Pauker MH, Hassan N, Noy E, Reicher B, Barda-Saad M, (2012) Studying the Dynamics of SLP-76, Nck, and Vav1 Multimolecular Complex Formation in Live Human Cells with Triple-Color FRET. Sci Signal 5: rs3.
    • (2012) Sci Signal , vol.5
    • Pauker, M.H.1    Hassan, N.2    Noy, E.3    Reicher, B.4    Barda-Saad, M.5
  • 40
    • 80053130680 scopus 로고    scopus 로고
    • New insights into the T cell synapse from single molecule techniques
    • Dustin ML, Depoil D, (2011) New insights into the T cell synapse from single molecule techniques. Nat Rev Immunol 11: 672-684.
    • (2011) Nat Rev Immunol , vol.11 , pp. 672-684
    • Dustin, M.L.1    Depoil, D.2
  • 42
    • 0034733743 scopus 로고    scopus 로고
    • Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402
    • Katagiri T, Takahashi T, Sasaki T, Nakamura S, Hattori S, (2000) Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402. J Biol Chem 275: 19645-19652.
    • (2000) J Biol Chem , vol.275 , pp. 19645-19652
    • Katagiri, T.1    Takahashi, T.2    Sasaki, T.3    Nakamura, S.4    Hattori, S.5
  • 43
    • 65649111192 scopus 로고    scopus 로고
    • A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation
    • Gao C, Blystone SD, (2009) A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation. Biochem J 420: 49-56.
    • (2009) Biochem J , vol.420 , pp. 49-56
    • Gao, C.1    Blystone, S.D.2
  • 44
    • 34247380314 scopus 로고    scopus 로고
    • Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells
    • Samayawardhena LA, Kapur R, Craig AW, (2007) Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. Blood 109: 3679-3686.
    • (2007) Blood , vol.109 , pp. 3679-3686
    • Samayawardhena, L.A.1    Kapur, R.2    Craig, A.W.3
  • 45
    • 33751376416 scopus 로고    scopus 로고
    • A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers
    • Dietz AB, Bulur PA, Emery RL, Winters JL, Epps DE, et al. (2006) A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers. Transfusion 46: 2083-2089.
    • (2006) Transfusion , vol.46 , pp. 2083-2089
    • Dietz, A.B.1    Bulur, P.A.2    Emery, R.L.3    Winters, J.L.4    Epps, D.E.5
  • 46
    • 61649128003 scopus 로고    scopus 로고
    • Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiency
    • Keck K, Volper EM, Spengler RM, Long DD, Chan CY, et al. (2009) Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiency. Mol Ther 17: 538-547.
    • (2009) Mol Ther , vol.17 , pp. 538-547
    • Keck, K.1    Volper, E.M.2    Spengler, R.M.3    Long, D.D.4    Chan, C.Y.5
  • 47
    • 65549139807 scopus 로고    scopus 로고
    • Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells
    • Bartelt RR, Cruz-Orcutt N, Collins M, Houtman JC, (2009) Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells. PLoS One 4: e5430.
    • (2009) PLoS One , vol.4
    • Bartelt, R.R.1    Cruz-Orcutt, N.2    Collins, M.3    Houtman, J.C.4
  • 48
    • 33749171235 scopus 로고    scopus 로고
    • Persistence of cooperatively stabilized signaling clusters drives T-cell activation
    • Bunnell SC, Singer AL, Hong DI, Jacque BH, Jordan MS, et al. (2006) Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol 26: 7155-7166.
    • (2006) Mol Cell Biol , vol.26 , pp. 7155-7166
    • Bunnell, S.C.1    Singer, A.L.2    Hong, D.I.3    Jacque, B.H.4    Jordan, M.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.